Evidence that pyrophosphate acts as an extracellular signalling molecule to exert direct functional effects in primary cultures of osteoblasts and osteoclasts von Bourne, Lucie E., Davies, Bethan K., Millan, Jose Luis, Arnett, Timothy R., Wheeler-Jones, Caroline P.D., Keen, Jacob A.C., Roberts, Scott J., Orriss, Isabel R.

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Novel insights on the effect of sclerostin on bone and other organs von Dreyer, Timothy, Keen, Jacob, Wells, Leah, Roberts, Scott

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Evidence that pyrophosphate acts as an extracellular signalling molecule to exert direct functional effects in primary cultures of osteoblasts and osteoclasts von Bourne, Lucie E, Davies, Bethan K, Millan, Jose Luis, Arnett, Timothy R, Wheeler-Jones, Caroline P.D, Keen, Jacob A.C, Roberts, Scott J, Orriss, Isabel R

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The allosteric inhibitor ABL001 enables dual targeting of BCR–ABL1 von Wylie, Andrew A., Schoepfer, Joseph, Jahnke, Wolfgang, Cowan-Jacob, Sandra W., Loo, Alice, Furet, Pascal, Marzinzik, Andreas L., Pelle, Xavier, Donovan, Jerry, Zhu, Wenjing, Buonamici, Silvia, Hassan, A. Quamrul, Lombardo, Franco, Iyer, Varsha, Palmer, Michael, Berellini, Giuliano, Dodd, Stephanie, Thohan, Sanjeev, Bitter, Hans, Branford, Susan, Ross, David M., Hughes, Timothy P., Petruzzelli, Lilli, Vanasse, K. Gary, Warmuth, Markus, Hofmann, Francesco, Keen, Nicholas J., Sellers, William R.

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Convection‐Permitting Simulations With the E3SM Global Atmosphere Model von Caldwell, P. M., Terai, C. R., Hillman, B., Keen, N. D., Bogenschutz, P., Lin, W., Beydoun, H., Taylor, M., Bertagna, L., Bradley, A. M., Clevenger, T. C., Donahue, A. S., Eldred, C., Foucar, J., Golaz, J.‐C., Guba, O., Jacob, R., Johnson, J., Krishna, J., Liu, W., Pressel, K., Salinger, A. G., Singh, B., Steyer, A., Ullrich, P., Wu, D., Yuan, X., Shpund, J., Ma, H.‐Y., Zender, C. S.

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The DOE E3SM Model Version 2: Overview of the Physical Model and Initial Model Evaluation von Golaz, Jean‐Christophe, Van Roekel, Luke P., Zheng, Xue, Roberts, Andrew F., Wolfe, Jonathan D., Lin, Wuyin, Bradley, Andrew M., Tang, Qi, Maltrud, Mathew E., Forsyth, Ryan M., Zhang, Chengzhu, Zhou, Tian, Zhang, Kai, Zender, Charles S., Wu, Mingxuan, Wang, Hailong, Turner, Adrian K., Singh, Balwinder, Richter, Jadwiga H., Qin, Yi, Petersen, Mark R., Mametjanov, Azamat, Ma, Po‐Lun, Larson, Vincent E., Krishna, Jayesh, Keen, Noel D., Jeffery, Nicole, Hunke, Elizabeth C., Hannah, Walter M., Guba, Oksana, Griffin, Brian M., Feng, Yan, Engwirda, Darren, Di Vittorio, Alan V., Dang, Cheng, Conlon, LeAnn M., Chen, Chih‐Chieh‐Jack, Brunke, Michael A., Bisht, Gautam, Benedict, James J., Asay‐Davis, Xylar S., Zhang, Yuying, Zhang, Meng, Zeng, Xubin, Xie, Shaocheng, Wolfram, Phillip J., Vo, Tom, Veneziani, Milena, Tesfa, Teklu K., Sreepathi, Sarat, Salinger, Andrew G., Reeves Eyre, J. E. Jack, Prather, Michael J., Mahajan, Salil, Li, Qing, Jones, Philip W., Jacob, Robert L., Huebler, Gunther W., Huang, Xianglei, Hillman, Benjamin R., Harrop, Bryce E., Foucar, James G., Fang, Yilin, Comeau, Darin S., Caldwell, Peter M., Bartoletti, Tony, Balaguru, Karthik, Taylor, Mark A., McCoy, Renata B., Leung, L. Ruby, Bader, David C.

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The fully coupled regionally refined model of E3SM version 2: overview of the atmosphere, land, and river results von Tang, Qi, Golaz, Jean-Christophe, Van Roekel, Luke P, Taylor, Mark A, Lin, Wuyin, Hillman, Benjamin R, Ullrich, Paul A, Bradley, Andrew M, Guba, Oksana, Wolfe, Jonathan D, Zhou, Tian, Zhang, Kai, Zheng, Xue, Zhang, Yunyan, Zhang, Meng, Wu, Mingxuan, Wang, Hailong, Tao, Cheng, Singh, Balwinder, Rhoades, Alan M, Qin, Yi, Li, Hong-Yi, Feng, Yan, Zhang, Yuying, Zhang, Chengzhu, Zender, Charles S, Xie, Shaocheng, Roesler, Erika L, Roberts, Andrew F, Mametjanov, Azamat, Maltrud, Mathew E, Keen, Noel D, Jacob, Robert L, Jablonowski, Christiane, Hughes, Owen K, Forsyth, Ryan M, Di Vittorio, Alan V, Caldwell, Peter M, Bisht, Gautam, McCoy, Renata B, Leung, L. Ruby, Bader, David C

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2D vs. 3D Ultrasound Diagnosis of Pediatric Supracondylar Fractures von Knight, Jessica, Alves-Pereira, Fatima, Keen, Christopher E, Jaremko, Jacob L

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Allosteric inhibition of SHP2 phosphatase inhibits cancers driven by receptor tyrosine kinases von Chen, Ying-Nan P., LaMarche, Matthew J., Chan, Ho Man, Fekkes, Peter, Garcia-Fortanet, Jorge, Acker, Michael G., Antonakos, Brandon, Chen, Christine Hiu-Tung, Chen, Zhouliang, Cooke, Vesselina G., Dobson, Jason R., Deng, Zhan, Fei, Feng, Firestone, Brant, Fodor, Michelle, Fridrich, Cary, Gao, Hui, Grunenfelder, Denise, Hao, Huai-Xiang, Jacob, Jaison, Ho, Samuel, Hsiao, Kathy, Kang, Zhao B., Karki, Rajesh, Kato, Mitsunori, Larrow, Jay, La Bonte, Laura R., Lenoir, Francois, Liu, Gang, Liu, Shumei, Majumdar, Dyuti, Meyer, Matthew J., Palermo, Mark, Perez, Lawrence, Pu, Minying, Price, Edmund, Quinn, Christopher, Shakya, Subarna, Shultz, Michael D., Slisz, Joanna, Venkatesan, Kavitha, Wang, Ping, Warmuth, Markus, Williams, Sarah, Yang, Guizhi, Yuan, Jing, Zhang, Ji-Hu, Zhu, Ping, Ramsey, Timothy, Keen, Nicholas J., Sellers, William R., Stams, Travis, Fortin, Pascal D.

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Global chromatin profiling reveals NSD2 mutations in pediatric acute lymphoblastic leukemia von Jaffe, Jacob D, Wang, Yan, Chan, Ho Man, Zhang, Jinghui, Huether, Robert, Kryukov, Gregory V, Bhang, Hyo-eun C, Taylor, Jordan E, Hu, Min, Englund, Nathan P, Yan, Feng, Wang, Zhaofu, Robert McDonald, E, Wei, Lei, Ma, Jing, Easton, John, Yu, Zhengtian, deBeaumount, Rosalie, Gibaja, Veronica, Venkatesan, Kavitha, Schlegel, Robert, Sellers, William R, Keen, Nicholas, Liu, Jun, Caponigro, Giordano, Barretina, Jordi, Cooke, Vesselina G, Mullighan, Charles, Carr, Steven A, Downing, James R, Garraway, Levi A, Stegmeier, Frank

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2D/3D ultrasound diagnosis of pediatric distal radius fractures by human readers vs artificial intelligence von Knight, Jessica, Zhou, Yuyue, Keen, Christopher, Hareendranathan, Abhilash Rakkunedeth, Alves-Pereira, Fatima, Ghasseminia, Siyavesh, Wichuk, Stephanie, Brilz, Alan, Kirschner, David, Jaremko, Jacob

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An Overview of the Atmospheric Component of the Energy Exascale Earth System Model von Rasch, P. J., Xie, S., Ma, P.‐L., Lin, W., Wang, H., Tang, Q., Burrows, S. M., Caldwell, P., Zhang, K., Easter, R. C., Cameron‐Smith, P., Singh, B., Wan, H., Golaz, J.‐C., Harrop, B. E., Roesler, E., Bacmeister, J., Larson, V. E., Evans, K. J., Qian, Y., Taylor, M., Leung, L. R., Zhang, Y., Brent, L., Branstetter, M., Hannay, C., Mahajan, S., Mametjanov, A., Neale, R., Richter, J. H., Yoon, J.‐H., Zender, C. S., Bader, D., Flanner, M., Foucar, J. G., Jacob, R., Keen, N., Klein, S. A., Liu, X., Salinger, A.G., Shrivastava, M., Yang, Y.

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Antitumor Properties of RAF709, a Highly Selective and Potent Inhibitor of RAF Kinase Dimers, in Tumors Driven by Mutant RAS or BRAF von Shao, Wenlin, Mishina, Yuji M, Feng, Yun, Caponigro, Giordano, Cooke, Vesselina G, Rivera, Stacy, Wang, Yingyun, Shen, Fang, Korn, Joshua M, Mathews Griner, Lesley A, Nishiguchi, Gisele, Rico, Alice, Tellew, John, Haling, Jacob R, Aversa, Robert, Polyakov, Valery, Zang, Richard, Hekmat-Nejad, Mohammad, Amiri, Payman, Singh, Mallika, Keen, Nicholas, Dillon, Michael P, Lees, Emma, Ramurthy, Savithri, Sellers, William R, Stuart, Darrin D

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The DOE E3SM Coupled Model Version 1: Description and Results at High Resolution von Caldwell, Peter M., Mametjanov, Azamat, Tang, Qi, Van Roekel, Luke P., Golaz, Jean‐Christophe, Lin, Wuyin, Bader, David C., Keen, Noel D., Feng, Yan, Jacob, Robert, Maltrud, Mathew E., Roberts, Andrew F., Taylor, Mark A., Veneziani, Milena, Wang, Hailong, Wolfe, Jonathan D., Balaguru, Karthik, Cameron‐Smith, Philip, Dong, Lu, Klein, Stephen A., Leung, L. Ruby, Li, Hong‐Yi, Li, Qing, Liu, Xiaohong, Neale, Richard B., Pinheiro, Marielle, Qian, Yun, Ullrich, Paul A., Xie, Shaocheng, Yang, Yang, Zhang, Yuying, Zhang, Kai, Zhou, Tian

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Long-term high copper intake: effects on indexes of copper status, antioxidant status, and immune function in young men von Turnlund, J.R, Jacob, R.A, Keen, C.L, Strain, J.J, Kelley, D.S, Domek, J.M, Keyes, W.R, Ensunsa, J.L, Lykkesfeldt, J, Coulter, J

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AZD9567 versus prednisolone in patients with active rheumatoid arthritis: A phase IIa, randomized, double‐blind, efficacy, and safety study von Laar, Jacob M., Lei, Alejhandra, Safy‐Khan, Mary, Almquist, Joachim, Belfield, Graham, Edman, Karl, Öberg, Lisa, Angermann, Bastian R., Dillmann, Inken, Berntsson, Pia, Etal, Damla, Dainty, Ian, Astbury, Carol, Belvisi, Maria G., Nemes, Szilárd, Platt, Adam, Prothon, Susanne, Samuelsson, Sara, Svanberg, Petter, Keen, Christina, Jacobs, J. W. G., Kaan, Ellen, Tubergen, Astrid, Hermans, Kasper, Vonkeman, Harald, Moghadam, Marjan Ghiti, Gjertsson, Inger, Ekwall, Anna‐Karin, Kapetanovic, Meliha, Einarsson, Jon Thorkell, Axelsson, Lena T., Olsson, Richard, Myrbäck, Tove Hegelund, Taib, Ziad, Vikman, Kerstin

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Design, synthesis and evaluation of potent and selective inhibitors of mono-(ADP-ribosyl)transferases PARP10 and PARP14 von Holechek, Jacob, Lease, Robert, Thorsell, Ann-Gerd, Karlberg, Tobias, McCadden, Caitlin, Grant, Ryan, Keen, Abby, Callahan, Evan, Schüler, Herwig, Ferraris, Dana

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A superconducting dual-rail cavity qubit with erasure-detected logical measurements von Chou, Kevin S., Shemma, Tali, McCarrick, Heather, Chien, Tzu-Chiao, Teoh, James D., Winkel, Patrick, Anderson, Amos, Chen, Jonathan, Curtis, Jacob C., de Graaf, Stijn J., Garmon, John W. O., Gudlewski, Benjamin, Kalfus, William D., Keen, Trevor, Khedkar, Nishaad, Lei, Chan U., Liu, Gangqiang, Lu, Pinlei, Lu, Yao, Maiti, Aniket, Mastalli-Kelly, Luke, Mehta, Nitish, Mundhada, Shantanu O., Narla, Anirudh, Noh, Taewan, Tsunoda, Takahiro, Xue, Sophia H., Yuan, Joseph O., Frunzio, Luigi, Aumentado, José, Puri, Shruti, Girvin, Steven M., Moseley, S. Harvey, Schoelkopf, Robert J.

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Using chromosomal and single-gene non-invasive prenatal testing to identify the cause of congenital heart defects von Hajjar, Mark, Mohan, Pooja, Wulff, Jacob, Maisenbacher, Melissa, Keen-Kim, J. Dianne, Billings, Paul, Jelsema, Russell

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eP498 - Using chromosomal and single-gene non-invasive prenatal testing to identify the cause of congenital heart defects von Hajjar, Mark, Mohan, Pooja, Wulff, Jacob, Maisenbacher, Melissa, Keen-Kim, J. Dianne, Billings, Paul, Jelsema, Russell

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