Applications of Fluorine in Medicinal Chemistry von Gillis, Eric P, Eastman, Kyle J, Hill, Matthew D, Donnelly, David J, Meanwell, Nicholas A

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Scalable Total Syntheses of N-Linked Tryptamine Dimers by Direct Indole−Aniline Coupling: Psychotrimine and Kapakahines B and F von Newhouse, Timothy, Lewis, Chad A, Eastman, Kyle J, Baran, Phil S

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Regulated induced proximity targeting chimeras—RIPTACs—A heterobifunctional small molecule strategy for cancer selective therapies von Raina, Kanak, Forbes, Chris D., Stronk, Rebecca, Rappi, Jonathan P., Eastman, Kyle J., Zaware, Nilesh, Yu, Xinheng, Li, Hao, Bhardwaj, Amit, Gerritz, Samuel W., Forgione, Mia, Hundt, Abigail, King, Madeline P., Posner, Zoe M., Correia, Allison D., McGovern, Andrew, Puleo, David E., Chenard, Rebekka, Mousseau, James J., Vergara, J. Ignacio, Garvin, Ethan, Macaluso, Jennifer, Martin, Michael, Bassoli, Kyle, Jones, Kelli, Garcia, Marco, Howard, Katia, Yaggi, Madeleine, Smith, Levi M., Chen, Jinshan M., Mayfield, Andrew B., De Leon, Cesar A., Hines, John, Kayser-Bricker, Katherine J., Crews, Craig M.

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Ferrocene-based inhibitors of hepatitis C virus replication that target NS5A with low picomolar in vitro antiviral activity von Gadhachanda, Venkat R., Eastman, Kyle J., Wang, Qiuping, Phadke, Avinash S., Patel, Dharaben, Yang, Wengang, Marlor, Christopher W., Deshpande, Milind, Huang, Mingjun, Wiles, Jason A.

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Studies on the Mechanism of Action of Prekinamycin, a Member of the Diazoparaquinone Family of Natural Products:  Evidence for Both sp2 Radical and Orthoquinonemethide Intermediate... von Feldman, Ken S, Eastman, Kyle J

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Phosphocholine conjugation: an unexpected in vivo conjugation pathway associated with hepatitis c ns5b inhibitors featuring a bicyclo[1.1.1]pentane von Zhuo, Xiaoliang, Cantone, Joseph L, Wang, Yingzi, Leet, John E, Drexler, Dieter M, Yeung, Kap-Sun, Huang, Xiaohua Stella, Eastman, Kyle J, Parcella, Kyle E, Mosure, Kathleen W, Soars, Matthew G, Kadow, John F, Johnson, Benjamin M

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The discovery of a pan-genotypic, primer grip inhibitor of HCV NS5B polymerase von Eastman, Kyle J, Parcella, Kyle, Yeung, Kap-Sun, Grant-Young, Katharine A, Zhu, Juliang, Wang, Tao, Zhang, Zhongxing, Yin, Zhiwei, Beno, Brett R, Sheriff, Steven, Kish, Kevin, Tredup, Jeffrey, Jardel, Adam G, Halan, Vivek, Ghosh, Kaushik, Parker, Dawn, Mosure, Kathy, Fang, Hua, Wang, Ying-Kai, Lemm, Julie, Zhuo, Xiaoliang, Hanumegowda, Umesh, Rigat, Karen, Donoso, Maria, Tuttle, Maria, Zvyaga, Tatyana, Haarhoff, Zuzana, Meanwell, Nicholas A, Soars, Matthew G, Roberts, Susan B, Kadow, John F

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Identification of a novel series of potent HCV NS5B Site I inhibitors von Eastman, Kyle J, Yang, Zhong, Bender, John A, Mosure, Kathy, Lemm, Julie A, Meanwell, Nicholas A, Roberts, Susan B, Knipe, Jay, Kadow, John F

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A Proposal for the Mechanism-of-Action of Diazoparaquinone Natural Products von Feldman, Ken S, Eastman, Kyle J

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Diazonamide Synthesis Studies:  Use of Negishi Coupling to Fashion Diazonamide-Related Biaryls with Defined Axial Chirality von Feldman, Ken S, Eastman, Kyle J, Lessene, Guillaume

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An oral androgen receptor RIPTAC for prostate cancer von Raina, Kanak, Eastman, Kyle J, Yu, Xinheng, Forbes, Chris D, Jones, Kelli M, Mousseau, James J, Li, Hao, Kayser-Bricker, Katherine J, Crews, Craig M

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Abstract 1629: Prostate cancer RIPTAC™ therapeutics demonstrate activity in preclinical models of Enzalutamide-resistant prostate cancer von Yu, Xinheng, Eastman, Kyle J., Raina, Kanak, Jones, Kelli M., Forbes, Chris D., Hundt, Abigail, Garcia, Marco, Stronk, Rebecca, Howard, Katia, McGovern, Andrew, Chenard, Rebekka, Denny, Allison, Forgione, Mia, Bassoli, Kyle, Garvin, Ethan, Mousseau, James J., Li, Hao, King, Madeline P., Bhardwaj, Amit, Kayser-Bricker, Katherine J., Crews, Craig M.

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ChemInform Abstract: Widman-Stoermer Cinnoline Synthesis von Eastman, Kyle J.

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ChemInform Abstract: Robinson-Schoepf Condensation von Eastman, Kyle J.

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Studies on the Mechanism of Action of Prekinamycin, a Member of the Diazoparaquinone Family of Natural Products:  Evidence for Both sp 2 Radical and Orthoquinonemethide Intermediat... von Feldman, Ken S., Eastman, Kyle J.

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The discovery of a pan-genotypic, primer grip inhibitor of HCV NS5B polymeraseThe authors declare no competing interests.Electronic supplementary information (ESI) available. See D... von Eastman, Kyle J, Parcella, Kyle, Yeung, Kap-Sun, Grant-Young, Katharine A, Zhu, Juliang, Wang, Tao, Zhang, Zhongxing, Yin, Zhiwei, Beno, Brett R, Sheriff, Steven, Kish, Kevin, Tredup, Jeffrey, Jardel, Adam G, Halan, Vivek, Ghosh, Kaushik, Parker, Dawn, Mosure, Kathy, Fang, Hua, Wang, Ying-Kai, Lemm, Julie, Zhuo, Xiaoliang, Hanumegowda, Umesh, Rigat, Karen, Donoso, Maria, Tuttle, Maria, Zvyaga, Tatyana, Haarhoff, Zuzana, Meanwell, Nicholas A, Soars, Matthew G, Roberts, Susan B, Kadow, John F

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The discovery of a pan-genotypic, primer grip inhibitor of HCV NS5B polymerase† †The authors declare no competing interests. ‡ ‡Electronic supplementary information (ESI) available... von Eastman, Kyle J., Parcella, Kyle, Yeung, Kap-Sun, Grant-Young, Katharine A., Zhu, Juliang, Wang, Tao, Zhang, Zhongxing, Yin, Zhiwei, Beno, Brett R., Sheriff, Steven, Kish, Kevin, Tredup, Jeffrey, Jardel, Adam G., Halan, Vivek, Ghosh, Kaushik, Parker, Dawn, Mosure, Kathy, Fang, Hua, Wang, Ying-Kai, Lemm, Julie, Zhuo, Xiaoliang, Hanumegowda, Umesh, Rigat, Karen, Donoso, Maria, Tuttle, Maria, Zvyaga, Tatyana, Haarhoff, Zuzana, Meanwell, Nicholas A., Soars, Matthew G., Roberts, Susan B., Kadow, John F.

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Studies on the mechanism of action of prekinamycin, a member of the diazoparaquinone family of natural products : Evidence for both sp2radical and orthoquinonemethide intermediates von FELDMAN, Ken S, EASTMAN, Kyle J

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PHARMACEUTICAL COMPOUNDS FOR THE TREATMENT OF COMPLEMENT MEDIATED DISORDERS von GADHACHANDA, Venkat, Rao, WILES, Jason, Allan, EASTMAN, Kyle, J

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PHARMACEUTICAL COMPOUNDS FOR THE TREATMENT OF COMPLEMENT MEDIATED DISORDERS von Wiles, Jason Allan, Eastman, Kyle J, Gadhachanda, Venkat Rao

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