Neurofilament Light Chain in Blood and CSF as Marker of Disease Progression in Mouse Models and in Neurodegenerative Diseases von Bacioglu, Mehtap, Maia, Luis F., Preische, Oliver, Schelle, Juliane, Apel, Anja, Kaeser, Stephan A., Schweighauser, Manuel, Eninger, Timo, Lambert, Marius, Pilotto, Andrea, Shimshek, Derya R., Neumann, Ulf, Kahle, Philipp J., Staufenbiel, Matthias, Neumann, Manuela, Maetzler, Walter, Kuhle, Jens, Jucker, Mathias

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Loss of function of the mitochondrial peptidase PITRM1 induces proteotoxic stress and Alzheimer’s disease-like pathology in human cerebral organoids von Pérez, María José, Ivanyuk, Dina, Panagiotakopoulou, Vasiliki, Di Napoli, Gabriele, Kalb, Stefanie, Brunetti, Dario, Al-Shaana, Rawaa, Kaeser, Stephan A., Fraschka, Sabine Anne-Kristin, Jucker, Mathias, Zeviani, Massimo, Viscomi, Carlo, Deleidi, Michela

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Amyloid polymorphisms constitute distinct clouds of conformational variants in different etiological subtypes of Alzheimer’s disease von Rasmussen, Jay, Mahler, Jasmin, Beschorner, Natalie, Kaeser, Stephan A., Häsler, Lisa M., Baumann, Frank, Nyström, Sofie, Portelius, Erik, Blennow, Kaj, Lashley, Tammaryn, Fox, Nick C., Sepulveda-Falla, Diego, Glatzel, Markus, Oblak, Adrian L., Ghetti, Bernardino, Nilsson, K. Peter R., Hammarström, Per, Staufenbiel, Matthias, Walker, Lary C., Jucker, Mathias

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Peripherally Applied Aβ-Containing Inoculates Induce Cerebral β-Amyloidosis von Eisele, Yvonne S, Obermüller, Ulrike, Heilbronner, Götz, Baumann, Frank, Kaeser, Stephan A, Wolburg, Hartwig, Walker, Lary C, Staufenbiel, Matthias, Heikenwalder, Mathias, Jucker, Mathias

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Acute targeting of pre-amyloid seeds in transgenic mice reduces Alzheimer-like pathology later in life von Uhlmann, Ruth E., Rother, Christine, Rasmussen, Jay, Schelle, Juliane, Bergmann, Carina, Ullrich Gavilanes, Emily M., Fritschi, Sarah K., Buehler, Anika, Baumann, Frank, Skodras, Angelos, Al-Shaana, Rawaa, Beschorner, Natalie, Ye, Lan, Kaeser, Stephan A., Obermüller, Ulrike, Christensen, Søren, Kartberg, Fredrik, Stavenhagen, Jeffrey B., Rahfeld, Jens-Ulrich, Cynis, Holger, Qian, Fang, Weinreb, Paul H., Bussiere, Thierry, Walker, Lary C., Staufenbiel, Matthias, Jucker, Mathias

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Neurofilaments in spinocerebellar ataxia type 3: blood biomarkers at the preataxic and ataxic stage in humans and mice von Wilke, Carlo, Haas, Eva, Reetz, Kathrin, Faber, Jennifer, Garcia‐Moreno, Hector, Santana, Magda M, van de Warrenburg, Bart, Hengel, Holger, Lima, Manuela, Filla, Alessandro, Durr, Alexandra, Melegh, Bela, Masciullo, Marcella, Infante, Jon, Giunti, Paola, Neumann, Manuela, de Vries, Jeroen, Pereira de Almeida, Luis, Rakowicz, Maria, Jacobi, Heike, Schüle, Rebecca, Kaeser, Stephan A, Kuhle, Jens, Klockgether, Thomas, Schöls, Ludger, Barro, Christian, Hübener‐Schmid, Jeannette, Synofzik, Matthis, Deuschle, Christian, Stransky, Elke, Brockmann, Kathrin, Schulz, Jörg B, Baliko, Laszlo, van Gaalen, Judith, Raposo, Mafalda, Jeromin, Andreas

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CSF p-tau increase in response to Aβ-type and Danish-type cerebral amyloidosis and in the absence of neurofibrillary tangles von Kaeser, Stephan A., Häsler, Lisa M., Lambert, Marius, Bergmann, Carina, Bottelbergs, Astrid, Theunis, Clara, Mercken, Marc, Jucker, Mathias

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Experimental evidence for temporal uncoupling of brain Aβ deposition and neurodegenerative sequelae von Rother, Christine, Uhlmann, Ruth E., Müller, Stephan A., Schelle, Juliane, Skodras, Angelos, Obermüller, Ulrike, Häsler, Lisa M., Lambert, Marius, Baumann, Frank, Xu, Ying, Bergmann, Carina, Salvadori, Giulia, Loos, Maarten, Brzak, Irena, Shimshek, Derya, Neumann, Ulf, Walker, Lary C., Schultz, Stephanie A., Chhatwal, Jasmeer P., Kaeser, Stephan A., Lichtenthaler, Stefan F., Staufenbiel, Matthias, Jucker, Mathias

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Aβ42-driven cerebral amyloidosis in transgenic mice reveals early and robust pathology von Radde, Rebecca, Bolmont, Tristan, Kaeser, Stephan A, Coomaraswamy, Janaky, Lindau, Dennis, Stoltze, Lars, Calhoun, Michael E, Jäggi, Fabienne, Wolburg, Hartwig, Gengler, Simon, Haass, Christian, Ghetti, Bernardino, Czech, Christian, Hölscher, Christian, Mathews, Paul M, Jucker, Mathias

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Formation and maintenance of Alzheimer's disease β-amyloid plaques in the absence of microglia von Heppner, Frank L, Jucker, Mathias, Grathwohl, Stefan A, Kälin, Roland E, Bolmont, Tristan, Prokop, Stefan, Winkelmann, Georg, Kaeser, Stephan A, Odenthal, Jörg, Radde, Rebecca, Eldh, Therese, Gandy, Sam, Aguzzi, Adriano, Staufenbiel, Matthias, Mathews, Paul M, Wolburg, Hartwig

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Neurofilament Light Chain in Blood and CSF as Marker of Disease Progression in Mouse Models and in Neurodegenerative Diseases von Bacioglu, Mehtap, Maia, Luis F., Preische, Oliver, Schelle, Juliane, Apel, Anja, Kaeser, Stephan A., Schweighauser, Manuel, Eninger, Timo, Lambert, Marius, Pilotto, Andrea, Shimshek, Derya R., Neumann, Ulf, Kahle, Philipp J., Staufenbiel, Matthias, Neumann, Manuela, Maetzler, Walter, Kuhle, Jens, Jucker, Mathias

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Cerebrospinal fluid cytokine levels are associated with macrophage infiltration into tumor tissues of glioma patients von Kemmerer, Constanze L., Schittenhelm, Jens, Dubois, Evelyn, Neumann, Laura, Haesler, Lisa M., Lambert, Marius, Renovanz, Mirjam, Kaeser, Stephan A., Tabatabai, Ghazaleh, Ziemann, Ulf, Naumann, Ulrike, Kowarik, Markus C.

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Signatures of glial activity can be detected in the CSF proteome von Eninger, Timo, Müller, Stephan A, Bacioglu, Mehtap, Schweighauser, Manuel, Lambert, Marius, Maia, Luis F, Neher, Jonas J, Hornfeck, Sarah M, Obermüller, Ulrike, Kleinberger, Gernot, Haass, Christian, Kahle, Philipp J, Staufenbiel, Matthias, Ping, Lingyan, Duong, Duc M, Levey, Allan I, Seyfried, Nicholas T, Lichtenthaler, Stefan F, Jucker, Mathias, Kaeser, Stephan A

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Seeded strain-like transmission of β-amyloid morphotypes in APP transgenic mice von Heilbronner, Götz, Eisele, Yvonne S, Langer, Franziska, Kaeser, Stephan A, Novotny, Renata, Nagarathinam, Amudha, Åslund, Andreas, Hammarström, Per, Nilsson, K Peter R, Jucker, Mathias

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Aβ seeding potency peaks in the early stages of cerebral β‐amyloidosis von Ye, Lan, Rasmussen, Jay, Kaeser, Stephan A, Marzesco, Anne‐Marie, Obermüller, Ulrike, Mahler, Jasmin, Schelle, Juliane, Odenthal, Jörg, Krüger, Christian, Fritschi, Sarah K, Walker, Lary C, Staufenbiel, Matthias, Baumann, Frank, Jucker, Mathias

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Highly potent soluble amyloid-β seeds in human Alzheimer brain but not cerebrospinal fluid von FRITSCHI, Sarah K, LANGER, Franziska, SPITZER, Philipp, WILTFANG, Jens, SCHIERLE, Gabriele S. Kaminski, ZETTERBERG, Henrik, STAUFENBIEL, Matthias, JUCKER, Mathias, KAESER, Stephan A, MAIA, Luis F, PORTELIUS, Erik, PINOTSI, Dorothea, KAMINSKI, Clemens F, WINKLER, David T, MAETZLER, Walter, KEYVANI, Kathy

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Persistence of Aβ seeds in APP null mouse brain von Ye, Lan, Fritschi, Sarah K, Schelle, Juliane, Obermüller, Ulrike, Degenhardt, Karoline, Kaeser, Stephan A, Eisele, Yvonne S, Walker, Lary C, Baumann, Frank, Staufenbiel, Matthias, Jucker, Mathias

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Increased CSF Aβ during the very early phase of cerebral Aβ deposition in mouse models von Maia, Luis F, Kaeser, Stephan A, Reichwald, Julia, Lambert, Marius, Obermüller, Ulrike, Schelle, Juliane, Odenthal, Jörg, Martus, Peter, Staufenbiel, Matthias, Jucker, Mathias

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Early Aβ reduction prevents progression of cerebral amyloid angiopathy von Schelle, Juliane, Wegenast‐Braun, Bettina M., Fritschi, Sarah K., Kaeser, Stephan A., Jährling, Nina, Eicke, Daniel, Skodras, Angelos, Beschorner, Natalie, Obermueller, Ulrike, Häsler, Lisa M., Wolfer, David P., Mueggler, Thomas, Shimshek, Derya R., Neumann, Ulf, Dodt, Hans‐Ulrich, Staufenbiel, Matthias, Jucker, Mathias

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Prevention of tau increase in cerebrospinal fluid of APP transgenic mice suggests downstream effect of BACE1 inhibition von Schelle, Juliane, Häsler, Lisa M, Göpfert, Jens C, Joos, Thomas O, Vanderstichele, Hugo, Stoops, Erik, Mandelkow, Eva-Maria, Neumann, Ulf, Shimshek, Derya R, Staufenbiel, Matthias, Jucker, Mathias, Kaeser, Stephan A

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