MYCN -Amplified Neuroblastoma Is Addicted to Iron and Vulnerable to Inhibition of the System Xc-/Glutathione Axis von Floros, Konstantinos V, Cai, JinYang, Jacob, Sheeba, Kurupi, Richard, Fairchild, Carter K, Shende, Mayuri, Coon, Colin M, Powell, Krista M, Belvin, Benjamin R, Hu, Bin, Puchalapalli, Madhavi, Ramamoorthy, Sivapriya, Swift, Kimberly, Lewis, Janina P, Dozmorov, Mikhail G, Glod, John, Koblinski, Jennifer E, Boikos, Sosipatros A, Faber, Anthony C

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Molecular profiling of the residual disease of triple-negative breast cancers after neoadjuvant chemotherapy identifies actionable therapeutic targets von Balko, Justin M, Giltnane, Jennifer M, Wang, Kai, Schwarz, Luis J, Young, Christian D, Cook, Rebecca S, Owens, Phillip, Sanders, Melinda E, Kuba, Maria G, Sánchez, Violeta, Kurupi, Richard, Moore, Preston D, Pinto, Joseph A, Doimi, Franco D, Gómez, Henry, Horiuchi, Dai, Goga, Andrei, Lehmann, Brian D, Bauer, Joshua A, Pietenpol, Jennifer A, Ross, Jeffrey S, Palmer, Gary A, Yelensky, Roman, Cronin, Maureen, Miller, Vincent A, Stephens, Phillip J, Arteaga, Carlos L

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High-risk neuroblastoma with NF1 loss of function is targetable using SHP2 inhibition von Cai, Jinyang, Jacob, Sheeba, Kurupi, Richard, Dalton, Krista M., Coon, Colin, Greninger, Patricia, Egan, Regina K., Stein, Giovanna T., Murchie, Ellen, McClanaghan, Joseph, Adachi, Yuta, Hirade, Kentaro, Dozmorov, Mikhail, Glod, John, Boikos, Sosipatros A., Ebi, Hiromichi, Hao, Huaixiang, Caponigro, Giordano, Benes, Cyril H., Faber, Anthony C.

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Targeting transcription of MCL-1 sensitizes HER2-amplified breast cancers to HER2 inhibitors von Floros, Konstantinos V., Jacob, Sheeba, Kurupi, Richard, Fairchild, Carter K., Hu, Bin, Puchalapalli, Madhavi, E. Koblinski, Jennifer, Dozmorov, Mikhail G., Boikos, Sosipatros A., Scaltriti, Maurizio, Faber, Anthony C.

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SHP2 inhibition-based combination targeted therapies for molecularly defined subgroups of HNSCC patients von KURUPI, RICHARD

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Activation of MAPK Pathways due to DUSP4 Loss Promotes Cancer Stem Cell-like Phenotypes in Basal-like Breast Cancer von BALKO, Justin M, SCHWARZ, Luis J, BHOLA, Neil E, KURUPI, Richard, OWENS, Phillip, MILLER, Todd W, GOMEZ, Henry, COOK, Rebecca S, ARTEAGA, Carlos L

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Catastrophic ATP loss underlies a metabolic combination therapy tailored for MYCN-amplified neuroblastoma von Dalton, Krista M., Lochmann, Timothy L., Floros, Konstantinos V., Calbert, Marissa L., Kurupi, Richard, Stein, Giovanna T., McClanaghan, Joseph, Murchie, Ellen, Egan, Regina K., Greninger, Patricia, Dozmorov, Mikhail, Ramamoorthy, Sivapriya, Puchalapalli, Madhavi, Hu, Bin, Shock, Lisa, Koblinski, Jennifer, Glod, John, Boikos, Sosipatros A., Benes, Cyril H., Faber, Anthony C.

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Combination of Antibody That Inhibits Ligand-Independent HER3 Dimerization and a p110α Inhibitor Potently Blocks PI3K Signaling and Growth of HER2+ Breast Cancers von GARRETT, Joan T, SUTTON, Cammie R, KURUPI, Richard, BIALUCHA, Carl Uli, ETTENBERG, Seth A, COLLINS, Scott D, QING SHENG, WALLWEBER, Jerry, DEFAZIO-ELI, Lisa, ARTEAGA, Carlos L

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Pharmaceutical Interference of the EWS-FLI1-driven Transcriptome By Cotargeting H3K27ac and RNA Polymerase Activity in Ewing Sarcoma von Heisey, Daniel A R, Jacob, Sheeba, Lochmann, Timothy L, Kurupi, Richard, Ghotra, Maninderjit S, Calbert, Marissa L, Shende, Mayuri, Maves, Yuki Kato, Koblinski, Jennifer E, Dozmorov, Mikhail G, Boikos, Sosipatros A, Benes, Cyril H, Faber, Anthony C

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Venetoclax-based Rational Combinations are Effective in Models of MYCN -amplified Neuroblastoma von Dalton, Krista M, Krytska, Kateryna, Lochmann, Timothy L, Sano, Renata, Casey, Colleen, D'Aulerio, Alessia, Khan, Qasim A, Crowther, Giovanna Stein, Coon, Colin, Cai, Jinyang, Jacob, Sheeba, Kurupi, Richard, Hu, Bin, Dozmorov, Mikhail, Greninger, Patricia, Souers, Andrew J, Benes, Cyril H, Mossé, Yael P, Faber, Anthony C

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Abstract PO-024: Catastrophic ATP loss underlines a metabolic combination therapy tailored for MYCN-amplified neuroblastoma von Powell, Krista M., Lochmann, Timonthy L., Floros, Konstantinos V., Calbert, Marissa L., Kurupi, Richard, Stein, Giovanna T., McClanaghan, Joseph, Murchie, Ellen, Egan, Regina K., Greninger, Patricia, Dozmorov, Mikhail, Ramamoorthy, Sivapriya, Puchalapalli, Madhavi, Hu, Bin, Shock, Lisa, Koblisnski, Jennifer, Glod, John, Boikos, Sosipatros A., Benes, Cyril H., Faber, Anthony C.

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Abstract 362: MYCN -amplified neuroblastoma is addicted to iron and vulnerable to ferroptosis von Floros, Konstantinos V., Johnson-Berro, Mia O., Kurupi, Richard, Fairchild, Carter K., Dalton, Krista, Hu, Bin, Puchalapalli, Madhavi, Dozmorov, Mikhail G., Koblinski, Jennifer E., Olzmann, James A., Cowart, Lauren A., Faber, Anthony C.

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Pharmacologic Inhibition of SHP2 Blocks Both PI3K and MEK Signaling in Low-epiregulin HNSCC via GAB1 von Kurupi, Richard, Floros, Konstantinos V, Jacob, Sheeba, Chawla, Ayesha T, Cai, Jinyang, Hu, Bin, Puchalapalli, Madhavi, Coon, Colin M, Khatri, Rishabh, Crowther, Giovanna Stein, Egan, Regina K, Murchie, Ellen, Greninger, Patricia, Dalton, Krista M, Ghotra, Maninderjit S, Boikos, Sosipatros A, Koblinski, Jennifer E, Harada, Hisashi, Sun, Yue, Morgan, Iain M, Basu, Devraj, Dozmorov, Mikhail G, Benes, Cyril H, Faber, Anthony C

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