A landmark in drug discovery based on complex natural product synthesis von Kawano, Satoshi, Ito, Ken, Yahata, Kenzo, Kira, Kazunobu, Abe, Takanori, Akagi, Tsuyoshi, Asano, Makoto, Iso, Kentaro, Sato, Yuki, Matsuura, Fumiyoshi, Ohashi, Isao, Matsumoto, Yasunobu, Isomura, Minetaka, Sasaki, Takeo, Fukuyama, Takashi, Miyashita, Yusuke, Kaburagi, Yosuke, Yokoi, Akira, Asano, Osamu, Owa, Takashi, Kishi, Yoshito

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Synthesis of the BCD-ring of ciguatoxin 1B using an acetylene cobalt complex and vinylsilane strategy von Kira, Kazunobu, Hamajima, Akinari, Isobe, Minoru

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Synthesis of the BCDE rings of ciguatoxin 1B via an acetylene biscobalthexacarbonyl–vinylsilane strategy von Kira, Kazunobu, Isobe, Minoru

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Mechanistic studies on the hydrosilylation of an acetylene cobalt complex; trapping an active catalyst Co2(CO)6 causing olefin-isomerization and O-silylation von Kira, Kazunobu, Tanda, Hiromichi, Hamajima, Akinari, Baba, Takayuki, Takai, Shigeyuki, Isobe, Minoru

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The combination of metformin and a dipeptidyl peptidase IV inhibitor prevents 5-fluorouracil-induced reduction of small intestine weight von Yamazaki, Kazuto, Yasuda, Nobuyuki, Inoue, Takashi, Nagakura, Tadashi, Kira, Kazunobu, Saeki, Takao, Tanaka, Isao

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What Does It Take to Develop Structurally Complex Molecules by Total Synthesis? Rapid Process Development and GMP Manufacturing of E7130 Drug Substance for First-in-Human Clinical... von Sasaki, Takeo, Yahata, Kenzo, Isomura, Minetaka, Ohashi, Isao, Fukuyama, Takashi, Miyashita, Yusuke, Watanabe, Yuzo, Murai, Norio, Matsuda, Masaaki, Kamada, Atsushi, Kaburagi, Yosuke, Kira, Kazunobu, Iso, Kentaro, Sato, Yuki, Matsuura, Fumiyoshi, Matsumoto, Yasunobu, Azuma, Hiroshi, Iida, Daisuke, Ishida, Tasuku, Itano, Wataru, Nagao, Satoshi, Seki, Masashi, Yamamoto, Akihiko, Yamamoto, Yuji, Yoneda, Naoki, Matsukura, Masayuki, Asano, Osamu, Kayano, Akio, Tagami, Katsuya, Owa, Takashi, Kishi, Yoshito

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syn-trans Fused Bicyclic Ether Formation via Acetylene-biscobalthexacarbonyl Complex von Isobe, Minoru, Hosokawa, Seijiro, Kira, Kazunobu

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Sodium Hypophosphite Decomplexation of Acetylenebiscobalthexacarbonyls to cis-Olefins von Takai, Shigeyuki, Ploypradith, Poonsakdi, Hamajima, Akinari, Kira, Kazunobu, Isobe, Minoru

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Abstract 4183: Mechanism of action analysis of anti-CAF activity of E7130, a novel tumor-microenvironment ameliorator von Abe, Takanori, Kawano, Satoshi, Ito, Ken, Yahata, Kenzo, Kira, Kazunobu, Akagi, Tsuyoshi, Asano, Makoto, Iso, Kentaro, Sato, Yuki, Matsuura, Fumiyoshi, Ohashi, Isao, Matsumoto, Yasunobu, Isomura, Minetaka, Sasaki, Takeo, Fukuyama, Takashi, Miyashita, Yusuke, Kaburagi, Yosuke, Yokoi, Akira, Asano, Osamu, Owa, Takashi, Kishi, Yoshito

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Selective tissue factor/factor VIIa Inhibitor, ER-410660, and its prodrug, E5539, have anti-venous and anti-arterial thrombotic effects with a low risk of bleeding von Nagakura, Tadashi, Tabata, Kimiyo, Kira, Kazunobu, Hirota, Shinsuke, Clark, Richard, Matsuura, Fumiyoshi, Hiyoshi, Hironobu

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Acetylene cobalt complex and vinylsilane strategy in the synthesis of ciguatoxin (D)EF analog von Kira, Kazunobu, Isobe, Minoru

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Abstract 414: Combined Tissue Factor/Factor VIIa Inhibitor and Acetylsalicylic Acid Show Increased Antithrombotic Potency Without Affecting Bleeding Time von Tabata, Kimiyo M, Nagakura, Tadashi, Kira, Kazunobu, Hirota, Shinsuke, Clark, Richard, Matsuura, Fumiyoshi, Azuma, Hiroshi, Yasui, Sou, Takemura, Atsushi, Kusano, Kazutomi, Mikamoto, Masaki, Omae, Takao, Inoue, Atsushi, Hiyoshi, Hironobu

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Ring Opening Reactions of Cyclic α,β-Epoxysilanes with BF3·Oet2 von Kira, Kazunobu, Isobe, Minoru

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MACROCYCLIC COMPOUNDS AND USES THEREOF von KIRA, Kazunobu, ITO, Ken, KISHI, Yoshito

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MACROCYCLIC COMPOUNDS AND USES THEREOF von Kishi, Yoshito, Kira, Kazunobu, Ito, Ken

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MACROCYCLIC COMPOUNDS AND USES THEREOF von KIRA, Kazunobu, ITO, Ken, KISHI, Yoshito

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Macrocyclic compound and uses thereof von Kishi, Yoshito, Kira, Kazunobu, Ito, Ken

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MACROCYCLIC COMPOUND AND USES THEREOF von Kishi, Yoshito, Kira, Kazunobu, Ito, Ken

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O3H-4-4 Finding of selective tissue factor/factor VIIa complex inhibitor as a novel anticoagulant with lower bleeding risk von Nagakura Tadashi, Kimiyo Tabata, Kazunobu Kira, Shinsuke Hirota, Clark Richard, Fumiyoshi Matsuura, Hironobu Hisyohi

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Macrocyclic compounds and uses thereof von Kishi, Yoshito, Kira, Kazunobu, Ito, Ken

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