Cell-Based Screening: Extracting Meaning from Complex Data von Finkbeiner, Steven, Frumkin, Michael, Kassner, Paul D.

Volltext

Measurement of Cancer Cell Growth Heterogeneity through Lentiviral Barcoding Identifies Clonal Dominance as a Characteristic of In Vivo Tumor Engraftment von Nolan-Stevaux, Olivier, Tedesco, Donato, Ragan, Seamus, Makhanov, Mikhail, Chenchik, Alex, Ruefli-Brasse, Astrid, Quon, Kim, Kassner, Paul D

Volltext

Identification of modulators of autophagic flux in an image-based high content siRNA screen von Hale, Christopher M., Cheng, Qingwen, Ortuno, Danny, Huang, Ming, Nojima, Dana, Kassner, Paul D., Wang, Songli, Ollmann, Michael M., Carlisle, Holly J.

Volltext

Sphingosine kinase activity is not required for tumor cell viability von Rex, Karen, Jeffries, Shawn, Brown, Matthew L, Carlson, Timothy, Coxon, Angela, Fajardo, Flordeliza, Frank, Brendon, Gustin, Darin, Kamb, Alexander, Kassner, Paul D, Li, Shyun, Li, Yihong, Morgenstern, Kurt, Plant, Matthew, Quon, Kim, Ruefli-Brasse, Astrid, Schmidt, Joanna, Swearingen, Elissa, Walker, Nigel, Wang, Zhulun, Watson, J E Vivienne, Wickramasinghe, Dineli, Wong, Mariwil, Xu, Guifen, Wesche, Holger

Volltext

Discovery of Potent, Selective, and Orally Bioavailable Inhibitors of USP7 with In Vivo Antitumor Activity von Leger, Paul R, Hu, Dennis X, Biannic, Berenger, Bui, Minna, Han, Xinping, Karbarz, Emily, Maung, Jack, Okano, Akinori, Osipov, Maksim, Shibuya, Grant M, Young, Kyle, Higgs, Christopher, Abraham, Betty, Bradford, Delia, Cho, Cynthia, Colas, Christophe, Jacobson, Scott, Ohol, Yamini M, Pookot, Deepa, Rana, Payal, Sanchez, Jerick, Shah, Niket, Sun, Michael, Wong, Steve, Brockstedt, Dirk G, Kassner, Paul D, Schwarz, Jacob B, Wustrow, David J

Volltext

Clinical and molecular effects of oral CCR4 antagonist RPT193 in atopic dermatitis: A Phase 1 study von Bissonnette, Robert, DuBois, Janet, Facheris, Paola, Del Duca, Ester, Kim, Madeline, Correa Da Rosa, Joel, Trujillo, Damian L., Bose, Swaroop, Pagan, Angel D., Wustrow, David, Brockstedt, Dirk G., Wong, Brian, Kassner, Paul D., Jankicevic, Jasmina, Ho, William, Cheng, Laurence E., Guttman‐Yassky, Emma

Volltext

Tumors establish resistance to immunotherapy by regulating T-reg recruitment via CCR4 von Marshall, Lisa A., Marubayashi, Sachie, Jorapur, Aparna, Jacobson, Scott, Zibinsky, Mikhail, Robles, Omar, Hu, Dennis Xiaozhou, Jackson, Jeffrey J., Pookot, Deepa, Sanchez, Jerick, Brovarney, Martin, Wadsworth, Angela, Chian, David, Wustrow, David, Kassner, Paul D., Cutler, Gene, Wong, Brian, Brockstedt, Dirk G., Talay, Oezcan

Volltext

EBV+ tumors exploit tumor cell-intrinsic and -extrinsic mechanisms to produce regulatory T cell-recruiting chemokines CCL17 and CCL22 von Jorapur, Aparna, Marshall, Lisa A, Jacobson, Scott, Xu, Mengshu, Marubayashi, Sachie, Zibinsky, Mikhail, Hu, Dennis X, Robles, Omar, Jackson, Jeffrey J, Baloche, Valentin, Busson, Pierre, Wustrow, David, Brockstedt, Dirk G, Talay, Oezcan, Kassner, Paul D, Cutler, Gene

Volltext

Novel Piperidinyl-Azetidines as Potent and Selective CCR4 Antagonists Elicit Antitumor Response as a Single Agent and in Combination with Checkpoint Inhibitors von Robles, Omar, Jackson, Jeffrey J, Marshall, Lisa, Talay, Oezcan, Chian, David, Cutler, Gene, Diokno, Raymond, Hu, Dennis X, Jacobson, Scott, Karbarz, Emily, Kassner, Paul D, Ketcham, John M, McKinnell, Jenny, Meleza, Cesar, Reilly, Maureen K, Riegler, Erin, Shunatona, Hunter P, Wadsworth, Angela, Younai, Ashkaan, Brockstedt, Dirk G, Wustrow, David J, Zibinsky, Mikhail

Volltext

STK33 Kinase Activity Is Nonessential in KRAS-Dependent Cancer Cells von BABIJ, Carol, YIHONG ZHANG, FAJARDO, Flordeliza, JACKSON, Angela, ZONDLO, James, YU SUN, ELLISON, Aaron R, PLEWA, Cherylene A, SAN MIGUEL, Tisha, ROBINSON, John, MCCARTER, John, SCHWANDNER, Ralf, KURZEJA, Robert J, JUDD, Ted, CARNAHAN, Josette, DUSSAULT, Isabelle, MUNZLI, Anke, SHEHABELDIN, Amro, FERNANDO, Manory, QUON, Kim, KASSNER, Paul D, RUEFLI-BRASSE, Astrid A, WATSON, Vivienne J

Volltext

Novel, Selective Inhibitors of USP7 Uncover Multiple Mechanisms of Antitumor Activity In Vitro and In Vivo von Ohol, Yamini M., Sun, Michael T., Cutler, Gene, Leger, Paul R., Hu, Dennis X., Biannic, Berenger, Rana, Payal, Cho, Cynthia, Jacobson, Scott, Wong, Steve T., Sanchez, Jerick, Shah, Niket, Pookot, Deepa, Abraham, Betty, Young, Kyle, Suthram, Silpa, Marshall, Lisa A., Bradford, Delia, Kozon, Nathan, Han, Xinping, Okano, Akinori, Maung, Jack, Colas, Christophe, Schwarz, Jacob, Wustrow, David, Brockstedt, Dirk G., Kassner, Paul D.

Volltext

Potent GCN2 Inhibitor Capable of Reversing MDSC-Driven T Cell Suppression Demonstrates In Vivo Efficacy as a Single Agent and in Combination with Anti-Angiogenesis Therapy von Jackson, Jeffrey J., Shibuya, Grant M., Ravishankar, Buvana, Adusumilli, Lavanya, Bradford, Delia, Brockstedt, Dirk G., Bucher, Cyril, Bui, Minna, Cho, Cynthia, Colas, Christoph, Cutler, Gene, Dukes, Adrian, Han, Xinping, Hu, Dennis X., Jacobson, Scott, Kassner, Paul D., Katibah, George E., Ko, Michelle Yoo Min, Kolhatkar, Urvi, Leger, Paul R., Ma, Anqi, Marshall, Lisa, Maung, Jack, Ng, Andrew A., Okano, Akinori, Pookot, Deepa, Poon, Daniel, Ramana, Chandru, Reilly, Maureen K., Robles, Omar, Schwarz, Jacob B., Shakhmin, Anton A., Shunatona, Hunter P., Sreenivasan, Raashi, Tivitmahaisoon, Parcharee, Xu, Mengshu, Zaw, Thant, Wustrow, David J., Zibinsky, Mikhail

Volltext

Discovery of a Potent and Selective CCR4 Antagonist That Inhibits Treg Trafficking into the Tumor Microenvironment von Jackson, Jeffrey J, Ketcham, John M, Younai, Ashkaan, Abraham, Betty, Biannic, Berenger, Beck, Hilary P, Bui, Minna H. T, Chian, David, Cutler, Gene, Diokno, Raymond, Hu, Dennis X, Jacobson, Scott, Karbarz, Emily, Kassner, Paul D, Marshall, Lisa, McKinnell, Jenny, Meleza, Cesar, Okal, Abood, Pookot, Deepa, Reilly, Maureen K, Robles, Omar, Shunatona, Hunter P, Talay, Oezcan, Walker, James R, Wadsworth, Angela, Wustrow, David J, Zibinsky, Mikhail

Volltext

Discovery of a Potent and Selective CCR4 Antagonist That Inhibits T reg Trafficking into the Tumor Microenvironment von Jackson, Jeffrey J, Ketcham, John M, Younai, Ashkaan, Abraham, Betty, Biannic, Berenger, Beck, Hilary P, Bui, Minna H T, Chian, David, Cutler, Gene, Diokno, Raymond, Hu, Dennis X, Jacobson, Scott, Karbarz, Emily, Kassner, Paul D, Marshall, Lisa, McKinnell, Jenny, Meleza, Cesar, Okal, Abood, Pookot, Deepa, Reilly, Maureen K, Robles, Omar, Shunatona, Hunter P, Talay, Oezcan, Walker, James R, Wadsworth, Angela, Wustrow, David J, Zibinsky, Mikhail

Volltext

Significant gene content variation characterizes the genomes of inbred mouse strains von Cutler, Gene, Marshall, Lisa A, Chin, Ni, Baribault, Helene, Kassner, Paul D

Volltext

RNA interference screening for the discovery of oncology targets von Quon, Kim, Kassner, Paul D

Volltext

The Integrin VLA-4 Supports Tethering and Rolling in Flow on VCAM-1 von Alon, Ronen, Kassner, Paul D., Carr, Michelle Woldemar, Finger, Erik B., Hemler, Martin E., Springer, Timothy A.

Volltext

Gene transfer to mammalian cells using genetically targeted filamentous bacteriophage von Larocca, David, Kassner, Paul D., Witte, Alison, Ladner, Robert Charles, Pierce, Glenn F., Baird, Andrew

Volltext

704 Biological activity of FLX475, an oral CCR4 antagonist, as monotherapy and in combination with pembrolizumab in advanced cancer von Adamik, Juraj, Grant, Adam, Trujillo, Damian, Goyal, Rakesh Kumar, Ho, William, Chisamore, Michael, Ikeda, Shoji, Au, Marvin, Nagata, Denise, Lurie, Eugene, Zhu, Qingfeng, Anders, Robert, Brockstedt, Dirk G, Ghomi, Mohsen Sabouri, Kassner, Paul D

Volltext

629-C Phase 2 safety and efficacy of oral CCR4 antagonist FLX475 (tivumecirnon) plus pembrolizumab in subjects with non-small cell lung cancer not previously treated with checkpoin... von Kim, Tae Min, Ngamphaiboon, Nuttapong, Lee, Ki Hyeong, Desai, Pratibha, Lin, Chia-Chi, Muzaffar, Jameel, Feng, Yin-Hsun, Wu, Shang-Yin, Brahmer, Julie, Chisamore, Michael, Kassner, Paul D, Brockstedt, Dirk G, Goyal, Rakesh Kumar, Nasrah, Nicole, Ho, William

Volltext