Crystal Structure of a Human IκB Kinase β Asymmetric Dimer von Liu, Shenping, Misquitta, Yohann R., Olland, Andrea, Johnson, Mark A., Kelleher, Kerry S., Kriz, Ron, Lin, Laura L., Stahl, Mark, Mosyak, Lidia

Volltext

Identification of Peptide Antagonists to Glycoprotein Ibα That Selectively Inhibit von Willebrand Factor Dependent Platelet Aggregation von Benard, Susan Adam, Smith, Thomas M, Cunningham, Kristina, Jacob, Jaison, DeSilva, Thamara, Lin, Laura, Shaw, Gray D, Kriz, Ron, Kelleher, Kerry S

Volltext

Relationship between domain closure and binding, catalysis, and regulation in Escherichia coli aspartate transcarbamylase von Ladjimi, Moncef M, Middleton, Steven A, Kelleher, Kerry S, Kantrowitz, Evan R

Volltext

Identification of peptide antagonists to glycoprotein Ibalpha that selectively inhibit von Willebrand factor dependent platelet aggregation von Benard, Susan Adam, Smith, Thomas M, Cunningham, Kristina, Jacob, Jaison, DeSilva, Thamara, Lin, Laura, Shaw, Gray D, Kriz, Ron, Kelleher, Kerry S

Volltext

Propagation of allosteric changes through the catalytic-regulatory interface of Escherichia coli aspartate transcarbamylase von Xu, Wei, Pitts, Margaret A, Middleton, Steven A, Kelleher, Kerry S, Kantrowitz, Evan R

Volltext

Photonic chip-based low-noise microwave oscillator von Kudelin, Igor, Groman, William, Ji, Qing-Xin, Guo, Joel, Kelleher, Megan L., Lee, Dahyeon, Nakamura, Takuma, McLemore, Charles A., Shirmohammadi, Pedram, Hanifi, Samin, Cheng, Haotian, Jin, Naijun, Wu, Lue, Halladay, Samuel, Luo, Yizhi, Dai, Zhaowei, Jin, Warren, Bai, Junwu, Liu, Yifan, Zhang, Wei, Xiang, Chao, Chang, Lin, Iltchenko, Vladimir, Miller, Owen, Matsko, Andrey, Bowers, Steven M., Rakich, Peter T., Campbell, Joe C., Bowers, John E., Vahala, Kerry J., Quinlan, Franklyn, Diddams, Scott A.

Volltext

Modeling and mitigation of high-concentration antibody viscosity through structure-based computer-aided protein design von Apgar, James R, Tam, Amy S P, Sorm, Rhady, Moesta, Sybille, King, Amy C, Yang, Han, Kelleher, Kerry, Murphy, Denise, D'Antona, Aaron M, Yan, Guoying, Zhong, Xiaotian, Rodriguez, Linette, Ma, Weijun, Ferguson, Darren E, Carven, Gregory J, Bennett, Eric M, Lin, Laura

Volltext

6 versus 12 months of adjuvant trastuzumab for HER2-positive early breast cancer (PERSEPHONE): 4-year disease-free survival results of a randomised phase 3 non-inferiority trial von Hiller, Louise, Vallier, Anne-Laure, McAdam, Karen, Hughes-Davies, Luke, Ah-See, Mei-Lin, Simcock, Richard, Rea, Daniel, Raj, Sanjay, Woodings, Pamela, Harries, Mark, Raynes, Kerry, Higgins, Helen B, Plummer, Chris, Mansi, Janine, Mahler–Araujo, Betania, Abraham, Jean E, Caldas, Carlos, McCabe, Christopher, Miles, David, Wardley, Andrew M, Cameron, David A, Agarwal, Roshan, Algurafi, Hafiz, Archer, Caroline, Armstrong, Anne, Bale, Catherine, Barraclough, Lisa, Barthakur, Urmila, Bedi, Carolyn, Benstead, Kim, Bloomfield, David, Bowen, Rebecca, Bradley, Chris, Brown, Jane, Butt, Mohammad, Churn, Mark, Cleator, Susan, Cliff, Joanne, Crellin, Perric, Daly, Margaret, De Silva-Minor, Shiroma, Dhadda, Amandeep, Din, Omar, Down, Sue, Earl, Helena, Eaton, David, Eichholz, Andrew, Epurescu, Daniel, Goh, Chee, Goodman, Andrew, Grieve, Robert, Hadaki, Maher, Harper-Wynne, Catherine, Harries, Mark, Hayward, Larry, Humphreys, Alison, Innes, Helen, Jafri, Mariam, Jegannathen, Apurna, Kelleher, Muireann, Kristeleit, Hartmut, Lee, Daniela, Lupton, Susan, MacGregor, Carol, Malik, Zafar, Mansi, Janine, Marshall, Jennifer, McAdam, Karen, McGolick, Trevor, Mehra, Rakesh, Miles, David, Mithal, Natasha, Moss, Charlotte, Moss, Aian, Nelmes, Daniel, Neville-Webbe, Helen, Newby, Jacqueline, O'Reilly, Susan, Ostler, Peter, Persic, Mojca, Pettit, Laura, Raj, Sanjay, Raja, Fharat, Rea, Daniel, Reed, Catherine, Rigg, Anne, Roe, Helen, Shah, Nihal, Simmonds, Peter, Sims, Eliot, Smith, Sarah, Storey, Nicola, Taylor, Wendy, Tipples, Karen, Vaidya, Jayant, Varughese, Mohini, Walji, Nawaz, Woodings, Pamela, Wright, Kathryn, Yahya, Sundus

Volltext

Chip-based laser with 1-hertz integrated linewidth von Guo, Joel, McLemore, Charles A., Xiang, Chao, Lee, Dahyeon, Wu, Lue, Jin, Warren, Kelleher, Megan, Jin, Naijun, Mason, David, Chang, Lin, Feshali, Avi, Paniccia, Mario, Rakich, Peter T., Vahala, Kerry J., Diddams, Scott A., Quinlan, Franklyn, Bowers, John E.

Volltext

Fc-GDF15 glyco-engineering and receptor binding affinity optimization for body weight regulation von Fung, Ella, Kang, Liya, Sapashnik, Diana, Benard, Susan, Sievers, Annette, Liu, Yan, Yan, Guoying, Zhou, Jing, Rodriguez, Linette, Ma, Weijun, Stochaj, Wayne R., LaVallie, Edward, Wroblewska, Liliana, Kelleher, Kerry, Tam, Amy, Bezy, Olivier, Breen, Danna, Chabot, Jeffrey R., He, Tao, Lin, Laura, Wu, Zhidan, Mosyak, Lidia

Volltext

Investigation of leucine‐rich repeat kinase 2 von Anand, Vasanti S., Reichling, Laurie J., Lipinski, Kerri, Stochaj, Wayne, Duan, Weili, Kelleher, Kerry, Pungaliya, Pooja, Brown, Eugene L., Reinhart, Peter H., Somberg, Richard, Hirst, Warren D., Riddle, Steven M., Braithwaite, Steven P.

Volltext

Developing a New PACU Overnight Unit Through Mentorship and Empowerment von Trefethen, Team Leader: Ian, Kelleher, Team Members: Evelyn, Kelly, Kerry, Moore, Erin, Salvi, Charlene

Volltext

In vitro affinity optimization of an anti-BDNF monoclonal antibody translates to improved potency in targeting chronic pain states in vivo von Stack, Edwina, McMurray, Sheridan, McMurray, Gordon, Wade, Jason, Clark, Melissa, Young, Gareth, Marquette, Kim, Jain, Sadhana, Kelleher, Kerry, Chen, Ting, Lin, Qingcong, Bloom, Laird, Lin, Laura, Finlay, William, Suzuki, Rie, Cunningham, Orla

Volltext

A Physiologically‐Based Pharmacokinetic Model for the Prediction of “Half‐Life Extension” and “Catch and Release” Monoclonal Antibody Pharmacokinetics von Jones, Hannah M., Tolsma, John, Zhang, Zhiwei, Jasper, Paul, Luo, Haobin, Weber, Gregory L., Wright, Katherine, Bard, Joel, Bell, Robert, Messing, Dean, Kelleher, Kerry, Piche‐Nicholas, Nicole, Webster, Robert

Volltext

Discovery and optimization of a novel anti-GUCY2c x CD3 bispecific antibody for the treatment of solid tumors von Root, Adam R, Guntas, Gurkan, Katragadda, Madan, Apgar, James R, Narula, Jatin, Chang, Chew Shun, Hanscom, Sara, McKenna, Matthew, Wade, Jason, Meade, Caryl, Ma, Weijun, Guo, Yongjing, Liu, Yan, Duan, Weili, Hendershot, Claire, King, Amy C, Zhang, Yan, Sousa, Eric, Tam, Amy, Benard, Susan, Yang, Han, Kelleher, Kerry, Jin, Fang, Piche-Nicholas, Nicole, Keating, Sinead E, Narciandi, Fernando, Lawrence-Henderson, Rosemary, Arai, Maya, Stochaj, Wayne R, Svenson, Kristine, Mosyak, Lidia, Lam, Khetemcnee, Francis, Christopher, Marquette, Kimberly, Wroblewska, Liliana, Zhu, H Lily, Sheehan, Alfredo Darmanin, LaVallie, Edward R, D'Antona, Aaron M, Betts, Alison, King, Lindsay, Rosfjord, Edward, Cunningham, Orla, Lin, Laura, Sapra, Puja, Tchistiakova, Lioudmila, Mathur, Divya, Bloom, Laird

Volltext

A Novel GUCY2C-CD3 T-Cell Engaging Bispecific Construct (PF-07062119) for the Treatment of Gastrointestinal Cancers von Mathur, Divya, Root, Adam R, Bugaj-Gaweda, Bozena, Bisulco, Stephanie, Tan, Xingzhi, Fang, Wei, Kearney, Jessica C, Lucas, Justin, Guffroy, Magali, Golas, Jonathan, Rohde, Cynthia M, Stevens, Chad, Kamperschroer, Cris, Kelleher, Kerry, Lawrence-Henderson, Rosemary F, Upeslacis, Erik, Yao, Johnny, Narula, Jatin, LaVallie, Edward R, Fernandez, Diane R, Buetow, Bernard S, Rosfjord, Edward, Bloom, Laird, King, Lindsay E, Tchistiakova, Lioudmila, Nguyen, Anhco, Sapra, Puja

Volltext

Photonic chip-based low-noise microwave oscillator von Kudelin, Igor, Groman, William, Ji, Qing-Xin, Guo, Joel, Kelleher, Megan L, Lee, Dahyeon, Nakamura, Takuma, McLemore, Charles A, Shirmohammadi, Pedram, Hanifi, Samin, Cheng, Haotian, Jin, Naijun, Wu, Lue, Halladay, Samuel, Luo, Yizhi, Dai, Zhaowei, Jin, Warren, Bai, Junwu, Liu, Yifan, Zhang, Wei, Xiang, Chao, Chang, Lin, Iltchenko, Vladimir, Miller, Owen, Matsko, Andrey, Bowers, Steven M, Rakich, Peter T, Campbell, Joe C, Bowers, John E, Vahala, Kerry J, Quinlan, Franklyn, Diddams, Scott A

Volltext

Anti-Extra Domain B Splice Variant of Fibronectin Antibody-Drug Conjugate Eliminates Tumors with Enhanced Efficacy When Combined with Checkpoint Blockade von Hooper, Andrea T, Marquette, Kimberly, Chang, Chao-Pei Betty, Golas, Jonathon, Jain, Sadhana, Lam, My-Hanh, Guffroy, Magali, Leal, Mauricio, Falahatpisheh, Hadi, Mathur, Divya, Chen, Ting, Kelleher, Kerry, Khandke, Kiran, Muszynska, Elwira, Loganzo, Frank, Rosfjord, Edward, Lucas, Judy, Kan, Zhengyan, Subramanyam, Chakrapani, O'Donnell, Christopher, Neri, Dario, Gerber, Hans-Peter, May, Chad, Sapra, Puja

Volltext

Photonic millimeter-wave generation beyond the cavity thermal limit von Groman, William, Kudelin, Igor, Lind, Alexander, Lee, Dahyeon, Nakamura, Takuma, Liu, Yifan, Kelleher, Megan L., McLemore, Charles A., Guo, Joel, Wu, Lue, Jin, Warren, Vahala, Kerry J., Bowers, John E., Quinlan, Franklyn, Diddams, Scott A.

Volltext

Growth differentiation factor 15 neutralization does not impact anorexia or survival in lipopolysaccharide-induced inflammation von Breen, Danna M., Jagarlapudi, Srinath, Patel, Anita, Zou, Chang, Joaquim, Stephanie, Li, Xiangping, Kang, Liya, Pang, Jincheng, Hales, Katherine, Ziso-Qejvanaj, Enida, Vera, Nicholas B., Bennett, Donald, He, Tao, Lambert, Matthew, Kelleher, Kerry, Wu, Zhidan, Zhang, Bei B., Lin, Laura, Seeley, Randy J., Bezy, Olivier

Volltext