Functional Anti-TIGIT Antibodies Regulate Development of Autoimmunity and Antitumor Immunity von Dixon, Karen O, Schorer, Michelle, Nevin, James, Etminan, Yassaman, Amoozgar, Zohreh, Kondo, Takaaki, Kurtulus, Sema, Kassam, Nasim, Sobel, Raymond A, Fukumura, Dai, Jain, Rakesh K, Anderson, Ana C, Kuchroo, Vijay K, Joller, Nicole

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Negative Immune Regulator Tim-3 Is Overexpressed on T Cells in Hepatitis C Virus Infection and Its Blockade Rescues Dysfunctional CD4+ and CD8+ T Cells von Golden-Mason, Lucy, Palmer, Brent E., Kassam, Nasim, Townshend-Bulson, Lisa, Livingston, Stephen, McMahon, Brian J., Castelblanco, Nicole, Kuchroo, Vijay, Gretch, David R., Rosen, Hugo R.

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Promotion of Tissue Inflammation by the Immune Receptor Tim-3 Expressed on Innate Immune Cells von Anderson, Ana C., Anderson, David E., Bregoli, Lisa, Hastings, William D., Kassam, Nasim, Lei, Charles, Chandwaskar, Rucha, Karman, Jozsef, Su, Ee W., Hirashima, Mitsuomi, Bruce, Jeffrey N., Kane, Lawrence P., Kuchroo, Vijay K., Hafler, David A.

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Blockade of Tim-3 binding to phosphatidylserine and CEACAM1 is a shared feature of anti-Tim-3 antibodies that have functional efficacy von Sabatos-Peyton, Catherine A., Nevin, James, Brock, Ansgar, Venable, John D., Tan, Dewar J., Kassam, Nasim, Xu, Fangmin, Taraszka, John, Wesemann, Luke, Pertel, Thomas, Acharya, Nandini, Klapholz, Max, Etminan, Yassaman, Jiang, Xiaomo, Huang, Yu-Hwa, Blumberg, Richard S., Kuchroo, Vijay K., Anderson, Ana C.

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Adaptive autoimmunity and Foxp3-based immunoregulation in zebrafish von Quintana, Francisco J, Iglesias, Antonio H, Farez, Mauricio F, Caccamo, Mario, Burns, Evan J, Kassam, Nasim, Oukka, Mohamed, Weiner, Howard L

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Cutting edge: TIGIT has T cell-intrinsic inhibitory functions von Joller, Nicole, Hafler, Jason P, Brynedal, Boel, Kassam, Nasim, Spoerl, Silvia, Levin, Steven D, Sharpe, Arlene H, Kuchroo, Vijay K

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TIM‐3 is expressed on activated human CD4+ T cells and regulates Th1 and Th17 cytokines von Hastings, William D., Anderson, David E., Kassam, Nasim, Koguchi, Ken, Greenfield, Edward A., Kent, Sally C., Zheng, Xin Xiao, Strom, Terry B., Hafler, David A., Kuchroo, Vijay K.

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Monoclonal antibodies to distinct regions of human myelin proteolipid protein simultaneously recognize central nervous system myelin and neurons of many vertebrate species von Greenfield, Edward A., Reddy, Jayagopala, Lees, Andrew, Dyer, Charissa A., Koul, Omanand, Nguyen, Khuong, Bell, Shannon, Kassam, Nasim, Hinojoza, Julian, Eaton, Mary Jane, Lees, Marjorie B., Kuchroo, Vijay K., Sobel, Raymond A.

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Novel cell-based high-throughput hybridoma screening method using the Celigo image cytometer for antibody discovery von Chan, Leo, Zhang, Haohai, Rice, William, Kassam, Nasim, Longhi, Maria Serena, Zhao, Haitao, Robson, Simon, Gao, Wenda, Wu, Yan

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Abstract 5774: Novel cell-based high-throughput hybridoma screening method using the Celigo image cytometer for antibody discovery von Chan, Leo L., Zhang, Haohai, Rice, William, Kassam, Nasim, Longhi, Maria S., Zhao, Haitao, Robson, Simon C., Gao, Wenda, Wu, Yan

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Novel high-throughput cell-based hybridoma screening methodology using the Celigo Image Cytometer von Zhang, Haohai, Chan, Leo Li-Ying, Rice, William, Kassam, Nasim, Longhi, Maria Serena, Zhao, Haitao, Robson, Simon C., Gao, Wenda, Wu, Yan

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Functional anti-TIGIT antibodies regulate development of autoimmunity and anti-tumor immunity von Dixon, Karen O., Schorer, Michelle, Nevin, James, Etminan, Yassaman, Amoozgar, Zohreh, Kondo, Takaaki, Kurtulus, Sema, Kassam, Nasim, Sobel, Raymond A., Fukumura, Dai, Jain, Rakesh K., Anderson, Ana C., Kuchroo, Vijay K., Joller, Nicole

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Functional Anti-TIGIT Antibodies Regulate Development of Autoimmunity and Antitumor Immunity von Dixon, Karen O, Schorer, Michelle, Nevin, James, Etminan, Yassaman, Amoozgar, Zohreh, Kondo, Takaaki, Kurtulus, Sema, Kassam, Nasim, Sobel, Raymond A, Fukumura, Dai, Jain, Rakesh K, Anderson, Ana C, Kuchroo, Vijay K, Joller, Nicole

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TIM-3 is a Negative Regulator of Human Th1 Cells von Anderson, David E., PhD, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, Kuchroo, Juhi, Womens Hospital and Harvard Medical School, Boston, MA, Kassam, Nasim, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, Hafler, David, Jack, Sadie and David Breakstone Professor of Neurology (Neuroscience), Brigham and Womens Hospital and Harvard Medical School, Boston, MA

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The chemokine receptors CXCR3 and CCR5 mark subsets of T cells associated with certain inflammatory reactions von Qin, S, Rottman, J B, Myers, P, Kassam, N, Weinblatt, M, Loetscher, M, Koch, A E, Moser, B, Mackay, C R

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Tim-4 Expressed on Antigen-presenting Cells Induces T Cell Expansion and Survival von Manzanet, Roselynn Rodriguez, Graduate Student, Brigham and Women's Hospital, Boston, MA, Hartt-Meyers, Jennifer, Post doctoral Fellow, LIR/NIAID/NIH, Bethesda, MD, Slavik, Jacqueline, Administrative Director, Brigham and Women's Hospital, Biomedical Research Institute, Boston, MA, Dardalhon, Valerie, Post doctoral Fellow, Brigham and Women's Hospital, Department of Neurology, Boston, MA, Kassam, Nasim, Research specialist, Brigham and Women's Hospital, Department of Neurology, Boston, MA, Greenfield, Edward A., Consultant, Brigham and Women's Hospital, Department of Neurology, Boston, MA, Sobel, Raymond A., Professor, Stanford School of Medicine, Department of Pathology, Palo Alto, CA, Strom, Terry B., Physician Professor, Beth Israel Deaconess Medical Center, Boston, MA, Hafler, David A., Professor, Brigham and Women's Hospital, Department of Neurology, Boston, MA, Kuchroo, Vijay K., Professor, Brigham and Women's Hospital, Department of Neurology, Boston, MA

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TIM-4 Expressed on APCs Induces T Cell Expansion and Survival von Rodriguez-Manzanet, Roselynn, Meyers, Jennifer Hartt, Balasubramanian, Savithri, Slavik, Jacqueline, Kassam, Nasim, Dardalhon, Valerie, Greenfield, Edward A, Anderson, Ana C, Sobel, Raymond A, Hafler, David A, Strom, Terry B, Kuchroo, Vijay K

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Human G protein-coupled receptor GPR-9-6/CC chemokine receptor 9 is selectively expressed on intestinal homing T lymphocytes, mucosal lymphocytes, and thymocytes and is required fo... von Zabel, B A, Agace, W W, Campbell, J J, Heath, H M, Parent, D, Roberts, A I, Ebert, E C, Kassam, N, Qin, S, Zovko, M, LaRosa, G J, Yang, L L, Soler, D, Butcher, E C, Ponath, P D, Parker, C M, Andrew, D P

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Human mucosal addressin cell adhesion molecule-1 is preferentially expressed in intestinal tract and associated lymphoid tissue von Briskin, M, Winsor-Hines, D, Shyjan, A, Cochran, N, Bloom, S, Wilson, J, McEvoy, LM, Butcher, EC, Kassam, N, Mackay, CR, Newman, W, Ringler, DJ

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CCR5 levels and expression pattern correlate with infectability by macrophage-tropic HIV-1, in vitro von Wu, L, Paxton, W A, Kassam, N, Ruffing, N, Rottman, J B, Sullivan, N, Choe, H, Sodroski, J, Newman, W, Koup, R A, Mackay, C R

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