Ripretinib (DCC-2618) Is a Switch Control Kinase Inhibitor of a Broad Spectrum of Oncogenic and Drug-Resistant KIT and PDGFRA Variants von Smith, Bryan D., Kaufman, Michael D., Lu, Wei-Ping, Gupta, Anu, Leary, Cynthia B., Wise, Scott C., Rutkoski, Thomas J., Ahn, Yu Mi, Al-Ani, Gada, Bulfer, Stacie L., Caldwell, Timothy M., Chun, Lawrence, Ensinger, Carol L., Hood, Molly M., McKinley, Arin, Patt, William C., Ruiz-Soto, Rodrigo, Su, Ying, Telikepalli, Hanumaiah, Town, Ajia, Turner, Benjamin A., Vogeti, Lakshminarayana, Vogeti, Subha, Yates, Karen, Janku, Filip, Abdul Razak, Albiruni Ryan, Rosen, Oliver, Heinrich, Michael C., Flynn, Daniel L.

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Inhibition of RAF Isoforms and Active Dimers by LY3009120 Leads to Anti-tumor Activities in RAS or BRAF Mutant Cancers von Peng, Sheng-Bin, Henry, James R., Kaufman, Michael D., Lu, Wei-Ping, Smith, Bryan D., Vogeti, Subha, Rutkoski, Thomas J., Wise, Scott, Chun, Lawrence, Zhang, Youyan, Van Horn, Robert D., Yin, Tinggui, Zhang, Xiaoyi, Yadav, Vipin, Chen, Shih-Hsun, Gong, Xueqian, Ma, Xiwen, Webster, Yue, Buchanan, Sean, Mochalkin, Igor, Huber, Lysiane, Kays, Lisa, Donoho, Gregory P., Walgren, Jennie, McCann, Denis, Patel, Phenil, Conti, Ilaria, Plowman, Gregory D., Starling, James J., Flynn, Daniel L.

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The Selective Tie2 Inhibitor Rebastinib Blocks Recruitment and Function of Tie2Hi Macrophages in Breast Cancer and Pancreatic Neuroendocrine Tumors von Harney, Allison S., Karagiannis, George S., Pignatelli, Jeanine, Smith, Bryan D., Kadioglu, Ece, Wise, Scott C., Hood, Molly M., Kaufman, Michael D., Leary, Cynthia B., Lu, Wei-Ping, Al-Ani, Gada, Chen, Xiaoming, Entenberg, David, Oktay, Maja H., Wang, Yarong, Chun, Lawrence, De Palma, Michele, Jones, Joan G., Flynn, Daniel L., Condeelis, John S.

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A Phase I Study of LY3009120, a Pan-RAF Inhibitor, in Patients with Advanced or Metastatic Cancer von Sullivan, Ryan J., Hollebecque, Antoine, Flaherty, Keith T., Shapiro, Geoffrey I., Ahnert, Jordi Rodon, Millward, Michael J., Zhang, Wei, Gao, Ling, Sykes, Amanda, Willard, Melinda D., Yu, Danni, Schade, Andrew E., Crowe, KrisAnne, Flynn, Daniel L., Kaufman, Michael D., Henry, James R., Peng, Sheng-Bin, Benhadji, Karim A., Conti, Ilaria, Gordon, Michael S., Tiu, Ramon V., Hong, David S.

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Evolution of a Gram-Scale Synthesis of (+)-Discodermolide von Smith, Amos B, Beauchamp, Thomas J, LaMarche, Matthew J, Kaufman, Michael D, Qiu, Yuping, Arimoto, Hirokazu, Jones, David R, Kobayashi, Kaoru

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Vimseltinib: A Precision CSF1R Therapy for Tenosynovial Giant Cell Tumors and Diseases Promoted by Macrophages von Smith, Bryan D., Kaufman, Michael D., Wise, Scott C., Ahn, Yu Mi, Caldwell, Timothy M., Leary, Cynthia B., Lu, Wei-Ping, Tan, Gege, Vogeti, Lakshminarayana, Vogeti, Subha, Wilky, Breelyn A., Davis, Lara E., Sharma, Maitreyi, Ruiz-Soto, Rodrigo, Flynn, Daniel L.

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Discovery of vimseltinib (DCC-3014), a highly selective CSF1R switch-control kinase inhibitor, in clinical development for the treatment of Tenosynovial Giant Cell Tumor (TGCT) von Caldwell, Timothy M., Ahn, Yu Mi, Bulfer, Stacie L., Leary, Cynthia B., Hood, Molly M., Lu, Wei-Ping, Vogeti, Lakshminarayana, Vogeti, Subha, Kaufman, Michael D., Wise, Scott C., Le Bourdonnec, Bertrand, Smith, Bryan D., Flynn, Daniel L.

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Conformational Control Inhibition of the BCR-ABL1 Tyrosine Kinase, Including the Gatekeeper T315I Mutant, by the Switch-Control Inhibitor DCC-2036 von Chan, Wayne W., Wise, Scott C., Kaufman, Michael D., Ahn, Yu Mi, Ensinger, Carol L., Haack, Torsten, Hood, Molly M., Jones, Jennifer, Lord, John W., Lu, Wei Ping, Miller, David, Patt, William C., Smith, Bryan D., Petillo, Peter A., Rutkoski, Thomas J., Telikepalli, Hanumaiah, Vogeti, Lakshminarayana, Yao, Tony, Chun, Lawrence, Clark, Robin, Evangelista, Peter, Gavrilescu, L. Cristina, Lazarides, Katherine, Zaleskas, Virginia M., Stewart, Lance J., Van Etten, Richard A., Flynn, Daniel L.

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Discovery of acyl ureas as highly selective small molecule CSF1R kinase inhibitors von Caldwell, Timothy M., Kaufman, Michael D., Wise, Scott C., Mi Ahn, Yu, Hood, Molly M., Lu, Wei-Ping, Patt, William C., Samarakoon, Thiwanka, Vogeti, Lakshminarayana, Vogeti, Subha, Yates, Karen M., Bulfer, Stacie L., Le Bourdonnec, Bertrand, Smith, Bryan D., Flynn, Daniel L.

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Discovery of 1‑(3,3-Dimethylbutyl)-3-(2-fluoro-4-methyl-5-(7-methyl-2-(methylamino)­pyrido[2,3‑d]pyrimidin-6-yl)phenyl)urea (LY3009120) as a Pan-RAF Inhibitor with Minimal Paradoxi... von Henry, James R, Kaufman, Michael D, Peng, Sheng-Bin, Ahn, Yu Mi, Caldwell, Timothy M, Vogeti, Lakshminarayana, Telikepalli, Hanumaiah, Lu, Wei-Ping, Hood, Molly M, Rutkoski, Thomas J, Smith, Bryan D, Vogeti, Subha, Miller, David, Wise, Scott C, Chun, Lawrence, Zhang, Xiaoyi, Zhang, Youyan, Kays, Lisa, Hipskind, Philip A, Wrobleski, Aaron D, Lobb, Karen L, Clay, Julia M, Cohen, Jeffrey D, Walgren, Jennie L, McCann, Denis, Patel, Phenil, Clawson, David K, Guo, Sherry, Manglicmot, Danalyn, Groshong, Chris, Logan, Cheyenne, Starling, James J, Flynn, Daniel L

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Altiratinib Inhibits Tumor Growth, Invasion, Angiogenesis, and Microenvironment-Mediated Drug Resistance via Balanced Inhibition of MET, TIE2, and VEGFR2 von Smith, Bryan D, Kaufman, Michael D, Leary, Cynthia B, Turner, Benjamin A, Wise, Scott C, Ahn, Yu Mi, Booth, R John, Caldwell, Timothy M, Ensinger, Carol L, Hood, Molly M, Lu, Wei-Ping, Patt, Tristan W, Patt, William C, Rutkoski, Thomas J, Samarakoon, Thiwanka, Telikepalli, Hanumaiah, Vogeti, Lakshminarayana, Vogeti, Subha, Yates, Karen M, Chun, Lawrence, Stewart, Lance J, Clare, Michael, Flynn, Daniel L

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Abstract 4889: The highly specific CSF1R inhibitor DCC-3014 exhibits immunomodulatory and anti-invasive activities in cancer models von Smith, Bryan D., Leary, Cynthia B., Lu, Wei-Ping, Kaufman, Michael D., Flynn, Daniel L.

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Update on Best Practice Recommendations for Anesthetic Perioperative Care and Pain Management in Weight Loss Surgery, 2004-2007 von Schumann, Roman, Jones, Stephanie B, Cooper, Bronwyn, Kelley, Scott D, Vanden Bosch, Mark, Ortiz, Vilma E, Connor, Kathleen A, Kaufman, Michael D, Harvey, Alan M, Carr, Daniel B

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Course of relapsing–remitting multiple sclerosis before, during and after natalizumab von Kaufman, Michael D, Lee, R, Norton, HJ

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Highly selective 2,4-diaminopyrimidine-5-carboxamide inhibitors of Sky kinase von Powell, Noel A., Hoffman, Jennifer K., Ciske, Fred L., Kaufman, Michael D., Kohrt, Jeffrey T., Quin, John, Sheehan, Derek J., Delaney, Amy, Baxi, Sangita M., Catana, Cornel, McConnell, Patrick, Ohren, Jeff, Perrin, Lisa A., Edmunds, Jeremy J.

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Double-Lumen Tubes: Which Lumen for the Gum Elastic Bougie? von Stix, Michael S., Ata, Sana, Wolckenhaar, Marten, Kaufman, Michael D.

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Taxol and Discodermolide Represent a Synergistic Drug Combination in Human Carcinoma Cell Lines von Martello, L A, McDaid, H M, Regl, D L, Yang, C P, Meng, D, Pettus, T R, Kaufman, M D, Arimoto, H, Danishefsky, S J, Smith, 3rd, A B, Horwitz, S B

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Switch control pocket inhibitors of p38-MAP kinase. Durable type II inhibitors that do not require binding into the canonical ATP hinge region von Ahn, Yu Mi, Clare, Michael, Ensinger, Carol L., Hood, Molly M., Lord, John W., Lu, Wei-Ping, Miller, David F., Patt, William C., Smith, Bryan D., Vogeti, Lakshminarayana, Kaufman, Michael D., Petillo, Peter A., Wise, Scott C., Abendroth, Jan, Chun, Lawrence, Clark, Robin, Feese, Michael, Kim, Hidong, Stewart, Lance, Flynn, Daniel L.

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Gram-Scale Synthesis of (+)-Discodermolide von Smith, Amos B, Kaufman, Michael D, Beauchamp, Thomas J, LaMarche, Matthew J, Arimoto, Hirokazu

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4-Anilino-5-carboxamido-2-pyridone Derivatives as Noncompetitive Inhibitors of Mitogen-Activated Protein Kinase Kinase von Spicer, Julie A, Rewcastle, Gordon W, Kaufman, Michael D, Black, Shannon L, Plummer, Mark S, Denny, William A, Quin, John, Shahripour, Aurash B, Barrett, Stephen D, Whitehead, Christopher E, Milbank, Jared B. J, Ohren, Jeffrey F, Gowan, Richard C, Omer, Charles, Camp, Heidi S, Esmaeil, Nadia, Moore, Kelley, Sebolt-Leopold, Judith S, Pryzbranowski, Sally, Merriman, Ronald L, Ortwine, Daniel F, Warmus, Joseph S, Flamme, Cathlin M, Pavlovsky, Alexander G, Tecle, Haile

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