Potency and Selectivity of BTK Inhibitors in Clinical Development for B-Cell Malignancies von Kaptein, Allard, de Bruin, Gerjan, Emmelot-van Hoek, Maaike, van de Kar, Bas, de Jong, Anouk, Gulrajani, Michael, Demont, Dennis, Covey, Todd, Mittag, Diana, Barf, Tjeerd

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Acalabrutinib (ACP-196): A Covalent Bruton Tyrosine Kinase Inhibitor with a Differentiated Selectivity and In Vivo Potency Profile von Barf, Tjeerd, Covey, Todd, Izumi, Raquel, van de Kar, Bas, Gulrajani, Michael, van Lith, Bart, van Hoek, Maaike, de Zwart, Edwin, Mittag, Diana, Demont, Dennis, Verkaik, Saskia, Krantz, Fanny, Pearson, Paul G, Ulrich, Roger, Kaptein, Allard

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Structure-based lead identification of ATP-competitive MK2 inhibitors von Barf, Tjeerd, Kaptein, Allard, Wilde, Sander de, Heijden, Ruud van der, Someren, Richard van, Demont, Dennis, Schultz-Fademrecht, Carsten, Versteegh, Judith, Zeeland, Mario van, Seegers, Nicole, Kazemier, Bert, Kar, Bas van de, Hoek, Maaike van, Roos, Jeroen de, Klop, Henri, Smeets, Ruben, Hofstra, Claudia, Hornberg, Jorrit, Oubrie, Arthur

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Discovery of selective and orally available spiro-3-piperidyl ATP-competitive MK2 inhibitors von Kaptein, Allard, Oubrie, Arthur, Zwart, Edwin de, Hoogenboom, Niels, Wit, Joeri de, Kar, Bas van de, Hoek, Maaike van, Vogel, Gerard, Kimpe, Vera de, Schultz-Fademrecht, Carsten, Borsboom, Judith, Zeeland, Mario van, Versteegh, Judith, Kazemier, Bert, Roos, Jeroen de, Wijnands, Frank, Dulos, John, Jaeger, Martin, Leandro-Garcia, Paula, Barf, Tjeerd

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Discovery and optimization of covalent EGFR T790M/L858R mutant inhibitors von Hoogenboom, Niels, Demont, Dennis, de Zwart, Edwin, Verkaik, Saskia, Emmelot, Maaike, van de Kar, Bas, Kaptein, Allard, Barf, Tjeerd

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Discovery of quinoline-based irreversible BTK inhibitors von de Bruin, Gerjan, Demont, Dennis, de Zwart, Edwin, Verkaik, Saskia, Hoogenboom, Niels, van de Kar, Bas, van Lith, Bart, Emmelot- van Hoek, Maaike, Gulrajani, Michael, Covey, Todd, Kaptein, Allard, Barf, Tjeerd

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Direct and two-step bioorthogonal probes for Bruton's tyrosine kinase based on ibrutinib: a comparative study von Liu, Nora, Hoogendoorn, Sascha, van de Kar, Bas, Kaptein, Allard, Barf, Tjeerd, Driessen, Christoph, Filippov, Dmitri V, van der Marel, Gijsbert A, van der Stelt, Mario, Overkleeft, Herman S

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Potency and Selectivity of BTK Inhibitors in Clinical Development for B-Cell Malignancies von Kaptein, Allard, de Bruin, Gerjan, Hoek, Maaike Emmelot-van, van de Kar, Bas, de Jong, Anouk, Gulrajani, Michael, Demont, Dennis, Covey, Todd, Mittag, Diana, Barf, Tjeerd

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Abstract 2596: ACP-196: a novel covalent Bruton's tyrosine kinase (Btk) inhibitor with improved selectivity and in vivo target coverage in chronic lymphocytic leukemia (CLL) patien... von Covey, Todd, Barf, Tjeerd, Gulrajani, Michael, Krantz, Fanny, van Lith, Bart, Bibikova, Elena, van de Kar, Bas, de Zwart, Edwin, Hamdy, Ahmed, Izumi, Raquel, Kaptein, Allard

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Direct and two-step bioorthogonal probes for Bruton's tyrosine kinase based on ibrutinib: a comparative studyElectronic supplementary information (ESI) available. See DOI: 10.1039/... von Liu, Nora, Hoogendoorn, Sascha, van de Kar, Bas, Kaptein, Allard, Barf, Tjeerd, Driessen, Christoph, Filippov, Dmitri V, van der Marel, Gijsbert A, van der Stelt, Mario, Overkleeft, Herman S

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Novel ATP competitive MK2 inhibitors with potent biochemical and cell-based activity throughout the series von Oubrie, Arthur, Kaptein, Allard, de Zwart, Edwin, Hoogenboom, Niels, Goorden, Rianne, van de Kar, Bas, van Hoek, Maaike, de Kimpe, Vera, van der Heijden, Ruud, Borsboom, Judith, Kazemier, Bert, de Roos, Jeroen, Scheffers, Michiel, Lommerse, Jos, Schultz-Fademrecht, Carsten, Barf, Tjeerd

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COMPOSITIONS AND METHODS FOR THE ASSESSMENT OF DRUG TARGET OCCUPANCY FOR BRUTON'S TYROSINE KINASE von VERKAIK, Saskia, GULRAJANI, Michael, BARF, Tjeerd, COVEY, Todd, DEMONT, Dennis, VAN DE KAR, Bas, KAPTEIN, Allard, VAN LITH, Bart

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Fruit consumption and the risk of bladder cancer: A pooled analysis by the Bladder Cancer Epidemiology and Nutritional Determinants Study von Jochems, Sylvia H. J., Reulen, Raoul C., Osch, Frits H. M., Witlox, Willem J. A., Goossens, Maria E., Brinkman, Maree, Giles, Graham G., Milne, Roger L., Brandt, Piet A., White, Emily, Weiderpass, Elisabete, Huybrechts, Inge, Hémon, Bertrand, Agudo, Antonio, Bueno‐de‐Mesquita, Bas, Cheng, Kar K., Schooten, Frederik J., Bryan, Richard T., Wesselius, Anke, Zeegers, Maurice P.

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The laboratory parameters-derived CoLab score as an indicator of the host response in ICU COVID-19 patients decreases over time: a prospective cohort study von Schoenmakers, Tom, Leers, Mathie P. G., Gorissen, Stefan H. M., van Loo, Inge H. M., van Rosmalen, Frank, Aydeniz, Eda, Schellens, Joep, Driessen, Marielle, Deneer, Ruben, de Venne, Wilhelmine P. H. G. Verboeket-van, Wolffs, Petra F. G., van Mook, Walther N. K. A., van Bussel, Bas C. T.

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Admission Blood Pressure in Relation to Clinical Outcomes and Successful Reperfusion After Endovascular Stroke Treatment von van den Berg, Sophie A., Uniken Venema, Simone M., Mulder, Maxim J.H.L., Treurniet, Kilian M., Samuels, Noor, Lingsma, Hester F., Goldhoorn, Robert-Jan B., Jansen, Ivo G.H., Coutinho, Jonathan M., Roozenbeek, Bob, Dippel, Diederik W.J., Roos, Yvo B.W.E.M., van der Worp, H. Bart, Nederkoorn, Paul J.

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Validating a clinical laboratory parameter-based deisolation algorithm for patients with COVID-19 in the intensive care unit using viability PCR: the CoLaIC multicentre cohort stud... von Schoenmakers, Tom, van Bussel, Bas C T, Gorissen, Stefan H M, van Loo, Inge H M, van Rosmalen, Frank, Verboeket-van de Venne, Wilhelmine P H G, Wolffs, Petra F G, van Mook, Walter N K A, Leers, Mathie P G, Ament, Stephanie MC, Sesmu Arbous, M, Bekers, Otto, Berkel, Miranda van, Boer, Arjen-Kars, Dam, Dirck W van, Deneer, Ruben, van Doorn, William PTM, Dormans, Tom P, Evers, Silvia MAA, Frenzel, Tim, Gillis, Judith, van der Horst, Iwan CC, Koek, W Nadia H, Linssen, Kitty CFM, Meex, Steven JR, Mostard, Guy JM, Mostard, Remy LM, Otterspoor, Luuk C, van Riel, Natal AW, Stals, Frans, Wolthuis, Albert

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Importance of Occlusion Site for Thrombectomy Technique in Stroke: Comparison Between Aspiration and Stent Retriever von Bernsen, Marie Louise E., Goldhoorn, Robert-Jan B., Lingsma, Hester F., van Oostenbrugge, Robert J., van Zwam, Wim H., Uyttenboogaart, Maarten, Roos, Yvo B.W.E.M., Martens, Jasper M., Hofmeijer, Jeannette

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Assessment of Recurrent Stroke Risk in Patients With a Carotid Web von Guglielmi, Valeria, Compagne, Kars C. J, Sarrami, Amir Hossein, Sluis, Wouter M, van den Berg, Lucie A, van der Sluijs, Pieter M, Mandell, Daniel M, van der Lugt, Aad, Roos, Yvo B. W. E. M, Majoie, Charles B. L. M, Dippel, Diederik W. J, Emmer, Bart J, van Es, Adriaan C. G. M, Coutinho, Jonathan M

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Clinical Outcome After Endovascular Treatment in Patients With Active Cancer and Ischemic Stroke: A MR CLEAN Registry Substudy von Verschoof, Merelijne A., Groot, Adrien E., de Bruijn, Sebastiaan F.T.M., Roozenbeek, Bob, van der Worp, H. Bart, Dippel, Diederik W.J., Emmer, Bart J., Roosendaal, Stefan D., Majoie, Charles B.L.M., Roos, Yvo B.W.E.M., Coutinho, Jonathan M.

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Determinants of Symptomatic Intracranial Hemorrhage After Endovascular Stroke Treatment: A Retrospective Cohort Study von van der Steen, Wouter, van der Ende, Nadinda A.M., van Kranendonk, Katinka R., Chalos, Vicky, van Oostenbrugge, Robert J., van Zwam, Wim H., Roos, Yvo B.W.E.M., van Doormaal, Pieter J., van Es, Adriaan C.G.M., Lingsma, Hester F., Majoie, Charles B.L.M., van der Lugt, Aad, Dippel, Diederik W.J., Roozenbeek, Bob

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