A Novel Spectroscopically Determined Pharmacodynamic Biomarker for Skin Toxicity in Cancer Patients Treated with Targeted Agents von Azan, Antoine, Caspers, Peter J, Bakker Schut, Tom C, Roy, Séverine, Boutros, Céline, Mateus, Christine, Routier, Emilie, Besse, Benjamin, Planchard, David, Seck, Atmane, Kamsu Kom, Nyam, Tomasic, Gorana, Koljenović, Senada, Noordhoek Hegt, Vincent, Texier, Matthieu, Lanoy, Emilie, Eggermont, Alexander M M, Paci, Angelo, Robert, Caroline, Puppels, Gerwin J, Mir, Lluis M

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eIF4F is a nexus of resistance to anti-BRAF and anti-MEK cancer therapies von Boussemart, Lise, Malka-Mahieu, Hélène, Girault, Isabelle, Allard, Delphine, Hemmingsson, Oskar, Tomasic, Gorana, Thomas, Marina, Basmadjian, Christine, Ribeiro, Nigel, Thuaud, Frédéric, Mateus, Christina, Routier, Emilie, Kamsu-Kom, Nyam, Agoussi, Sandrine, Eggermont, Alexander M., Désaubry, Laurent, Robert, Caroline, Vagner, Stéphan

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Skin Tumors Induced by Sorafenib; Paradoxic RAS―RAF Pathway Activation and Oncogenic Mutations of HRAS, TP53, and TGFBR1 von ARNAULT, Jean Philippe, MATEUS, Christine, ANDRE, Jocelyne, KAMSU-KOM, Nyam, BOUSSEMART, Lise, LACROIX, Ludovic, SPATZ, Alain, EGGERMONT, Alexander M, DRUILLENNEC, Sabine, VAGNER, Stephan, EYCHENE, Alain, DUMAZ, Nicolas, ESCUDIER, Bernard, ROBERT, Caroline, TOMASIC, Gorana, WECHSLER, Janine, HOLLVILLE, Emilie, SORIA, Jean-Charles, MALKA, David, SARASIN, Alain, LARCHER, Magalie

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Rapid and objective CT scan prognostic scoring identifies metastatic patients with long-term clinical benefit on anti-PD-1/-L1 therapy von Dercle, Laurent, Ammari, Samy, Champiat, Stéphane, Massard, Christophe, Ferté, Charles, Taihi, Lokmane, Seban, Romain-David, Aspeslagh, Sandrine, Mahjoubi, Linda, Kamsu-Kom, Nyam, Robert, Caroline, Marabelle, Aurélien, Schlumberger, Martin, Soria, Jean-Charles, Postel-Vinay, Sophie

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Secondary Tumors Arising in Patients Undergoing BRAF Inhibitor Therapy Exhibit Increased BRAF-CRAF Heterodimerization von Boussemart, Lise, Girault, Isabelle, Malka-Mahieu, Hélène, Mateus, Christine, Routier, Emilie, Rubington, Margot, Kamsu-Kom, Nyam, Thomas, Marina, Tomasic, Gorana, Agoussi, Sandrine, Breckler, Marie, Laporte, Mélanie, Lacroix, Ludovic, Eggermont, Alexander M, Cavalcanti, Andrea, Grange, Florent, Adam, Julien, Vagner, Stéphan, Robert, Caroline

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Synergistic effects of eIF4A and MEK inhibitors on proliferation of NRAS-mutant melanoma cell lines von Malka-Mahieu, Hélène, Girault, Isabelle, Rubington, Margot, Leriche, Melissa, Welsch, Caroline, Kamsu-Kom, Nyam, Zhao, Qian, Desaubry, Laurent, Vagner, Stéphan, Robert, Caroline

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Transcriptional response to hypoxic stress in melanoma and prognostic potential of GBE1 and BNIP3 von Buart, Stéphanie, Terry, Stéphane, Noman, Muhammad Z, Lanoy, Emilie, Boutros, Céline, Fogel, Paul, Dessen, Philippe, Meurice, Guillaume, Gaston-Mathé, Yann, Vielh, Philippe, Roy, Séverine, Routier, Emilie, Marty, Virginie, Ferlicot, Sophie, Legrès, Luc, Bouchtaoui, Morad El, Kamsu-Kom, Nyam, Muret, Jane, Deutsch, Eric, Eggermont, Alexander, Soria, Jean-Charles, Robert, Caroline, Chouaib, Salem

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EGFR- and VEGF(R)-Targeted Small Molecules Show Synergistic Activity in Colorectal Cancer Models Refractory to Combinations of Monoclonal Antibodies von POINDESSOUS, Virginie, OUARET, Djamila, CERVERA, Pascale, FLEJOU, Jean-Franpois, ANDRE, Thierry, TOURNIGAND, Christophe, CHIBAUDEL, Benoist, DE GRAMONT, Aimery, LARSEN, Annette K, EL OUADRANI, Karima, BATTISTELLA, Aude, MEGALOPHONOS, Virginie F, KAMSU-KOM, Nyam, PETITPREZ, Amélie, ESCARGUEIL, Alexandre E, BOUDOU, Pascaline, DUMONT, Sylvie

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Abstract A23: eIF4F is a key and targetable convergence nexus of multiple mechanisms of resistance to anti-BRAF and anti-MEK cancer therapies von Boussemart, Lise, Malka-Mahieu, Helene, Girault, Isabelle, Allard, Delphine, Hemmingson, Oskar, Kamsu-Kom, Nyam, Agoussi, Sandrine, Eggermont, Alexander, Desaubry, Laurent, Robert, Caroline, Vagner, Stephan

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Abstract 934: BRAF inhibitors induce skin and extra-cutaneous tumors via paradoxical activation of the MAPK pathway: Molecular study of 66 tumors and visualization of BRAF/CRAF pro... von Boussemart, Lise, Girault, Isabelle, Mateus, Christine, Thomas, Marina, Routier, Emilie, Cazenave, Hugo, Tomasic, Gorana, Wechlser, Janine, Kamsu-Kom, Nyam, Roy, Séverine, Favre, Michel, Lacroix, Ludovic, Eggermont, Alexander, Vagner, Stéphan, Robert, Caroline

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Genotype characterization and prognosis of unknown primary melanoma patients with nodal metastases von Gos, Aleksandra, Robert, Caroline, Jurkowska, Monika, Kamsu-Kom, Nyam, Michej, Wanda, Jeziorski, Arkadiusz, Voit, Christiane A., Roewert-Huber, Joachim, Siedlecki, Janusz A, Van Akkooi, Alexander Christopher Jonathan, Eggermont, Alexander M., Rutkowski, Piotr

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Abstract A240: Synergistic effects of a small molecule EGFR/HER2 inhibitor in combination with a triple angiokinase inhibitor in colorectal cancer xenografts refractory to combinat... von Poindessous, Virginie, Kamsu-Kom, Nyam, Ouaret, Djamila, Boudou, Pascaline, El Ouadrani, Karima, Escargueil, Alexandre E., Petitprez, Amélie, Dumont, Sylvie, Cervera, Pascale, Fléjou, Jean-François, Tournigand, Christophe, Louvet, Christophe, de Gramont, Aimery, Larsen, Annette K.

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Synergistic effects of eIF4A and MEK inhibitors on proliferation of NRAS-mutant melanoma cell lines von Malka-Mahieu, Hélène, Girault, Isabelle, Rubington, Margot, Leriche, Melissa, Welsch, Caroline, Nyam Kamsu-Kom, Zhao, Qian, Desaubry, Laurent, Vagner, Stéphan, Robert, Caroline

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