The impact of obesity on adipocyte-derived extracellular vesicles von Kwan, Hiu Yee, Chen, Minting, Xu, Keyang, Chen, Baisen

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Protein Biomarker Quantification by Immunoaffinity Liquid Chromatography-Tandem Mass Spectrometry: Current State and Future Vision von Neubert, Hendrik, Shuford, Christopher M, Olah, Timothy V, Garofolo, Fabio, Schultz, Gary A, Jones, Barry R, Amaravadi, Lakshmi, Laterza, Omar F, Xu, Keyang, Ackermann, Bradley L

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Conjugation site modulates the in vivo stability and therapeutic activity of antibody-drug conjugates von Shen, Ben-Quan, Xu, Keyang, Liu, Luna, Raab, Helga, Bhakta, Sunil, Kenrick, Margaret, Parsons-Reponte, Kathryn L, Tien, Janet, Yu, Shang-Fan, Mai, Elaine, Li, Dongwei, Tibbitts, Jay, Baudys, Jakub, Saad, Ola M, Scales, Suzie J, McDonald, Paul J, Hass, Philip E, Eigenbrot, Charles, Nguyen, Trung, Solis, Willy A, Fuji, Reina N, Flagella, Kelly M, Patel, Darshana, Spencer, Susan D, Khawli, Leslie A, Ebens, Allen, Wong, Wai Lee, Vandlen, Richard, Kaur, Surinder, Sliwkowski, Mark X, Scheller, Richard H, Polakis, Paul, Junutula, Jagath R

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Automated, Generic Reagent and Ultratargeted 2D-LC-MS/MS Enabling Quantification of Biotherapeutics and Soluble Targets down to pg/mL Range in Serum von He, Jintang, Meng, Lingyao, Ruppel, Jane, Yang, Jie, Kaur, Surinder, Xu, Keyang

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Toll-like receptor 4 is a master regulator for colorectal cancer growth under high-fat diet by programming cancer metabolism von Hu, Xianjing, Fatima, Sarwat, Chen, Minting, Xu, Keyang, Huang, Chunhua, Gong, Rui-Hong, Su, Tao, Wong, Hoi Leong Xavier, Bian, Zhaoxiang, Kwan, Hiu Yee

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Custom-Designed Affinity Capture LC-MS F(ab′)2 Assay for Biotransformation Assessment of Site-Specific Antibody Drug Conjugates von Su, Dian, Ng, Carl, Khosraviani, Mehraban, Yu, Shang-Fan, Cosino, Ely, Kaur, Surinder, Xu, Keyang

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Roles of Identified Long Noncoding RNA in Diabetic Nephropathy von Cao, Yifang, Chen, Sixiang, Xu, Kechen, Xu, Keyang, Li, Yan, Zhan, Huakui

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Elevated extracellular matrix protein 1 in circulating extracellular vesicles supports breast cancer progression under obesity conditions von Xu, Keyang, Fu, Ai, Li, Zhaoyi, Miao, Liangbin, Lou, Zhonghan, Jiang, Keying, Lau, Condon, Su, Tao, Tong, Tiejun, Bao, Jianfeng, Lyu, Aiping, Kwan, Hiu Yee

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Regulation of age-associated insulin resistance by MT1-MMP-mediated cleavage of insulin receptor von Guo, Xuanming, Asthana, Pallavi, Gurung, Susma, Zhang, Shuo, Wong, Sheung Kin Ken, Fallah, Samane, Chow, Chi Fung Willis, Che, Sijia, Zhai, Lixiang, Wang, Zening, Ge, Xin, Jiang, Zhixin, Wu, Jiayan, Zhang, Yijing, Wu, Xiaoyu, Xu, Keyang, Lin, Cheng Yuan, Kwan, Hiu Yee, Lyu, Aiping, Zhou, Zhongjun, Bian, Zhao-Xiang, Wong, Hoi Leong Xavier

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Bioanalytical Assay Strategies for The Development of Antibody–Drug Conjugate Biotherapeutics von Kaur, Surinder, Xu, Keyang, Saad, Ola M, Dere, Randall C, Carrasco-Triguero, Montserrat

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Targeted drug delivery through the traceless release of tertiary and heteroaryl amines from antibody–drug conjugates von Staben, Leanna R., Koenig, Stefan G., Lehar, Sophie M., Vandlen, Richard, Zhang, Donglu, Chuh, Josefa, Yu, Shang-Fan, Ng, Carl, Guo, Jun, Liu, Yanzhou, Fourie-O'Donohue, Aimee, Go, MaryAnn, Linghu, Xin, Segraves, Nathaniel L., Wang, Tao, Chen, Jinhua, Wei, BinQing, Phillips, Gail D. Lewis, Xu, Keyang, Kozak, Katherine R., Mariathasan, Sanjeev, Flygare, John A., Pillow, Thomas H.

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Recommendations for Validation of LC-MS/MS Bioanalytical Methods for Protein Biotherapeutics von Jenkins, Rand, Duggan, Jeffrey X., Aubry, Anne-Françoise, Zeng, Jianing, Lee, Jean W., Cojocaru, Laura, Dufield, Dawn, Garofolo, Fabio, Kaur, Surinder, Schultz, Gary A., Xu, Keyang, Yang, Ziping, Yu, John, Zhang, Yan J., Vazvaei, Faye

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RNA N6-methyladenosine: a promising molecular target in metabolic diseases von Li, Yan, Wang, Jiawen, Huang, Chunyan, Shen, Meng, Zhan, Huakui, Xu, Keyang

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Discovery of Peptidomimetic Antibody–Drug Conjugate Linkers with Enhanced Protease Specificity von Wei, BinQing, Gunzner-Toste, Janet, Yao, Hui, Wang, Tao, Wang, Jing, Xu, Zijin, Chen, Jinhua, Wai, John, Nonomiya, Jim, Tsai, Siao Ping, Chuh, Josefa, Kozak, Katherine R, Liu, Yichin, Yu, Shang-Fan, Lau, Jeff, Li, Guangmin, Phillips, Gail D, Leipold, Doug, Kamath, Amrita, Su, Dian, Xu, Keyang, Eigenbrot, Charles, Steinbacher, Stefan, Ohri, Rachana, Raab, Helga, Staben, Leanna R, Zhao, Guiling, Flygare, John A, Pillow, Thomas H, Verma, Vishal, Masterson, Luke A, Howard, Philip W, Safina, Brian

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Brevilin A is a potent anti-metastatic CRC agent that targets the VEGF-IL6-STAT3 axis in the HSCs-CRC interplay von Fan, Xueying, Meng, Mingjing, Li, Baoting, Chen, Hui, Tan, Jincheng, Xu, Keyang, Xiao, Shilin, Kwan, Hiu-Yee, Liu, Zhongqiu, Su, Tao

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Characterization of intact antibody–drug conjugates from plasma/serum in vivo by affinity capture capillary liquid chromatography–mass spectrometry von Xu, Keyang, Liu, Luna, Saad, Ola M., Baudys, Jakub, Williams, Lara, Leipold, Douglas, Shen, Ben, Raab, Helga, Junutula, Jagath R., Kim, Amy, Kaur, Surinder

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High-Resolution Accurate-Mass Mass Spectrometry Enabling In-Depth Characterization of in Vivo Biotransformations for Intact Antibody-Drug Conjugates von He, Jintang, Su, Dian, Ng, Carl, Liu, Luna, Yu, Shang-Fan, Pillow, Thomas H, Del Rosario, Geoffrey, Darwish, Martine, Lee, Byoung-Chul, Ohri, Rachana, Zhou, Hongxiang, Wang, Xueji, Lu, Jiawei, Kaur, Surinder, Xu, Keyang

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Modulating Therapeutic Activity and Toxicity of Pyrrolobenzodiazepine Antibody-Drug Conjugates with Self-Immolative Disulfide Linkers von Pillow, Thomas H, Schutten, Melissa, Yu, Shang-Fan, Ohri, Rachana, Sadowsky, Jack, Poon, Kirsten Achilles, Solis, Willy, Zhong, Fiona, Del Rosario, Geoffrey, Go, Mary Ann T, Lau, Jeffrey, Yee, Sharon, He, Jintang, Liu, Luna, Ng, Carl, Xu, Keyang, Leipold, Douglas D, Kamath, Amrita V, Zhang, Donglu, Masterson, Luke, Gregson, Stephen J, Howard, Philip W, Fang, Fan, Chen, Jinhua, Gunzner-Toste, Janet, Kozak, Katherine K, Spencer, Susan, Polakis, Paul, Polson, Andrew G, Flygare, John A, Junutula, Jagath R

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Intratumoral Payload Concentration Correlates with the Activity of Antibody-Drug Conjugates von Zhang, Donglu, Yu, Shang-Fan, Khojasteh, S Cyrus, Ma, Yong, Pillow, Thomas H, Sadowsky, Jack D, Su, Dian, Kozak, Katherine R, Xu, Keyang, Polson, Andrew G, Dragovich, Peter S, Hop, Cornelis E C A

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Systematic Variation of Pyrrolobenzodiazepine (PBD)-Dimer Payload Physicochemical Properties Impacts Efficacy and Tolerability of the Corresponding Antibody–Drug Conjugates von Staben, Leanna R, Chen, Jinhua, Cruz-Chuh, Josefa dela, del Rosario, Geoff, Go, Mary Ann, Guo, Jun, Khojasteh, S. Cyrus, Kozak, Katherine R, Li, Guangmin, Ng, Carl, Lewis Phillips, Gail D, Pillow, Thomas H, Rowntree, Rebecca K, Wai, John, Wei, BinQing, Xu, Keyang, Xu, Zijin, Yu, Shang-Fan, Zhang, Donglu, Dragovich, Peter S

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