Cysteine‐Selective Phosphonamidate Electrophiles for Modular Protein Bioconjugations von Kasper, Marc‐André, Glanz, Maria, Stengl, Andreas, Penkert, Martin, Klenk, Simon, Sauer, Tom, Schumacher, Dominik, Helma, Jonas, Krause, Eberhard, Cardoso, M. Cristina, Leonhardt, Heinrich, Hackenberger, Christian P. R.

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Ethynylphosphonamidates for the Rapid and Cysteine‐Selective Generation of Efficacious Antibody–Drug Conjugates von Kasper, Marc‐André, Stengl, Andreas, Ochtrop, Philipp, Gerlach, Marcus, Stoschek, Tina, Schumacher, Dominik, Helma, Jonas, Penkert, Martin, Krause, Eberhard, Leonhardt, Heinrich, Hackenberger, Christian P. R.

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(3+2)‐Cyclization Reactions of Unsaturated Phosphonites with Aldehydes and Thioketones von Munasinghe, Don S., Kasper, Marc‐André, Jasiński, Radomir, Kula, Karolina, Palusiak, Marcin, Celeda, Małgorzata, Mlostoń, Grzegorz, Hackenberger, Christian P. R.

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Vinylphosphonites for Staudinger-induced chemoselective peptide cyclization and functionalization von Kasper, Marc-André, Glanz, Maria, Oder, Andreas, Schmieder, Peter, von Kries, Jens P, Hackenberger, Christian P. R

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Bis‐ethynylphosphonamidates as an Modular Conjugation Platform to Generate Multi‐Functional Protein‐ and Antibody‐Drug‐Conjugates von Kasper, Marc‐André, Lassak, Lukas, Vogl, Annette M., Mai, Isabelle, Helma, Jonas, Schumacher, Dominik, Hackenberger, Christian P. R.

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Protein Modification of Lysine with 2‑(2-Styrylcyclopropyl)ethanal von Apel, Caroline, Kasper, Marc-André, Stieger, Christian E, Hackenberger, Christian P. R, Christmann, Mathias

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Compact hydrophilic electrophiles enable highly efficacious high DAR ADCs with excellent in vivo PK profile von Ochtrop, Philipp, Jahzerah, Jahaziel, Machui, Paul, Mai, Isabelle, Schumacher, Dominik, Helma, Jonas, Kasper, Marc-André, Hackenberger, Christian P R

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N‐Hydroxysuccinimide‐Modified Ethynylphosphonamidates Enable the Synthesis of Configurationally Defined Protein Conjugates von Kasper, Marc‐André, Gerlach, Marcus, Schneider, Anselm F. L., Groneberg, Christiane, Ochtrop, Philipp, Boldt, Stefanie, Schumacher, Dominik, Helma, Jonas, Leonhardt, Heinrich, Christmann, Mathias, Hackenberger, Christian P. R.

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Targeting FLT3 with a new-generation antibody-drug conjugate in combination with kinase inhibitors for treatment of AML von Roas, Maike, Vick, Binje, Kasper, Marc-André, Able, Marina, Polzer, Harald, Gerlach, Marcus, Kremmer, Elisabeth, Hecker, Judith S., Schmitt, Saskia, Stengl, Andreas, Waller, Verena, Hohmann, Natascha, Festini, Moreno, Ludwig, Alexander, Rohrbacher, Lisa, Herold, Tobias, Subklewe, Marion, Götze, Katharina S., Hackenberger, Christian P. R., Schumacher, Dominik, Helma-Smets, Jonas, Jeremias, Irmela, Leonhardt, Heinrich, Spiekermann, Karsten

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β-Carotene Revisited by Transient Absorption and Stimulated Raman Spectroscopy von Quick, Martin, Kasper, Marc-André, Richter, Celin, Mahrwald, Rainer, Dobryakov, Alexander L., Kovalenko, Sergey A., Ernsting, Nikolaus P.

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TuPPL: Tub-tag mediated C-terminal protein-protein-ligation using complementary click-chemistry handles von Stengl, Andreas, Gerlach, Marcus, Kasper, Marc-André, Hackenberger, Christian P. R, Leonhardt, Heinrich, Schumacher, Dominik, Helma, Jonas

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Cell-permeable nanobodies for targeted immunolabelling and antigen manipulation in living cells von Herce, Henry D., Schumacher, Dominik, Schneider, Anselm F. L., Ludwig, Anne K., Mann, Florian A., Fillies, Marion, Kasper, Marc-André, Reinke, Stefan, Krause, Eberhard, Leonhardt, Heinrich, Cardoso, M. Cristina, Hackenberger, Christian P. R.

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Cell-permeable nanobodies for targeted immunolabelling and antigen manipulation in living cells von Herce, Henry D., Schumacher, Dominik, Schneider, Anselm F. L., Ludwig, Anne K., Mann, Florian A., Fillies, Marion, Kasper, Marc-André, Reinke, Stefan, Krause, Eberhard, Leonhardt, Heinrich, Cardoso, M. Cristina, Hackenberger, Christian P. R.

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The mechanism behind enhanced reactivity of unsaturated phosphorus() electrophiles towards thiols von Park, Yerin, Baumann, Alice L, Moon, Hyejin, Byrne, Stephen, Kasper, Marc-André, Hwang, Songhwan, Sun, Han, Baik, Mu-Hyun, Hackenberger, Christian P. R

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Cysteinselektive phosphonamidatbasierte Elektrophile für modulare Biokonjugationen von Kasper, Marc‐André, Glanz, Maria, Stengl, Andreas, Penkert, Martin, Klenk, Simon, Sauer, Tom, Schumacher, Dominik, Helma, Jonas, Krause, Eberhard, Cardoso, M. Cristina, Leonhardt, Heinrich, Hackenberger, Christian P. R.

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Ethynylphosphonamidates for the Rapid and Cysteine‐Selective Generation of Efficacious Antibody–Drug Conjugates von Kasper, Marc‐André, Stengl, Andreas, Ochtrop, Philipp, Gerlach, Marcus, Stoschek, Tina, Schumacher, Dominik, Helma, Jonas, Penkert, Martin, Krause, Eberhard, Leonhardt, Heinrich, Hackenberger, Christian P. R.

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Compact hydrophilic electrophiles enable highly efficacious high DAR ADCs with excellent PK profile von Ochtrop, Philipp, Jahzerah, Jahaziel, Machui, Paul, Mai, Isabelle, Schumacher, Dominik, Helma, Jonas, Kasper, Marc-André, Hackenberger, Christian P. R

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Tub-010, a Novel Antibody-Drug-Conjugate with Reduced Nonspecific Toxicity Profile Based on Tub-Tag Technology Widens the Therapeutic Window for the Treatment of CD30+ Malignancies von Gerlach, Marcus, Schmitt, Saskia, Cyprys, Philipp, Kasper, Marc-André, Mai, Isabelle, Vermeer, Maarten H., Horwitz, Steven M., Fingerle-Rowson, Guenter R, Vogl, Annette, Schumacher, Dominik, Helma-Smets, Jonas

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Vinylphosphonites for Staudinger-induced chemoselective peptide cyclization and functionalization† †This work is dedicated to Prof. Ron Raines on the occasion of his 60th birthday.... von Kasper, Marc-André, Glanz, Maria, Oder, Andreas, Schmieder, Peter, von Kries, Jens P., Hackenberger, Christian P. R.

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Front Cover: N‐Hydroxysuccinimide‐Modified Ethynylphosphonamidates Enable the Synthesis of Configurationally Defined Protein Conjugates (ChemBioChem 1‐2/2020) von Kasper, Marc‐André, Gerlach, Marcus, Schneider, Anselm F. L., Groneberg, Christiane, Ochtrop, Philipp, Boldt, Stefanie, Schumacher, Dominik, Helma, Jonas, Leonhardt, Heinrich, Christmann, Mathias, Hackenberger, Christian P. R.

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