Inhibition of Crystal Nucleation and Growth by Water-Soluble Polymers and its Impact on the Supersaturation Profiles of Amorphous Drugs von Ozaki, Shunsuke, Kushida, Ikuo, Yamashita, Taro, Hasebe, Takashi, Shirai, Osamu, Kano, Kenji

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Crystal structure and dehydration behavior of E6070, a novel IKKβ protein kinase inhibitor for the treatment of rheumatoid arthritis von Kushida, Ikuo

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Solvent shift method for anti-precipitant screening of poorly soluble drugs using biorelevant medium and dimethyl sulfoxide von Yamashita, Taro, Ozaki, Shunsuke, Kushida, Ikuo

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Quantitative crystallinity determination for E1010, a novel carbapenem antibiotic, using differential scanning calorimetry von Kushida, Ikuo

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Supersaturation–Nucleation Behavior of Poorly Soluble Drugs and its Impact on the Oral Absorption of Drugs in Thermodynamically High-Energy Forms von Ozaki, Shunsuke, Minamisono, Takuma, Yamashita, Taro, Kato, Takashi, Kushida, Ikuo

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Investigation for the amorphous state of ER-34122, a dual 5-lipoxygenase/cyclooxygenase inhibitor with poor aqueous solubility, in HPMC solid dispersion prepared by the solvent eva... von Kushida, Ikuo, Gotoda, Masaharu

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E7386, a Selective Inhibitor of the Interaction between beta-Catenin and CBP, Exerts Antitumor Activity in Tumor Models with Activated Canonical Wnt Signaling von Yamada, Kazuhiko, Hori, Yusaku, Inoue, Satoshi, Yamamoto, Yuji, Iso, Kentaro, Kamiyama, Hiroshi, Yamaguchi, Atsumi, Kimura, Takayuki, Uesugi, Mai, Ito, Junichi, Matsuki, Masahiro, Nakamoto, Kazutaka, Harada, Hitoshi, Yoneda, Naoki, Takemura, Atsushi, Kushida, Ikuo, Wakayama, Naomi, Kubara, Kenji, Kato, Yu, Semba, Taro, Yokoi, Akira, Matsukura, Masayuki, Odagami, Takenao, Iwata, Masao, Tsuruoka, Akihiko, Uenaka, Toshimitsu, Matsui, Junji, Matsushima, Tomohiro, Nomoto, Kenichi, Kouji, Hiroyuki, Owa, Takashi, Funahashi, Yasuhiro, Ozawa, Yoichi

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Solid State Characterization of E2101, A Novel Antispastic Drug von Kushida, Ikuo, Ashizawa, Kazuhide

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Evaluation of Drug Supersaturation by Thermodynamic and Kinetic Approaches for the Prediction of Oral Absorbability in Amorphous Pharmaceuticals von Ozaki, Shunsuke, Kushida, Ikuo, Yamashita, Taro, Hasebe, Takashi, Shirai, Osamu, Kano, Kenji

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Design, synthesis, and structure–activity relationships of a series of novel N-aryl-2-phenylcyclopropanecarboxamide that are potent and orally active orexin receptor antagonists von Yoshida, Yu, Terauchi, Taro, Naoe, Yoshimitsu, Kazuta, Yuji, Ozaki, Fumihiro, Beuckmann, Carsten T., Nakagawa, Makoto, Suzuki, Michiyuki, Kushida, Ikuo, Takenaka, Osamu, Ueno, Takashi, Yonaga, Masahiro

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Frozen water phase method for log D measurement using a 96-well plate von Yamashita, Taro, Yamamoto, Eiichi, Kushida, Ikuo

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Frozen water phase method for logD measurement using a 96-well plate von Yamashita, Taro, Yamamoto, Eiichi, Kushida, Ikuo

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Corrigendum to “Design, synthesis, and structure–activity relationships of a series of novel N-aryl-2-phenylcyclopropanecarboxamide that are potent and orally active orexin recepto... von Yoshida, Yu, Terauchi, Taro, Naoe, Yoshimitsu, Kazuta, Yuji, Ozaki, Fumihiro, Beuckmann, Carsten T., Nakagawa, Makoto, Suzuki, Michiyuki, Kushida, Ikuo, Takenaka, Osamu, Ueno, Takashi, Yonaga, Masahiro

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Improvement of Dissolution and Oral Absorption of ER-34122, A Poorly Water-Soluble Dual 5-Lipoxygenase/Cyclooxygenase Inhibitor With Anti-Inflammatory Activity by Preparing Solid D... von Kushida, Ikuo, Ichikawa, Masaki, Asakawa, Naoki

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CRYSTAL OF (6S,9AS)-N-BENZYL-8-({6-[3-(4-ETHYLPIPERAZIN-1-YL)AZETIDIN-1-YL]PYRIDIN-2-YL}METHYL)-6-(2-FLUORO-4-HYDROXYBENZYL)-4,7-DIOXO-2-(PROP-2-EN-1-YL)HEXAHYDRO-2H-PYRAZINO[2,1-C... von KUSHIDA, IKUO, ITO, YOKO

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Crystal of (6S,9aS)-N-benzyl-8-({6-[3-(4-ethylpiperazin-1-yl)azetidin-1-yl]pyridin-2-yl}methyl)-6-(2-fluoro-4-hydroxybenzyl)-4,7-dioxo-2-(prop-2-en-1-yl)hexahydro-2H-pyrazino[2,1-c... von KUSHIDA Ikuo, ITO Yoko

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SALT OF HETEROCYCLIC COMPOUND WITH ANTI-MALARIA ACTIVITY, AND CRYSTALS THEREOF von SHIBUGUCHI Nao, KOMURA Fusae, KUSHIDA Ikuo

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Reliable on-line sample preparation of basic compounds from plasma using a reversed phase restricted access media in column-switching LC von Yamamoto, Eiichi, Igarashi, Hatsue, Sato, Yoshiaki, Kushida, Ikuo, Kato, Takashi, Kajima, Takashi, Asakawa, Naoki

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Crystal of (6S,9aS)-N-benzyl-8-({6-[3-(4-ethylpiperazin-1- yl)azetidin-1-yl]pyridin-2-yl}methyl)-6-(2-fluoro-4- hydroxybenzyl)-4,7-dioxo-2-(prop-2-en-1-yl)hexahydro-2Hpyrazino[ 2,1... von Ito, Yoko, Kushida, Ikuo

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Effective on-line purification for cationic compounds in rat bile using a column-switching LC technique von Sakaguchi, Takahisa, Yamamoto, Eiichi, Kushida, Ikuo, Kajima, Takashi, Asakawa, Naoki

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