Genome Sequencing Reveals Loci under Artificial Selection that Underlie Disease Phenotypes in the Laboratory Rat von Atanur, Santosh S., Diaz, Ana Garcia, Maratou, Klio, Sarkis, Allison, Rotival, Maxime, Game, Laurence, Tschannen, Michael R., Kaisaki, Pamela J., Otto, Georg W., Ma, Man Chun John, Keane, Thomas M., Hummel, Oliver, Saar, Kathrin, Chen, Wei, Guryev, Victor, Gopalakrishnan, Kathirvel, Garrett, Michael R., Joe, Bina, Citterio, Lorena, Bianchi, Giuseppe, McBride, Martin, Dominiczak, Anna, Adams, David J., Serikawa, Tadao, Flicek, Paul, Cuppen, Edwin, Hubner, Norbert, Petretto, Enrico, Gauguier, Dominique, Kwitek, Anne, Jacob, Howard, Aitman, Timothy J.

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Aryl hydrocarbon receptor nuclear translocator-like (BMAL1) is associated with susceptibility to hypertension and type 2 diabetes von Woon, Peng Y, Kaisaki, Pamela J, Bragança, José, Bihoreau, Marie-Thérèse, Levy, Jonathan C, Farrall, Martin, Gauguier, Dominique

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Delineation of dominant and recessive forms of LZTR1‐associated Noonan syndrome von Pagnamenta, Alistair T., Kaisaki, Pamela J., Bennett, Fenella, Burkitt‐Wright, Emma, Martin, Hilary C., Ferla, Matteo P., Taylor, John M., Gompertz, Lianne, Lahiri, Nayana, Tatton‐Brown, Katrina, Newbury‐Ecob, Ruth, Henderson, Alex, Joss, Shelagh, Weber, Astrid, Carmichael, Jenny, Turnpenny, Peter D., McKee, Shane, Forzano, Francesca, Ashraf, Tazeen, Bradbury, Kimberley, Shears, Deborah, Kini, Usha, de Burca, Anna, Blair, Edward, Taylor, Jenny C., Stewart, Helen

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Targeted Next-Generation Sequencing of Plasma DNA from Cancer Patients: Factors Influencing Consistency with Tumour DNA and Prospective Investigation of Its Utility for Diagnosis von Kaisaki, Pamela J, Cutts, Anthony, Popitsch, Niko, Camps, Carme, Pentony, Melissa M, Wilson, Gareth, Page, Suzanne, Kaur, Kulvinder, Vavoulis, Dimitris, Henderson, Shirley, Gupta, Avinash, Middleton, Mark R, Karydis, Ioannis, Talbot, Denis C, Schuh, Anna, Taylor, Jenny C

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Molecular genetics of the transcription factor GLIS3 identifies its dual function in beta cells and neurons von Calderari, Sophie, Ria, Massimiliano, Gérard, Christelle, Nogueira, Tatiane C., Villate, Olatz, Collins, Stephan C., Neil, Helen, Gervasi, Nicolas, Hue, Christophe, Suarez-Zamorano, Nicolas, Prado, Cécilia, Cnop, Miriam, Bihoreau, Marie-Thérèse, Kaisaki, Pamela J., Cazier, Jean-Baptiste, Julier, Cécile, Lathrop, Mark, Werner, Michel, Eizirik, Decio L., Gauguier, Dominique

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MicroRNA-125a is over-expressed in insulin target tissues in a spontaneous rat model of Type 2 Diabetes von Herrera, Blanca M, Lockstone, Helen E, Taylor, Jennifer M, Wills, Quin F, Kaisaki, Pamela J, Barrett, Amy, Camps, Carme, Fernandez, Christina, Ragoussis, Jiannis, Gauguier, Dominique, McCarthy, Mark I, Lindgren, Cecilia M

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Conserved properties of genetic architecture of renal and fat transcriptomes in rat models of insulin resistance von Otto, Georg W, Kaisaki, Pamela J, Brial, Francois, Le Lay, Aurélie, Cazier, Jean-Baptiste, Mott, Richard, Gauguier, Dominique

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Genetic control of differential acetylation in diabetic rats von Kaisaki, Pamela J, Otto, Georg W, McGouran, Joanna F, Toubal, Amine, Argoud, Karène, Waller-Evans, Helen, Finlay, Clare, Caldérari, Sophie, Bihoreau, Marie-Thérèse, Kessler, Benedikt M, Gauguier, Dominique, Mott, Richard

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Untargeted Metabolome Quantitative Trait Locus Mapping Associates Variation in Urine Glycerate to Mutant Glycerate Kinase von Cazier, Jean-Baptise, Kaisaki, Pamela J, Argoud, Karène, Blaise, Benjamin J, Veselkov, Kirill, Ebbels, Timothy M. D, Tsang, Tsz, Wang, Yulan, Bihoreau, Marie-Thérèse, Mitchell, Steve C, Holmes, Elaine C, Lindon, John C, Scott, James, Nicholson, Jeremy K, Dumas, Marc-Emmanuel, Gauguier, Dominique

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Transcriptome Profiling in Rat Inbred Strains and Experimental Cross Reveals Discrepant Genetic Architecture of Genome-Wide Gene Expression von Kaisaki, Pamela J, Otto, Georg W, Argoud, Karène, Collins, Stephan C, Wallis, Robert H, Wilder, Steven P, Yau, Anthony C Y, Hue, Christophe, Calderari, Sophie, Bihoreau, Marie-Thérèse, Cazier, Jean-Baptiste, Mott, Richard, Gauguier, Dominique

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Polymorphisms in Type II SH2 Domain–Containing Inositol 5-Phosphatase (INPPL1, SHIP2) Are Associated With Physiological Abnormalities of the Metabolic Syndrome von KAISAKI, Pamela J, DELEPINE, Marc, SCHURMANS, Stéphane, LEVY, Jonathan C, LATHROP, Mark, FARRALL, Martin, GAUGUIER, Dominique, WORN, Peng Y, SEBAG-MONTEFIORE, Liam, WILDER, Steven P, MENZEL, Stephan, VIONNET, Nathalie, MARION, Evelyne, RIVELINE, Jean-Pierre, CHARPENTIER, Guillaume

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Pathophysiological, genetic and gene expression features of a novel rodent model of the cardio-metabolic syndrome von Wallis, Robert H, Collins, Stephan C, Kaisaki, Pamela J, Argoud, Karène, Wilder, Steven P, Wallace, Karin J, Ria, Massimiliano, Ktorza, Alain, Rorsman, Patrik, Bihoreau, Marie-Thérèse, Gauguier, Dominique

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Comparative analysis of methods for gene transcription profiling data derived from different microarray technologies in rat and mouse models of diabetes von Wilder, Steven P, Kaisaki, Pamela J, Argoud, Karène, Salhan, Anita, Ragoussis, Jiannis, Bihoreau, Marie-Thérèse, Gauguier, Dominique

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Identification of Circulating Genomic and Metabolic Biomarkers in Intrahepatic Cholangiocarcinoma von Winter, Helen, Kaisaki, Pamela J, Harvey, Joe, Giacopuzzi, Edoardo, Ferla, Matteo P, Pentony, Melissa M, Knight, Samantha J L, Sharma, Ricky A, Taylor, Jenny C, McCullagh, James S O

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Mutation burden and other molecular markers of prognosis in colorectal cancer treated with curative intent: results from the QUASAR 2 clinical trial and an Australian community-bas... von Domingo, Enric, Camps, Carme, Kaisaki, Pamela J, Parsons, Marie J, Mouradov, Dmitri, Pentony, Melissa M, Makino, Seiko, Palmieri, Michelle, Ward, Robyn L, Hawkins, Nicholas J, Gibbs, Peter, Askautrud, Hanne, Oukrif, Dahmane, Wang, Haitao, Wood, Joe, Tomlinson, Evie, Bark, Yasmine, Kaur, Kulvinder, Johnstone, Elaine C, Palles, Claire, Church, David N, Novelli, Marco, Danielsen, Havard E, Sherlock, Jon, Kerr, David, Kerr, Rachel, Sieber, Oliver, Taylor, Jenny C, Tomlinson, Ian

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Mutations in the hepatocyte nuclear factor-4α gene in maturity-onset diabetes of the young (MODY1) von Yamagata, Kazuya, Furuta, Hiroto, Oda, Naohisa, Kaisaki, Pamela J, Menzel, Stephan, Cox, Nancy J, Fajans, Stefan S, Signorini, Stefano, Stoffel, Markus, Bell, Graeme I

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Mutations in the hepatocyte nuclear factor-1α gene in maturity-onset diabetes of the young (MODY3) von Yamagata, Kazuya, Oda, Naohisa, Kaisaki, Pamela J, Menzel, Stephan, Furuta, Hiroto, Vaxillaire, Martine, Southam, Lorraine, Cox, Roger D, Lathrop, G. Mark, Boriraj, V. Vicky, Chen, Xiangna, Cox, Nancy J, Oda, Yukie, Yano, Hideki, Le Beau, Michelle M, Yamada, Shirou, Nishigori, Hidekazu, Takeda, Jun, Fajans, Stefan S, Hattersley, Andrew T, Iwasaki, Naoko, Hansen, Torben, Pedersen, Oluf, Polonsky, Kenneth S, Turner, Robert C, Velho, Gilberto, Chèvre, Jean-Claude, Froguel, Philippe, Bell, Graeme I

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Functional annotations of diabetes nephropathy susceptibility loci through analysis of genome-wide renal gene expression in rat models of diabetes mellitus von Hu, Yaomin, Kaisaki, Pamela J, Argoud, Karène, Wilder, Steven P, Wallace, Karin J, Woon, Peng Y, Blancher, Christine, Tarnow, Lise, Groop, Per-Henrik, Hadjadj, Samy, Marre, Michel, Parving, Hans-Henrik, Farrall, Martin, Cox, Roger D, Lathrop, Mark, Vionnet, Nathalie, Bihoreau, Marie-Thérèse, Gauguier, Dominique

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Missense mutation in sterile alpha motif of novel protein SamCystin is associated with polycystic kidney disease in (cy/+) rat von Brown, Joanna H, Bihoreau, Marie-Thérèse, Hoffmann, Sigrid, Kränzlin, Bettina, Tychinskaya, Iulia, Obermüller, Nicholas, Podlich, Dirk, Boehn, Suzanne N, Kaisaki, Pamela J, Megel, Natalia, Danoy, Patrick, Copley, Richard R, Broxholme, John, Witzgall, Ralph, Lathrop, Mark, Gretz, Norbert, Gauguier, Dominique

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Broad-Ranging Natural Metabotype Variation Drives Physiological Plasticity in Healthy Control Inbred Rat Strains von Pontoizeau, Clément, Fearnside, Jane F, Navratil, Vincent, Domange, Céline, Cazier, Jean-Baptiste, Fernández-Santamaría, Cristina, Kaisaki, Pamela J, Emsley, Lyndon, Toulhoat, Pierre, Bihoreau, Marie-Thérèse, Nicholson, Jeremy K, Gauguier, Dominique, Dumas, Marc E

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