Chimeric Antigen Receptor T Cell Therapies: A Review of Cellular Kinetic‐Pharmacodynamic Modeling Approaches von Chaudhury, Anwesha, Zhu, Xu, Chu, Lulu, Goliaei, Ardeshir, June, Carl H., Kearns, Jeffrey D., Stein, Andrew M.

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CHD1L Regulates Cell Survival in Breast Cancer and Its Inhibition by OTI-611 Impedes the DNA Damage Response and Induces PARthanatos von Sala, Rita, Esquer, Hector, Kellett, Timothy, Kearns, Jeffrey T, Awolade, Paul, Zhou, Qiong, LaBarbera, Daniel V

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Discovery, Preclinical Characterization, and Early Clinical Activity of JDQ443, a Structurally Novel, Potent, and Selective Covalent Oral Inhibitor of KRASG12C von Weiss, Andreas, Lorthiois, Edwige, Barys, Louise, Beyer, Kim S, Bomio-Confaglia, Claudio, Burks, Heather, Chen, Xueying, Cui, Xiaoming, de Kanter, Ruben, Dharmarajan, Lekshmi, Fedele, Carmine, Gerspacher, Marc, Guthy, Daniel Alexander, Head, Victoria, Jaeger, Ashley, Núñez, Eloísa Jiménez, Kearns, Jeffrey D, Leblanc, Catherine, Maira, Sauveur-Michel, Murphy, Jason, Oakman, Helen, Ostermann, Nils, Ottl, Johannes, Rigollier, Pascal, Roman, Danielle, Schnell, Christian, Sedrani, Richard, Shimizu, Toshio, Stringer, Rowan, Vaupel, Andrea, Voshol, Hans, Wessels, Peter, Widmer, Toni, Wilcken, Rainer, Xu, Kun, Zecri, Frederic, Farago, Anna F, Cotesta, Simona, Brachmann, Saskia M

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Promises and pitfalls for recombinant oligoclonal antibodies-based therapeutics in cancer and infectious disease von Corti, Davide, Kearns, Jeffrey D

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Control of RelB during dendritic cell activation integrates canonical and noncanonical NF-κB pathways von Shih, Vincent F-S, Davis-Turak, Jeremy, Macal, Monica, Huang, Jenny Q, Ponomarenko, Julia, Kearns, Jeffrey D, Yu, Tony, Fagerlund, Riku, Asagiri, Masataka, Zuniga, Elina I, Hoffmann, Alexander

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USP28 deletion and small-molecule inhibition destabilizes c-MYC and elicits regression of squamous cell lung carcinoma von Ruiz, E Josue, Pinto-Fernandez, Adan, Turnbull, Andrew P, Lan, Linxiang, Charlton, Thomas M, Scott, Hannah C, Damianou, Andreas, Vere, George, Riising, Eva M, Da Costa, Clive, Krajewski, Wojciech W, Guerin, David, Kearns, Jeffrey D, Ioannidis, Stephanos, Katz, Marie, McKinnon, Crystal, O'Connell, Jonathan, Moncaut, Natalia, Rosewell, Ian, Nye, Emma, Jones, Neil, Heride, Claire, Gersch, Malte, Wu, Min, Dinsmore, Christopher J, Hammonds, Tim R, Kim, Sunkyu, Komander, David, Urbe, Sylvie, Clague, Michael J, Kessler, Benedikt M, Behrens, Axel

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MM-131, a bispecific anti-Met/EpCAM mAb, inhibits HGF-dependent and HGF-independent Met signaling through concurrent binding to EpCAM von Casaletto, Jessica B., Geddie, Melissa L., Abu-Yousif, Adnan O., Masson, Kristina, Fulgham, Aaron, Boudot, Antoine, Maiwald, Tim, Kearns, Jeffrey D., Kohli, Neeraj, Su, Stephen, Razlog, Maja, Raue, Andreas, Kalra, Ashish, Håkansson, Maria, Logan, Derek T., Welin, Martin, Chattopadhyay, Shrikanta, Harms, Brian D., Nielsen, Ulrik B., Schoeberl, Birgit, Lugovskoy, Alexey A., MacBeath, Gavin

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Understanding the role of cross-arm binding efficiency in the activity of monoclonal and multispecific therapeutic antibodies von Harms, Brian D., Kearns, Jeffrey D., Iadevaia, Sergio, Lugovskoy, Alexey A.

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IκBε Provides Negative Feedback to Control NF-κB Oscillations, Signaling Dynamics, and Inflammatory Gene Expression von Jeffrey D. Kearns, Soumen Basak, Werner, Shannon L., Christine S. Huang, Hoffmann, Alexander

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IκBβ enhances the generation of the low-affinity NFκB/RelA homodimer von Tsui, Rachel, Kearns, Jeffrey D., Lynch, Candace, Vu, Don, Ngo, Kim A., Basak, Soumen, Ghosh, Gourisankar, Hoffmann, Alexander

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The validation of new CHD1L inhibitors as a therapeutic strategy for cancer von Clune, Sophia, Awolade, Paul, Zhou, Qiong, Esquer, Hector, Matter, Brock, Kearns, Jeffrey T., Kellett, Timothy, Akintayo, Damilola Caleb, Kompella, Uday B., LaBarbera, Daniel V.

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Dual delayed feedback provides sensitivity and robustness to the NF-κB signaling module von Longo, Diane M, Selimkhanov, Jangir, Kearns, Jeffrey D, Hasty, Jeff, Hoffmann, Alexander, Tsimring, Lev S

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Kinetic control of negative feedback regulators of NF-κB/RelA determines their pathogen- and cytokine-receptor signaling specificity von Shih, Vincent F.-S, Kearns, Jeffrey D, Basak, Soumen, Savinova, Olga V, Ghosh, Gourisankar, Hoffmann, Alexander

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Navigating Between Right, Wrong, and Relevant: The Use of Mathematical Modeling in Preclinical Decision Making von Kondic, Anna, Bottino, Dean, Harrold, John, Kearns, Jeffrey D, Musante, C J, Odinecs, Aleksandrs, Ramanujan, Saroja, Selimkhanov, Jangir, Schoeberl, Birgit

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Enhanced Targeting of the EGFR Network with MM-151, an Oligoclonal Anti-EGFR Antibody Therapeutic von Kearns, Jeffrey D, Bukhalid, Raghida, Sevecka, Mark, Tan, Gege, Gerami-Moayed, Nastaran, Werner, Shannon L, Kohli, Neeraj, Burenkova, Olga, Sloss, Callum M, King, Anne M, Fitzgerald, Jonathan B, Nielsen, Ulrik B, Wolf, Beni B

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A homeostatic model of IκB metabolism to control constitutive NF-κB activity von Hoffmann, Alexander, O'Dea, Ellen L, Barken, Derren, Peralta, Raechel Q, Tran, Kim T, Werner, Shannon L, Kearns, Jeffrey D, Levchenko, Andre

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A model-informed method to retrieve intrinsic from apparent cooperativity and project cellular target occupancy for ternary complex-forming compounds von Stein, Richard R, Fouché, Marianne, Kearns, Jeffrey D, Roth, Hans-Joerg

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Integrating Computational and Biochemical Studies to Explore Mechanisms in NF-κB Signaling von Kearns, Jeffrey D., Hoffmann, Alexander

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Stabilization of RelB Requires Multidomain Interactions with p100/p52 von Fusco, Amanda J., Savinova, Olga V., Talwar, Rashmi, Kearns, Jeffrey D., Hoffmann, Alexander, Ghosh, Gourisankar

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