Bispecific Antibodies and Antibody-Drug Conjugates (ADCs) Bridging HER2 and Prolactin Receptor Improve Efficacy of HER2 ADCs von Andreev, Julian, Thambi, Nithya, Perez Bay, Andres E, Delfino, Frank, Martin, Joel, Kelly, Marcus P, Kirshner, Jessica R, Rafique, Ashique, Kunz, Arthur, Nittoli, Thomas, MacDonald, Douglas, Daly, Christopher, Olson, William, Thurston, Gavin

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A Biparatopic Antibody-Drug Conjugate to Treat MET-Expressing Cancers, Including Those that Are Unresponsive to MET Pathway Blockade von DaSilva, John O., Yang, Katie, Surriga, Oliver, Nittoli, Thomas, Kunz, Arthur, Franklin, Matthew C., Delfino, Frank J., Mao, Shu, Zhao, Feng, Giurleo, Jason T., Kelly, Marcus P., Makonnen, Sosina, Hickey, Carlos, Krueger, Pamela, Foster, Randi, Chen, Zhaoyuan, Retter, Marc W., Slim, Rabih, Young, Tara M., Olson, William C., Thurston, Gavin, Daly, Christopher

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Antibody-targeted NY-ESO-1 to mannose receptor or DEC-205 in vitro elicits dual human CD8+ and CD4+ T cell responses with broad antigen specificity von Tsuji, Takemasa, Matsuzaki, Junko, Kelly, Marcus P, Ramakrishna, Venky, Vitale, Laura, He, Li-Zhen, Keler, Tibor, Odunsi, Kunle, Old, Lloyd J, Ritter, Gerd, Gnjatic, Sacha

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Antibody drug conjugates of cleavable amino-alkyl and aryl maytansinoids von Nittoli, Thomas, Kelly, Marcus P., Delfino, Frank, Rudge, John, Kunz, Arthur, Markotan, Thomas, Spink, Jan, Chen, Zhaoyuan, Shan, Jing, Navarro, Elizabeth, Tait, Michele, Provoncha, Kathleen, Giurleo, Jason, Zhao, Feng, Jiang, Xiaobo, Hylton, Donna, Makonnen, Sosina, Hickey, Carlos, Kirshner, Jessica R., Thurston, Gavin, Papadopoulos, Nicholas

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Preclinical Activity of the Novel Anti-Prolactin Receptor (PRLR) Antibody-Drug Conjugate REGN2878-DM1 in PRLR-Positive Breast Cancers von Kelly, Marcus P, Hickey, Carlos, Makonnen, Sosina, Coetzee, Sandra, Jalal, Sumreen, Wang, Yu, Delfino, Frank, Shan, Jing, Potocky, Terra B, Chatterjee, Ishita, Andreev, Julian, Kunz, Arthur, D'Souza, Christopher, Giurleo, Jason T, Nittoli, Thomas, Trail, Pamela A, Thurston, Gavin, Kirshner, Jessica R

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Preclinical PET imaging with the novel human antibody 89 Zr-DFO-REGN3504 sensitively detects PD-L1 expression in tumors and normal tissues von Kelly, Marcus P, Makonnen, Sosina, Hickey, Carlos, Arnold, T Cody, Giurleo, Jason T, Tavaré, Richard, Danton, Makenzie, Granados, Christian, Chatterjee, Ishita, Dudgeon, Drew, Retter, Marc W, Ma, Dangshe, Olson, William C, Thurston, Gavin, Kirshner, Jessica R

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Immuno-PET Monitoring of Lymphocytes Using the CD8-Specific Antibody REGN5054 von Tavaré, Richard, Danton, Makenzie, Giurleo, Jason T, Makonnen, Sosina, Hickey, Carlos, Arnold, Tomas C, Kelly, Marcus P, Fredriksson, Fanny, Bruestle, Karina, Hermann, Aynur, Ullman, Erica, Edelmann, Kurt H, Potocky, Terra, Dudgeon, Drew, Bhatt, Nikunj B, Doubrovin, Mikhail, Barry, Thomas, Kyratsous, Christos A, Gurer, Cagan, Tu, Naxin, Gartner, Hans, Murphy, Andrew, Macdonald, Lynn E, Popke, Jon, Mintz, Akiva, Griesemer, Adam, Olson, William C, Thurston, Gavin, Ma, Dangshe, Kirshner, Jessica R

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ImmunoPET Imaging of Endogenous and Transfected Prolactin Receptor Tumor Xenografts von Cheal, Sarah M, Ruan, Shutian, Veach, Darren R, Longo, Valerie A, Punzalan, Blesida J, Wu, Jiong, Fung, Edward K, Kelly, Marcus P, Kirshner, Jessica R, Giurleo, Jason T, Ehrlich, George, Han, Amy Q, Thurston, Gavin, Olson, William C, Zanzonico, Pat B, Larson, Steven M, Carrasquillo, Jorge A

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Radioimmunotherapy with α-Particle–Emitting 213Bi-C-Functionalized trans-Cyclohexyl-Diethylenetriaminepentaacetic Acid-Humanized 3S193 Is Enhanced by Combination with Paclitaxel Ch... von KELLY, Marcus P, LEE, Fook T, TAHTIS, Kiki, SMYTH, Fiona E, BRECHBIEL, Martin W, SCOTT, Andrew M

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Differential and Synergistic Effects of Epidermal Growth Factor Receptor Antibodies on Unliganded ErbB Dimers and Oligomers von Kozer, Noga, Kelly, Marcus P, Orchard, Suzanne, Burgess, Antony W, Scott, Andrew M, Clayton, Andrew H. A

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Preclinical PET imaging with the novel human antibody 89Zr-DFO-REGN3504 sensitively detects PD-L1 expression in tumors and normal tissues von Kelly, Marcus P, Makonnen, Sosina, Hickey, Carlos, Arnold, T Cody, Giurleo, Jason T, Tavaré, Richard, Danton, Makenzie, Granados, Christian, Chatterjee, Ishita, Dudgeon, Drew, Retter, Marc W, Ma, Dangshe, Olson, William C, Thurston, Gavin, Kirshner, Jessica R

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Therapeutic efficacy of 177Lu-CHX-A″-DTPA-hu3S193 radioimmunotherapy in prostate cancer is enhanced by EGFR inhibition or docetaxel chemotherapy von Kelly, Marcus P., Lee, Sze Ting, Lee, F.-T., Smyth, Fiona E., Davis, Ian D., Brechbiel, Martin W., Scott, Andrew M.

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Enhanced Efficacy of Radioimmunotherapy with 90Y-CHX-A″-DTPA-hu3S193 by Inhibition of Epidermal Growth Factor Receptor (EGFR) Signaling with EGFR Tyrosine Kinase Inhibitor AG1478 von LEE, Fook T, MOUNTAIN, Angela J, SCOTT, Andrew M, KELLY, Marcus P, HALL, Cathrine, RIGOPOULOS, Angela, JOHNS, Terrance G, SMYTH, Fiona E, BRECHBIEL, Martin W, NICE, Edouard C, BURGESS, Antony W

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Tumor targeting by a multivalent single-chain Fv (scFv) anti-Lewis Y antibody construct von Kelly, Marcus P, Lee, F-T, Tahtis, Kiki, Power, Barbara E, Smyth, Fiona E, Brechbiel, Martin W, Hudson, Peter J, Scott, Andrew M

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Abstract P134: Novel EGFRvIII-selective antibody-drug conjugate REGN3124-PBD is strongly efficacious against orthotopic glioblastoma multiforme patient derived xenografts von Kelly, Marcus P., Makonnen, Sosina, Hickey, Carlos, Mao, Shu, Zhao, Feng, Kunz, Arthur, Delfino, Frank, Nittoli, Thomas, Ma, Dangshe, Olson, William C., Thurston, Gavin, Kirshner, Jessica R.

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Generation of T-cell-redirecting bispecific antibodies with differentiated profiles of cytokine release and biodistribution by CD3 affinity tuning von Haber, Lauric, Olson, Kara, Kelly, Marcus P., Crawford, Alison, DiLillo, David J., Tavaré, Richard, Ullman, Erica, Mao, Shu, Canova, Lauren, Sineshchekova, Olga, Finney, Jennifer, Pawashe, Arpita, Patel, Supriya, McKay, Ryan, Rizvi, Sahar, Damko, Ermelinda, Chiu, Danica, Vazzana, Kristin, Ram, Priyanka, Mohrs, Katja, D’Orvilliers, Amanda, Xiao, Jenny, Makonnen, Sosina, Hickey, Carlos, Arnold, Cody, Giurleo, Jason, Chen, Ya Ping, Thwaites, Courtney, Dudgeon, Drew, Bray, Kevin, Rafique, Ashique, Huang, Tammy, Delfino, Frank, Hermann, Aynur, Kirshner, Jessica R., Retter, Marc W., Babb, Robert, MacDonald, Douglas, Chen, Gang, Olson, William C., Thurston, Gavin, Davis, Samuel, Lin, John C., Smith, Eric

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Abstract 1131: CD8 immuno-PET using a fully human mAb can detect increases in tumor-infiltrating T cells by a T cell activating immunotherapy von Tavare, Richard, Danton, Makenzie, Giurleo, Jason T., Kelly, Marcus P., Makonnen, Sosina, Hickey, Carlos, Arnold, Tomas C., Ma, Dangshe, Olson, William C., Thurston, Gavin, Kirshner, Jessica R.

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Abstract 3033: Immuno-PET detection of LAG-3 expressing intratumoral lymphocytes using the zirconium-89 radiolabeled fully human anti-LAG-3 antibody REGN3767 von Kelly, Marcus P., Tavare, Richard, Giurleo, Jason T., Makonnen, Sosina, Hickey, Carlos, Danton, Makenzie A., Arnold, T Cody, Ma, Dangshe, Dai, Jie, Pei, Jerry, Kirshner, Jessica R., Olson, William C., Thurston, Gavin

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Preclinical PET imaging with the novel human antibody Zr-89-DFO-REGN3504 sensitively detects PD-L1 expression in tumors and normal tissues von Kelly, Marcus P., Makonnen, Sosina, Hickey, Carlos, Arnold, T. Cody, Giurleo, Jason T., Tavare, Richard, Danton, Makenzie, Granados, Christian, Chatterjee, Ishita, Dudgeon, Drew, Retter, Marc W., Ma, Dangshe, Olson, William C., Thurston, Gavin, Kirshner, Jessica R.

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Abstract A131: Rapid constitutive internalization and degradation of prolactin receptor (PRLR) is associated with potent cell killing by PRLR antibody drug conjugates (ADC) von Andreev, Julian, Thambi, NIthya, Delfino, Frank, Martin, Joel, Kelly, Marcus P., Kirshner, Jessica R., MacDonald, Douglas, Popadopoulos, Nicholas, Olson, Willian, Thurston, Gavin

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