Targeting Excessive EZH1 and EZH2 Activities for Abnormal Histone Methylation and Transcription Network in Malignant Lymphomas von Yamagishi, Makoto, Hori, Makoto, Fujikawa, Dai, Ohsugi, Takeo, Honma, Daisuke, Adachi, Nobuaki, Katano, Harutaka, Hishima, Tsunekazu, Kobayashi, Seiichiro, Nakano, Kazumi, Nakashima, Makoto, Iwanaga, Masako, Utsunomiya, Atae, Tanaka, Yuetsu, Okada, Seiji, Tsukasaki, Kunihiro, Tobinai, Kensei, Araki, Kazushi, Watanabe, Toshiki, Uchimaru, Kaoru

Volltext

CDKN1C‐mediated growth inhibition by an EZH1/2 dual inhibitor overcomes resistance of mantle cell lymphoma to ibrutinib von Kagiyama, Yuki, Fujita, Shuhei, Shima, Yutaka, Yamagata, Kazutsune, Katsumoto, Takuo, Nakagawa, Makoto, Honma, Daisuke, Adachi, Nobuaki, Araki, Kazushi, Kato, Ayako, Inaki, Koichiro, Ono, Yoshimasa, Fukuhara, Suguru, Kobayashi, Yukio, Tobinai, Kensei, Kitabayashi, Issay

Volltext

Dual inhibition of enhancer of zeste homolog 1/2 overactivates WNT signaling to deplete cancer stem cells in multiple myeloma von Nakagawa, Makoto, Fujita, Shuhei, Katsumoto, Takuo, Yamagata, Kazutsune, Ogawara, Yoko, Hattori, Ayuna, Kagiyama, Yuki, Honma, Daisuke, Araki, Kazushi, Inoue, Tatsuya, Kato, Ayako, Inaki, Koichiro, Wada, Chisa, Ono, Yoshimasa, Yamamoto, Masahide, Miura, Osamu, Nakashima, Yasuharu, Kitabayashi, Issay

Volltext

IDH2 and NPM1 Mutations Cooperate to Activate Hoxa9/Meis1 and Hypoxia Pathways in Acute Myeloid Leukemia von Ogawara, Yoko, Katsumoto, Takuo, Aikawa, Yukiko, Shima, Yutaka, Kagiyama, Yuki, Soga, Tomoyoshi, Matsunaga, Hironori, Seki, Takahiko, Araki, Kazushi, Kitabayashi, Issay

Volltext

EZH1/2 dual inhibitors suppress HTLV-1-infected cell proliferation and hyperimmune response in HTLV-1-associated myelopathy von Koseki, Akihito, Araya, Natsumi, Yamagishi, Makoto, Yamauchi, Junji, Yagishita, Naoko, Takao, Naoki, Takahashi, Katsunori, Kunitomo, Yasuo, Honma, Daisuke, Araki, Kazushi, Uchimaru, Kaoru, Sato, Tomoo, Yamano, Yoshihisa

Volltext

Structure–Activity Relationship Studies of 3- or 4‑Pyridine Derivatives of DS-6930 von Shinozuka, Tsuyoshi, Tsukada, Tomoharu, Fujii, Kunihiko, Tokumaru, Eri, Matsui, Yumi, Wakimoto, Satoko, Ogata, Tsuneaki, Araki, Kazushi, Sawamura, Ryoko, Watanabe, Nobuaki, Mori, Makoto, Tanaka, Jun

Volltext

Development and Molecular Analysis of Synthetic Lethality By Targeting EZH1 and EZH2 in Non-Hodgkin Lymphomas von Yamagishi, Makoto, Hori, Makoto, Fujikawa, Dai, Honma, Daisuke, Adachi, Nobuaki, Ohsugi, Takeo, Nakano, Kazumi, Nakashima, Makoto, Kobayashi, Seiichiro, Iwanaga, Masako, Utsunomiya, Atae, Okada, Seiji, Tsukasaki, Kunihiro, Tobinai, Kensei, Araki, Kazushi, Watanabe, Toshiki, Uchimaru, Kaoru

Volltext

Role of Rho-kinase in regulation of insulin action and glucose homeostasis von Furukawa, Noboru, Ongusaha, Pat, Jahng, Wan Jin, Araki, Kazushi, Choi, Cheol Soo, Kim, Hyo-Jeong, Lee, Yong Hee, Kaibuchi, Kozo, Kahn, Barbara B., Masuzaki, Hiroaki, Kim, Jason K., Lee, Sam W., Kim, Young-Bum

Volltext

Potent Antidiabetic Effects of Rivoglitazone, a Novel Peroxisome Proliferator–Activated Receptor-γ Agonist, in Obese Diabetic Rodent Models von Kanda, Shoichi, Nakashima, Ryutaro, Takahashi, Kanako, Tanaka, Jun, Ogawa, Junko, Ogata, Tsuneaki, Yachi, Makoto, Araki, Kazushi, Ohsumi, Jun

Volltext

Pharmacology and in Vitro Profiling of a Novel Peroxisome Proliferator-Activated Receptor γ Ligand, Cerco-A von Wakabayashi, Kenji, Hayashi, Shinko, Matsui, Yumi, Matsumoto, Takuo, Furukawa, Akihiro, Kuroha, Masanori, Tanaka, Naomi, Inaba, Tomoko, Kanda, Shoichi, Tanaka, Jun, Okuyama, Ryo, Wakimoto, Satoko, Ogata, Tsuneaki, Araki, Kazushi, Ohsumi, Jun

Volltext

Identification of Molecular Target of AMP-activated Protein Kinase Activator by Affinity Purification and Mass Spectrometry von Kosaka, Toshiyuki, Okuyama, Ryo, Sun, Weiyong, Ogata, Tsuneaki, Harada, Jun, Araki, Kazushi, Izumi, Masanori, Yoshida, Taishi, Okuno, Akira, Fujiwara, Toshihiko, Ohsumi, Jun, Ichikawa, Kimihisa

Volltext

Abstract 4670: Identification of a possible therapeutic candidate for multiple myeloma based on dual inhibition of EZH1/EZH2 von Nakagawa, Makoto, Fujita, Shuhei, Honma, Daisuke, Araki, Kazushi, Kitabayashi, Issay

Volltext

Abstract 4672: Novel epigenetic approach to relapsed mantle cell lymphoma based on dual inhibition of EZH1/EZH2 von Fujita, Shuhei, Kagiyama, Yuki, Honma, Daisuke, Adachi, Nobuaki, Araki, Kazushi, Kitabayashi, Issay

Volltext

Abstract 913: Novel leukemia stem cell-targeted therapy for acute myeloid leukemia based on dual inhibition of EZH1EZH2 von Fujita, Shuhei, Honma, Daisuke, Araki, Kazushi, Aoyama, Kazumasa, Iwama, Atsushi, Kitabayashi, Issay

Volltext

Abstract 3101: The mutant IDH1 inhibitor prevents growth of glioblastoma with IDH1 mutation in patient-derived xenograft (PDX) model von Machida, Yukino, Ogawara, Yoko, Ichimura, Koichi, Matsunaga, Hironori, Takahiko, Seki, Araki, Kazushi, Kitabayashi, Issay

Volltext

Abstract 913: Novel leukemia stem cell-targeted therapy for acute myeloid leukemia based on dual inhibition of EZH1/EZH2 von Fujita, Shuhei, Honma, Daisuke, Araki, Kazushi, Aoyama, Kazumasa, Iwama, Atsushi, Kitabayashi, Issay

Volltext

First-in-Human Study of the EZH1/2 Dual Inhibitor Valemetostat in Relapsed or Refractory Non-Hodgkin Lymphoma (NHL) - Updated Results Focusing on Adult T-Cell Leukemia-Lymphoma (AT... von Morishima, Satoko, Ishitsuka, Kenji, Izutsu, Koji, Kusumoto, Shigeru, Makiyama, Junya, Utsunomiya, Atae, Nosaka, Kisato, Ishida, Takashi, Imaizumi, Yoshitaka, Yamauchi, Nobuhiko, Araki, Kazushi, Adachi, Nobuaki, Yamashita, Tomonari, Atsumi, Ryo, Tsukasaki, Kunihiro, Tobinai, Kensei

Volltext

Discovery of DS-6930, a potent selective PPARγ modulator. Part I: Lead identification von Shinozuka, Tsuyoshi, Tsukada, Tomoharu, Fujii, Kunihiko, Tokumaru, Eri, Shimada, Kousei, Onishi, Yoshiyuki, Matsui, Yumi, Wakimoto, Satoko, Kuroha, Masanori, Ogata, Tsuneaki, Araki, Kazushi, Ohsumi, Jun, Sawamura, Ryoko, Watanabe, Nobuaki, Yamamoto, Hideki, Fujimoto, Kazunori, Tani, Yoshiro, Mori, Makoto, Tanaka, Jun

Volltext

The Role of IDH Mutants, Which Are Promising Therapeutic Targets for Acute Myeloid Leukemia von Ogawara, Yoko, Matsunaga, Hironori, Seki, Takahiko, Machida, Yukino, Araki, Kazushi, Kitabayashi, Issay

Volltext

Novel Leukemia Stem Cell-Targeted Therapy for Acute Myeloid Leukemia Based on Dual Inhibition of Ezh1/Ezh2 von Fujita, Shuhei, Honma, Daisuke, Adachi, Nobuaki, Araki, Kazushi, Takamatsu, Emi, Aoyama, Kazumasa, Iwama, Atsushi, Kitabayashi, Issay

Volltext