Role of PINK1 Binding to the TOM Complex and Alternate Intracellular Membranes in Recruitment and Activation of the E3 Ligase Parkin von Lazarou, Michael, Jin, Seok Min, Kane, Lesley A., Youle, Richard J.

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The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy von Lazarou, Michael, Sliter, Danielle A., Kane, Lesley A., Sarraf, Shireen A., Wang, Chunxin, Burman, Jonathon L., Sideris, Dionisia P., Fogel, Adam I., Youle, Richard J.

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PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activity von Kane, Lesley A, Lazarou, Michael, Fogel, Adam I, Li, Yan, Yamano, Koji, Sarraf, Shireen A, Banerjee, Soojay, Youle, Richard J

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Mitochondrial membrane potential regulates PINK1 import and proteolytic destabilization by PARL von Jin, Seok Min, Lazarou, Michael, Wang, Chunxin, Kane, Lesley A, Narendra, Derek P, Youle, Richard J

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p62/SQSTM1 is required for Parkin-induced mitochondrial clustering but not mitophagy; VDAC1 is dispensable for both von Narendra, Derek, Kane, Lesley A., Hauser, David N., Fearnley, Ian M., Youle, Richard J.

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High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy von Hasson, Samuel A., Kane, Lesley A., Yamano, Koji, Huang, Chiu-Hui, Sliter, Danielle A., Buehler, Eugen, Wang, Chunxin, Heman-Ackah, Sabrina M., Hessa, Tara, Guha, Rajarshi, Martin, Scott E., Youle, Richard J.

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PINK1 and Parkin Flag Miro to Direct Mitochondrial Traffic von Kane, Lesley A., Youle, Richard J.

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SARM1 is responsible for calpain-dependent dendrite degeneration in mouse hippocampal neurons von Miyamoto, Takashi, Kim, Chaeyoung, Chow, Johann, Dugas, Jason C., DeGroot, Jack, Bagdasarian, Alex L., Thottumkara, Arun P., Larhammar, Martin, Calvert, Meredith EK, Fox, Brian M., Lewcock, Joseph W., Kane, Lesley A.

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Polyubiquitin-sensor proteins reveal localization and linkage-type dependence of cellular ubiquitin signaling von Sims, Joshua J, Scavone, Francesco, Cooper, Eric M, Kane, Lesley A, Youle, Richard J, Boeke, Jef D, Cohen, Robert E

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Highly divergent mitochondrial ATP synthase complexes in Tetrahymena thermophila von Balabaskaran Nina, Praveen, Dudkina, Natalya V, Kane, Lesley A, van Eyk, Jennifer E, Boekema, Egbert J, Mather, Michael W, Vaidya, Akhil B

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Decreased lipidated ApoE-receptor interactions confer protection against pathogenicity of ApoE and its lipid cargoes in lysosomes von Guo, Jing L., Braun, Dylan, Fitzgerald, Gabriel A., Hsieh, Yun-Ting, Rougé, Lionel, Litvinchuk, Alexandra, Steffek, Micah, Propson, Nicholas E., Heffner, Catherine M., Discenza, Claire, Han, Suk Ji, Rana, Anil, Skuja, Lukas L., Lin, Bi Qi, Sun, Elizabeth W., Davis, Sonnet S., Balasundar, Srijana, Becerra, Isabel, Dugas, Jason C., Ha, Connie, Hsiao-Nakamoto, Jennifer, Huang, Fen, Jain, Shourya, Kung, Jennifer E., Liau, Nicholas P.D., Mahon, Cathal S., Nguyen, Hoang N., Nguyen, Nathan, Samaddar, Madhuja, Shi, Yajuan, Tatarakis, David, Tian, Yuxi, Zhu, Yuda, Suh, Jung H., Sandmann, Thomas, Calvert, Meredith E.K., Arguello, Annie, Kane, Lesley A., Lewcock, Joseph W., Holtzman, David M., Koth, Christopher M., Di Paolo, Gilbert

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DNL343 is an investigational CNS penetrant eukaryotic initiation factor 2B activator that prevents and reverses the effects of neurodegeneration caused by the integrated stress res... von Yulyaningsih, Ernie, Suh, Jung H, Fanok, Melania, Chau, Roni, Solanoy, Hilda, Takahashi, Ryan, Bakardjiev, Anna I, Becerra, Isabel, Benitez, N Butch, Chiu, Chi-Lu, Davis, Sonnet S, Dowdle, William E, Earr, Timothy, Estrada, Anthony A, Gill, Audrey, Ha, Connie, Haddick, Patrick C G, Henne, Kirk R, Larhammar, Martin, Leung, Amy W-S, Maciuca, Romeo, Memarzadeh, Bahram, Nguyen, Hoang N, Nugent, Alicia A, Osipov, Maksim, Ran, Yingqing, Rebadulla, Kevin, Roche, Elysia, Sandman, Thomas, Wang, Jing, Lewcock, Joseph W, Scearce-Levie, Kimberly, Kane, Lesley A, Sanchez, Pascal E

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Discovery of DNL343: A Potent, Selective, and Brain-Penetrant eIF2B Activator Designed for the Treatment of Neurodegenerative Diseases von Craig, Robert A., De Vicente, Javier, Estrada, Anthony A., Feng, Jianwen A., Lexa, Katrina W., Canet, Mark J., Dowdle, William E., Erickson, Rebecca I., Flores, Brittany N., Haddick, Patrick C. G., Kane, Lesley A., Lewcock, Joseph W., Moerke, Nathan J., Poda, Suresh B., Sweeney, Zachary, Takahashi, Ryan H., Tong, Vincent, Wang, Jing, Yulyaningsih, Ernie, Solanoy, Hilda, Scearce-Levie, Kimberly, Sanchez, Pascal E., Tang, Liwei, Xu, Musheng, Zhang, Rui, Osipov, Maksim

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Discovery of Potent and Selective Dual Leucine Zipper Kinase/Leucine Zipper-Bearing Kinase Inhibitors with Neuroprotective Properties in In Vitro and In Vivo Models of Amyotrophic... von Craig, Robert A., Fox, Brian M., Hu, Cheng, Lexa, Katrina W., Osipov, Maksim, Thottumkara, Arun P., Larhammar, Martin, Miyamoto, Takashi, Rana, Anil, Kane, Lesley A., Yulyaningsih, Ernie, Solanoy, Hilda, Nguyen, Hoang, Chau, Roni, Earr, Timothy, Kajiwara, Yuji, Fleck, Daniel, Lucas, Anthony, Haddick, Patrick C. G., Takahashi, Ryan H., Tong, Vincent, Wang, Jing, Canet, Mark J., Poda, Suresh B., Scearce-Levie, Kimberly, Srivastava, Ankita, Sweeney, Zachary K., Xu, Musheng, Zhang, Rui, He, Jianrong, Lei, Yanan, Zhuo, Zheng, de Vicente, Javier

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Preparation of proteins and peptides for mass spectrometry analysis in a bottom-up proteomics workflow von Gundry, Rebekah L, White, Melanie Y, Murray, Christopher I, Kane, Lesley A, Fu, Qin, Stanley, Brian A, Van Eyk, Jennifer E

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Site-Mapping of In Vitro S-nitrosation in Cardiac Mitochondria: Implications for Cardioprotection von Murray, Christopher I., Kane, Lesley A., Uhrigshardt, Helge, Wang, Sheng-Bing, Van Eyk, Jennifer E.

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Mitochondrial fission and fusion and their roles in the heart von Kane, Lesley A., Youle, Richard J.

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Type I Keratin 17 Protein Is Phosphorylated on Serine 44 by p90 Ribosomal Protein S6 Kinase 1 (RSK1) in a Growth- and Stress-dependent Fashion von Pan, Xiaoou, Kane, Lesley A., Van Eyk, Jennifer E., Coulombe, Pierre A.

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Modulation of Mitochondrial Proteome and Improved Mitochondrial Function by Biventricular Pacing of Dyssynchronous Failing Hearts von Agnetti, Giulio, Kaludercic, Nina, Kane, Lesley A, Elliott, Steven T, Guo, Yurong, Chakir, Khalid, Samantapudi, Daya, Paolocci, Nazareno, Tomaselli, Gordon F, Kass, David A, Van Eyk, Jennifer E

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Phosphorylation of the F1Fo ATP Synthase β Subunit: Functional and Structural Consequences Assessed in a Model System von Kane, Lesley A, Youngman, Matthew J, Jensen, Robert E, Van Eyk, Jennifer E

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