Distinct routes of lineage development reshape the human blood hierarchy across ontogeny von Notta, Faiyaz, Zandi, Sasan, Takayama, Naoya, Dobson, Stephanie, Gan, Olga I., Wilson, Gavin, Kaufmann, Kerstin B., McLeod, Jessica, Laurenti, Elisa, Dunant, Cyrille F., McPherson, John D., Stein, Lincoln D., Dror, Yigal, Dick, John E.

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Gene therapy on the move von Kaufmann, Kerstin B., Büning, Hildegard, Galy, Anne, Schambach, Axel, Grez, Manuel

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Sphingolipid Modulation Activates Proteostasis Programs to Govern Human Hematopoietic Stem Cell Self-Renewal von Xie, Stephanie Z., Garcia-Prat, Laura, Voisin, Veronique, Ferrari, Robin, Gan, Olga I., Wagenblast, Elvin, Kaufmann, Kerstin B., Zeng, Andy G.X., Takayanagi, Shin-ichiro, Patel, Ishita, Lee, Esther K., Jargstorf, Joseph, Holmes, Gareth, Romm, Guy, Pan, Kristele, Shoong, Michelle, Vedi, Aditi, Luberto, Chiara, Minden, Mark D., Bader, Gary D., Laurenti, Elisa, Dick, John E.

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The Transition from Quiescent to Activated States in Human Hematopoietic Stem Cells Is Governed by Dynamic 3D Genome Reorganization von Takayama, Naoya, Murison, Alex, Takayanagi, Shin-ichiro, Arlidge, Christopher, Zhou, Stanley, Garcia-Prat, Laura, Chan-Seng-Yue, Michelle, Zandi, Sasan, Gan, Olga I., Boutzen, Héléna, Kaufmann, Kerstin B., Trotman-Grant, Aaron, Schoof, Erwin, Kron, Ken, Díaz, Noelia, Lee, John J.Y., Medina, Tiago, De Carvalho, Daniel D., Taylor, Michael D., Vaquerizas, Juan M., Xie, Stephanie Z., Dick, John E., Lupien, Mathieu

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miR-126 Regulates Distinct Self-Renewal Outcomes in Normal and Malignant Hematopoietic Stem Cells von Lechman, Eric R., Gentner, Bernhard, Ng, Stanley W.K., Schoof, Erwin M., van Galen, Peter, Kennedy, James A., Nucera, Silvia, Ciceri, Fabio, Kaufmann, Kerstin B., Takayama, Naoya, Dobson, Stephanie M., Trotman-Grant, Aaron, Krivdova, Gabriela, Elzinga, Janneke, Mitchell, Amanda, Nilsson, Björn, Hermans, Karin G., Eppert, Kolja, Marke, Rene, Isserlin, Ruth, Voisin, Veronique, Bader, Gary D., Zandstra, Peter W., Golub, Todd R., Ebert, Benjamin L., Lu, Jun, Minden, Mark, Wang, Jean C.Y., Naldini, Luigi, Dick, John E.

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Surface Functionalization of Orthopedic Titanium Implants with Bone Sialoprotein von Baranowski, Andreas, Klein, Anja, Ritz, Ulrike, Ackermann, Angelika, Anthonissen, Joris, Kaufmann, Kerstin B, Brendel, Christian, Götz, Hermann, Rommens, Pol M, Hofmann, Alexander

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Sphingosine-1-phosphate receptor 3 potentiates inflammatory programs in normal and leukemia stem cells to promote differentiation von Xie, Stephanie Z, Kaufmann, Kerstin B, Wang, Weijia, Chan-Seng-Yue, Michelle, Gan, Olga I, Laurenti, Elisa, Garcia-Prat, Laura, Takayanagi, Shin-Ichiro, Ng, Stanley W K, Xu, ChangJiang, Zeng, Andy G X, Jin, Liqing, McLeod, Jessica, Wagenblast, Elvin, Mitchell, Amanda, Kennedy, James A, Liu, Qiang, Boutzen, Héléna, Kleinau, Melissa, Jargstorf, Joseph, Holmes, Gareth, Zhang, Yang, Voisin, Veronique, Bader, Gary D, Wang, Jean C Y, Hannun, Yusuf A, Luberto, Chiara, Schroeder, Timm, Minden, Mark D, Dick, John E

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Alpharetroviral Self-inactivating Vectors: Long-term Transgene Expression in Murine Hematopoietic Cells and Low Genotoxicity von Suerth, Julia D, Maetzig, Tobias, Brugman, Martijn H, Heinz, Niels, Appelt, Jens-Uwe, Kaufmann, Kerstin B, Schmidt, Manfred, Grez, Manuel, Modlich, Ute, Baum, Christopher, Schambach, Axel

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Alpharetroviral Vector-mediated Gene Therapy for X-CGD: Functional Correction and Lack of Aberrant Splicing von Kaufmann, Kerstin B., Brendel, Christian, Suerth, Julia D., Mueller-Kuller, Uta, Chen-Wichmann, Linping, Schwäble, Joachim, Pahujani, Shweta, Kunkel, Hana, Schambach, Axel, Baum, Christopher, Grez, Manuel

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Reactive oxygen species regulate hematopoietic stem cell self-renewal, migration and development, as well as their bone marrow microenvironment von Ludin, Aya, Gur-Cohen, Shiri, Golan, Karin, Kaufmann, Kerstin B, Itkin, Tomer, Medaglia, Chiara, Lu, Xin-Jiang, Ledergor, Guy, Kollet, Orit, Lapidot, Tsvee

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T Cells Engineered with a Cytomegalovirus-Specific Chimeric Immunoreceptor von FULL, Florian, LEHNER, Manfred, THONN, Veronika, GOETZ, Gabriel, SCHOLZ, Brigitte, KAUFMANN, Kerstin B, MACH, Michael, ABKEN, Hinrich, HOLTER, Wolfgang, ENSSER, Armin

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TFEB-mediated endolysosomal activity controls human hematopoietic stem cell fate von García-Prat, Laura, Kaufmann, Kerstin B., Schneiter, Florin, Voisin, Veronique, Murison, Alex, Chen, Jocelyn, Chan-Seng-Yue, Michelle, Gan, Olga I., McLeod, Jessica L., Smith, Sabrina A., Shoong, Michelle C., Parris, Darrien, Pan, Kristele, Zeng, Andy G.X., Krivdova, Gabriela, Gupta, Kinam, Takayanagi, Shin-Ichiro, Wagenblast, Elvin, Wang, Weijia, Lupien, Mathieu, Schroeder, Timm, Xie, Stephanie Z., Dick, John E.

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Deregulation of DUX4 and ERG in acute lymphoblastic leukemia von Zhang, Jinghui, McCastlain, Kelly, Yoshihara, Hiroki, Xu, Beisi, Chang, Yunchao, Churchman, Michelle L, Wu, Gang, Li, Yongjin, Wei, Lei, Iacobucci, Ilaria, Liu, Yu, Qu, Chunxu, Wen, Ji, Edmonson, Michael, Payne-Turner, Debbie, Kaufmann, Kerstin B, Takayanagi, Shin-ichiro, Wienholds, Erno, Waanders, Esmé, Ntziachristos, Panagiotis, Bakogianni, Sofia, Wang, Jingjing, Aifantis, Iannis, Roberts, Kathryn G, Ma, Jing, Song, Guangchun, Easton, John, Mulder, Heather L, Chen, Xiang, Newman, Scott, Ma, Xiaotu, Rusch, Michael, Gupta, Pankaj, Boggs, Kristy, Vadodaria, Bhavin, Dalton, James, Liu, Yanling, Valentine, Marcus L, Ding, Li, Lu, Charles, Fulton, Robert S, Fulton, Lucinda, Tabib, Yashodhan, Ochoa, Kerri, Devidas, Meenakshi, Pei, Deqing, Cheng, Cheng, Yang, Jun, Evans, William E, Relling, Mary V, Pui, Ching-Hon, Jeha, Sima, Harvey, Richard C, Chen, I-Ming L, Willman, Cheryl L, Marcucci, Guido, Bloomfield, Clara D, Kohlschmidt, Jessica, Mrózek, Krzysztof, Paietta, Elisabeth, Tallman, Martin S, Stock, Wendy, Foster, Matthew C, Racevskis, Janis, Rowe, Jacob M, Luger, Selina, Kornblau, Steven M, Shurtleff, Sheila A, Raimondi, Susana C, Mardis, Elaine R, Wilson, Richard K, Dick, John E, Hunger, Stephen P, Loh, Mignon L, Downing, James R, Mullighan, Charles G

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Identification of leukemia stem cell subsets with distinct transcriptional, epigenetic and functional properties von Boutzen, Héléna, Murison, Alex, Oriecuia, Alexa, Bansal, Suraj, Arlidge, Christopher, Wang, Jean C. Y., Lupien, Mathieu, Kaufmann, Kerstin B., Dick, John E.

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The metabolic enzyme hexokinase 2 localizes to the nucleus in AML and normal haematopoietic stem and progenitor cells to maintain stemness von Thomas, Geethu Emily, Egan, Grace, García-Prat, Laura, Botham, Aaron, Voisin, Veronique, Patel, Parasvi S., Hoff, Fieke W., Chin, Jordan, Nachmias, Boaz, Kaufmann, Kerstin B., Khan, Dilshad H., Hurren, Rose, Wang, Xiaoming, Gronda, Marcela, MacLean, Neil, O’Brien, Cristiana, Singh, Rashim P., Jones, Courtney L., Harding, Shane M., Raught, Brian, Arruda, Andrea, Minden, Mark D., Bader, Gary D., Hakem, Razq, Kornblau, Steve, Dick, John E., Schimmer, Aaron D.

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A latent subset of human hematopoietic stem cells resists regenerative stress to preserve stemness von Kaufmann, Kerstin B., Zeng, Andy G. X., Coyaud, Etienne, Garcia-Prat, Laura, Papalexi, Efthymia, Murison, Alex, Laurent, Estelle M. N., Chan-Seng-Yue, Michelle, Gan, Olga I., Pan, Kristele, McLeod, Jessica, Boutzen, Héléna, Zandi, Sasan, Takayanagi, Shin-ichiro, Satija, Rahul, Raught, Brian, Xie, Stephanie Z., Dick, John E.

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A primary hierarchically organized patient-derived model enables in depth interrogation of stemness driven by the coding and non-coding genome von Boutzen, Héléna, Madani Tonekaboni, Seyed Ali, Chan-Seng-Yue, Michelle, Murison, Alex, Takayama, Naoya, Mbong, Nathan, Wagenblast, Elvin, Orouji, Elias, Arruda, Andrea, Mitchell, Amanda, Notta, Faiyaz, Minden, Mark D., Lupien, Mathieu, Kaufmann, Kerstin B., Dick, John E.

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A stemness screen reveals C3orf54/INKA1 as a promoter of human leukemia stem cell latency von Kaufmann, Kerstin B., Garcia-Prat, Laura, Liu, Qiang, Ng, Stanley W.K., Takayanagi, Shin-Ichiro, Mitchell, Amanda, Wienholds, Erno, van Galen, Peter, Cumbaa, Christian A., Tsay, Mike J., Pastrello, Chiara, Wagenblast, Elvin, Krivdova, Gabriela, Minden, Mark D., Lechman, Eric R., Zandi, Sasan, Jurisica, Igor, Wang, Jean C.Y., Xie, Stephanie Z., Dick, John E.

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miR-126 Regulates Distinct Self-Renewal Outcomes in Normal and Malignant Hematopoietic Stem Cells von Lechman, Eric R., Gentner, Bernhard, Ng, Stanley W.K., Schoof, Erwin M., van Galen, Peter, Kennedy, James A., Nucera, Silvia, Ciceri, Fabio, Kaufmann, Kerstin B., Takayama, Naoya, Dobson, Stephanie M., Trotman-Grant, Aaron, Krivdova, Gabriela, Elzinga, Janneke, Mitchell, Amanda, Nilsson, Björn, Hermans, Karin G., Eppert, Kolja, Marke, Rene, Isserlin, Ruth, Voisin, Veronique, Bader, Gary D., Zandstra, Peter W., Golub, Todd R., Ebert, Benjamin L., Lu, Jun, Minden, Mark, Wang, Jean C.Y., Naldini, Luigi, Dick, John E.

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Fibroblast growth factor signaling promotes physiological bone remodeling and stem cell self-renewal von Itkin, Tomer, Kaufmann, Kerstin B, Gur-Cohen, Shiri, Ludin, Aya, Lapidot, Tsvee

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