Genetic Basis for Clinical Response to CTLA-4 Blockade in Melanoma von Snyder, Alexandra, Makarov, Vladimir, Merghoub, Taha, Yuan, Jianda, Zaretsky, Jesse M, Desrichard, Alexis, Walsh, Logan A, Postow, Michael A, Wong, Phillip, Ho, Teresa S, Hollmann, Travis J, Bruggeman, Cameron, Kannan, Kasthuri, Li, Yanyun, Elipenahli, Ceyhan, Liu, Cailian, Harbison, Christopher T, Wang, Lisu, Ribas, Antoni, Wolchok, Jedd D, Chan, Timothy A

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Tissue resident and follicular Treg cell differentiation is regulated by CRAC channels von Vaeth, Martin, Wang, Yin-Hu, Eckstein, Miriam, Yang, Jun, Silverman, Gregg J., Lacruz, Rodrigo S., Kannan, Kasthuri, Feske, Stefan

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Gibbs process distinguishes survival and reveals contact-inhibition genes in Glioblastoma multiforme von Jahedi, Afrooz, Kumar, Gayatri, Kannan, Lavanya, Agarwal, Tarjani, Huse, Jason, Bhat, Krishna, Kannan, Kasthuri

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Atrx inactivation drives disease-defining phenotypes in glioma cells of origin through global epigenomic remodeling von Danussi, Carla, Bose, Promita, Parthasarathy, Prasanna T., Silberman, Pedro C., Van Arnam, John S., Vitucci, Mark, Tang, Oliver Y., Heguy, Adriana, Wang, Yuxiang, Chan, Timothy A., Riggins, Gregory J., Sulman, Erik P., Lang, Frederick F., Creighton, Chad J., Deneen, Benjamin, Miller, C. Ryan, Picketts, David J., Kannan, Kasthuri, Huse, Jason T.

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Critical Role of Amyloid-like Oligomers of Drosophila Orb2 in the Persistence of Memory von Majumdar, Amitabha, Cesario, Wanda Colón, White-Grindley, Erica, Jiang, Huoqing, Ren, Fengzhen, Khan, Mohammed “Repon”, Li, Liying, Choi, Edward Man-Lik, Kannan, Kasthuri, Guo, Fengli, Unruh, Jay, Slaughter, Brian, Si, Kausik

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Recurrent somatic mutation of FAT1 in multiple human cancers leads to aberrant Wnt activation von Morris, Luc G T, Kaufman, Andrew M, Gong, Yongxing, Ramaswami, Deepa, Walsh, Logan A, Turcan, Şevin, Eng, Stephanie, Kannan, Kasthuri, Zou, Yilong, Peng, Luke, Banuchi, Victoria E, Paty, Phillip, Zeng, Zhaoshi, Vakiani, Efsevia, Solit, David, Singh, Bhuvanesh, Ganly, Ian, Liau, Linda, Cloughesy, Timothy C, Mischel, Paul S, Mellinghoff, Ingo K, Chan, Timothy A

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Genomic Dissection of Hurthle Cell Carcinoma Reveals a Unique Class of Thyroid Malignancy von Ganly, Ian, Ricarte Filho, Julio, Eng, Stephanie, Ghossein, Ronald, Morris, Luc G. T, Liang, Yupu, Socci, Nicholas, Kannan, Kasthuri, Mo, Qianxing, Fagin, James A, Chan, Timothy A

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Author Correction: Atrx inactivation drives disease-defining phenotypes in glioma cells of origin through global epigenomic remodeling von Danussi, Carla, Bose, Promita, Parthasarathy, Prasanna T., Silberman, Pedro C., Van Arnam, John S., Vitucci, Mark, Tang, Oliver Y., Heguy, Adriana, Wang, Yuxiang, Chan, Timothy A., Riggins, Gregory J., Sulman, Erik P., Lang, Frederick F., Creighton, Chad J., Deneen, Benjamin, Miller, C. Ryan, Picketts, David J., Kannan, Kasthuri, Huse, Jason T.

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Effector memory cytotoxic CD3+/CD8+/CD45RO+ T cells are predictive of good survival and a lower risk of recurrence in triple-negative breast cancer von Sun, Xiangjie, Zhai, Jie, Sun, Baohua, Parra, Edwin Roger, Jiang, Mei, Ma, Wencai, Wang, Jing, Kang, Anthony M., Kannan, Kasthuri, Pandurengan, Renganayaki, Zhang, Shanyu, Solis, Luisa Maren, Haymaker, Cara L., Raso, Maria Gabriela, Mendoza Perez, Julia, Sahin, Aysegul A., Wistuba, Ignacio I., Yam, Clinton, Litton, Jennifer K., Yang, Fei

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Recurrent homozygous deletion of DROSHA and microduplication of PDE4DIP in pineoblastoma von Snuderl, Matija, Kannan, Kasthuri, Pfaff, Elke, Wang, Shiyang, Stafford, James M., Serrano, Jonathan, Heguy, Adriana, Ray, Karina, Faustin, Arline, Aminova, Olga, Dolgalev, Igor, Stapleton, Stacie L., Zagzag, David, Chiriboga, Luis, Gardner, Sharon L., Wisoff, Jeffrey H., Golfinos, John G., Capper, David, Hovestadt, Volker, Rosenblum, Marc K., Placantonakis, Dimitris G., LeBoeuf, Sarah E., Papagiannakopoulos, Thales Y., Chavez, Lukas, Ahsan, Sama, Eberhart, Charles G., Pfister, Stefan M., Jones, David T. W., Karajannis, Matthias A.

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Whole exome sequencing identifies ATRX mutation as a key molecular determinant in lower-grade glioma von Kannan, Kasthuri, Inagaki, Akiko, Silber, Joachim, Gorovets, Daniel, Zhang, Jianan, Kastenhuber, Edward R., Heguy, Adriana, Petrini, John H., Chan, Timothy A., Huse, Jason T.

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BIOM-49. PATIENT-CENTRIC INTEGRATED GRAPH DATABASE REVEALS CRITICAL BIOMARKERS IN THE RECURRENCE OF IDH WILD-TYPE GLIOMA von Liu, Yang, Kannan, Kasthuri, Huse, Jason

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Why do mutant allele frequencies in oncogenes peak around .40 and rapidly decrease? von Kannan, Kasthuri, Heguy, Adriana

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NIMG-50. MULTIPARAMETRIC MRI DISTINGUISHES NEURONAL AND IMMUNE SIGNATURES IN INVASIVE HIGH-GRADE GLIOMA RIM THROUGH GRAPH NETWORK ANALYSIS von Flick, Matthew, Stevens, Victoria, Plaisier, Christopher, Barajas, Ramon, Tran, Nhan, Kannan, Kasthuri, Hu, Leland

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TMIC-68. DEEP LEARNING OF THE SPATIAL IMMUNE ENGAGEMENT IN GLIOBLASTOMA UNDER TEMOZOLOMIDE TREATMENT von Castillo, Simon, Jahedi, Afrooz, Gupta, Pravesh, Huse, Jason, Kannan, Kasthuri, Yuan, Yinyin, Bhat, Krishna

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ANGI-09. GRAPH NETWORK ANALYSIS IDENTIFIES GENETIC COMMUNITIES OF CSF2RA AND RBFOX1 AS REGULATORS OF INVASIVE HIGH-GRADE GLIOMA BIOLOGY von Flick, Matthew, Stevens, Victoria, Sereduk, Christopher, Plaisier, Christopher, Barajas, Ramon, Hu, Leland, Kannan, Kasthuri, Tran, Nhan

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ANGI-10. NETWORK ANALYSIS ESTABLISHES CSF2RA’S REGIONAL INFLUENCE ON HYPOXIA RESPONSE IN THE INVASIVE RIM OF HIGH GRADE GLIOMA von Flick, Matthew, Stevens, Victoria, Sereduk, Christopher, Plaisier, Christopher, Barajas, Ramon, Hu, Leland, Kannan, Kasthuri, Tran, Nhan

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EPCO-08. ATRX DEFICIENCY INDUCES DYSFUNCTIONAL HETEROCHROMATIN ARCHITECTURE IN GLIOMAS AND ESTABLISHES DISEASE-DEFINING TRANSCRIPTIONAL NETWORKS von Malgulwar, Prit Benny, Danussi, Carla, Singh, Anand, Kannan, Kasthuri, Rai, Kunal, Huse, Jason

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Role of Dysregulated Cytokine Signaling and Bacterial Triggers in the Pathogenesis of Cutaneous T-Cell Lymphoma von Fanok, Melania H., Sun, Amy, Fogli, Laura K., Narendran, Vijay, Eckstein, Miriam, Kannan, Kasthuri, Dolgalev, Igor, Lazaris, Charalampos, Heguy, Adriana, Laird, Mary E., Sundrud, Mark S., Liu, Cynthia, Kutok, Jeff, Lacruz, Rodrigo S., Latkowski, Jo-Ann, Aifantis, Iannis, Ødum, Niels, Hymes, Kenneth B., Goel, Swati, Koralov, Sergei B.

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Abstract 345: Characterizing and therapeutically targeting G-quadruplex DNA in ATRX -mutant glioma von Wang, Yuxiang, Danussi, Carla, Kannan, Kasthuri, Chan, Timothy A., Huse, Jason T.

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