Optimized base editors enable efficient editing in cells, organoids and mice von Zafra, Maria Paz, Schatoff, Emma M, Katti, Alyna, Foronda, Miguel, Breinig, Marco, Schweitzer, Anabel Y, Simon, Amber, Han, Teng, Goswami, Sukanya, Montgomery, Emma, Thibado, Jordana, Kastenhuber, Edward R, Sánchez-Rivera, Francisco J, Shi, Junwei, Vakoc, Christopher R, Lowe, Scott W, Tschaharganeh, Darjus F, Dow, Lukas E

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Inducible in vivo genome editing with CRISPR-Cas9 von Dow, Lukas E, Fisher, Jonathan, O'Rourke, Kevin P, Muley, Ashlesha, Kastenhuber, Edward R, Livshits, Geulah, Tschaharganeh, Darjus F, Socci, Nicholas D, Lowe, Scott W

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p53-Dependent Nestin Regulation Links Tumor Suppression to Cellular Plasticity in Liver Cancer von Tschaharganeh, Darjus F., Xue, Wen, Calvisi, Diego F., Evert, Matthias, Michurina, Tatyana V., Dow, Lukas E., Banito, Ana, Katz, Sarah F., Kastenhuber, Edward R., Weissmueller, Susann, Huang, Chun-Hao, Lechel, Andre, Andersen, Jesper B., Capper, David, Zender, Lars, Longerich, Thomas, Enikolopov, Grigori, Lowe, Scott W.

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Pten loss promotes MAPK pathway dependency in HER2/neu breast carcinomas von Ebbesen, Saya H., Scaltriti, Maurizio, Bialucha, Carl U., Morse, Natasha, Kastenhuber, Edward R., Wen, Hannah Y., Dow, Lukas E., Baselga, José, Lowe, Scott W.

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Epinephrine inhibits PI3Kα via the Hippo kinases von Lin, Ting-Yu, Ramsamooj, Shakti, Perrier, Tiffany, Liberatore, Katarina, Lantier, Louise, Vasan, Neil, Karukurichi, Kannan, Hwang, Seo-Kyoung, Kesicki, Edward A., Kastenhuber, Edward R., Wiederhold, Thorsten, Yaron, Tomer M., Huntsman, Emily M., Zhu, Mengmeng, Ma, Yilun, Paddock, Marcia N., Zhang, Guoan, Hopkins, Benjamin D., McGuinness, Owen, Schwartz, Robert E., Ersoy, Baran A., Cantley, Lewis C., Johnson, Jared L., Goncalves, Marcus D.

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Dicer-regulated microRNAs 222 and 339 promote resistance of cancer cells to cytotoxic T-lymphocytes by down-regulation of ICAM-1 von Ueda, Ryo, Kohanbash, Gary, Sasaki, Kotaro, Fujita, Mitsugu, Zhu, Xinmei, Kastenhuber, Edward R, McDonald, Heather A, Potter, Douglas M, Hamilton, Ronald L, Lotze, Michael T, Khan, Saleem A, Sobol, Robert W, Okada, Hideho

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TP53 exon-6 truncating mutations produce separation of function isoforms with pro-tumorigenic functions von Shirole, Nitin H, Pal, Debjani, Kastenhuber, Edward R, Senturk, Serif, Boroda, Joseph, Pisterzi, Paola, Miller, Madison, Munoz, Gustavo, Anderluh, Marko, Ladanyi, Marc, Lowe, Scott W, Sordella, Raffaella

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Whole-exome sequencing identifies ATRX mutation as a key molecular determinant in lower-grade glioma von Kannan, Kasthuri, Inagaki, Akiko, Silber, Joachim, Gorovets, Daniel, Zhang, Jianan, Kastenhuber, Edward R, Heguy, Adriana, Petrini, John H, Chan, Timothy A, Huse, Jason T

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Role of Type 1 IFNs in Antiglioma Immunosurveillance-Using Mouse Studies to Guide Examination of Novel Prognostic Markers in Humans von FUJITA, Mitsugu, SCHEURER, Michael E, DECKER, Stacy A, MCDONALD, Heather A, KOHANBASH, Gary, KASTENHUBER, Edward R, KATO, Hisashi, BONDY, Melissa L, OHLFEST, John R, OKADA, Hideho

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Effective Immunotherapy against Murine Gliomas Using Type 1 Polarizing Dendritic Cells―Significant Roles of CXCL10 von FUJITA, Mitsugu, XINMEI ZHU, KALINSKI, Pawel, OKADA, Hideho, UEDA, Ryo, SASAKI, Kotaro, KOHANBASH, Gary, KASTENHUBER, Edward R, MCDONALD, Heather A, GIBSON, Gregory A, WATKINS, Simon C, MUTHUSWAMY, Ravikumar

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Deletions linked to TP53 loss drive cancer through p53-independent mechanisms von Liu, Yu, Chen, Chong, Xu, Zhengmin, Scuoppo, Claudio, Rillahan, Cory D., Gao, Jianjiong, Spitzer, Barbara, Bosbach, Benedikt, Kastenhuber, Edward R., Baslan, Timour, Ackermann, Sarah, Cheng, Lihua, Wang, Qingguo, Niu, Ting, Schultz, Nikolaus, Levine, Ross L., Mills, Alea A., Lowe, Scott W.

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Whole exome sequencing identifies ATRX mutation as a key molecular determinant in lower-grade glioma von Kannan, Kasthuri, Inagaki, Akiko, Silber, Joachim, Gorovets, Daniel, Zhang, Jianan, Kastenhuber, Edward R., Heguy, Adriana, Petrini, John H., Chan, Timothy A., Huse, Jason T.

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p53-Dependent Nestin Regulation Links Tumor Suppression to Cellular Plasticity in Liver Cancer von Tschaharganeh, Darjus F., Xue, Wen, Calvisi, Diego F., Evert, Matthias, Michurina, Tatyana V., Dow, Lukas E., Banito, Ana, Katz, Sarah F., Kastenhuber, Edward R., Weissmueller, Susann, Huang, Chun-Hao, Lechel, Andre, Andersen, Jesper B., Capper, David, Zender, Lars, Longerich, Thomas, Enikolopov, Grigori, Lowe, Scott W.

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An atlas of substrate specificities for the human serine/threonine kinome von Johnson, Jared L., Yaron, Tomer M., Huntsman, Emily M., Kerelsky, Alexander, Song, Junho, Regev, Amit, Lin, Ting-Yu, Liberatore, Katarina, Cizin, Daniel M., Cohen, Benjamin M., Vasan, Neil, Ma, Yilun, Krismer, Konstantin, Robles, Jaylissa Torres, van de Kooij, Bert, van Vlimmeren, Anne E., Andrée-Busch, Nicole, Käufer, Norbert F., Dorovkov, Maxim V., Ryazanov, Alexey G., Takagi, Yuichiro, Kastenhuber, Edward R., Goncalves, Marcus D., Hopkins, Benjamin D., Elemento, Olivier, Taatjes, Dylan J., Maucuer, Alexandre, Yamashita, Akio, Degterev, Alexei, Uduman, Mohamed, Lu, Jingyi, Landry, Sean D., Zhang, Bin, Cossentino, Ian, Linding, Rune, Blenis, John, Hornbeck, Peter V., Turk, Benjamin E., Yaffe, Michael B., Cantley, Lewis C.

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Correction: TP53 exon-6 truncating mutations produce separation of function isoforms with pro-tumorigenic functions von Shirole, Nitin H, Pal, Debjani, Kastenhuber, Edward R, Senturk, Serif, Boroda, Joseph, Pisterzi, Paola, Miller, Madison, Munoz, Gustavo, Anderluh, Marko, Ladanyi, Marc, Lowe, Scott W, Sordella, Raffaella

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Limited Environmental Serine and Glycine Confer Brain Metastasis Sensitivity to PHGDH Inhibition von Ngo, Bryan, Kim, Eugenie, Osorio-Vasquez, Victoria, Doll, Sophia, Bustraan, Sophia, Liang, Roger J., Luengo, Alba, Davidson, Shawn M., Ali, Ahmed, Ferraro, Gino B., Fischer, Grant M., Eskandari, Roozbeh, Kang, Diane S., Ni, Jing, Plasger, Ariana, Rajasekhar, Vinagolu K., Kastenhuber, Edward R., Bacha, Sarah, Sriram, Roshan K., Stein, Benjamin D., Bakhoum, Samuel F., Snuderl, Matija, Cotzia, Paolo, Healey, John H., Mainolfi, Nello, Suri, Vipin, Friedman, Adam, Manfredi, Mark, Sabatini, David M., Jones, Drew R., Yu, Min, Zhao, Jean J., Jain, Rakesh K., Keshari, Kayvan R., Davies, Michael A., Vander Heiden, Matthew G., Hernando, Eva, Mann, Matthias, Cantley, Lewis C., Pacold, Michael E.

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Host protein kinases required for SARS-CoV-2 nucleocapsid phosphorylation and viral replication von Yaron, Tomer M, Heaton, Brook E, Levy, Tyler M, Johnson, Jared L, Jordan, Tristan X, Cohen, Benjamin M, Kerelsky, Alexander, Lin, Ting-Yu, Liberatore, Katarina M, Bulaon, Danielle K, Van Nest, Samantha J, Koundouros, Nikos, Kastenhuber, Edward R, Mercadante, Marisa N, Shobana-Ganesh, Kripa, He, Long, Schwartz, Robert E, Chen, Shuibing, Weinstein, Harel, Elemento, Olivier, Piskounova, Elena, Nilsson-Payant, Benjamin E, Lee, Gina, Trimarco, Joseph D, Burke, Kaitlyn N, Hamele, Cait E, Chaparian, Ryan R, Harding, Alfred T, Tata, Aleksandra, Zhu, Xinyu, Tata, Purushothama Rao, Smith, Clare M, Possemato, Anthony P, Tkachev, Sasha L, Hornbeck, Peter V, Beausoleil, Sean A, Anand, Shankara K, Aguet, François, Getz, Gad, Davidson, Andrew D, Heesom, Kate, Kavanagh-Williamson, Maia, Matthews, David A, tenOever, Benjamin R, Cantley, Lewis C, Blenis, John, Heaton, Nicholas S

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MicroRNA-375 Suppresses the Growth and Invasion of Fibrolamellar CarcinomaSummary von Timothy A. Dinh, Mark L. Jewell, Matt Kanke, Adam Francisco, Ramja Sritharan, Rigney E. Turnham, Seona Lee, Edward R. Kastenhuber, Eliane Wauthier, Cynthia D. Guy, Raymond S. Yeung, Scott W. Lowe, Lola M. Reid, John D. Scott, Anna M. Diehl, Praveen Sethupathy

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p53 promotes peroxisomal fatty acid β-oxidation to repress purine biosynthesis and mediate tumor suppression von Zhao, Jianhong, Zhou, Xiaojun, Chen, Baoxiang, Lu, Mingzhu, Wang, Genxin, Elumalai, Nagarajan, Tian, Chenhui, Zhang, Jinmiao, Liu, Yanliang, Chen, Zhiqiang, Zhou, Xinyi, Wu, Mingzhi, Li, Mengjiao, Prochownik, Edward V., Tavassoli, Ali, Jiang, Congqing, Li, Youjun

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Bcl-2-associated athanogene 5 (BAG5) regulates Parkin-dependent mitophagy and cell death von De Snoo, Mitchell L., Friesen, Erik L., Zhang, Yu Tong, Earnshaw, Rebecca, Dorval, Geneviève, Kapadia, Minesh, O’Hara, Darren M., Agapova, Victoria, Chau, Hien, Pellerito, Ornella, Tang, Matthew Y., Wang, Xinzhu, Schmitt-Ulms, Gerold, Durcan, Thomas M., Fon, Edward A., Kalia, Lorraine V., Kalia, Suneil K.

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