An endoplasmic reticulum-engineered yeast platform for overproduction of triterpenoids von Arendt, Philipp, Miettinen, Karel, Pollier, Jacob, De Rycke, Riet, Callewaert, Nico, Goossens, Alain

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The seco-iridoid pathway from Catharanthus roseus von Miettinen, Karel, Dong, Lemeng, Navrot, Nicolas, Schneider, Thomas, Burlat, Vincent, Pollier, Jacob, Woittiez, Lotte, van der Krol, Sander, Lugan, Raphaël, Ilc, Tina, Verpoorte, Robert, Oksman-Caldentey, Kirsi-Marja, Martinoia, Enrico, Bouwmeester, Harro, Goossens, Alain, Memelink, Johan, Werck-Reichhart, Danièle

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A translational synthetic biology platform for rapid access to gram-scale quantities of novel drug-like molecules von Reed, James, Stephenson, Michael J., Miettinen, Karel, Brouwer, Bastiaan, Leveau, Aymeric, Brett, Paul, Goss, Rebecca J.M., Goossens, Alain, O’Connell, Maria A., Osbourn, Anne

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The ancient CYP716 family is a major contributor to the diversification of eudicot triterpenoid biosynthesis von Miettinen, Karel, Pollier, Jacob, Buyst, Dieter, Arendt, Philipp, Csuk, René, Sommerwerk, Sven, Moses, Tessa, Mertens, Jan, Sonawane, Prashant D, Pauwels, Laurens, Aharoni, Asaph, Martins, José, Nelson, David R., Goossens, Alain

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The basic helix‐loop‐helix transcription factor BIS2 is essential for monoterpenoid indole alkaloid production in the medicinal plant Catharanthus roseus von Van Moerkercke, Alex, Steensma, Priscille, Gariboldi, Ivo, Espoz, Javiera, Purnama, Purin C., Schweizer, Fabian, Miettinen, Karel, Vanden Bossche, Robin, De Clercq, Rebecca, Memelink, Johan, Goossens, Alain

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bHLH transcription factor BIS1 controls the iridoid branch of the monoterpenoid indole alkaloid pathway in Catharanthus roseus von Van Moerkercke, Alex, Priscille Steensma, Fabian Schweizer, Jacob Pollier, Ivo Gariboldi, Richard Payne, Robin Vanden Bossche, Karel Miettinen, Javiera Espoz, Purin Candra Purnama, Franziska Kellner, Tuulikki Seppänen-Laakso, Sarah E. O’Connor, Heiko Rischer, Johan Memelink, Alain Goossens

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A GPCR-based yeast biosensor for biomedical, biotechnological, and point-of-use cannabinoid determination von Miettinen, Karel, Leelahakorn, Nattawat, Almeida, Aldo, Zhao, Yong, Hansen, Lukas R., Nikolajsen, Iben E., Andersen, Jens B., Givskov, Michael, Staerk, Dan, Bak, Søren, Kampranis, Sotirios C.

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The TriForC database: a comprehensive up-to-date resource of plant triterpene biosynthesis von Miettinen, Karel, Iñigo, Sabrina, Kreft, Lukasz, Pollier, Jacob, De Bo, Christof, Botzki, Alexander, Coppens, Frederik, Bak, Søren, Goossens, Alain

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Expanding the terpene biosynthetic code with non-canonical 16 carbon atom building blocks von Ignea, Codruta, Raadam, Morten H., Koutsaviti, Aikaterini, Zhao, Yong, Duan, Yao-Tao, Harizani, Maria, Miettinen, Karel, Georgantea, Panagiota, Rosenfeldt, Mads, Viejo-Ledesma, Sara E., Petersen, Mikael A., Bredie, Wender L. P., Staerk, Dan, Roussis, Vassilios, Ioannou, Efstathia, Kampranis, Sotirios C.

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Integrating pathway elucidation with yeast engineering to produce polpunonic acid the precursor of the anti-obesity agent celastrol von Hansen, Nikolaj L, Miettinen, Karel, Zhao, Yong, Ignea, Codruta, Andreadelli, Aggeliki, Raadam, Morten H, Makris, Antonios M, Møller, Birger L, Stærk, Dan, Bak, Søren, Kampranis, Sotirios C

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Characterization of the plastidial geraniol synthase from Madagascar periwinkle which initiates the monoterpenoid branch of the alkaloid pathway in internal phloem associated paren... von Simkin, Andrew J, Miettinen, Karel, Claudel, Patricia, Burlat, Vincent, Guirimand, Grégory, Courdavault, Vincent, Papon, Nicolas, Meyer, Sophie, Godet, Stéphanie, St-Pierre, Benoit, Giglioli-Guivarc’h, Nathalie, Fischer, Marc J.C, Memelink, Johan, Clastre, Marc

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Characterization of two geraniol synthases from Valeriana officinalis and Lippia dulcis: Similar activity but difference in subcellular localization von Dong, Lemeng, Miettinen, Karel, Goedbloed, Miriam, Verstappen, Francel W.A., Voster, Alessandra, Jongsma, Maarten A., Memelink, Johan, Krol, Sander van der, Bouwmeester, Harro J.

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Celastrol: A century-long journey from the isolation to the biotechnological production and the development of an antiobesity drug von Zhao, Yong, Miettinen, Karel, Kampranis, Sotirios C.

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Structure-Agnostic Bioactivity-Driven Combinatorial Biosynthesis Reveals New Antidiabetic and Anticancer Triterpenoids von Zhao, Yong, Duan, Yao-Tao, Zang, Jie, Raadam, Morten H, Pateraki, Irini, Miettinen, Karel, Staerk, Dan, Kampranis, Sotirios C

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Biosynthesis and biotechnological production of the anti-obesity agent celastrol von Zhao, Yong, Hansen, Nikolaj L., Duan, Yao-Tao, Prasad, Meera, Motawia, Mohammed S., Møller, Birger L., Pateraki, Irini, Staerk, Dan, Bak, Søren, Miettinen, Karel, Kampranis, Sotirios C.

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An Independent Evolutionary Origin for Insect Deterrent Cucurbitacins in Iberis amara von Dong, Lemeng, Almeida, Aldo, Pollier, Jacob, Khakimov, Bekzod, Bassard, Jean-Etienne, Miettinen, Karel, Stærk, Dan, Mehran, Rahimi, Olsen, Carl Erik, Motawia, Mohammed Saddik, Goossens, Alain, Bak, Søren

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Structure‐Agnostic Bioactivity‐Driven Combinatorial Biosynthesis Reveals New Antidiabetic and Anticancer Triterpenoids von Zhao, Yong, Duan, Yao‐Tao, Zang, Jie, Raadam, Morten H., Pateraki, Irini, Miettinen, Karel, Staerk, Dan, Kampranis, Sotirios C.

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The TriForC database : a comprehensive up-to-date resource of plant triterpene biosynthesis von Miettinen, Karel, Iñigo, Sabrina, Kreft, Lukasz, Pollier, Jacob, De Bo, Christof, Botzki, Alexander, Coppens, Frederik, Bak, Soren, Goossens, Alain

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Metabolic alteration of Catharanthus roseus cell suspension cultures overexpressing geraniol synthase in the plastids or cytosol von Saiman, Mohd Zuwairi, Miettinen, Karel, Mustafa, Natali Rianika, Choi, Young Hae, Verpoorte, Robert, Schulte, Anna Elisabeth

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Iridoid Synthase Activity Is Common among the Plant Progesterone 5β-Reductase Family von Munkert, Jennifer, Pollier, Jacob, Miettinen, Karel, Van Moerkercke, Alex, Payne, Richard, Müller-Uri, Frieder, Burlat, Vincent, O’Connor, Sarah E., Memelink, Johan, Kreis, Wolfgang, Goossens, Alain

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