Whole-genome sequencing reveals clinically relevant insights into the aetiology of familial breast cancers von Nones, K., Johnson, J., Newell, F., Patch, A.M., Thorne, H., Kazakoff, S.H., de Luca, X.M., Parsons, M.T., Ferguson, K., Reid, L.E., McCart Reed, A.E., Srihari, S., Lakis, V., Davidson, A.L., Mukhopadhyay, P., Holmes, O., Xu, Q., Wood, S., Leonard, C., Beesley, J., Harris, J.M., Barnes, D., Degasperi, A., Ragan, M.A., Spurdle, A.B., Khanna, K.K., Lakhani, S.R., Pearson, J.V., Nik-Zainal, S., Chenevix-Trench, G., Waddell, N., Simpson, P.T.

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Prognostic impact of HLA‐I neoantigen‐specific CD8+ T cells in limited‐stage follicular lymphoma von Tobin, J. W., Tsang, H., Patch, A., Keane, C., Law, S. C., Gunawardana, J., Blombery, P., Thompson, E. R., Sabdia, M. B., Long, L. M., Nath, K., Kazakoff, S. H., Cheah, C., Amanuel, B., Cochrane, T., Butler, J., Johnston, A., Shanavas, M., Li, L., Shelton, V., Hershenfeld, S., Kridel, R., Seymour, J. F., MacManus, M., Gandhi, M. K.

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Identification of unique neoantigen qualities in long-term survivors of pancreatic cancer von Balachandran, Vinod P., Łuksza, Marta, Zhao, Julia N., Makarov, Vladimir, Moral, John Alec, Remark, Romain, Herbst, Brian, Askan, Gokce, Bhanot, Umesh, Senbabaoglu, Yasin, Wells, Daniel K., Cary, Charles Ian Ormsby, Grbovic-Huezo, Olivera, Attiyeh, Marc, Medina, Benjamin, Zhang, Jennifer, Loo, Jennifer, Saglimbeni, Joseph, Abu-Akeel, Mohsen, Zappasodi, Roberta, Riaz, Nadeem, Smoragiewicz, Martin, Kelley, Z. Larkin, Basturk, Olca, Gönen, Mithat, Levine, Arnold J., Allen, Peter J., Fearon, Douglas T., Merad, Miriam, Gnjatic, Sacha, Iacobuzio-Donahue, Christine A., Wolchok, Jedd D., DeMatteo, Ronald P., Chan, Timothy A., Greenbaum, Benjamin D., Merghoub, Taha, Leach, Steven D.

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Genomic analyses identify molecular subtypes of pancreatic cancer von Bailey, Peter, Chang, David K., Nones, Katia, Johns, Amber L., Patch, Ann-Marie, Gingras, Marie-Claude, Miller, David K., Christ, Angelika N., Bruxner, Tim J. C., Quinn, Michael C., Nourse, Craig, Murtaugh, L. Charles, Harliwong, Ivon, Idrisoglu, Senel, Manning, Suzanne, Nourbakhsh, Ehsan, Wani, Shivangi, Fink, Lynn, Holmes, Oliver, Chin, Venessa, Anderson, Matthew J., Kazakoff, Stephen, Leonard, Conrad, Newell, Felicity, Waddell, Nick, Wood, Scott, Xu, Qinying, Wilson, Peter J., Cloonan, Nicole, Kassahn, Karin S., Taylor, Darrin, Quek, Kelly, Robertson, Alan, Pantano, Lorena, Mincarelli, Laura, Sanchez, Luis N., Evers, Lisa, Wu, Jianmin, Pinese, Mark, Cowley, Mark J., Jones, Marc D., Colvin, Emily K., Nagrial, Adnan M., Humphrey, Emily S., Chantrill, Lorraine A., Mawson, Amanda, Humphris, Jeremy, Chou, Angela, Pajic, Marina, Scarlett, Christopher J., Pinho, Andreia V., Giry-Laterriere, Marc, Rooman, Ilse, Samra, Jaswinder S., Kench, James G., Lovell, Jessica A., Merrett, Neil D., Toon, Christopher W., Epari, Krishna, Nguyen, Nam Q., Barbour, Andrew, Zeps, Nikolajs, Moran-Jones, Kim, Jamieson, Nigel B., Graham, Janet S., Duthie, Fraser, Oien, Karin, Hair, Jane, Grützmann, Robert, Maitra, Anirban, Iacobuzio-Donahue, Christine A., Wolfgang, Christopher L., Morgan, Richard A., Lawlor, Rita T., Corbo, Vincenzo, Bassi, Claudio, Rusev, Borislav, Capelli, Paola, Salvia, Roberto, Tortora, Giampaolo, Mukhopadhyay, Debabrata, Petersen, Gloria M., Munzy, Donna M., Fisher, William E., Karim, Saadia A., Eshleman, James R., Hruban, Ralph H., Pilarsky, Christian, Sansom, Owen J., Scarpa, Aldo, Bailey, Ulla-Maja Hagbo, Hofmann, Oliver, Sutherland, Robert L., Wheeler, David A., Gill, Anthony J., Gibbs, Richard A., Pearson, John V., Waddell, Nicola, Biankin, Andrew V., Grimmond, Sean M.

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Whole genomes redefine the mutational landscape of pancreatic cancer von Waddell, Nicola, Pajic, Marina, Patch, Ann-Marie, Chang, David K., Kassahn, Karin S., Bailey, Peter, Johns, Amber L., Miller, David, Nones, Katia, Quek, Kelly, Quinn, Michael C. J., Robertson, Alan J., Fadlullah, Muhammad Z. H., Bruxner, Tim J. C., Christ, Angelika N., Harliwong, Ivon, Idrisoglu, Senel, Manning, Suzanne, Nourse, Craig, Nourbakhsh, Ehsan, Wani, Shivangi, Wilson, Peter J., Markham, Emma, Cloonan, Nicole, Anderson, Matthew J., Fink, J. Lynn, Holmes, Oliver, Kazakoff, Stephen H., Leonard, Conrad, Newell, Felicity, Poudel, Barsha, Song, Sarah, Taylor, Darrin, Waddell, Nick, Wood, Scott, Xu, Qinying, Wu, Jianmin, Pinese, Mark, Cowley, Mark J., Lee, Hong C., Jones, Marc D., Nagrial, Adnan M., Humphris, Jeremy, Chantrill, Lorraine A., Chin, Venessa, Steinmann, Angela M., Mawson, Amanda, Humphrey, Emily S., Colvin, Emily K., Chou, Angela, Scarlett, Christopher J., Pinho, Andreia V., Giry-Laterriere, Marc, Rooman, Ilse, Samra, Jaswinder S., Kench, James G., Pettitt, Jessica A., Merrett, Neil D., Toon, Christopher, Epari, Krishna, Nguyen, Nam Q., Barbour, Andrew, Zeps, Nikolajs, Jamieson, Nigel B., Graham, Janet S., Niclou, Simone P., Bjerkvig, Rolf, Grützmann, Robert, Aust, Daniela, Hruban, Ralph H., Maitra, Anirban, Iacobuzio-Donahue, Christine A., Wolfgang, Christopher L., Morgan, Richard A., Lawlor, Rita T., Corbo, Vincenzo, Bassi, Claudio, Falconi, Massimo, Zamboni, Giuseppe, Tortora, Giampaolo, Tempero, Margaret A., Gill, Anthony J., Eshleman, James R., Pilarsky, Christian, Scarpa, Aldo, Musgrove, Elizabeth A., Pearson, John V., Biankin, Andrew V., Grimmond, Sean M.

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CAF hierarchy driven by pancreatic cancer cell p53-status creates a pro-metastatic and chemoresistant environment via perlecan von Vennin, Claire, Mélénec, Pauline, Rouet, Romain, Nobis, Max, Cazet, Aurélie S., Murphy, Kendelle J., Herrmann, David, Reed, Daniel A., Lucas, Morghan C., Warren, Sean C., Elgundi, Zehra, Pinese, Mark, Kalna, Gabriella, Roden, Daniel, Samuel, Monisha, Zaratzian, Anaiis, Grey, Shane T., Da Silva, Andrew, Leung, Wilfred, Mathivanan, Suresh, Wang, Yingxiao, Braithwaite, Anthony W., Christ, Daniel, Benda, Ales, Parkin, Ashleigh, Phillips, Phoebe A., Whitelock, John M., Gill, Anthony J., Sansom, Owen J., Croucher, David R., Parker, Benjamin L., Pajic, Marina, Morton, Jennifer P., Cox, Thomas R., Timpson, Paul

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115PDetection of actionable variants in various cancer types reveals value of whole-genome sequencing over in-silico whole-exome and hotspot panel sequencing von Ramarao-Milne, K P, Patch, A-M, Nones, K, Koufariotis, R, Newell, F, Addala, V R, Kondrashova, O, Mukhopadhyay, P, Kazakoff, S H, Lakis, V, Holmes, O, Leonard, C, Wood, S, Xu, C, Pearson, J V, Hollway, G, Waddell, N

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A Common Variant at the 14q32 Endometrial Cancer Risk Locus Activates AKT1 through YY1 Binding von Painter, Jodie N., Kaufmann, Susanne, O’Mara, Tracy A., Hillman, Kristine M., Sivakumaran, Haran, Darabi, Hatef, Cheng, Timothy H.T., Pearson, John, Kazakoff, Stephen, Waddell, Nicola, Hoivik, Erling A., Goode, Ellen L., Scott, Rodney J., Tomlinson, Ian, Dunning, Alison M., Easton, Douglas F., French, Juliet D., Salvesen, Helga B., Pollock, Pamela M., Thompson, Deborah J., Spurdle, Amanda B., Edwards, Stacey L.

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HNF4A and GATA6 Loss Reveals Therapeutically Actionable Subtypes in Pancreatic Cancer von Brunton, Holly, Caligiuri, Giuseppina, Cunningham, Richard, Upstill-Goddard, Rosie, Garner, Ian M., Nourse, Craig, Wright, Derek W., Nixon, Colin, Jamieson, Nigel B., McGregor, Grant A., Evers, Lisa, McKay, Colin J., Gulati, Aditi, Brough, Rachel, Pettitt, Stephen J., Dziubinski, Michele L., Grützmann, Robert, Curry, Edward, Allison, Sarah, Biankin, Andrew V., Dreyer, Stephan, McDade, Brian, McElroy, Daniel, Ramsay, Donna, Upstill-Goddard, Rosie, Jamieson, Nigel B., Westwood, Paul, Mawson, Amanda, Scarlett, Christopher J., Brancato, Mary-Anne L., Simpson, Skye H., Thomas, Michelle T., Chin, Venessa T., Humphris, Jeremy L., Mead, R. Scott, Nagrial, Adnan M., Pettit, Jessica, Wu, Jianmin, DiPietro, Renee, Steinmann, Angela, Pinho, Andreia V., Giry-Laterriere, Marc, Musgrove, Elizabeth A., Miller, David K., Song, Sarah, Nourbakhsh, Ehsan, Wani, Shivangi, Gongora, Milena, Anderson, Matthew, Holmes, Oliver, Leonard, Conrad, Wood, Scott, Bruxner, Tim, Pearson, John V., Nagaraj, Shivashankar, Kazakoff, Stephen, Waddell, Nick, Quek, Kelly, Pavlakis, Nick, Asghari, Ray, Pavey, Darren, Das, Amitabha, Ismail, Kasim, Lam, Vincent W., Richardson, Arthur, James, Virginia, Kench, James G., Joseph, David, Laycock, Andrew, Epari, Krishna P., Fletcher, David R., Zeps, Nikolajs, Beilin, Maria, Feeney, Kynan, Worthley, Chris, Tan, Chuan P., Debrencini, Tamara, Chen, John, Brooke-Smith, Mark E., Tang, Henry, Clouston, Andrew D., Fawcett, Jonathan W., Slater, Kellee, Hatzifotis, Michael, Nikfarjam, Mehrdad, Eshleman, James R., Hruban, Ralph H., Schulick, Richard D., Scarpa, Aldo, Scardoni, Maria, Tempero, Margaret A., Pajic, Marina, Petersen, Gloria M., Shanks, Emma, Pilarsky, Christian, Grimmond, Sean E., Morton, Jennifer P., Chang, David K., Bailey, Peter J., Biankin, Andrew V.

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Abstract P5-10-01: Using whole genome sequencing and somatic mutation signatures to unravel insight into familial breast cancer aetiology von Simpson, P, Nones, K, Johnson, J, Newell, F, Patch, A-M, Thorne, H, Kazakoff, S, De Luca, X, Parsons, M, Ferguson, K, Reid, L, McCart Reed, A, Srihari, S, Lakis, V, Davidson, A, Mukhopadhyay, P, Holmes, O, Xu, Q, Wood, S, Leonard, C, Beasley, J, Degasperi, A, Nik-Zainal, S, Ragan, M, Spurdle, A, Khanna, KK, Lakhani, S, Pearson, J, Chenevix-Trench, G, Waddell, N

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Genomic and Molecular Analyses Identify Molecular Subtypes of Pancreatic Cancer Recurrence von Dreyer, Stephan B., Upstill-Goddard, Rosie, Legrini, Assya, Biankin, Andrew V., Allison, Sarah, Biankin, Andrew V., Beraldi, Dario, Cameron, Euan, Cunningham, Richard, Dreyer, Stephan, Grimwood, Paul, Kelly, Shane, Marshall, John, McDade, Brian, Musgrove, Elizabeth A., Ramsay, Donna, Upstill-Goddard, Rosie, Rebus, Selma, Rahib, Lola, Serrels, Bryan, Jamieson, Nigel B., McKay, Colin J., Westwood, Paul, Williams, Nicola, Duthie, Fraser, Shen, William, Pea, Antonio, Johns, Amber L., Gill, Anthony J., Timpson, Paul, Chou, Angela, Pajic, Marina, Dwarte, Tanya, Herrmann, David, Vennin, Claire, Cox, Thomas R., Pereira, Brooke, Ritchiee, Shona, Reed, Daniel A., Chambers, Cecilia R., Metcalf, Xanthe, Nobis, Max, Jeong, Gloria, Kenyon, Lara, Lyons, Ruth J., Waddell, Nicola, Pearson, John V., Patch, Ann-Marie, Newell, Felicity, Addala, Venkateswar, Kazakoff, Stephen, Holmes, Oliver, Leonard, Conrad, Grimmond, Sean M., Hofmann, Oliver, Samra, Jaswinder S., Pavlakis, Nick, Arena, Jennifer, High, Hilda A., Asghari, Ray, Merrett, Neil D., Cosman, Peter H., Williams, David, Spigellman, Allan, McLeod, Duncan, Kirk, Judy, Kench, James G., Sandroussi, Charbel, Goodwin, Annabel, Andrews, Lesley, Texler, Michael, Forrest, Cindy, Ballal, Mo, Fletcher, David, Beilin, Maria, Feeney, Kynan, Epari, Krishna, Zeps, Nikolajs, Nguyen, Nan Q., Ruszkiewicz, Andrew R., Worthley, Chris, Brooke-Smith, Mark E., Papangelis, Virginia, Clouston, Andrew D., Barbour, Andrew P., O’Rourke, Thomas J., Fawcett, Jonathan W., Hatzifotis, Michael, Nikfarjam, Mehrdad, Eshleman, James R., Hruban, Ralph H., Wolfgang, Christopher L., Scarpa, Aldo, Biankin, Andrew V., Jamieson, Nigel B., Chang, David K., Jamieson, Nigel B., Chang, David K., Jamieson, Nigel B., Chang, David K.

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Abstract P3-08-03: Dissecting the heterogeneity of metaplastic breast cancer: A morphological, immunohistochemical and genomic analysis of a large cohort von McCart Reed, AE, Kalaw, E, Nones, K, Bettington, M, Lim, M, Bennett, J, Johnstone, K, Kutasovic, JR, Kazakoff, S, Xu, QC, Saunus, JM, Reid, LE, Black, D, Niland, C, Ferguson, K, Gresshoff, I, Raghavendra, A, Liu, JC, Kalinowski, L, Reid, AS, Davidson, M, Pearson, JV, Yamaguchi, R, Harris, G, Tse, G, Papadimos, D, Pathmanathan, R, Pathmanathan, N, Tan, PH, Fox, S, O'Toole, S, Waddell, N, Simpson, PT, Lakhani, SR

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ROR1 and ROR2 expression in pancreatic cancer von Liu, Dongli, Sharbeen, George, Phillips, Phoebe, Ford, Caroline E.

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A first-in-class pan-lysyl oxidase inhibitor impairs stromal remodeling and enhances gemcitabine response and survival in pancreatic cancer von Chitty, Jessica L, Yam, Michelle, Perryman, Lara, Parker, Amelia L, Skhinas, Joanna N, Setargew, Yordanos F I, Mok, Ellie T Y, Tran, Emmi, Grant, Rhiannon D, Latham, Sharissa L, Pereira, Brooke A, Ritchie, Shona C, Murphy, Kendelle J, Trpceski, Michael, Findlay, Alison D, Melenec, Pauline, Filipe, Elysse C, Nadalini, Audrey, Velayuthar, Sipiththa, Major, Gretel, Wyllie, Kaitlin, Papanicolaou, Michael, Ratnaseelan, Shivanjali, Phillips, Phoebe A, Sharbeen, George, Youkhana, Janet, Russo, Alice, Blackwell, Antonia, Hastings, Jordan F, Lucas, Morghan C, Chambers, Cecilia R, Reed, Daniel A, Stoehr, Janett, Vennin, Claire, Pidsley, Ruth, Zaratzian, Anaiis, Da Silva, Andrew M, Tayao, Michael, Charlton, Brett, Herrmann, David, Nobis, Max, Clark, Susan J, Biankin, Andrew V, Johns, Amber L, Croucher, David R, Nagrial, Adnan, Gill, Anthony J, Grimmond, Sean M, Pajic, Marina, Timpson, Paul, Jarolimek, Wolfgang, Cox, Thomas R

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Whole-genome sequencing reveals clinically relevant insights into the aetiology of familial breast cancers von Nones, K, Johnson, J, Newell, F, Patch, A M, Thorne, H, Kazakoff, S H, de Luca, X M, Parsons, M T, Ferguson, K, Reid, L E, McCart Reed, A E, Srihari, S, Lakis, V, Davidson, A L, Mukhopadhyay, P, Holmes, O, Xu, Q, Wood, S, Leonard, C, Beesley, J, Harris, J M, Barnes, D, Degasperi, A, Ragan, M A, Spurdle, A B, Khanna, K K, Lakhani, S R, Pearson, J V, Nik-Zainal, S, Chenevix-Trench, G, Waddell, N, Simpson, P T

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Finding the way forward von Kazakoff, Lois

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Facebook or facetime? von Kazakoff, Lois

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Non-coding RNAs underlie genetic predisposition to breast cancer von Moradi Marjaneh, M, Beesley, J, O'Mara, TA, Mukhopadhyay, P, Koufariotis, LT, Kazakoff, S, Hussein, N, Fachal, L, Bartonicek, N, Hillman, KM, Kaufmann, S, Sivakumaran, H, Smart, CE, McCart Reed, AE, Ferguson, K, Saunus, JM, Lakhani, SR, Barnes, DR, Antoniou, AC, Dinger, ME, Waddell, N, Easton, DF, Dunning, AM, Chenevix-Trench, G, Edwards, SL, French, JD

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Lost in translation: Returning germline genetic results in genome-scale cancer research von Johns, A, McKay, S, Humphris, J, Pinese, M, Chantrill, L, Mead, R, Tucker, K, Andrews, L, Goodwin, A, Leonard, C, High, H, Nones, K, Waddell, N, Patch, A, Merrett, N, Pavlakis, N, Kassahn, K, Samra, J, Miller, D, Chang, D, Pajic, M, Pearson, J, Grimmond, S, Zeps, Nikolajs, Gill, A, Biankin, A, Chin, V, Chou, A, Steinmann, A, Arshi, M, Drury, A, Froio, D, Morgan, A, Timpson, P, Hermann, D, Vennin, C, Warren, S, Wu, J, Pinho, A, Newell, F, Mukhopadhyay, P, Addala, V, Kazakoff, S, Holmes, O, Wood, S, Xu, C, Hofmann, O, Wilson, P, Christ, A, Bruxner, T, Samra, S, Arena, J, Mittal, A, Asghari, R, Pavey, D, Das, A, Cosman, P, Ismail, K, O'Connnor, C, Williams, D, Spigellman, A, Lam, W, McLeod, D, Nagrial, A

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Lost in translation: Returning germline genetic results in genome-scale cancer research von Johns, AL, McKay, SH, Humphris, JL, Pinese, M, Chantrill, LA, Mead, RS, Tucker, K, Andrews, L, Goodwin, A, Leonard, C, High, HA, Nones, K, Waddell, N, Patch, AM, Merrett, ND, Pavlakis, N, Kassahn, KS, Samra, JS, Miller, DK, Chang, DK, Pajic, M, Pearson, JV, Grimmond, SM, Zeps, N, Gill, AJ, Biankin, AV, Chin, VT, Chou, A, Steinmann, A, Arshi, M, Drury, A, Froio, D, Morgan, A, Timpson, P, Hermann, D, Vennin, C, Warren, S, Wu, J, Pinho, AV, Newell, F, Mukhopadhyay, P, Addala, V, Kazakoff, S, Holmes, O, Wood, S, Xu, C, Hofmann, O, Wilson, PJ, Christ, A, Bruxner, T, Samra, S, Arena, J, Mittal, A, Asghari, R, Pavey, D, Das, A, Cosman, PH, Ismail, K, O'Connnor, C, Williams, D, Spigellman, A, Lam, W, McLeod, D, Nagrial, AM, Kirk, J, James, V, Grimison, P, Cooper, CL, Sandroussi, C, Forest, C, Epari, KP, Ballal, M, Fletcher, DR, Mukhedkar, S, Beilin, M, Feeney, K, Nguyen, NQ, Ruszkiewicz, AR, Brooke-Smith, ME, Papangelis, V, Clouston, AD, Martin, P, Barbour, AP, O'Rourke, TJ, Fawcett, JW, Slater, K, Hatzifotis, M, Hodgkinson, P, Hruban, RH, Wolfgang, CL, Hodgin, M, Lawlor, RT, Beghelli, S, Corbo, V, Scardoni, M, Bassi, C, Bailey, P, Martin, S, Musgrove, EA, Herrmann, David

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