HIF prolyl 4-hydroxylase-2 inhibition improves glucose and lipid metabolism and protects against obesity and metabolic dysfunction von Rahtu-Korpela, Lea, Karsikas, Sara, Hörkkö, Sohvi, Blanco Sequeiros, Roberto, Lammentausta, Eveliina, Mäkelä, Kari A, Herzig, Karl-Heinz, Walkinshaw, Gail, Kivirikko, Kari I, Myllyharju, Johanna, Serpi, Raisa, Koivunen, Peppi

Volltext

Hypoxia-Inducible Factor Prolyl 4-Hydroxylase-2 Inhibition Protects Against Development of Atherosclerosis von Rahtu-Korpela, Lea, Määttä, Jenni, Dimova, Elitsa Y, Hörkkö, Sohvi, Gylling, Helena, Walkinshaw, Gail, Hakkola, Jukka, Kivirikko, Kari I, Myllyharju, Johanna, Serpi, Raisa, Koivunen, Peppi

Volltext

Characterization of the Human Prolyl 4-Hydroxylases That Modify the Hypoxia-inducible Factor von Hirsilä, Maija, Koivunen, Peppi, Günzler, Volkmar, Kivirikko, Kari I., Myllyharju, Johanna

Volltext

Catalytic Properties of the Asparaginyl Hydroxylase (FIH) in the Oxygen Sensing Pathway Are Distinct from Those of Its Prolyl 4-Hydroxylases von Koivunen, Peppi, Hirsilä, Maija, Günzler, Volkmar, Kivirikko, Kari I., Myllyharju, Johanna

Volltext

The Length of Peptide Substrates Has a Marked Effect on Hydroxylation by the Hypoxia-inducible Factor Prolyl 4-Hydroxylases von Koivunen, Peppi, Hirsilä, Maija, Kivirikko, Kari I., Myllyharju, Johanna

Volltext

Hearts of Hypoxia-inducible Factor Prolyl 4-Hydroxylase-2 Hypomorphic Mice Show Protection against Acute Ischemia-Reperfusion Injury von Hyvärinen, Jaana, Hassinen, Ilmo E., Sormunen, Raija, Mäki, Joni M., Kivirikko, Kari I., Koivunen, Peppi, Myllyharju, Johanna

Volltext

Transmembrane prolyl 4-hydroxylase is a fourth prolyl 4-hydroxylase regulating EPO production and erythropoiesis von Laitala, Anu, Aro, Ellinoora, Walkinshaw, Gail, Mäki, Joni M., Rossi, Maarit, Heikkilä, Minna, Savolainen, Eeva-Riitta, Arend, Michael, Kivirikko, Kari I., Koivunen, Peppi, Myllyharju, Johanna

Volltext

Activation of Hypoxia Response in Endothelial Cells Contributes to Ischemic Cardioprotection von Kerkelä, Risto, Karsikas, Sara, Szabo, Zoltan, Serpi, Raisa, Magga, Johanna, Gao, Erhe, Alitalo, Kari, Anisimov, Andrey, Sormunen, Raija, Pietilä, Ilkka, Vainio, Laura, Koch, Walter J., Kivirikko, Kari I., Myllyharju, Johanna, Koivunen, Peppi

Volltext

Effect of desferrioxamine and metals on the hydroxylases in the oxygen sensing pathway von Hirsilä, Maija, Koivunen, Peppi, Xu, Leon, Seeley, Todd, Kivirikko, Kari I, Myllyharju, Johanna

Volltext

Lack of P4H-TM in mice results in age-related retinal and renal alterations von Leinonen, Henri, Rossi, Maarit, Salo, Antti M, Tiainen, Päivi, Hyvärinen, Jaana, Pitkänen, Marja, Sormunen, Raija, Miinalainen, Ilkka, Zhang, Chi, Soininen, Raija, Kivirikko, Kari I, Koskelainen, Ari, Tanila, Heikki, Myllyharju, Johanna, Koivunen, Peppi

Volltext

Roles of the human hypoxia-inducible factor (HIF)-3α variants in the hypoxia response von Heikkilä, Minna, Pasanen, Annika, Kivirikko, Kari I., Myllyharju, Johanna

Volltext

LOXL1 and LOXL4 are epigenetically silenced and can inhibit ras/extracellular signal-regulated kinase signaling pathway in human bladder cancer von GUOJUN WU, ZHONGMIN GUO, SIDRANSKY, David, XIAOFEI CHANG, MYOUNG SOOK KIM, NAGPAL, Jatin K, JUNWEI LIU, MAKI, Joni M, KIVIRIKKO, Kari I, ETHIER, Stephen P, TRINK, Barry

Volltext

Loss of Assembly of the Main Basement Membrane Collagen, Type IV, but Not Fibril-forming Collagens and Embryonic Death in Collagen Prolyl 4-Hydroxylase I Null Mice von Holster, Tiina, Pakkanen, Outi, Soininen, Raija, Sormunen, Raija, Nokelainen, Minna, Kivirikko, Kari I., Myllyharju, Johanna

Volltext

Collagens, modifying enzymes and their mutations in humans, flies and worms von Myllyharju, Johanna, Kivirikko, Kari I.

Volltext

Identification and Characterization of a Third Human, Rat, and Mouse Collagen Prolyl 4-Hydroxylase Isoenzyme von Kukkola, Liisa, Hieta, Reija, Kivirikko, Kari I, Myllyharju, Johanna

Volltext

Molecular Characterization of the Principal Substrate Binding Site of the Ubiquitous Folding Catalyst Protein Disulfide Isomerase von Pirneskoski, Annamari, Klappa, Peter, Lobell, Mario, Williamson, Richard A., Byrne, Lee, Alanen, Heli I., Salo, Kirsi E.H., Kivirikko, Kari I., Freedman, Robert B., Ruddock, Lloyd W.

Volltext

Tissue-specific Changes in the Hydroxylysine Content and Cross-links of Collagens and Alterations in Fibril Morphology in Lysyl Hydroxylase 1 Knock-out Mice von Takaluoma, Kati, Hyry, Marjo, Lantto, Juha, Sormunen, Raija, Bank, Ruud A., Kivirikko, Kari I., Myllyharju, Johanna, Soininen, Raija

Volltext

Premature Aggregation of Type IV Collagen and Early Lethality in Lysyl Hydroxylase 3 Null Mice von Rautavuoma, Kati, Takaluoma, Kati, Sormunen, Raija, Myllyharju, Johanna, Kivirikko, Kari I., Soininen, Raija, Ruoslahti, Erkki

Volltext

The Active Site of an Algal Prolyl 4-Hydroxylase Has a Large Structural Plasticity von Koski, M. Kristian, Hieta, Reija, Böllner, Claudia, Kivirikko, Kari I., Myllyharju, Johanna, Wierenga, Rik K.

Volltext

Inhibition of Hypoxia-inducible Factor (HIF) Hydroxylases by Citric Acid Cycle Intermediates: POSSIBLE LINKS BETWEEN CELL METABOLISM AND STABILIZATION OF HIF von Koivunen, Peppi, Hirsilä, Maija, Remes, Anne M, Hassinen, Ilmo E, Kivirikko, Kari I, Myllyharju, Johanna

Volltext