Tau Post-translational Modifications: Dynamic Transformers of Tau Function, Degradation, and Aggregation von Alquezar, Carolina, Arya, Shruti, Kao, Aimee W.

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Progranulin Stimulates the In Vitro Maturation of Pro-Cathepsin D at Acidic pH von Butler, Victoria J., Cortopassi, Wilian A., Argouarch, Andrea R., Ivry, Sam L., Craik, Charles S., Jacobson, Matthew P., Kao, Aimee W.

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Age- and stress-associated C. elegans granulins impair lysosomal function and induce a compensatory HLH-30/TFEB transcriptional response von Butler, Victoria J, Gao, Fuying, Corrales, Christian I, Cortopassi, Wilian A, Caballero, Benjamin, Vohra, Mihir, Ashrafi, Kaveh, Cuervo, Ana Maria, Jacobson, Matthew P, Coppola, Giovanni, Kao, Aimee W

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Protons in small spaces: Discrete simulations of vesicle acidification von Singh, Apeksha, Marcoline, Frank V, Veshaguri, Salome, Kao, Aimee W, Bruchez, Marcel, Mindell, Joseph A, Stamou, Dimitrios, Grabe, Michael

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Processing of progranulin into granulins involves multiple lysosomal proteases and is affected in frontotemporal lobar degeneration von Mohan, Swetha, Sampognaro, Paul J., Argouarch, Andrea R., Maynard, Jason C., Welch, Mackenzie, Patwardhan, Anand, Courtney, Emma C., Zhang, Jiasheng, Mason, Amanda, Li, Kathy H., Huang, Eric J., Seeley, William W., Miller, Bruce L., Burlingame, Alma, Jacobson, Mathew P., Kao, Aimee W.

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A shift to organismal stress resistance in programmed cell death mutants von Judy, Meredith E, Nakamura, Ayumi, Huang, Anne, Grant, Harli, McCurdy, Helen, Weiberth, Kurt F, Gao, Fuying, Coppola, Giovanni, Kenyon, Cynthia, Kao, Aimee W

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Mutations in α-synuclein, TDP-43 and tau prolong protein half-life through diminished degradation by lysosomal proteases von Sampognaro, Paul J, Arya, Shruti, Knudsen, Giselle M, Gunderson, Emma L, Sandoval-Perez, Angelica, Hodul, Molly, Bowles, Kathryn, Craik, Charles S, Jacobson, Matthew P, Kao, Aimee W

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A Comprehensive Resource for Induced Pluripotent Stem Cells from Patients with Primary Tauopathies von Karch, Celeste M., Kao, Aimee W., Karydas, Anna, Onanuga, Khadijah, Martinez, Rita, Argouarch, Andrea, Wang, Chao, Huang, Cindy, Sohn, Peter Dongmin, Bowles, Kathryn R., Spina, Salvatore, Silva, M. Catarina, Marsh, Jacob A., Hsu, Simon, Pugh, Derian A., Ghoshal, Nupur, Norton, Joanne, Huang, Yadong, Lee, Suzee E., Seeley, William W., Theofilas, Panagiotis, Grinberg, Lea T., Moreno, Fermin, McIlroy, Kathryn, Boeve, Bradley F., Cairns, Nigel J., Crary, John F., Haggarty, Stephen J., Ichida, Justin K., Kosik, Kenneth S., Miller, Bruce L., Gan, Li, Goate, Alison M., Temple, Sally, Alquezar, Carolina, Bowles, Kathryn, Butler, David, Crary, John F., Gan, Li, Goate, Alison M., Hernandez, Israel, Hennes, Valerie, Huang, Cindy, Ichida, Justin K., Kampmann, Martin, Kao, Aimee W., Karch, Celeste M., Karydas, Anna, Kosik, Kenneth S., Martinez, Rita, Temple, Sally, Wang, Chao

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Progranulin Adsorbs to Polypropylene Tubes and Disrupts Functional Assays: Implications for Research, Biomarker Studies, and Therapeutics von Gururaj, Sushmitha, Sampognaro, Paul J., Argouarch, Andrea R., Kao, Aimee W.

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neurodegenerative disease mutation that accelerates the clearance of apoptotic cells von Kao, Aimee W, Eisenhut, Robin J, Martens, Lauren Herl, Nakamura, Ayumi, Huang, Anne, Bagley, Josh A, Zhou, Ping, de Luis, Alberto, Neukomm, Lukas J, Cabello, Juan, Farese, Robert V. Jr, Kenyon, Cynthia

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Genetically Encoded, pH-Sensitive mTFP1 Biosensor for Probing Lysosomal pH von Chin, Marcus Y, Patwardhan, Anand R, Ang, Kean-Hooi, Wang, Austin L, Alquezar, Carolina, Welch, Mackenzie, Nguyen, Phi T, Grabe, Michael, Molofsky, Anna V, Arkin, Michelle R, Kao, Aimee W

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MCP-1 and eotaxin-1 selectively and negatively associate with memory in MCI and Alzheimer's disease dementia phenotypes von Bettcher, Brianne M, Fitch, Ryan, Wynn, Matthew J, Lalli, Matthew A, Elofson, Jonathan, Jastrzab, Laura, Mitic, Laura, Miller, Zachary A, Rabinovici, Gil D, Miller, Bruce L, Kao, Aimee W, Kosik, Kenneth S, Kramer, Joel H

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Correction: Mutations in α-synuclein, TDP-43 and tau prolong protein half-life through diminished degradation by lysosomal proteases von Sampognaro, Paul J, Arya, Shruti, Knudsen, Giselle M, Gunderson, Emma L, Sandoval-Perez, Angelica, Hodul, Molly, Bowles, Kathryn, Craik, Charles S, Jacobson, Matthew P, Kao, Aimee W

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Tauopathy-associated PERK alleles are functional hypomorphs that increase neuronal vulnerability to ER stress von Yuan, Shauna H, Hiramatsu, Nobuhiko, Liu, Qing, Sun, Xuehan Victoria, Lenh, David, Chan, Priscilla, Chiang, Karen, Koo, Edward H, Kao, Aimee W, Litvan, Irene, Lin, Jonathan H

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Progranulin, lysosomal regulation and neurodegenerative disease von Kao, Aimee W., McKay, Andrew, Singh, Param Priya, Brunet, Anne, Huang, Eric J.

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Multi-Granulin Domain Peptides Bind to Pro-Cathepsin D and Stimulate Its Enzymatic Activity More Effectively Than Progranulin in Vitro von Butler, Victoria J, Cortopassi, Wilian A, Gururaj, Sushmitha, Wang, Austin L, Pierce, Olivia M, Jacobson, Matthew P, Kao, Aimee W

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Heavy metals contaminating the environment of a progressive supranuclear palsy cluster induce tau accumulation and cell death in cultured neurons von Alquezar, Carolina, Felix, Jessica B., McCandlish, Elizabeth, Buckley, Brian T., Caparros-Lefebvre, Dominique, Karch, Celeste M., Golbe, Lawrence I., Kao, Aimee W.

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Tuberous sclerosis complex is associated with a novel human tauopathy von Hwang, Ji-Hye L., Perloff, Olga S., Gaus, Stephanie E., Benitez, Camila, Alquezar, Carolina, Cosme, Celica Q., Nana, Alissa L., Vatsavayai, Sarat C., Ramos, Eliana M., Geschwind, Daniel H., Miller, Bruce L., Kao, Aimee W., Seeley, William W.

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The Progranulin Cleavage Products, Granulins, Exacerbate TDP-43 Toxicity and Increase TDP-43 Levels von Salazar, Dominique A, Butler, Victoria J, Argouarch, Andrea R, Hsu, Tsung-Yuan, Mason, Amanda, Nakamura, Ayumi, McCurdy, Helen, Cox, David, Ng, Rachel, Pan, Gloria, Seeley, William W, Miller, Bruce L, Kao, Aimee W

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Tau/MAPT disease-associated variant A152T alters tau function and toxicity via impaired retrograde axonal transport von Butler, Victoria J, Salazar, Dominique A, Soriano-Castell, David, Alves-Ferreira, Miguel, Dennissen, Frank J A, Vohra, Mihir, Oses-Prieto, Juan A, Li, Kathy H, Wang, Austin L, Jing, Beibei, Li, Biao, Groisman, Alex, Gutierrez, Edgar, Mooney, Sean, Burlingame, Alma L, Ashrafi, Kaveh, Mandelkow, Eva-Maria, Encalada, Sandra E, Kao, Aimee W

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