Developing a new class of engineered live bacterial therapeutics to treat human diseases von Charbonneau, Mark R., Isabella, Vincent M., Li, Ning, Kurtz, Caroline B.

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Development of a synthetic live bacterial therapeutic for the human metabolic disease phenylketonuria von Isabella, Vincent M, Ha, Binh N, Castillo, Mary Joan, Lubkowicz, David J, Rowe, Sarah E, Millet, Yves A, Anderson, Cami L, Li, Ning, Fisher, Adam B, West, Kip A, Reeder, Philippa J, Momin, Munira M, Bergeron, Christopher G, Guilmain, Sarah E, Miller, Paul F, Kurtz, Caroline B, Falb, Dean

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Linaclotide Inhibits Colonic Nociceptors and Relieves Abdominal Pain via Guanylate Cyclase-C and Extracellular Cyclic Guanosine 3′,5′-Monophosphate von Castro, Joel, Harrington, Andrea M, Hughes, Patrick A, Martin, Christopher M, Ge, Pei, Shea, Courtney M, Jin, Hong, Jacobson, Sarah, Hannig, Gerhard, Mann, Elizabeth, Cohen, Mitchell B, MacDougall, James E, Lavins, Bernard J, Kurtz, Caroline B, Silos-Santiago, Inmaculada, Johnston, Jeffrey M, Currie, Mark G, Blackshaw, L. Ashley, Brierley, Stuart M

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Two Randomized Trials of Linaclotide for Chronic Constipation von Lembo, Anthony J, Schneier, Harvey A, Shiff, Steven J, Kurtz, Caroline B, MacDougall, James E, Jia, Xinwei D, Shao, James Z, Lavins, Bernard J, Currie, Mark G, Fitch, Donald A, Jeglinski, Brenda I, Eng, Paul, Fox, Susan M, Johnston, Jeffrey M

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An engineered bacterial therapeutic lowers urinary oxalate in preclinical models and in silico simulations of enteric hyperoxaluria von Lubkowicz, David, Horvath, Nicholas G, James, Michael J, Cantarella, Pasquale, Renaud, Lauren, Bergeron, Christopher G, Shmueli, Ron B, Anderson, Cami, Gao, Jian‐Rong, Kurtz, Caroline B, Perreault, Mylene, Charbonneau, Mark R, Isabella, Vincent M, Hava, David L

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Linaclotide in Chronic Idiopathic Constipation Patients with Moderate to Severe Abdominal Bloating: A Randomized, Controlled Trial von Lacy, Brian E, Schey, Ron, Shiff, Steven J, Lavins, Bernard J, Fox, Susan M, Jia, Xinwei D, Blakesley, Rick E, Hao, Xinming, Cronin, Jacquelyn A, Currie, Mark G, Kurtz, Caroline B, Johnston, Jeffrey M, Lembo, Anthony J

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Linaclotide, through activation of guanylate cyclase C, acts locally in the gastrointestinal tract to elicit enhanced intestinal secretion and transit von Busby, Robert W., Bryant, Alexander P., Bartolini, Wilmin P., Cordero, Etchell A., Hannig, Gerhard, Kessler, Marco M., Mahajan-Miklos, Shalina, Pierce, Christine M., Solinga, Robert M., Sun, Li Jing, Tobin, Jenny V., Kurtz, Caroline B., Currie, Mark G.

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Guanylate cyclase-C/cGMP: an emerging pathway in the regulation of visceral pain von Hannig, Gerhard, Tchernychev, Boris, Kurtz, Caroline B, Bryant, Alexander P, Currie, Mark G, Silos-Santiago, Inmaculada

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Linaclotide Improves Abdominal Pain and Bowel Habits in a Phase IIb Study of Patients With Irritable Bowel Syndrome With Constipation von Johnston, Jeffrey M, Kurtz, Caroline B, MacDougall, James E, Lavins, Bernard J, Currie, Mark G, Fitch, Donald A, O'Dea, Chris, Baird, Mollie, Lembo, Anthony J

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Guanylate cyclase 2C agonism corrects CFTR mutants von Arora, Kavisha, Huang, Yunjie, Mun, Kyushik, Yarlagadda, Sunitha, Sundaram, Nambirajan, Kessler, Marco M, Hannig, Gerhard, Kurtz, Caroline B, Silos-Santiago, Inmaculada, Helmrath, Michael, Palermo, Joseph J, Clancy, John P, Steinbrecher, Kris A, Naren, Anjaparavanda P

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Efficacy of Linaclotide for Patients With Chronic Constipation von Lembo, Anthony J, Kurtz, Caroline B, MacDougall, James E, Lavins, B.J, Currie, Mark G, Fitch, Donald A, Jeglinski, Brenda I, Johnston, Jeffrey M

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Pharmacologic properties, metabolism, and disposition of linaclotide, a novel therapeutic peptide approved for the treatment of irritable bowel syndrome with constipation and chron... von Busby, Robert W, Kessler, Marco M, Bartolini, Wilmin P, Bryant, Alexander P, Hannig, Gerhard, Higgins, Carolyn S, Solinga, Robert M, Tobin, Jenny V, Wakefield, James D, Kurtz, Caroline B, Currie, Mark G

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Safety and pharmacodynamics of an engineered E. coli Nissle for the treatment of phenylketonuria: a first-in-human phase 1/2a study von Puurunen, Marja K., Vockley, Jerry, Searle, Shawn L., Sacharow, Stephanie J., Phillips, John A., Denney, William S., Goodlett, Benjamin D., Wagner, David A., Blankstein, Larry, Castillo, Mary J., Charbonneau, Mark R., Isabella, Vincent M., Sethuraman, Vasu V., Riese, Richard J., Kurtz, Caroline B., Brennan, Aoife M.

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Genetically engineered E. coli Nissle attenuates hyperammonemia and prevents memory impairment in bile‐duct ligated rats von Ochoa‐Sanchez, Rafael, Oliveira, Mariana M., Tremblay, Mélanie, Petrazzo, Grégory, Pant, Asha, Bosoi, Cristina R., Perreault, Mylene, Querbes, William, Kurtz, Caroline B., Rose, Christopher F.

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Effect of 5 Days Linaclotide on Transit and Bowel Function in Females With Constipation-Predominant Irritable Bowel Syndrome von Andresen, Viola, Camilleri, Michael, Busciglio, Irene A, Grudell, April, Burton, Duane, McKinzie, Sanna, Foxx–Orenstein, Amy, Kurtz, Caroline B, Sharma, Vineeta, Johnston, Jeffrey M, Currie, Mark G, Zinsmeister, Alan R

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Linaclotide is a potent and selective guanylate cyclase C agonist that elicits pharmacological effects locally in the gastrointestinal tract von Bryant, Alexander P., Busby, Robert W., Bartolini, Wilmin P., Cordero, Etchell A., Hannig, Gerhard, Kessler, Marco M., Pierce, Christine M., Solinga, Robert M., Tobin, Jenny V., Mahajan-Miklos, Shalina, Cohen, Mitchell B., Kurtz, Caroline B., Currie, Mark G.

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Effect of Linaclotide on Severe Abdominal Symptoms in Patients With Irritable Bowel Syndrome With Constipation von Rao, Satish S.C, Quigley, Eamonn M.M, Shiff, Steven J, Lavins, Bernard J, Kurtz, Caroline B, MacDougall, James E, Currie, Mark G, Johnston, Jeffrey M

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Chronic linaclotide treatment reduces colitis-induced neuroplasticity and reverses persistent bladder dysfunction von Grundy, Luke, Harrington, Andrea M, Castro, Joel, Garcia-Caraballo, Sonia, Deiteren, Annemie, Maddern, Jessica, Rychkov, Grigori Y, Ge, Pei, Peters, Stefanie, Feil, Robert, Miller, Paul, Ghetti, Andre, Hannig, Gerhard, Kurtz, Caroline B, Silos-Santiago, Inmaculada, Brierley, Stuart M

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MRP4 Modulation of the Guanylate Cyclase-C/cGMP Pathway: Effects on Linaclotide-Induced Electrolyte Secretion and cGMP Efflux von Tchernychev, Boris, Ge, Pei, Kessler, Marco M, Solinga, Robert M, Wachtel, Derek, Tobin, Jenny V, Thomas, Sara R, Lunte, Craig E, Fretzen, Angelika, Hannig, Gerhard, Bryant, Alexander P, Kurtz, Caroline B, Currie, Mark G, Silos-Santiago, Inmaculada

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561 Chronic Oral Administration of the Guanylate Cyclase-C Agonist Linaclotide Attenuates Colitis Induced Bladder Afferent Hyperactivity von Grundy, Luke A, Garcia-Carraballo, Sonia, Maddern, Jessica, Rychkov, Grigori, Hannig, Gerhard, Kurtz, Caroline B, Silos-Santiago, Ada, Brierley, Stuart

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