Plitidepsin has potent preclinical efficacy against SARS-CoV-2 by targeting the host protein eEF1A von White, Kris M, Rosales, Romel, Yildiz, Soner, Kehrer, Thomas, Miorin, Lisa, Moreno, Elena, Jangra, Sonia, Uccellini, Melissa B, Rathnasinghe, Raveen, Coughlan, Lynda, Martinez-Romero, Carles, Batra, Jyoti, Rojc, Ajda, Bouhaddou, Mehdi, Fabius, Jacqueline M, Obernier, Kirsten, Dejosez, Marion, Guillén, María José, Losada, Alejandro, Avilés, Pablo, Schotsaert, Michael, Zwaka, Thomas, Vignuzzi, Marco, Shokat, Kevan M, Krogan, Nevan J, García-Sastre, Adolfo

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SARS-CoV-2 Orf6 hijacks Nup98 to block STAT nuclear import and antagonize interferon signaling von Miorin, Lisa, Kehrer, Thomas, Sanchez-Aparicio, Maria Teresa, Zhang, Ke, Cohen, Phillip, Patel, Roosheel S., Cupic, Anastasija, Makio, Tadashi, Mei, Menghan, Moreno, Elena, Danziger, Oded, White, Kris M., Rathnasinghe, Raveen, Uccellini, Melissa, Gao, Shengyan, Aydillo, Teresa, Mena, Ignacio, Yin, Xin, Martin-Sancho, Laura, Krogan, Nevan J., Chanda, Sumit K., Schotsaert, Michael, Wozniak, Richard W., Ren, Yi, Rosenberg, Brad R., Fontoura, Beatriz M. A., García-Sastre, Adolfo

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Hepatitis C virus drugs that inhibit SARS-CoV-2 papain-like protease synergize with remdesivir to suppress viral replication in cell culture von Bafna, Khushboo, White, Kris, Harish, Balasubramanian, Rosales, Romel, Ramelot, Theresa A., Acton, Thomas B., Moreno, Elena, Kehrer, Thomas, Miorin, Lisa, Royer, Catherine A., García-Sastre, Adolfo, Krug, Robert M., Montelione, Gaetano T.

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Nsp1 protein of SARS-CoV-2 disrupts the mRNA export machinery to inhibit host gene expression von Zhang, Ke, Miorin, Lisa, Makio, Tadashi, Dehghan, Ishmael, Gao, Shengyan, Xie, Yihu, Zhong, Hualin, Esparza, Matthew, Kehrer, Thomas, Kumar, Anil, Hobman, Tom C, Ptak, Christopher, Gao, Boning, Minna, John D, Chen, Zhijian, García-Sastre, Adolfo, Ren, Yi, Wozniak, Richard W, Fontoura, Beatriz M A

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Control of Innate Immune Activation by Severe Acute Respiratory Syndrome Coronavirus 2 and Other Coronaviruses von Kehrer, Thomas, García-Sastre, Adolfo, Miorin, Lisa

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Characterization of SARS-CoV-2 Spike mutations important for infection of mice and escape from human immune sera von Rathnasinghe, Raveen, Jangra, Sonia, Ye, Chengjin, Cupic, Anastasija, Singh, Gagandeep, Martínez-Romero, Carles, Mulder, Lubbertus C. F., Kehrer, Thomas, Yildiz, Soner, Choi, Angela, Yeung, Stephen T., Mena, Ignacio, Gillespie, Virginia, De Vrieze, Jana, Aslam, Sadaf, Stadlbauer, Daniel, Meekins, David A., McDowell, Chester D., Balaraman, Velmurugan, Corley, Michael J., Richt, Juergen A., De Geest, Bruno G., Miorin, Lisa, Krammer, Florian, Martinez-Sobrido, Luis, Simon, Viviana, García-Sastre, Adolfo, Schotsaert, Michael

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Interferon mediated prophylactic protection against respiratory viruses conferred by a prototype live attenuated influenza virus vaccine lacking non-structural protein 1 von Rathnasinghe, Raveen, Salvatore, Mirella, Zheng, Hongyong, Jangra, Sonia, Kehrer, Thomas, Mena, Ignacio, Schotsaert, Michael, Muster, Thomas, Palese, Peter, García-Sastre, Adolfo

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A household case evidences shorter shedding of SARS-CoV-2 in naturally infected cats compared to their human owners von Neira, Víctor, Brito, Bárbara, Agüero, Belén, Berrios, Felipe, Valdés, Valentina, Gutierrez, Alberto, Ariyama, Naomi, Espinoza, Patricio, Retamal, Patricio, Holmes, Edward C., Gonzalez-Reiche, Ana S., Khan, Zenab, van de Guchte, Adriana, Dutta, Jayeeta, Miorin, Lisa, Kehrer, Thomas, Galarce, Nicolás, Almonacid, Leonardo I., Levican, Jorge, van Bakel, Harm, García-Sastre, Adolfo, Medina, Rafael A.

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HIV protease cleaves the antiviral m6A reader protein YTHDF3 in the viral particle von Jurczyszak, Denise, Zhang, Wen, Terry, Sandra N, Kehrer, Thomas, Bermúdez González, Maria C, McGregor, Emma, Mulder, Lubbertus C F, Eckwahl, Matthew J, Pan, Tao, Simon, Viviana

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Unambiguous detection of SARS-CoV-2 subgenomic mRNAs with single-cell RNA sequencing von Cohen, Phillip, DeGrace, Emma J, Danziger, Oded, Patel, Roosheel S, Barrall, Erika A, Bobrowski, Tesia, Kehrer, Thomas, Cupic, Anastija, Miorin, Lisa, García-Sastre, Adolfo, Rosenberg, Brad R

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Mutations in SARS-CoV-2 variants of concern link to increased spike cleavage and virus transmission von Escalera, Alba, Gonzalez-Reiche, Ana S., Aslam, Sadaf, Mena, Ignacio, Laporte, Manon, Pearl, Rebecca L., Fossati, Andrea, Rathnasinghe, Raveen, Alshammary, Hala, van de Guchte, Adriana, Farrugia, Keith, Qin, Yiren, Bouhaddou, Mehdi, Kehrer, Thomas, Zuliani-Alvarez, Lorena, Meekins, David A., Balaraman, Velmurugan, McDowell, Chester, Richt, Jürgen A., Bajic, Goran, Sordillo, Emilia Mia, Dejosez, Marion, Zwaka, Thomas P., Krogan, Nevan J., Simon, Viviana, Albrecht, Randy A., van Bakel, Harm, García-Sastre, Adolfo, Aydillo, Teresa

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Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms von Gordon, David E, Hiatt, Joseph, Bouhaddou, Mehdi, Rezelj, Veronica V, Ulferts, Svenja, Braberg, Hannes, Jureka, Alexander S, Obernier, Kirsten, Guo, Jeffrey Z, Batra, Jyoti, Kaake, Robyn M, Weckstein, Andrew R, Owens, Tristan W, Gupta, Meghna, Pourmal, Sergei, Titus, Erron W, Cakir, Merve, Soucheray, Margaret, McGregor, Michael, Cakir, Zeynep, Jang, Gwendolyn, O'Meara, Matthew J, Tummino, Tia A, Zhang, Ziyang, Foussard, Helene, Rojc, Ajda, Zhou, Yuan, Kuchenov, Dmitry, Hüttenhain, Ruth, Xu, Jiewei, Eckhardt, Manon, Swaney, Danielle L, Fabius, Jacqueline M, Ummadi, Manisha, Tutuncuoglu, Beril, Rathore, Ujjwal, Modak, Maya, Haas, Paige, Haas, Kelsey M, Naing, Zun Zar Chi, Pulido, Ernst H, Shi, Ying, Barrio-Hernandez, Inigo, Memon, Danish, Petsalaki, Eirini, Dunham, Alistair, Marrero, Miguel Correa, Burke, David, Koh, Cassandra, Vallet, Thomas, Silvas, Jesus A, Azumaya, Caleigh M, Billesbølle, Christian, Brilot, Axel F, Campbell, Melody G, Diallo, Amy, Dickinson, Miles Sasha, Diwanji, Devan, Herrera, Nadia, Hoppe, Nick, Kratochvil, Huong T, Liu, Yanxin, Merz, Gregory E, Moritz, Michelle, Nguyen, Henry C, Nowotny, Carlos, Puchades, Cristina, Rizo, Alexandrea N, Schulze-Gahmen, Ursula, Smith, Amber M, Sun, Ming, Young, Iris D, Zhao, Jianhua, Asarnow, Daniel, Biel, Justin, Bowen, Alisa, Braxton, Julian R, Chen, Jen, Chio, Cynthia M, Chio, Un Seng, Deshpande, Ishan, Doan, Loan, Faust, Bryan, Flores, Sebastian, Jin, Mingliang, Kim, Kate, Lam, Victor L, Li, Fei, Li, Junrui, Li, Yen-Li, Li, Yang, Liu, Xi, Lo, Megan, Lopez, Kyle E, Melo, Arthur A, Moss, 3rd, Frank R, Nguyen, Phuong, Paulino, Joana, Pawar, Komal Ishwar, Peters, Jessica K

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Contribution of SARS-CoV-2 Accessory Proteins to Viral Pathogenicity in K18 Human ACE2 Transgenic Mice von Silvas, Jesus A, Vasquez, Desarey Morales, Park, Jun-Gyu, Chiem, Kevin, Allué-Guardia, Anna, Garcia-Vilanova, Andreu, Platt, Roy Neal, Miorin, Lisa, Kehrer, Thomas, Cupic, Anastasija, Gonzalez-Reiche, Ana S, Bakel, Harm van, García-Sastre, Adolfo, Anderson, Tim, Torrelles, Jordi B, Ye, Chengjin, Martinez-Sobrido, Luis

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SARS-CoV-2 viral protein ORF3A injures renal tubules by interacting with TRIM59 to induce STAT3 activation von Cai, Hong, Chen, Ya, Feng, Ye, Asadi, Morad, Kaufman, Lewis, Lee, Kyung, Kehrer, Thomas, Miorin, Lisa, Garcia-Sastre, Adolfo, Gusella, G. Luca, Gu, Leyi, Ni, Zhaohui, Mou, Shan, He, John Cijiang, Zhou, Weibin

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Structure function characterization of SARS CoV2 proteases for COVID19 antiviral development von Greene-Cramer, Rebecca, Bafna, Khushboo, White, Kris, Harish, Balasubramanian, Rosales, Romel, Ramelot, Theresa, Acton, Thomas B., Del Olmo, Elena Moreno, Kehrer, Thomas, Miorin, Lisa, Royer, Catherine A., Garcia-Sastre, Adolfo, Krug, Robert, Montelione, Gaetano T.

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Impact of SARS-CoV-2 ORF6 and its variant polymorphisms on host responses and viral pathogenesis von Kehrer, Thomas, Cupic, Anastasija, Ye, Chengjin, Yildiz, Soner, Bouhaddou, Mehdi, Crossland, Nicholas A., Barrall, Erika A., Cohen, Phillip, Tseng, Anna, Çağatay, Tolga, Rathnasinghe, Raveen, Flores, Daniel, Jangra, Sonia, Alam, Fahmida, Mena, Ignacio, Aslam, Sadaf, Saqi, Anjali, Rutkowska, Magdalena, Ummadi, Manisha R., Pisanelli, Giuseppe, Richardson, R. Blake, Veit, Ethan C., Fabius, Jacqueline M., Soucheray, Margaret, Polacco, Benjamin J., Ak, Baran, Marin, Arturo, Evans, Matthew J., Swaney, Danielle L., Gonzalez-Reiche, Ana S., Sordillo, Emilia M., van Bakel, Harm, Simon, Viviana, Zuliani-Alvarez, Lorena, Fontoura, Beatriz M.A., Rosenberg, Brad R., Krogan, Nevan J., Martinez-Sobrido, Luis, García-Sastre, Adolfo, Miorin, Lisa

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Functional Effects of Cardiomyocyte Injury in COVID-19 von Siddiq, Mustafa M, Chan, Angel T, Miorin, Lisa, Yadaw, Arjun S, Beaumont, Kristin G, Kehrer, Thomas, Cupic, Anastasija, White, Kris M, Tolentino, Rosa E, Hu, Bin, Stern, Alan D, Tavassoly, Iman, Hansen, Jens, Sebra, Robert, Martinez, Pedro, Prabha, Som, Dubois, Nicole, Schaniel, Christoph, Iyengar-Kapuganti, Rupa, Kukar, Nina, Giustino, Gennaro, Sud, Karan, Nirenberg, Sharon, Kovatch, Patricia, Albrecht, Randy A, Goldfarb, Joseph, Croft, Lori, McLaughlin, Maryann A, Argulian, Edgar, Lerakis, Stamatios, Narula, Jagat, García-Sastre, Adolfo, Iyengar, Ravi

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HIV protease cleaves the antiviral m.sup.6A reader protein YTHDF3 in the viral particle von Jurczyszak, Denise, Zhang, Wen, Terry, Sandra N, Kehrer, Thomas, Bermúdez González, Maria C, McGregor, Emma, Mulder, Lubbertus C. F, Eckwahl, Matthew J, Pan, Tao, Simon, Viviana

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Mutations in SARS-CoV-2 variants of concern link to increased spike cleavage von Escalera, Alba, Gonzalez-Reiche, Ana S, Aslam, Sadaf, Mena, Ignacio, Laporte, Manon, Pearl, Rebecca L, Fossati, Andrea, Rathnasinghe, Raveen, Alshammary, Hala, van de Guchte, Adriana, Farrugia, Keith, Qin, Yiren, Bouhaddou, Mehdi, Kehrer, Thomas, Zuliani-Alvarez, Lorena, Meekins, David A, Balaraman, Velmurugan, McDowell, Chester, Richt, Jurgen A, Bajic, Goran, Sordillo, Emilia Mia, Dejosez, Marion, Zwaka, Thomas P, Krogan, Nevan J, Simon, Viviana, Albrecht, Randy A, van Bakel, Harm, Garcia-Sastre, Adolfo, Aydillo, Teresa

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The IRE1α-XBP1 arm of the unfolded protein response is a host factor activated in SARS-CoV-2 infection von Fernández, Jose Javier, Marín, Arturo, Rosales, Romel, Penrice-Randal, Rebekah, Mlcochova, Petra, Alvarez, Yolanda, Villalón-Letelier, Fernando, Yildiz, Soner, Pérez, Enrique, Rathnasinghe, Raveen, Cupic, Anastasija, Kehrer, Thomas, Uccellini, Melissa B., Alonso, Sara, Martínez, Fernando, McGovern, Briana Lynn, Clark, Jordan J., Sharma, Parul, Bayón, Yolanda, Alonso, Andrés, Albrecht, Randy A., White, Kris M., Schotsaert, Michael, Miorin, Lisa, Stewart, James P., Hiscox, Julian A., Gupta, Ravindra K., Irigoyen, Nerea, García-Sastre, Adolfo, Crespo, Mariano Sánchez, Fernández, Nieves

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