VEGF receptor Flt-1 spatially modulates Flk-1 signaling and blood vessel branching von Kappas, Nicholas C, Zeng, Gefei, Chappell, John C, Kearney, Joseph B, Hazarika, Surovi, Kallianos, Kimberly G, Patterson, Cam, Annex, Brian H, Bautch, Victoria L

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Orientation of endothelial cell division is regulated by VEGF signaling during blood vessel formation von Zeng, Gefei, Taylor, Sarah M., McColm, Janet R., Kappas, Nicholas C., Kearney, Joseph B., Williams, Lucy H., Hartnett, Mary E., Bautch, Victoria L.

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The VEGF receptor flt-1 (VEGFR-1) is a positive modulator of vascular sprout formation and branching morphogenesis von Kearney, Joseph B., Kappas, Nicholas C., Ellerstrom, Catharina, DiPaola, Frank W., Bautch, Victoria L.

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The VEGF receptor Flt-1 spatially modulates Flk-1 signaling and blood vessel branching von Kappas, Nicholas C., Zeng, Gefei, Chappell, John C., Kearney, Joseph B., Hazarika, Surovi, Kallianos, Kimberly G., Patterson, Cam, Annex, Brian H., Bautch, Victoria L.

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Maintenance and In Vitro Differentiation of Mouse Embryonic Stem Cells to Form Blood Vessels von Kappas, Nicholas C., Bautch, Victoria L.

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Dissection of the XChk1 signaling pathway in Xenopus laevis embryos von Kappas, N C, Savage, P, Chen, K C, Walls, A T, Sible, J C

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Altered expression of Chk1 disrupts cell cycle remodeling at the midblastula transition in Xenopus laevis embryos von Petrus, Matthew J, Wilhelm, Dayna E, Murakami, Monica, Kappas, Nicholas C, Carter, Ayesha D, Wroble, Brian N, Sible, Jill C

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Altered Expression of Chk1 Disrupts Cell Cycle Remodeling at the Midblastula Transition in Xenopus laevis Embryos von Petrus, Matthew J., Wilhelm, Dayna E., Murakami, Monica, Kappas, Nicholas C., Carter, Ayesha D., Wroble, Brian N., Sible, Jill C.

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The Role of Flt‐1 (VEGFR‐1) in Vascular Morphogenesis von Bautch, Victoria L, Zeng, Gefei, Kearney, Joseph B, Nanney, Allan, Patterson, Cam, Kappas, Nicholas C

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Orientation of endothelial cell division is regulated by VEGF signaling during blood vessel formation. Commentary von CLAESSON-WELSH, Lena, GEFEI ZENG, TAYLOR, Sarah M, MCCOLM, Janet R, KAPPAS, Nicholas C, KEARNEY, Joseph B, WILLIAMS, Lucy H, HARTNETT, Mary E, BAUTCH, Victoria L

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Flt-1 functions as a ligand sink for VEGF in early vascular development von Kappas, Nicholas C, Zeng, Gefei, Nanney, Allan, Schimizzi, Amanda, Kearney, Joseph B., Bautch, Victoria L

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THE VEGF RECEPTOR FLT-1 (VEGFR-1) IS A POSITIVE MODULATOR OF VASCULAR SPROUT FORMATION AND BRANCHING MORPHOGENESIS von Kearney, Joseph, Kappas, Nicholas, Ellerstrom, Catharina, DiPaola, Frank, Bautch, Victoria

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(A and B) Day 8 differentiated ES cell cultures were reacted with the PECAM antibody, and representative areas were analyzed for vessel area (A) or branch point frequency (B) von Kappas, Nicholas C., Gefei Zeng, Chappell, John C., Kearney, Joseph B., Surovi Hazarika, Kallianos, Kimberly G., Patterson, Cam, Annex, Brian H., Bautch, Victoria L.

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WT ES cell cultures were used (day 0) or differentiated for the indicated number of days, and total RNA was isolated for real-time PCR analysis von Kappas, Nicholas C., Gefei Zeng, Chappell, John C., Kearney, Joseph B., Surovi Hazarika, Kallianos, Kimberly G., Patterson, Cam, Annex, Brian H., Bautch, Victoria L.

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Day 8 differentiated cultures were fixed and stained with antibodies to β-galactosidase and PECAM-1 von Kappas, Nicholas C., Gefei Zeng, Chappell, John C., Kearney, Joseph B., Surovi Hazarika, Kallianos, Kimberly G., Patterson, Cam, Annex, Brian H., Bautch, Victoria L.

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Day 8 differentiated cultures were fixed and stained with antibodies to total Flk-1 and pFlk (Tyr-1173/1175) von Kappas, Nicholas C., Gefei Zeng, Chappell, John C., Kearney, Joseph B., Surovi Hazarika, Kallianos, Kimberly G., Patterson, Cam, Annex, Brian H., Bautch, Victoria L.

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(A–F) Day 7 differentiated cultures were fixed and stained for PECAM-1 (green), the mitotic marker antiphosphohistone H3 (red), and the nuclear dye DRAQ 5 (blue) von Kappas, Nicholas C., Gefei Zeng, Chappell, John C., Kearney, Joseph B., Surovi Hazarika, Kallianos, Kimberly G., Patterson, Cam, Annex, Brian H., Bautch, Victoria L.

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Day 8 differentiated cultures were processed for Western blot analysis with antibodies to total Flk-1 and pFlk (Tyr-1173/1175) von Kappas, Nicholas C., Gefei Zeng, Chappell, John C., Kearney, Joseph B., Surovi Hazarika, Kallianos, Kimberly G., Patterson, Cam, Annex, Brian H., Bautch, Victoria L.

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Day 8 differentiated ES cultures were stained for PECAM von Kappas, Nicholas C., Gefei Zeng, Chappell, John C., Kearney, Joseph B., Surovi Hazarika, Kallianos, Kimberly G., Patterson, Cam, Annex, Brian H., Bautch, Victoria L.

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(A) Flt-1 isoform transgene targeting von Kappas, Nicholas C., Gefei Zeng, Chappell, John C., Kearney, Joseph B., Surovi Hazarika, Kallianos, Kimberly G., Patterson, Cam, Annex, Brian H., Bautch, Victoria L.

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