TRPA1 Modulation of Spontaneous and Mechanically Evoked Firing of Spinal Neurons in Uninjured, Osteoarthritic, and Inflamed Rats von McGaraughty, Steve, Chu, Katharine L, Perner, Richard J, DiDomenico, Stan, Kort, Michael E, Kym, Philip R

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Selective blockade of TRPA1 channel attenuates pathological pain without altering noxious cold sensation or body temperature regulation von Chen, Jun, Joshi, Shailen K., DiDomenico, Stanley, Perner, Richard J., Mikusa, Joe P., Gauvin, Donna M., Segreti, Jason A., Han, Ping, Zhang, Xu-Feng, Niforatos, Wende, Bianchi, Bruce R., Baker, Scott J., Zhong, Chengmin, Simler, Gricelda H., McDonald, Heath A., Schmidt, Robert G., McGaraughty, Steve P., Chu, Katharine L., Faltynek, Connie R., Kort, Michael E., Reilly, Regina M., Kym, Philip R.

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Targeting TRP channels for pain relief von Brederson, Jill-Desiree, Kym, Philip R., Szallasi, Arpad

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Pore Dilation Occurs in TRPA1 but Not in TRPM8 Channels von Chen, Jun, Kim, Donghee, Bianchi, Bruce R, Cavanaugh, Eric J, Faltynek, Connie R, Kym, Philip R, Reilly, Regina M

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Molecular Determinants of Species-Specific Activation or Blockade of TRPA1 Channels von Chen, Jun, Zhang, Xu-Feng, Kort, Michael E, Huth, Jeffrey R, Sun, Chaohong, Miesbauer, Laura J, Cassar, Steven C, Neelands, Torben, Scott, Victoria E, Moreland, Robert B, Reilly, Regina M, Hajduk, Philip J, Kym, Philip R, Hutchins, Charles W, Faltynek, Connie R

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Validation of Diacyl Glycerolacyltransferase I as a Novel Target for the Treatment of Obesity and Dyslipidemia Using a Potent and Selective Small Molecule Inhibitor von Zhao, Gang, Souers, Andrew J, Voorbach, Martin, Falls, H. Doug, Droz, Brian, Brodjian, Sevan, Lau, Yau Yi, Iyengar, Rajesh R, Gao, Ju, Judd, Andrew S, Wagaw, Seble H, Ravn, Matthew M, Engstrom, Kenneth M, Lynch, John K, Mulhern, Mathew M, Freeman, Jennifer, Dayton, Brian D, Wang, Xiaojun, Grihalde, Nelson, Fry, Dennis, Beno, David W. A, Marsh, Kennan C, Su, Zhi, Diaz, Gilbert J, Collins, Christine A, Sham, Hing, Reilly, Regina M, Brune, Michael E, Kym, Philip R

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Discovery of Potent, Selective, Orally Bioavailable Stearoyl-CoA Desaturase 1 Inhibitors von Liu, Gang, Lynch, John K, Freeman, Jennifer, Liu, Bo, Xin, Zhili, Zhao, Hongyu, Serby, Michael D, Kym, Philip R, Suhar, Tom S, Smith, Harriet T, Cao, Ning, Yang, Ruojing, Janis, Rich S, Krauser, Joel A, Cepa, Steven P, Beno, David W. A, Sham, Hing L, Collins, Christine A, Surowy, Teresa K, Camp, Heidi S

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TRPV1-related modulation of spinal neuronal activity and behavior in a rat model of osteoarthritic pain von Chu, Katharine L, Chandran, Prasant, Joshi, Shailen K, Jarvis, Michael F, Kym, Philip R, McGaraughty, Steve

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Diacylglycerol Acyltransferase 1 Inhibition Lowers Serum Triglycerides in the Zucker Fatty Rat and the Hyperlipidemic Hamster von King, Andrew J, Segreti, Jason A, Larson, Kelly J, Souers, Andrew J, Kym, Philip R, Reilly, Regina M, Zhao, Gang, Mittelstadt, Scott W, Cox, Bryan F

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Foslevodopa/Foscarbidopa: A New Subcutaneous Treatment for Parkinson's Disease von Rosebraugh, Matthew, Voight, Eric A., Moussa, Ehab M., Jameel, Feroz, Lou, Xiaochun, Zhang, Geoff G. Z., Mayer, Peter T., Stolarik, Deanne, Carr, Robert A., Enright, Brian P., Liu, Wei, Facheris, Maurizio F., Kym, Philip R.

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Parkinson’s Disease: Advances in Treatment and the Syntheses of Various Classes of Pharmaceutical Drug Substances von Hill, David R., Huters, Alexander D., Towne, Timothy B., Reddy, Rajarathnam E., Fogle, Jace L., Voight, Eric A., Kym, Philip R.

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Synthesis and biological evaluation of 5-substituted and 4,5-disubstituted-2-arylamino oxazole TRPV1 antagonists von Perner, Richard J., Koenig, John R., DiDomenico, Stanley, Gomtsyan, Arthur, Schmidt, Robert G., Lee, Chih-Hung, Hsu, Margaret C., McDonald, Heath A., Gauvin, Donna M., Joshi, Shailen, Turner, Teresa M., Reilly, Regina M., Kym, Philip R., Kort, Michael E.

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Free Energy Perturbation Approach for Accurate Crystalline Aqueous Solubility Predictions von Hong, Richard S., Rojas, Ana V., Bhardwaj, Rajni Miglani, Wang, Lingle, Mattei, Alessandra, Abraham, Nathan S., Cusack, Kevin P., Pierce, M. Olivia, Mondal, Sayan, Mehio, Nada, Bordawekar, Shailendra, Kym, Philip R., Abel, Robert, Sheikh, Ahmad Y.

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Fueling the Pipeline via Innovations in Organic Synthesis von Voight, Eric A, Greszler, Stephen N, Kym, Philip R

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TRPV1 antagonist, A-889425, inhibits mechanotransmission in a subclass of rat primary afferent neurons following peripheral inflammation von Brederson, Jill-Desiree, Chu, Katharine L., Reilly, Regina M., Brown, Brian S., Kym, Philip R., Jarvis, Michael F., McGaraughty, Steve

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Antagonism of TRPV1 receptors indirectly modulates activity of thermoregulatory neurons in the medial preoptic area of rats von McGaraughty, Steve, Segreti, Jason A, Fryer, Ryan M, Brown, Brian S, Faltynek, Connie R, Kym, Philip R

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Biological Characterization of F508delCFTR Protein Processing by the CFTR Corrector ABBV-2222/GLPG2222 von Singh, Ashvani K., Fan, Yihong, Balut, Corina, Alani, Sara, Manelli, Arlene M., Swensen, Andrew M., Jia, Ying, Neelands, Torben R., Vortherms, Timothy A., Liu, Bo, Searle, Xenia B., Wang, Xueqing, Gao, Wenqing, Hwang, Tzyh-Chang, Ren, Hong Y., Cyr, Douglas, Kym, Philip R., Conrath, Katja, Tse, Chris

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Nonsteroidal Selective Glucocorticoid Modulators:  The Effect of C-10 Substitution on Receptor Selectivity and Functional Potency of 5-Allyl-2,5-dihydro-2,2,4-trimethyl-1H-[1]benzo... von Kym, Philip R, Kort, Michael E, Coghlan, Michael J, Moore, Jimmie L, Tang, Rui, Ratajczyk, James D, Larson, Daniel P, Elmore, Steven W, Pratt, John K, Stashko, Michael A, Falls, H. Douglass, Lin, Chun W, Nakane, Masake, Miller, Loan, Tyree, Curtis M, Miner, Jeffery N, Jacobson, Peer B, Wilcox, Denise M, Nguyen, Phong, Lane, Benjamin C

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Transient receptor potential channel ankyrin-1 is not a cold sensor for autonomic thermoregulation in rodents von de Oliveira, Cristiane, Garami, Andras, Lehto, Sonya G, Pakai, Eszter, Tekus, Valeria, Pohoczky, Krisztina, Youngblood, Beth D, Wang, Weiya, Kort, Michael E, Kym, Philip R, Pinter, Erika, Gavva, Narender R, Romanovsky, Andrej A

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Analgesic potential of TRPV1 antagonists von Kym, Philip R., Kort, Michael E., Hutchins, Charles W.

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