Mechanisms of resistance to immune checkpoint inhibitors von Jenkins, Russell W, Barbie, David A, Flaherty, Keith T

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Targeted agents and immunotherapies: optimizing outcomes in melanoma von Luke, Jason J., Flaherty, Keith T., Ribas, Antoni, Long, Georgina V.

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Vemurafenib von Flaherty, Keith. T, Yasothan, Uma, Kirkpatrick, Peter

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Resistance to BRAF-targeted therapy in melanoma von Sullivan, Ryan J, Flaherty, Keith T

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The Conundrum of Genetic "Drivers" in Benign Conditions von Kato, Shumei, Lippman, Scott M, Flaherty, Keith T, Kurzrock, Razelle

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Potential role of intratumor bacteria in mediating tumor resistance to the chemotherapeutic drug gemcitabine von Geller, Leore T., Barzily-Rokni, Michal, Danino, Tal, Jonas, Oliver H., Shental, Noam, Nejman, Deborah, Gavert, Nancy, Zwang, Yaara, Cooper, Zachary A., Shee, Kevin, Thaiss, Christoph A., Reuben, Alexandre, Livny, Jonathan, Avraham, Roi, Frederick, Dennie T., Ligorio, Matteo, Chatman, Kelly, Johnston, Stephen E., Mosher, Carrie M., Brandis, Alexander, Fuks, Garold, Gurbatri, Candice, Gopalakrishnan, Vancheswaran, Kim, Michael, Hurd, Mark W., Katz, Matthew, Fleming, Jason, Maitra, Anirban, Smith, David A., Skalak, Matt, Bu, Jeffrey, Michaud, Monia, Trauger, Sunia A., Barshack, Iris, Golan, Talia, Sandbank, Judith, Flaherty, Keith T., Mandinova, Anna, Garrett, Wendy S., Thayer, Sarah P., Ferrone, Cristina R., Huttenhower, Curtis, Bhatia, Sangeeta N., Gevers, Dirk, Wargo, Jennifer A., Golub, Todd R., Straussman, Ravid

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Toward Minimal Residual Disease-Directed Therapy in Melanoma von Rambow, Florian, Rogiers, Aljosja, Marin-Bejar, Oskar, Aibar, Sara, Femel, Julia, Dewaele, Michael, Karras, Panagiotis, Brown, Daniel, Chang, Young Hwan, Debiec-Rychter, Maria, Adriaens, Carmen, Radaelli, Enrico, Wolter, Pascal, Bechter, Oliver, Dummer, Reinhard, Levesque, Mitchell, Piris, Adriano, Frederick, Dennie T., Boland, Genevieve, Flaherty, Keith T., van den Oord, Joost, Voet, Thierry, Aerts, Stein, Lund, Amanda W., Marine, Jean-Christophe

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Melanoma Cell-Intrinsic PD-1 Receptor Functions Promote Tumor Growth von Kleffel, Sonja, Posch, Christian, Barthel, Steven R., Mueller, Hansgeorg, Schlapbach, Christoph, Guenova, Emmanuella, Elco, Christopher P., Lee, Nayoung, Juneja, Vikram R., Zhan, Qian, Lian, Christine G., Thomi, Rahel, Hoetzenecker, Wolfram, Cozzio, Antonio, Dummer, Reinhard, Mihm, Martin C., Flaherty, Keith T., Frank, Markus H., Murphy, George F., Sharpe, Arlene H., Kupper, Thomas S., Schatton, Tobias

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Inhibiting Drivers of Non-mutational Drug Tolerance Is a Salvage Strategy for Targeted Melanoma Therapy von Smith, Michael P., Brunton, Holly, Rowling, Emily J., Ferguson, Jennifer, Arozarena, Imanol, Miskolczi, Zsofia, Lee, Jessica L., Girotti, Maria R., Marais, Richard, Levesque, Mitchell P., Dummer, Reinhard, Frederick, Dennie T., Flaherty, Keith T., Cooper, Zachary A., Wargo, Jennifer A., Wellbrock, Claudia

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Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq von Tirosh, Itay, Izar, Benjamin, Prakadan, Sanjay M., Wadsworth, Marc H., Treacy, Daniel, Trombetta, John J., Rotem, Asaf, Rodman, Christopher, Lian, Christine, Murphy, George, Fallahi-Sichani, Mohammad, Dutton-Regester, Ken, Lin, Jia-Ren, Cohen, Ofir, Shah, Parin, Lu, Diana, Genshaft, Alex S., Hughes, Travis K., Ziegler, Carly G. K., Kazer, Samuel W., Gaillard, Aleth, Kolb, Kellie E., Villani, Alexandra-Chloé, Johannessen, Cory M., Andreev, Aleksandr Y., Van Allen, Eliezer M., Bertagnolli, Monica, Sorger, Peter K., Sullivan, Ryan J., Flaherty, Keith T., Frederick, Dennie T., Jané-Valbuena, Judit, Yoon, Charles H., Rozenblatt-Rosen, Orit, Shalek, Alex K., Regev, Aviv, Garraway, Levi A.

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Factors predictive of response, disease progression, and overall survival after dabrafenib and trametinib combination treatment: a pooled analysis of individual patient data from r... von Long, Georgina V, Prof, Grob, Jean-Jacques, Prof, Nathan, Paul, MD, Ribas, Antoni, Prof, Robert, Caroline, MD, Schadendorf, Dirk, Prof, Lane, Stephen R, MSc, Mak, Carmen, PhD, Legenne, Philippe, MD, Flaherty, Keith T, Prof, Davies, Michael A, MD

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Inhibition of Mutated, Activated BRAF in Metastatic Melanoma von Flaherty, Keith T, Puzanov, Igor, Kim, Kevin B, Ribas, Antoni, McArthur, Grant A, Sosman, Jeffrey A, O'Dwyer, Peter J, Lee, Richard J, Grippo, Joseph F, Nolop, Keith, Chapman, Paul B

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Molecular Landscape and Actionable Alterations in a Genomically Guided Cancer Clinical Trial: National Cancer Institute Molecular Analysis for Therapy Choice (NCI-MATCH) von Flaherty, Keith T, Gray, Robert J, Chen, Alice P, Li, Shuli, McShane, Lisa M, Patton, David, Hamilton, Stanley R, Williams, P Mickey, Iafrate, A John, Sklar, Jeffrey, Mitchell, Edith P, Harris, Lyndsay N, Takebe, Naoko, Sims, David J, Coffey, Brent, Fu, Tony, Routbort, Mark, Zwiebel, James A, Rubinstein, Larry V, Little, Richard F, Arteaga, Carlos L, Comis, Robert, Abrams, Jeffrey S, O'Dwyer, Peter J, Conley, Barbara A

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Adjuvant sunitinib or sorafenib for high-risk, non-metastatic renal-cell carcinoma (ECOG-ACRIN E2805): a double-blind, placebo-controlled, randomised, phase 3 trial von Haas, Naomi B, Dr, Manola, Judith, MS, Uzzo, Robert G, Prof, Flaherty, Keith T, MD, Wood, Christopher G, Prof, Kane, Christopher, Prof, Jewett, Michael, Prof, Dutcher, Janice P, Prof, Atkins, Michael B, Prof, Pins, Michael, Prof, Wilding, George, Prof, Cella, David, Prof, Wagner, Lynne, Prof, Matin, Surena, Prof, Kuzel, Timothy M, Prof, Sexton, Wade J, Prof, Wong, Yu-Ning, MD, Choueiri, Toni K, MD, Pili, Roberto, Prof, Puzanov, Igor, MD, Kohli, Manish, MD, Stadler, Walter, Prof, Carducci, Michael, Prof, Coomes, Robert, DiPaola, Robert S, Prof

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The Hippo effector YAP promotes resistance to RAF- and MEK-targeted cancer therapies von Lin, Luping, Sabnis, Amit J, Chan, Elton, Olivas, Victor, Cade, Lindsay, Pazarentzos, Evangelos, Asthana, Saurabh, Neel, Dana, Yan, Jenny Jiacheng, Lu, Xinyuan, Pham, Luu, Wang, Mingxue M, Karachaliou, Niki, Cao, Maria Gonzalez, Manzano, Jose Luis, Ramirez, Jose Luis, Torres, Jose Miguel Sanchez, Buttitta, Fiamma, Rudin, Charles M, Collisson, Eric A, Algazi, Alain, Robinson, Eric, Osman, Iman, Muñoz-Couselo, Eva, Cortes, Javier, Frederick, Dennie T, Cooper, Zachary A, McMahon, Martin, Marchetti, Antonio, Rosell, Rafael, Flaherty, Keith T, Wargo, Jennifer A, Bivona, Trever G

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Phase III Trial of Carboplatin and Paclitaxel With or Without Sorafenib in Metastatic Melanoma von FLAHERTY, Keith T, LEE, Sandra J, FENGMIN ZHAO, SCHUCHTER, Lynn M, FLAHERTY, Lawrence, KEFFORD, Richard, ATKINS, Michael B, LEMING, Philip, KIRKWOOD, John M

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RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E) von Poulikakos, Poulikos I., Persaud, Yogindra, Janakiraman, Manickam, Kong, Xiangju, Ng, Charles, Moriceau, Gatien, Shi, Hubing, Atefi, Mohammad, Titz, Bjoern, Gabay, May Tal, Salton, Maayan, Dahlman, Kimberly B., Tadi, Madhavi, Wargo, Jennifer A., Flaherty, Keith T., Kelley, Mark C., Misteli, Tom, Chapman, Paul B., Sosman, Jeffrey A., Graeber, Thomas G., Ribas, Antoni, Lo, Roger S., Rosen, Neal, Solit, David B.

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BRAF inhibitors for the treatment of metastatic melanoma: clinical trials and mechanisms of resistance von Alcalá, Alexander Marzuka, Flaherty, Keith T

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Extreme Vulnerability of IDH1 Mutant Cancers to NAD+ Depletion von Tateishi, Kensuke, Wakimoto, Hiroaki, Iafrate, A. John, Tanaka, Shota, Loebel, Franziska, Lelic, Nina, Wiederschain, Dmitri, Bedel, Olivier, Deng, Gejing, Zhang, Bailin, He, Timothy, Shi, Xu, Gerszten, Robert E., Zhang, Yiyun, Yeh, Jing-Ruey J., Curry, William T., Zhao, Dan, Sundaram, Sudhandra, Nigim, Fares, Koerner, Mara V.A., Ho, Quan, Fisher, David E., Roider, Elisabeth M., Kemeny, Lajos V., Samuels, Yardena, Flaherty, Keith T., Batchelor, Tracy T., Chi, Andrew S., Cahill, Daniel P.

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Phase II, Open-Label, Single-Arm Trial of Imatinib Mesylate in Patients With Metastatic Melanoma Harboring c-Kit Mutation or Amplification von Guo, Jun, Si, Lu, Kong, Yan, Flaherty, Keith T, Xu, Xiaowei, Zhu, Yanyan, Corless, Christopher L, Li, Li, Li, Haifu, Sheng, Xinan, Cui, Chuanliang, Chi, Zhihong, Li, Siming, Han, Mei, Mao, Lili, Lin, Xuede, Du, Nan, Zhang, Xiaoshi, Li, Junling, Wang, Baocheng, Qin, Shukui

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