Multitargeted Compounds Derived from (2,5-Dioxopyrrolidin-1-yl)(phenyl)-Acetamides as Candidates for Effective Anticonvulsant and Antinociceptive Agents von Abram, Michał, Rapacz, Anna, Mogilski, Szczepan, Latacz, Gniewomir, Lubelska, Annamaria, Kamiński, Rafał M, Kamiński, Krzysztof

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Discovery of (R)‑N‑Benzyl-2-(2,5-dioxopyrrolidin-1-yl)propanamide [(R)-AS‑1], a Novel Orally Bioavailable EAAT2 Modulator with Drug-like Properties and Potent Antiseizure Activity... von Abram, Michał, Jakubiec, Marcin, Reeb, Katelyn, Cheng, Mary Hongying, Gedschold, Robin, Rapacz, Anna, Mogilski, Szczepan, Socała, Katarzyna, Nieoczym, Dorota, Szafarz, Małgorzata, Latacz, Gniewomir, Szulczyk, Bartłomiej, Kalinowska-Tłuścik, Justyna, Gawel, Kinga, Esguerra, Camila V., Wyska, Elżbieta, Müller, Christa E., Bahar, Ivet, Fontana, Andréia C. K., Wlaź, Piotr, Kamiński, Rafał M., Kamiński, Krzysztof

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The Search for New Anticonvulsants in a Group of (2,5-Dioxopyrrolidin-1-yl)(phenyl)Acetamides with Hybrid Structure-Synthesis and In Vivo/In Vitro Studies von Abram, Michał, Jakubiec, Marcin, Rapacz, Anna, Mogilski, Szczepan, Latacz, Gniewomir, Kamiński, Rafał M, Kamiński, Krzysztof

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Identification of New Compounds with Anticonvulsant and Antinociceptive Properties in a Group of 3-substituted (2,5-dioxo-pyrrolidin-1-yl)(phenyl)-Acetamides von Abram, Michał, Jakubiec, Marcin, Rapacz, Anna, Mogilski, Szczepan, Latacz, Gniewomir, Szulczyk, Bartłomiej, Szafarz, Małgorzata, Socała, Katarzyna, Nieoczym, Dorota, Wyska, Elżbieta, Wlaź, Piotr, Kamiński, Rafał M, Kamiński, Krzysztof

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TRPV1 channel in the pathophysiology of epilepsy and its potential as a molecular target for the development of new antiseizure drug candidates von Socała, Katarzyna, Jakubiec, Marcin, Abram, Michał, Mlost, Jakub, Starowicz, Katarzyna, Kamiński, Rafał M., Ciepiela, Katarzyna, Andres-Mach, Marta, Zagaja, Mirosław, Metcalf, Cameron S., Zawadzki, Przemysław, Wlaź, Piotr, Kamiński, Krzysztof

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KA‐104, a new multitargeted anticonvulsant with potent antinociceptive activity in preclinical models von Kamiński, Krzysztof, Mogilski, Szczepan, Abram, Michał, Rapacz, Anna, Latacz, Gniewomir, Szulczyk, Bartłomiej, Walczak, Maria, Kuś, Kamil, Matyjaszczyk, Karolina, Kamiński, Rafał M.

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Novel Alaninamide Derivatives with Drug-like Potential for Development as Antiseizure and Antinociceptive TherapiesIn Vitro and In Vivo Characterization von Jakubiec, Marcin, Abram, Michał, Zagaja, Mirosław, Andres-Mach, Marta, Szala-Rycaj, Joanna, Latacz, Gniewomir, Honkisz-Orzechowska, Ewelina, Mogilski, Szczepan, Kubacka, Monika, Szafarz, Małgorzata, Pociecha, Krzysztof, Przejczowska-Pomierny, Katarzyna, Wyska, Elżbieta, Socała, Katarzyna, Nieoczym, Dorota, Szulczyk, Bartłomiej, Wlaź, Piotr, Metcalf, Cameron S., Wilcox, Karen, Kamiński, Rafał M., Kamiński, Krzysztof

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Enhancement of Glutamate Uptake as Novel Antiseizure Approach: Preclinical Proof of Concept von Kamiński, Krzysztof, Socała, Katarzyna, Abram, Michał, Jakubiec, Marcin, Reeb, Katelyn L, Temmermand, Rhea, Zagaja, Mirosław, Maj, Maciej, Kolasa, Magdalena, Faron-Górecka, Agata, Andres-Mach, Marta, Szewczyk, Aleksandra, Hameed, Mustafa Q, Fontana, Andréia C K, Rotenberg, Alexander, Kamiński, Rafał M

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Discovery and Profiling of New Multimodal Phenylglycinamide Derivatives as Potent Antiseizure and Antinociceptive Drug Candidates von Jakubiec, Marcin, Abram, Michał, Zagaja, Mirosław, Socała, Katarzyna, Panic, Vanja, Latacz, Gniewomir, Mogilski, Szczepan, Szafarz, Małgorzata, Szala-Rycaj, Joanna, Saunders, Jerry, West, Peter J., Nieoczym, Dorota, Przejczowska-Pomierny, Katarzyna, Szulczyk, Bartłomiej, Krupa, Anna, Wyska, Elżbieta, Wlaź, Piotr, Metcalf, Cameron S., Wilcox, Karen, Andres-Mach, Marta, Kamiński, Rafał M., Kamiński, Krzysztof

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Inhibition of CHIT1 as a novel therapeutic approach in idiopathic pulmonary fibrosis von Sklepkiewicz, Piotr, Dymek, Barbara A., Mlacki, Michal, Koralewski, Robert, Mazur, Marzena, Nejman-Gryz, Patrycja, Korur, Serdar, Zagozdzon, Agnieszka, Rymaszewska, Aleksandra, von der Thüsen, Jan H., Siwińska, Anna M., Güner, Nazan Cemre, Cheda, Łukasz, Paplinska-Goryca, Magdalena, Proboszcz, Małgorzata, van den Bosch, Thierry P.P., Górska, Katarzyna, Golab, Jakub, Kamiński, Rafał M., Krenke, Rafał, Golebiowski, Adam, Dzwonek, Karolina, Dobrzanski, Pawel

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Effects of selective inhibition of N-acetylated-α-linked-acidic dipeptidase (NAALADase) on mice in learning and memory tasks von Łukawski, Krzysztof, Kamiński, Rafał M., Czuczwar, Stanisław J.

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Repurposed molecules for antiepileptogenesis: Missing an opportunity to prevent epilepsy? von Klein, Pavel, Friedman, Alon, Hameed, Mustafa Q., Kaminski, Rafal M., Bar‐Klein, Guy, Klitgaard, Henrik, Koepp, Mathias, Jozwiak, Sergiusz, Prince, David A., Rotenberg, Alexander, Twyman, Roy, Vezzani, Annamaria, Wong, Michael, Löscher, Wolfgang

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Neuroinflammatory targets and treatments for epilepsy validated in experimental models von Aronica, Eleonora, Bauer, Sebastian, Bozzi, Yuri, Caleo, Matteo, Dingledine, Raymond, Gorter, Jan A., Henshall, David C., Kaufer, Daniela, Koh, Sookyong, Löscher, Wolfgang, Louboutin, Jean‐Pierre, Mishto, Michele, Norwood, Braxton A., Palma, Eleonora, Poulter, Michael O., Terrone, Gaetano, Vezzani, Annamaria, Kaminski, Rafal M.

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Asymmetric synthesis and in vivo/in vitro characterization of new hybrid anticonvulsants derived from (2,5-dioxopyrrolidin-1-yl)phenylacetamides von Abram, Michał, Rapacz, Anna, Latacz, Gniewomir, Szulczyk, Bartłomiej, Kalinowska-Tłuścik, Justyna, Otto-Ślusarczyk, Dagmara, Struga, Marta, Kamiński, Rafał M., Kamiński, Krzysztof

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Brivaracetam: Rationale for discovery and preclinical profile of a selective SV2A ligand for epilepsy treatment von Klitgaard, Henrik, Matagne, Alain, Nicolas, Jean‐Marie, Gillard, Michel, Lamberty, Yves, De Ryck, Marc, Kaminski, Rafal M., Leclercq, Karine, Niespodziany, Isabelle, Wolff, Christian, Wood, Martyn, Hannestad, Jonas, Kervyn, Sophie, Kenda, Benoit

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Nrf2 defense pathway: Experimental evidence for its protective role in epilepsy von Mazzuferi, Manuela, Kumar, Gaurav, van Eyll, Jonathan, Danis, Benedicte, Foerch, Patrik, Kaminski, Rafal M.

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Rapid epileptogenesis in the mouse pilocarpine model: Video-EEG, pharmacokinetic and histopathological characterization von Mazzuferi, Manuela, Kumar, Gaurav, Rospo, Chiara, Kaminski, Rafal M.

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n-3 Docosapentaenoic acid-derived protectin D1 promotes resolution of neuroinflammation and arrests epileptogenesis von Frigerio, Federica, Pasqualini, Giulia, Craparotta, Ilaria, Marchini, Sergio, van Vliet, Erwin A, Foerch, Patrick, Vandenplas, Catherine, Leclercq, Karin, Aronica, Eleonora, Porcu, Luca, Pistorius, Kimberly, Colas, Romain A, Hansen, Trond V, Perretti, Mauro, Kaminski, Rafal M, Dalli, Jesmond, Vezzani, Annamaria

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New Phenylglycinamide Derivatives with Hybrid Structure as Candidates for New Broad-Spectrum Anticonvulsants von Jakubiec, Marcin, Abram, Michał, Zagaja, Mirosław, Andres-Mach, Marta, Szewczyk, Aleksandra, Latacz, Gniewomir, Szulczyk, Bartłomiej, Socała, Katarzyna, Nieoczym, Dorota, Wlaź, Piotr, Metcalf, Cameron S., Wilcox, Karen, Kamiński, Rafał M., Kamiński, Krzysztof

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A systems-level framework for drug discovery identifies Csf1R as an anti-epileptic drug target von Srivastava, Prashant K., van Eyll, Jonathan, Godard, Patrice, Mazzuferi, Manuela, Delahaye-Duriez, Andree, Van Steenwinckel, Juliette, Gressens, Pierre, Danis, Benedicte, Vandenplas, Catherine, Foerch, Patrik, Leclercq, Karine, Mairet-Coello, Georges, Cardenas, Alvaro, Vanclef, Frederic, Laaniste, Liisi, Niespodziany, Isabelle, Keaney, James, Gasser, Julien, Gillet, Gaelle, Shkura, Kirill, Chong, Seon-Ah, Behmoaras, Jacques, Kadiu, Irena, Petretto, Enrico, Kaminski, Rafal M., Johnson, Michael R.

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