Overcoming the immortality of tumour cells by telomere and telomerase based cancer therapeutics – current status and future prospects von Kelland, Lloyd R.

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“Of mice and men”: values and liabilities of the athymic nude mouse model in anticancer drug development von Kelland, L.R.

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Guidelines for the welfare and use of animals in cancer research von Workman, P, Aboagye, E O, Balkwill, F, Balmain, A, Bruder, G, Chaplin, D J, Double, J A, Everitt, J, Farningham, D A H, Glennie, M J, Kelland, L R, Robinson, V, Stratford, I J, Tozer, G M, Watson, S, Wedge, S R, Eccles, S A

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Preclinical perspectives on platinum resistance von Kelland, L R

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In vitro circumvention of cisplatin resistance by the novel sterically hindered platinum complex AMD473 von Holford, J, Sharp, SY, Murrer, BA, Abrams, M, Kelland, LR

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A G-Quadruplex-Interactive Potent Small-Molecule Inhibitor of Telomerase Exhibiting in Vitro and in Vivo Antitumor Activity von Gowan, Sharon M, Harrison, John R, Patterson, Lisa, Valenti, Melanie, Read, Martin A, Neidle, Stephen, Kelland, Lloyd R

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Structure-Based Design of Selective and Potent G Quadruplex-Mediated Telomerase Inhibitors von Read, Martin, Harrison, R. John, Romagnoli, Barbara, Tanious, Farial A., Gowan, Sharon H., Reszka, Anthony P., Wilson, W. David, Kelland, Lloyd R., Neidle, Stephen

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A New Class of Symmetric Bisbenzimidazole-Based DNA Minor Groove-Binding Agents Showing Antitumor Activity von Mann, John, Baron, Anne, Opoku-Boahen, Yaw, Johansson, Eric, Parkinson, Gary, Kelland, Lloyd R, Neidle, Stephen

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A G-quadruplex telomere targeting agent produces p16-associated senescence and chromosomal fusions in human prostate cancer cells von Incles, Christopher M, Schultes, Christoph M, Kempski, Helena, Koehler, Heike, Kelland, Lloyd R, Neidle, Stephen

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DT-diaphorase expression and tumor cell sensitivity to 17-allylamino, 17-demethoxygeldanamycin, an inhibitor of heat shock protein 90 von KELLAND, L. R, SHARP, S. Y, ROGERS, P. M, MYERS, T. G, WORKMAN, P

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Flavopiridol, the first cyclin-dependent kinase inhibitor to enter the clinic: current status von Kelland, Lloyd R

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Short Tandem Repeat Profiling Provides an International Reference Standard for Human Cell Lines von Masters, John R., Thomson, Jim A., Daly-Burns, Bernadette, Reid, Yvonne A., Dirks, Wilhelm G., Packer, Phil, Toji, Lorraine H., Ohno, Tadao, Tanabe, Hideyuki, Arlett, Colin F., Kelland, Lloyd R., Harrison, Maureen, Virmani, Arvind, Ward, Timothy H., Ayres, Karen L., Debenham, Paul G.

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Potent Inhibition of Telomerase by Small-Molecule Pentacyclic Acridines Capable of Interacting with G-Quadruplexes von Gowan, S M, Heald, R, Stevens, M F, Kelland, L R

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Trisubstituted Acridine Derivatives as Potent and Selective Telomerase Inhibitors von Harrison, R. John, Cuesta, Javier, Chessari, Gianni, Read, Martin A, Basra, Sanji K, Reszka, Anthony P, Morrell, James, Gowan, Sharon M, Incles, Christopher M, Tanious, Farial A, Wilson, W. David, Kelland, Lloyd R, Neidle, Stephen

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In vitro and In vivo Pharmacokinetic-Pharmacodynamic Relationships for the Trisubstituted Aminopurine Cyclin-Dependent Kinase Inhibitors Olomoucine, Bohemine and CYC202 von RAYNAUD, Florence I, WHITTAKER, Steven R, VALENTI, Melanie, BRUNTON, Lisa, ECCLES, Suzanne, LANE, David P, WORKMAN, Paul, FISCHER, Peter M, MCCLUE, Steven, WALTON, Michael I, BARRIE, S. Elaine, GARRETT, Michelle D, ROGERS, Paul, CLARKE, Simon J, KELLAND, Lloyd R

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Preclinical pharmacokinetics and metabolism of a novel prototype DNA-PK inhibitor NU7026 von Nutley, B P, Smith, N F, Hayes, A, Kelland, L R, Brunton, L, Golding, B T, Smith, G C M, Martin, N M B, Workman, P, Raynaud, F I

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Design, Synthesis, and Evaluation of a Novel Pyrrolobenzodiazepine DNA-Interactive Agent with Highly Efficient Cross-Linking Ability and Potent Cytotoxicity von Gregson, Stephen J, Howard, Philip W, Hartley, John A, Brooks, Natalie A, Adams, Lesley J, Jenkins, Terence C, Kelland, Lloyd R, Thurston, David E

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Mechanisms of tumor vascular shutdown induced by 5,6‐dimethylxanthenone‐4‐acetic acid (DMXAA): Increased tumor vascular permeability von Zhao, Liangli, Ching, Lai‐Ming, Kestell, Philip, Kelland, Lloyd R., Baguley, Bruce C.

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BBR 3464: A Novel Triplatinum Complex, Exhibiting a Preclinical Profile of Antitumor Efficacy Different from Cisplatin von MANZOTTI, C, PRATESI, G, PEZZONI, G, ZUNINO, F, MENTA, E, DI DOMENICO, R, CAVALLETTI, E, FIEBIG, H. H, KELLAND, L. R, FARRELL, N, POLIZZI, D, SUPINO, R

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New developments and approaches in the platinum arena von Judson, I, Kelland, L R

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