Antiviral Drug Discovery for the Treatment of COVID-19 Infections von Ng, Teresa I, Correia, Ivan, Seagal, Jane, DeGoey, David A, Schrimpf, Michael R, Hardee, David J, Noey, Elizabeth L, Kati, Warren M

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HEXIM1 as a Robust Pharmacodynamic Marker for Monitoring Target Engagement of BET Family Bromodomain Inhibitors in Tumors and Surrogate Tissues von Lin, Xiaoyu, Huang, Xiaoli, Uziel, Tamar, Hessler, Paul, Albert, Daniel H, Roberts-Rapp, Lisa A, McDaniel, Keith F, Kati, Warren M, Shen, Yu

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Selective inhibition of the BD2 bromodomain of BET proteins in prostate cancer von Faivre, Emily J., McDaniel, Keith F., Albert, Daniel H., Mantena, Srinivasa R., Plotnik, Joshua P., Wilcox, Denise, Zhang, Lu, Bui, Mai H., Sheppard, George S., Wang, Le, Sehgal, Vasudha, Lin, Xiaoyu, Huang, Xiaoli, Lu, Xin, Uziel, Tamar, Hessler, Paul, Lam, Lloyd T., Bellin, Richard J., Mehta, Gaurav, Fidanze, Steve, Pratt, John K., Liu, Dachun, Hasvold, Lisa A., Sun, Chaohong, Panchal, Sanjay C., Nicolette, John J., Fossey, Stacey L., Park, Chang H., Longenecker, Kenton, Bigelow, Lance, Torrent, Maricel, Rosenberg, Saul H., Kati, Warren M., Shen, Yu

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Discovery of N‑Ethyl-4-[2-(4-fluoro-2,6-dimethyl-phenoxy)-5-(1-hydroxy-1-methyl-ethyl)phenyl]-6-methyl-7-oxo‑1H‑pyrrolo[2,3‑c]pyridine-2-carboxamide (ABBV-744), a BET Bromodomain I... von Sheppard, George S, Wang, Le, Fidanze, Steven D, Hasvold, Lisa A, Liu, Dachun, Pratt, John K, Park, Chang H, Longenecker, Kenton, Qiu, Wei, Torrent, Maricel, Kovar, Peter J, Bui, Mai, Faivre, Emily, Huang, Xiaoli, Lin, Xiaoyu, Wilcox, Denise, Zhang, Lu, Shen, Yu, Albert, Daniel H, Magoc, Terrance J, Rajaraman, Ganesh, Kati, Warren M, McDaniel, Keith F

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Discovery of N -Ethyl-4-[2-(4-fluoro-2,6-dimethyl-phenoxy)-5-(1-hydroxy-1-methyl-ethyl)phenyl]-6-methyl-7-oxo-1 H -pyrrolo[2,3- c ]pyridine-2-carboxamide (ABBV-744), a BET Bromodom... von Sheppard, George S, Wang, Le, Fidanze, Steven D, Hasvold, Lisa A, Liu, Dachun, Pratt, John K, Park, Chang H, Longenecker, Kenton, Qiu, Wei, Torrent, Maricel, Kovar, Peter J, Bui, Mai, Faivre, Emily, Huang, Xiaoli, Lin, Xiaoyu, Wilcox, Denise, Zhang, Lu, Shen, Yu, Albert, Daniel H, Magoc, Terrance J, Rajaraman, Ganesh, Kati, Warren M, McDaniel, Keith F

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Identification of aryl dihydrouracil derivatives as palm initiation site inhibitors of HCV NS5B polymerase von Liu, Yaya, Lim, Ben Hock, Jiang, Wen W., Flentge, Charles A., Hutchinson, Douglas K., Madigan, Darold L., Randolph, John T., Wagner, Rolf, Maring, Clarence J., Kati, Warren M., Molla, Akhteruzzaman

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Preclinical Characterization of BET Family Bromodomain Inhibitor ABBV-075 Suggests Combination Therapeutic Strategies von Bui, Mai H, Lin, Xiaoyu, Albert, Daniel H, Li, Leiming, Lam, Lloyd T, Faivre, Emily J, Warder, Scott E, Huang, Xiaoli, Wilcox, Denise, Donawho, Cherrie K, Sheppard, George S, Wang, Le, Fidanze, Steve, Pratt, John K, Liu, Dachun, Hasvold, Lisa, Uziel, Tamar, Lu, Xin, Kohlhapp, Fred, Fang, Guowei, Elmore, Steven W, Rosenberg, Saul H, McDaniel, Keith F, Kati, Warren M, Shen, Yu

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Discovery of N‑(4-(2,4-Difluorophenoxy)-3-(6-methyl-7-oxo-6,7-dihydro‑1H‑pyrrolo[2,3‑c]pyridin-4-yl)phenyl)ethanesulfonamide (ABBV-075/Mivebresib), a Potent and Orally Available Br... von McDaniel, Keith F, Wang, Le, Soltwedel, Todd, Fidanze, Steven D, Hasvold, Lisa A, Liu, Dachun, Mantei, Robert A, Pratt, John K, Sheppard, George S, Bui, Mai H, Faivre, Emily J, Huang, Xiaoli, Li, Leiming, Lin, Xiaoyu, Wang, Rongqi, Warder, Scott E, Wilcox, Denise, Albert, Daniel H, Magoc, Terrance J, Rajaraman, Ganesh, Park, Chang H, Hutchins, Charles W, Shen, Jianwei J, Edalji, Rohinton P, Sun, Chaohong C, Martin, Ruth, Gao, Wenqing, Wong, Shekman, Fang, Guowei, Elmore, Steven W, Shen, Yu, Kati, Warren M

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Vulnerability of Small-Cell Lung Cancer to Apoptosis Induced by the Combination of BET Bromodomain Proteins and BCL2 Inhibitors von Lam, Lloyd T, Lin, Xiaoyu, Faivre, Emily J, Yang, Ziping, Huang, Xiaoli, Wilcox, Denise M, Bellin, Richard J, Jin, Sha, Tahir, Stephen K, Mitten, Michael, Magoc, Terry, Bhathena, Anahita, Kati, Warren M, Albert, Daniel H, Shen, Yu, Uziel, Tamar

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Discovery of a Potent Chloroacetamide GPX4 Inhibitor with Bioavailability to Enable Target Engagement in Mice, a Potential Tool Compound for Inducing Ferroptosis In Vivo von Randolph, John T., O’Connor, Matthew J., Han, Fei, Hutchins, Charles W., Siu, Y. Amy, Cho, Min, Zheng, Yunan, Hickson, Jonathan A., Markley, Jana L., Manaves, Vlasios, Algire, Mikkel, Baker, Kenton A., Chapman, Alex M., Gopalakrishnan, Sujatha M., Panchal, Sanjay C., Foster-Duke, Kelly, Stolarik, DeAnne F., Kempf-Grote, Anita, Dammeier, Darby, Fossey, Stacey, Sun, Qi, Sun, Chaohong, Shen, Yu, Dart, Michael J., Kati, Warren M., Lai, Albert, Firestone, Ari J., Kort, Michael E.

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Mechanism of Inhibition of HIV-1 Reverse Transcriptase by Nonnucleoside Inhibitors von Spence, Rebecca A., Kati, Warren M., Anderson, Karen S., Johnson, Kenneth A.

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Activity of a Potent Hepatitis C Virus Polymerase Inhibitor in the Chimpanzee Model von Chen, Chih-Ming, He, Yupeng, Lu, Liangjun, Lim, Hock Ben, Tripathi, Rakesh L, Middleton, Tim, Hernandez, Lisa E, Beno, David W A, Long, Michelle A, Kati, Warren M, Bosse, Todd D, Larson, Daniel P, Wagner, Rolf, Lanford, Robert E, Kohlbrenner, William E, Kempf, Dale J, Pilot-Matias, Tami J, Molla, Akhteruzzaman

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Mechanistic Study of HCV Polymerase Inhibitors at Individual Steps of the Polymerization Reaction von Liu, Yaya, Jiang, Wen W, Pratt, John, Rockway, Todd, Harris, Kevin, Vasavanonda, Sudthida, Tripathi, Rakesh, Pithawalla, Ron, Kati, Warren M

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Selective Inhibition of the Second Bromodomain of BET Family Proteins Results in Robust Antitumor Activity in Preclinical Models of Acute Myeloid Leukemia von Zhang, Lu, Cai, Tianyu, Lin, Xiaoyu, Huang, Xiaoli, Bui, Mai H., Plotnik, Joshua P., Bellin, Richard J., Faivre, Emily J., Kuruvilla, Vinitha M., Lam, Lloyd T., Lu, Xin, Zha, Zheng, Feng, Weiguo, Hessler, Paul, Uziel, Tamar, Zhang, Qi, Cavazos, Antonio, Han, Lina, Ferguson, Debra C., Mehta, Gaurav, Shanmugavelandy, Sriram S., Magoc, Terrance J., Rowe, Jenny, Goodwin, Neal C., Dorritie, Kathleen A., Boyiadzis, Michael, Albert, Daniel H., McDaniel, Keith F., Kati, Warren M., Konopleva, Marina, Shen, Yu

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In Vitro Characterization of A-315675, a Highly Potent Inhibitor of A and B Strain Influenza Virus Neuraminidases and Influenza Virus Replication von KATI, Warren M, MONTGOMERY, Debra, KOHLBRENNER, William, CARRICK, Robert, GUBAREVA, Larisa, MARING, Clarence, MCDANIEL, Keith, STEFFY, Kevin, MOLLA, Akhteruzzaman, HAYDEN, Frederick, KEMPF, Dale

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Highlights of the Structure–Activity Relationships of Benzimidazole Linked Pyrrolidines Leading to the Discovery of the Hepatitis C Virus NS5A Inhibitor Pibrentasvir (ABT-530) von Wagner, Rolf, Randolph, John T, Patel, Sachin V, Nelson, Lissa, Matulenko, Mark A, Keddy, Ryan, Pratt, John K, Liu, Dachun, Krueger, A. Chris, Donner, Pamela L, Hutchinson, Douglas K, Flentge, Charles, Betebenner, David, Rockway, Todd, Maring, Clarence J, Ng, Teresa I, Krishnan, Preethi, Pilot-Matias, Tami, Collins, Christine, Panchal, Neeta, Reisch, Thomas, Dekhtyar, Tatyana, Mondal, Rubina, Stolarik, DeAnne F, Gao, Yi, Gao, Wenqing, Beno, David A, Kati, Warren M

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Fragment-Based, Structure-Enabled Discovery of Novel Pyridones and Pyridone Macrocycles as Potent Bromodomain and Extra-Terminal Domain (BET) Family Bromodomain Inhibitors von Wang, Le, Pratt, John K, Soltwedel, Todd, Sheppard, George S, Fidanze, Steven D, Liu, Dachun, Hasvold, Lisa A, Mantei, Robert A, Holms, James H, McClellan, William J, Wendt, Michael D, Wada, Carol, Frey, Robin, Hansen, T. Matthew, Hubbard, Robert, Park, Chang H, Li, Leiming, Magoc, Terrance J, Albert, Daniel H, Lin, Xiaoyu, Warder, Scott E, Kovar, Peter, Huang, Xiaoli, Wilcox, Denise, Wang, Rongqi, Rajaraman, Ganesh, Petros, Andrew M, Hutchins, Charles W, Panchal, Sanjay C, Sun, Chaohong, Elmore, Steven W, Shen, Yu, Kati, Warren M, McDaniel, Keith F

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Discovery of ABT-267, a Pan-Genotypic Inhibitor of HCV NS5A von DeGoey, David A., Randolph, John T., Liu, Dachun, Pratt, John, Hutchins, Charles, Donner, Pamela, Krueger, A. Chris, Matulenko, Mark, Patel, Sachin, Motter, Christopher E., Nelson, Lissa, Keddy, Ryan, Tufano, Michael, Caspi, Daniel D., Krishnan, Preethi, Mistry, Neeta, Koev, Gennadiy, Reisch, Thomas J., Mondal, Rubina, Pilot-Matias, Tami, Gao, Yi, Beno, David W. A., Maring, Clarence J., Molla, Akhter, Dumas, Emily, Campbell, Andrew, Williams, Laura, Collins, Christine, Wagner, Rolf, Kati, Warren M.

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Co-clinical Modeling of the Activity of the BET Inhibitor Mivebresib (ABBV-075) in AML von ALBERT, DANIEL H., GOODWIN, NEAL C., DAVIES, ANGELA M., ROWE, JENNY, FEUER, GEROLD, BOYIADZIS, MICHAEL, DORRITIE, KATHLEEN A., MANCINI, MARIA, GANDOUR-EDWARDS, REGINA, JONAS, BRIAN A., BORTHAKUR, GAUTAM, ALDOSS, IBRAHIM, RIZZIERI, DAVID A., ODENIKE, OLATOYOSI, PREBET, THOMAS, SINGH, SANJANA, POPOVIC, RELJA, SHEN, YU, MCDANIEL, KEITH F., KATI, WARREN M., MODI, DIMPLE A., MOTWANI, MONICA, WOLFF, JOHANNES E., FROST, DAVID J.

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Estimation of Serum-Free 50-Percent Inhibitory Concentrations for Human Immunodeficiency Virus Protease Inhibitors Lopinavir and Ritonavir von HICKMAN, Dean, VASAVANONDA, Sudthida, NEQUIST, George, COLLETTI, Lynn, KATI, Warren M, BERTZ, Richard, HSU, Ann, KEMPF, Dale J

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