Targeting Janus Kinases and Signal Transducer and Activator of Transcription 3 to Treat Inflammation, Fibrosis, and Cancer: Rationale, Progress, and Caution von Bharadwaj, Uddalak, Kasembeli, Moses M, Robinson, Prema, Tweardy, David J

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Contribution of STAT3 to Inflammatory and Fibrotic Diseases and Prospects for its Targeting for Treatment von Kasembeli, Moses M, Bharadwaj, Uddalak, Robinson, Prema, Tweardy, David J

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Blockade of the PD-1/PD-L1 Immune Checkpoint Pathway Improves Infection Outcomes and Enhances Fungicidal Host Defense in a Murine Model of Invasive Pulmonary Mucormycosis von Wurster, Sebastian, Albert, Nathaniel D, Bharadwaj, Uddalak, Kasembeli, Moses M, Tarrand, Jeffrey J, Daver, Naval, Kontoyiannis, Dimitrios P

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Small-molecule inhibition of STAT3 in radioresistant head and neck squamous cell carcinoma von Bharadwaj, Uddalak, Eckols, T Kris, Xu, Xuejun, Kasembeli, Moses M, Chen, Yunyun, Adachi, Makoto, Song, Yongcheng, Mo, Qianxing, Lai, Stephen Y, Tweardy, David J

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Chemical probes that competitively and selectively inhibit Stat3 activation von Xu, Xuejun, Kasembeli, Moses M, Jiang, Xueqing, Tweardy, Benjamin J, Tweardy, David J

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Small-molecule targeting of signal transducer and activator of transcription (STAT) 3 to treat non-small cell lung cancer von Lewis, Katherine M, Bharadwaj, Uddalak, Eckols, T. Kris, Kolosov, Mikhail, Kasembeli, Moses M, Fridley, Colleen, Siller, Ricardo, Tweardy, David J

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Chaperonin TRiC/CCT Recognizes Fusion Oncoprotein AML1-ETO through Subunit-Specific Interactions von Roh, Soung-Hun, Kasembeli, Moses M., Galaz-Montoya, Jesús G., Chiu, Wah, Tweardy, David J.

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Aberrant function of pathogenic STAT3 mutant proteins is linked to altered stability of monomers and homodimers von Kasembeli, Moses M., Kaparos, Efiyenia, Bharadwaj, Uddalak, Allaw, Ahmad, Khouri, Alain, Acot, Bianca, Tweardy, David J.

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TTI-101: A competitive inhibitor of STAT3 that spares oxidative phosphorylation and reverses mechanical allodynia in mouse models of neuropathic pain von Kasembeli, Moses M., Singhmar, Pooja, Ma, Jiacheng, Edralin, Jules, Tang, Yongfu, Adams, Clydell, Heijnen, Cobi J., Kavelaars, Annemieke, Tweardy, David J.

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Pharmacokinetics and pharmacodynamics of TTI-101, a STAT3 inhibitor that blocks muscle proteolysis in rats with chronic kidney disease von Zhang, Liping, Wang, Ying, Dong, Yanlan, Chen, Zihong, Eckols, Thomas K, Kasembeli, Moses M, Tweardy, David J, Mitch, William E

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SH2 domain binding to phosphopeptide ligands: potential for drug targeting von Kasembeli, Moses M, Xu, Xuejun, Tweardy, David J

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Corrigendum to “TTI-101: A competitive inhibitor of STAT3 that spares oxidative phosphorylation and reverses mechanical allodynia in mouse models of neuropathic pain” [Biochem. Pha... von Kasembeli, Moses M., Singhmar, Pooja, Ma, Jiacheng, Edralin, Jules, Tang, Yongfu, Adams, Clydell, Heijnen, Cobi J., Kavelaars, Annemieke, Tweardy, David J.

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Protein stabilization improves STAT3 function in autosomal dominant hyper-IgE syndrome von Bocchini, Claire E., Nahmod, Karen, Katsonis, Panagiotis, Kim, Sang, Kasembeli, Moses M., Freeman, Alexandra, Lichtarge, Olivier, Makedonas, George, Tweardy, David J.

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Novel STAT3 small-molecule inhibitors identified by structure-based virtual ligand screening incorporating SH2 domain flexibility von Kong, Ren, Bharadwaj, Uddalak, Eckols, T. Kris, Kolosov, Mikhail, Wu, Haoyi, Cruz-Pavlovich, Francisco J. Santa, Shaw, Alison, Ifelayo, Oluwatomilona I., Zhao, Hong, Kasembeli, Moses M., Wong, Stephen T.C., Tweardy, David J.

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Targeting STAT3 anti-apoptosis pathways with organic and hybrid organic-inorganic inhibitors von Minus, Matthew B, Wang, Haopei, Munoz, Jaime O, Stevens, Alexandra M, Mangubat-Medina, Alicia E, Krueger, Michael J, Liu, Wei, Kasembeli, Moses M, Cooper, Julian C, Kolosov, Mikhail I, Tweardy, David J, Redell, Michele S, Ball, Zachary T

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Rhodium(II) Proximity-Labeling Identifies a Novel Target Site on STAT3 for Inhibitors with Potent Anti-Leukemia Activity von Minus, Matthew B., Liu, Wei, Vohidov, Farrukh, Kasembeli, Moses M., Long, Xin, Krueger, Michael J., Stevens, Alexandra, Kolosov, Mikhail I., Tweardy, David J., Sison, Edward Allan R., Redell, Michele S., Ball, Zachary T.

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Correction: Small-molecule inhibition of STAT3 in radioresistant head and neck squamous cell carcinoma von Bharadwaj, Uddalak, Eckols, T Kris, Xu, Xuejun, Kasembeli, Moses M, Chen, Yunyun, Adachi, Makoto, Song, Yongcheng, Mo, Qianxing, Lai, Stephen Y, Tweardy, David J

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Signal Transducer and Activator of Transcription (Stat)3 Signaling and Targeting for Treatment and Prevention of Non-small Cell Lung Cancer von Lewis, Katherine, Bharadwaj, Uddalak, Eckols, T. Kris, Kolosov, Mikhail, Kasembeli, Moses M, Cho, Sung-Nam, Liu, Jian, DeMayo, Francesco J, Tweardy, David J

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Monoclonal Antibodies Specific for STAT3β Reveal Its Contribution to Constitutive STAT3 Phosphorylation in Breast Cancer von Bharadwaj, Uddalak, Kasembeli, Moses M, Eckols, T Kris, Kolosov, Mikhail, Lang, Paul, Christensen, Kurt, Edwards, Dean P, Tweardy, David J

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Drug-repositioning screening identified piperlongumine as a direct STAT3 inhibitor with potent activity against breast cancer von Bharadwaj, U, Eckols, T K, Kolosov, M, Kasembeli, M M, Adam, A, Torres, D, Zhang, X, Dobrolecki, L E, Wei, W, Lewis, M T, Dave, B, Chang, J C, Landis, M D, Creighton, C J, Mancini, M A, Tweardy, D J

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