l-Serine Deficiency Elicits Intracellular Accumulation of Cytotoxic Deoxysphingolipids and Lipid Body Formation von Esaki, Kayoko, Sayano, Tomoko, Sonoda, Chiaki, Akagi, Takumi, Suzuki, Takeshi, Ogawa, Takuya, Okamoto, Masahiro, Yoshikawa, Takeo, Hirabayashi, Yoshio, Furuya, Shigeki

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Deficiency of Schnurri-2, an MHC Enhancer Binding Protein, Induces Mild Chronic Inflammation in the Brain and Confers Molecular, Neuronal, and Behavioral Phenotypes Related to Schi... von TAKAO, Keizo, KOBAYASHI, Katsunori, KUROIWA, Mahomi, MAEDA, Jun, ATSUZAWA, Kimie, ESAKI, Kayoko, YAMAGUCHI, Shun, FURUYA, Shigeki, TAKAGI, Tsuyoshi, WALTON, Noah M, HAYASHI, Nobuhiro, SUZUKI, Hidenori, HAGIHARA, Hideo, HIGUCHI, Makoto, USUDA, Nobuteru, SUHARA, Tetsuya, NISHI, Akinori, MATSUMOTO, Mitsuyuki, ISHII, Shunsuke, MIYAKAWA, Tsuyoshi, OHIRA, Koji, SHOJI, Hirotaka, HATTORI, Satoko, KOSHIMIZU, Hisatsugu, UMEMORI, Juzoh, TOYAMA, Keiko, NAKAMURA, Hironori K

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Hepatocyte-Specific Phgdh-Deficient Mice Culminate in Mild Obesity, Insulin Resistance, and Enhanced Vulnerability to Protein Starvation von Hamano, Momoko, Esaki, Kayoko, Moriyasu, Kazuki, Yasuda, Tokio, Mohri, Sinya, Tashiro, Kosuke, Hirabayashi, Yoshio, Furuya, Shigeki

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Brain-specific Phgdh Deletion Reveals a Pivotal Role for l-Serine Biosynthesis in Controlling the Level of d-Serine, an N-methyl-d-aspartate Receptor Co-agonist, in Adult Brain von Yang, Jung Hoon, Wada, Akira, Yoshida, Kazuyuki, Miyoshi, Yurika, Sayano, Tomoko, Esaki, Kayoko, Kinoshita, Masami O., Tomonaga, Shozo, Azuma, Norihiro, Watanabe, Masahiko, Hamase, Kenji, Zaitsu, Kiyoshi, Machida, Takeo, Messing, Albee, Itohara, Shigeyoshi, Hirabayashi, Yoshio, Furuya, Shigeki

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Investigation of betaine as a novel psychotherapeutic for schizophrenia von Ohnishi, Tetsuo, Balan, Shabeesh, Toyoshima, Manabu, Maekawa, Motoko, Ohba, Hisako, Watanabe, Akiko, Iwayama, Yoshimi, Fujita, Yuko, Tan, Yunfei, Hisano, Yasuko, Shimamoto-Mitsuyama, Chie, Nozaki, Yayoi, Esaki, Kayoko, Nagaoka, Atsuko, Matsumoto, Junya, Hino, Mizuki, Mataga, Nobuko, Hayashi-Takagi, Akiko, Hashimoto, Kenji, Kunii, Yasuto, Kakita, Akiyoshi, Yabe, Hirooki, Yoshikawa, Takeo

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Increased Tyrosine in the Brain and Serum of Mice by Orally Administering Dipeptide SY von ESAKI, Kayoko, OHMORI, Taketo, MAEBUCHI, Motohiro, NAKAMORI, Toshihiro, OHSHIMA, Toshihisa, FURUYA, Shigeki

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SPTLC2 variants are associated with early‐onset ALS and FTD due to aberrant sphingolipid synthesis von Naruse, Hiroya, Ishiura, Hiroyuki, Esaki, Kayoko, Mitsui, Jun, Satake, Wataru, Greimel, Peter, Shingai, Nanoka, Machino, Yuka, Kokubo, Yasumasa, Hamaguchi, Hirotoshi, Oda, Tetsuya, Ikkaku, Tomoko, Yokota, Ichiro, Takahashi, Yuji, Suzuki, Yuta, Matsukawa, Takashi, Goto, Jun, Koh, Kishin, Takiyama, Yoshihisa, Morishita, Shinichi, Yoshikawa, Takeo, Tsuji, Shoji, Toda, Tatsushi

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l‐Serine deficiency caused by genetic Phgdh deletion leads to robust induction of 4E‐BP1 and subsequent repression of translation initiation in the developing central nervous syste... von Sayano, Tomoko, Kawakami, Yuriko, Kusada, Wataru, Suzuki, Takeshi, Kawano, Yuki, Watanabe, Akihiro, Takashima, Kana, Arimoto, Yashiho, Esaki, Kayoko, Wada, Akira, Yoshizawa, Fumiaki, Watanabe, Masahiko, Okamoto, Masahiro, Hirabayashi, Yoshio, Furuya, Shigeki

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A potential role of fatty acid binding protein 4 in the pathophysiology of autism spectrum disorder von Maekawa, Motoko, Ohnishi, Tetsuo, Toyoshima, Manabu, Shimamoto-Mitsuyama, Chie, Hamazaki, Kei, Balan, Shabeesh, Wada, Yuina, Esaki, Kayoko, Takagai, Shu, Tsuchiya, Kenji J, Nakamura, Kazuhiko, Iwata, Yasuhide, Nara, Takahiro, Iwayama, Yoshimi, Toyota, Tomoko, Nozaki, Yayoi, Ohba, Hisako, Watanabe, Akiko, Hisano, Yasuko, Matsuoka, Shigeru, Tsujii, Masatsugu, Mori, Norio, Matsuzaki, Hideo, Yoshikawa, Takeo

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Exon resequencing of H3K9 methyltransferase complex genes, EHMT1, EHTM2 and WIZ, in Japanese autism subjects von Balan, Shabeesh, Iwayama, Yoshimi, Maekawa, Motoko, Toyota, Tomoko, Ohnishi, Tetsuo, Toyoshima, Manabu, Shimamoto, Chie, Esaki, Kayoko, Yamada, Kazuo, Iwata, Yasuhide, Suzuki, Katsuaki, Ide, Masayuki, Ota, Motonori, Fukuchi, Satoshi, Tsujii, Masatsugu, Mori, Norio, Shinkai, Yoichi, Yoshikawa, Takeo

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Adaptive response to l‐serine deficiency is mediated by p38 MAPK activation via 1‐deoxysphinganine in normal fibroblasts von Sayano, Tomoko, Kawano, Yuki, Kusada, Wataru, Arimoto, Yashiho, Esaki, Kayoko, Hamano, Momoko, Udono, Miyako, Katakura, Yoshinori, Ogawa, Takuya, Kato, Hisanori, Hirabayashi, Yoshio, Furuya, Shigeki

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Evidence for Altered Metabolism of Sphingosine-1-Phosphate in the Corpus Callosum of Patients with Schizophrenia von Esaki, Kayoko, Balan, Shabeesh, Iwayama, Yoshimi, Shimamoto-Mitsuyama, Chie, Hirabayashi, Yoshio, Dean, Brian, Yoshikawa, Takeo

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Lipid Pathology of the Corpus Callosum in Schizophrenia and the Potential Role of Abnormal Gene Regulatory Networks with Reduced Microglial Marker Expression von Shimamoto-Mitsuyama, Chie, Nakaya, Akihiro, Esaki, Kayoko, Balan, Shabeesh, Iwayama, Yoshimi, Ohnishi, Tetsuo, Maekawa, Motoko, Toyota, Tomoko, Dean, Brian, Yoshikawa, Takeo

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Genetic and functional analyses of SPTLC1 in juvenile amyotrophic lateral sclerosis von Okubo, So, Naruse, Hiroya, Ishiura, Hiroyuki, Sudo, Atsushi, Esaki, Kayoko, Mitsui, Jun, Matsukawa, Takashi, Satake, Wataru, Greimel, Peter, Shingai, Nanoka, Oya, Yasushi, Yoshikawa, Takeo, Tsuji, Shoji, Toda, Tatsushi

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ASCT1 (Slc1a4) transporter is a physiologic regulator of brain D-serine and neurodevelopment von Kaplan, Eitan, Zubedat, Salman, Radzishevsky, Inna, Valenta, Alec C., Rechnitz, Ohad, Sason, Hagit, Sajrawi, Clara, Bodner, Oded, Konno, Kohtarou, Esaki, Kayoko, Derdikman, Dori, Yoshikawa, Takeo, Watanabe, Masahiko, Kennedy, Robert T., Billard, Jean-Marie, Avital, Avi, Wolosker, Herman

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Impairment of serine transport across the blood-brain barrier by deletion of Slc38a5 causes developmental delay and motor dysfunction von Radzishevsky, Inna, Odeh, Maali, Bodner, Oded, Zubedat, Salman, Shaulov, Lihi, Litvak, Maxim, Esaki, Kayoko, Yoshikawa, Takeo, Agranovich, Bella, Li, Wen-Hong, Radzishevsky, Alex, Gottlieb, Eyal, Avital, Avi, Wolosker, Herman

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Altered regulation of sphingolipid metabolism in the postmortem corpus callosum of patients with schizophrenia von Esaki, Kayoko, Yoshikawa, Takeo

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COMPREHENSIVE PHENOTYPIC ANALYSIS OF LIVER HEPATOCYTE-SPECIFIC PHGDH DEFICIENT MICE von Hamano, Momoko, Esaki, Kayoko, Moriyasu, Kazuki, Mori, Shinya, Hirabayashi, Yoshio, Furuya, Shigeki

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Investigation of betaine as a novel psychotherapeutic for schizophreniaResearch in context von Tetsuo Ohnishi, Shabeesh Balan, Manabu Toyoshima, Motoko Maekawa, Hisako Ohba, Akiko Watanabe, Yoshimi Iwayama, Yuko Fujita, Yunfei Tan, Yasuko Hisano, Chie Shimamoto-Mitsuyama, Yayoi Nozaki, Kayoko Esaki, Atsuko Nagaoka, Junya Matsumoto, Mizuki Hino, Nobuko Mataga, Akiko Hayashi-Takagi, Kenji Hashimoto, Yasuto Kunii, Akiyoshi Kakita, Hirooki Yabe, Takeo Yoshikawa

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l ‐Serine deficiency caused by genetic P hgdh deletion leads to robust induction of 4E‐ BP 1 and subsequent repression of translation initiation in the developing central nervous s... von Sayano, Tomoko, Kawakami, Yuriko, Kusada, Wataru, Suzuki, Takeshi, Kawano, Yuki, Watanabe, Akihiro, Takashima, Kana, Arimoto, Yashiho, Esaki, Kayoko, Wada, Akira, Yoshizawa, Fumiaki, Watanabe, Masahiko, Okamoto, Masahiro, Hirabayashi, Yoshio, Furuya, Shigeki

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