Mechanical signaling through the cytoskeleton regulates cell proliferation by coordinated focal adhesion and Rho GTPase signaling von Provenzano, Paolo P, Keely, Patricia J

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Biomechanical Remodeling of the Microenvironment by Stromal Caveolin-1 Favors Tumor Invasion and Metastasis von Goetz, Jacky G., Minguet, Susana, Navarro-Lérida, Inmaculada, Lazcano, Juan José, Samaniego, Rafael, Calvo, Enrique, Tello, Marta, Osteso-Ibáñez, Teresa, Pellinen, Teijo, Echarri, Asier, Cerezo, Ana, Klein-Szanto, Andres J.P., Garcia, Ricardo, Keely, Patricia J., Sánchez-Mateos, Paloma, Cukierman, Edna, Del Pozo, Miguel A.

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Mechanisms by Which the Extracellular Matrix and Integrin Signaling Act to Regulate the Switch Between Tumor Suppression and Tumor Promotion von Keely, Patricia J.

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The collagen receptor discoidin domain receptor 2 stabilizes SNAIL1 to facilitate breast cancer metastasis von Zhang, Kun, Corsa, Callie A., Ponik, Suzanne M., Prior, Julie L., Piwnica-Worms, David, Eliceiri, Kevin W., Keely, Patricia J., Longmore, Gregory D.

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3D Collagen Alignment Limits Protrusions to Enhance Breast Cancer Cell Persistence von Riching, Kristin M., Cox, Benjamin L., Salick, Max R., Pehlke, Carolyn, Riching, Andrew S., Ponik, Susan M., Bass, Benjamin R., Crone, Wendy C., Jiang, Yi, Weaver, Alissa M., Eliceiri, Kevin W., Keely, Patricia J.

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Why the stroma matters in breast cancer: Insights into breast cancer patient outcomes through the examination of stromal biomarkers von Conklin, Matthew W., Keely, Patricia J.

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Collagen reorganization at the tumor-stromal interface facilitates local invasion von Provenzano, Paolo P, Eliceiri, Kevin W, Campbell, Jay M, Inman, David R, White, John G, Keely, Patricia J

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Postpartum mammary gland involution drives progression of ductal carcinoma in situ through collagen and COX-2 von Lyons, Traci R, O'Brien, Jenean, Borges, Virginia F, Conklin, Matthew W, Keely, Patricia J, Eliceiri, Kevin W, Marusyk, Andriy, Tan, Aik-Choon, Schedin, Pepper

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A three-dimensional computational model of collagen network mechanics von Lee, Byoungkoo, Zhou, Xin, Riching, Kristin, Eliceiri, Kevin W, Keely, Patricia J, Guelcher, Scott A, Weaver, Alissa M, Jiang, Yi

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Mechano-Signal Transduction in Mesenchymal Stem Cells Induces Prosaposin Secretion to Drive the Proliferation of Breast Cancer Cells von Ishihara, Seiichiro, Inman, David R, Li, Wan-Ju, Ponik, Suzanne M, Keely, Patricia J

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Computational segmentation of collagen fibers from second-harmonic generation images of breast cancer von Bredfeldt, Jeremy S, Liu, Yuming, Pehlke, Carolyn A, Conklin, Matthew W, Szulczewski, Joseph M, Inman, David R, Keely, Patricia J, Nowak, Robert D, Mackie, Thomas R, Eliceiri, Kevin W

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Stiff stroma increases breast cancer risk by inducing the oncogene ZNF217 von Northey, Jason J., Barrett, Alexander S., Acerbi, Irene, Hayward, Mary-Kate, Talamantes, Stephanie, Dean, Ivory S., Mouw, Janna K., Ponik, Suzanne M., Lakins, Jonathon N., Huang, Po-Jui, Wu, Junmin, Shi, Quanming, Samson, Susan, Keely, Patricia J., Mukhtar, Rita A., Liphardt, Jan T., Shepherd, John A., Hwang, E. Shelley, Chen, Yunn-Yi, Hansen, Kirk C., Littlepage, Laurie E., Weaver, Valerie M.

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Contact Guidance Mediated Three-Dimensional Cell Migration is Regulated by Rho/ROCK-Dependent Matrix Reorganization von Provenzano, Paolo P., Inman, David R., Eliceiri, Kevin W., Trier, Steven M., Keely, Patricia J.

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The Action of Discoidin Domain Receptor 2 in Basal Tumor Cells and Stromal Cancer-Associated Fibroblasts Is Critical for Breast Cancer Metastasis von Corsa, Callie A.S., Brenot, Audrey, Grither, Whitney R., Van Hove, Samantha, Loza, Andrew J., Zhang, Kun, Ponik, Suzanne M., Liu, Yuming, DeNardo, David G., Eliceiri, Kevin W., Keely, Patricia J., Longmore, Gregory D.

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Tumor Cell-Driven Extracellular Matrix Remodeling Drives Haptotaxis during Metastatic Progression von Oudin, Madeleine J, Jonas, Oliver, Kosciuk, Tatsiana, Broye, Liliane C, Guido, Bruna C, Wyckoff, Jeff, Riquelme, Daisy, Lamar, John M, Asokan, Sreeja B, Whittaker, Charlie, Ma, Duanduan, Langer, Robert, Cima, Michael J, Wisinski, Kari B, Hynes, Richard O, Lauffenburger, Douglas A, Keely, Patricia J, Bear, James E, Gertler, Frank B

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Mechanical signals regulate and activate SNAIL1 protein to control the fibrogenic response of cancer-associated fibroblasts von Zhang, Kun, Grither, Whitney R, Van Hove, Samantha, Biswas, Hirak, Ponik, Suzanne M, Eliceiri, Kevin W, Keely, Patricia J, Longmore, Gregory D

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Targeted matrisome analysis identifies thrombospondin-2 and tenascin-C in aligned collagen stroma from invasive breast carcinoma von Tomko, Lucas A., Hill, Ryan C., Barrett, Alexander, Szulczewski, Joseph M., Conklin, Matthew W., Eliceiri, Kevin W., Keely, Patricia J., Hansen, Kirk C., Ponik, Suzanne M.

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Multiphoton microscopy and fluorescence lifetime imaging microscopy (FLIM) to monitor metastasis and the tumor microenvironment von Provenzano, Paolo P, Eliceiri, Kevin W, Keely, Patricia J

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Dense collagen-I matrices enhance pro-tumorigenic estrogen-prolactin crosstalk in MCF-7 and T47D breast cancer cells von Barcus, Craig E, Holt, Elizabeth C, Keely, Patricia J, Eliceiri, Kevin W, Schuler, Linda A

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Mammary collagen architecture and its association with mammographic density and lesion severity among women undergoing image-guided breast biopsy von Bodelon, Clara, Mullooly, Maeve, Pfeiffer, Ruth M., Fan, Shaoqi, Abubakar, Mustapha, Lenz, Petra, Vacek, Pamela M., Weaver, Donald L., Herschorn, Sally D., Johnson, Jason M., Sprague, Brian L., Hewitt, Stephen, Shepherd, John, Malkov, Serghei, Keely, Patricia J., Eliceiri, Kevin W., Sherman, Mark E., Conklin, Matthew W., Gierach, Gretchen L.

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