Adaptive resistance to anti-PD1 therapy by Tim-3 upregulation is mediated by the PI3K-Akt pathway in head and neck cancer von Shayan, Gulidanna, Srivastava, Raghvendra, Li, Jing, Schmitt, Nicole, Kane, Lawrence P., Ferris, Robert L.

Volltext

TIM-3 as a Target for Cancer Immunotherapy and Mechanisms of Action von Du, Wenwen, Yang, Min, Turner, Abbey, Xu, Chunling, Ferris, Robert L, Huang, Jianan, Kane, Lawrence P, Lu, Binfeng

Volltext

Immune regulation by Tim-3 von Banerjee, Hridesh, Kane, Lawrence P

Volltext

The costimulatory activity of Tim-3 requires Akt and MAPK signaling and its recruitment to the immune synapse von Kataoka, Shunsuke, Manandhar, Priyanka, Lee, Judong, Workman, Creg J., Banerjee, Hridesh, Szymczak-Workman, Andrea L., Kvorjak, Michael, Lohmueller, Jason, Kane, Lawrence P.

Volltext

Phosphotyrosine-Dependent Coupling of Tim-3 to T-Cell Receptor Signaling Pathways von Lee, Judong, Su, Ee Wern, Zhu, Chen, Hainline, Sarah, Phuah, Jiayao, Moroco, Jamie A., Smithgall, Thomas E., Kuchroo, Vijay K., Kane, Lawrence P.

Volltext

Expression of Tim-3 drives phenotypic and functional changes in Treg cells in secondary lymphoid organs and the tumor microenvironment von Banerjee, Hridesh, Nieves-Rosado, Hector, Kulkarni, Aditi, Murter, Benjamin, McGrath, Kyle V., Chandran, Uma R., Chang, Alexander, Szymczak-Workman, Andrea L., Vujanovic, Lazar, Delgoffe, Greg M., Ferris, Robert L., Kane, Lawrence P.

Volltext

Cutting Edge: Murine Mast Cells Rapidly Modulate Metabolic Pathways Essential for Distinct Effector Functions von Phong, Binh, Avery, Lyndsay, Menk, Ashley V, Delgoffe, Greg M, Kane, Lawrence P

Volltext

Promotion of Tissue Inflammation by the Immune Receptor Tim-3 Expressed on Innate Immune Cells von Anderson, Ana C., Anderson, David E., Bregoli, Lisa, Hastings, William D., Kassam, Nasim, Lei, Charles, Chandwaskar, Rucha, Karman, Jozsef, Su, Ee W., Hirashima, Mitsuomi, Bruce, Jeffrey N., Kane, Lawrence P., Kuchroo, Vijay K., Hafler, David A.

Volltext

Tim-3 mediates T cell trogocytosis to limit antitumor immunity von Pagliano, Ornella, Morrison, Robert M, Chauvin, Joe-Marc, Banerjee, Hridesh, Davar, Diwakar, Ding, Quanquan, Tanegashima, Tokiyoshi, Gao, Wentao, Chakka, Saranya R, DeBlasio, Richelle, Lowin, Ava, Kara, Kevin, Ka, Mignane, Zidi, Bochra, Amin, Rada, Raphael, Itay, Zhang, Shuowen, Watkins, Simon C, Sander, Cindy, Kirkwood, John M, Bosenberg, Marcus, Anderson, Ana C, Kuchroo, Vijay K, Kane, Lawrence P, Korman, Alan J, Rajpal, Arvind, West, Sean M, Han, Minhua, Bee, Christine, Deng, Xiaodi, Schebye, Xiao Min, Strop, Pavel, Zarour, Hassane M

Volltext

Regulation of Tim-3 function by binding to phosphatidylserine von Kane, Lawrence P.

Volltext

Control of T lymphocyte fate decisions by PI3K signaling [version 1; peer review: awaiting peer review] von Murter, Benjamin, Kane, Lawrence P

Volltext

Tim-3 co-stimulation promotes short-lived effector T cells, restricts memory precursors, and is dispensable for T cell exhaustion von Avery, Lyndsay, Filderman, Jessica, Szymczak-Workman, Andrea L., Kane, Lawrence P.

Volltext

IL-17RC is required for immune signaling via an extended SEF/IL-17R signaling domain in the cytoplasmic tail von Ho, Allen W, Shen, Fang, Conti, Heather R, Patel, Nayan, Childs, Erin E, Peterson, Alanna C, Hernández-Santos, Nydiaris, Kolls, Jay K, Kane, Lawrence P, Ouyang, Wenjun, Gaffen, Sarah L

Volltext

Too much of a good thing? Tim-3 and TCR signaling in T cell exhaustion von Ferris, Robert L, Lu, Binfeng, Kane, Lawrence P

Volltext

TIM-3 on myeloid cells promotes pulmonary inflammation through increased production of galectin-3 von Kim, Ki Sun, Lee, Chanju, Kim, Hyung-Seok, Gu, Su Jeong, Yoon, Hee Jung, Won, Su Bin, Lee, Ho, Lee, Yong Sun, Kim, Sang Soo, Kane, Lawrence P., Park, Eun Jung

Volltext

T Cell Ig and Mucin 1 (TIM-1) Is Expressed on in vivo-Activated T Cells and Provides a Costimulatory Signal for T Cell Activation von Anjali J. de Souza, Timothy B. Oriss, Katherine J. O'Malley, Ray, Anuradha, Kane, Lawrence P.

Volltext

Tim-3 Is Not Required for Establishment of CD8+ T Cell Memory to Lymphocytic Choriomeningitis Virus von Manandhar, Priyanka, Szymczak-Workman, Andrea L, Kane, Lawrence P

Volltext

Complement component C5a permits the coexistence of pathogenic Th17 cells and type I IFN in lupus von Pawaria, Sudesh, Ramani, Kritika, Maers, Kelly, Liu, Youhua, Kane, Lawrence P, Levesque, Marc C, Biswas, Partha S

Volltext

TIM-1 and TIM-3 proteins in immune regulation von Su, Ee Wern, Lin, Jean Y., Kane, Lawrence P.

Volltext

T Cell Ig and Mucin Domain Proteins and Immunity von Kane, Lawrence P

Volltext