White-to-brown metabolic conversion of human adipocytes by JAK inhibition von Moisan, Annie, Lee, Youn-Kyoung, Zhang, Jitao David, Hudak, Carolyn S., Meyer, Claas A., Prummer, Michael, Zoffmann, Sannah, Truong, Hoa Hue, Ebeling, Martin, Kiialainen, Anna, Gérard, Régine, Xia, Fang, Schinzel, Robert T., Amrein, Kurt E., Cowan, Chad A.

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A novel antibiotic class targeting the lipopolysaccharide transporter von Zampaloni, Claudia, Mattei, Patrizio, Bleicher, Konrad, Winther, Lotte, Thäte, Claudia, Bucher, Christian, Adam, Jean-Michel, Alanine, Alexander, Amrein, Kurt E., Baidin, Vadim, Bieniossek, Christoph, Bissantz, Caterina, Boess, Franziska, Cantrill, Carina, Clairfeuille, Thomas, Dey, Fabian, Di Giorgio, Patrick, du Castel, Pauline, Dylus, David, Dzygiel, Pawel, Felici, Antonio, García-Alcalde, Fernando, Haldimann, Andreas, Leipner, Matthew, Leyn, Semen, Louvel, Séverine, Misson, Pauline, Osterman, Andrei, Pahil, Karanbir, Rigo, Sébastien, Schäublin, Adrian, Scharf, Sebastian, Schmitz, Petra, Stoll, Theodor, Trauner, Andrej, Zoffmann, Sannah, Kahne, Daniel, Young, John A. T., Lobritz, Michael A., Bradley, Kenneth A.

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Machine learning-powered antibiotics phenotypic drug discovery von Zoffmann, Sannah, Vercruysse, Maarten, Benmansour, Fethallah, Maunz, Andreas, Wolf, Luise, Blum Marti, Rita, Heckel, Tobias, Ding, Haiyuan, Truong, Hoa Hue, Prummer, Michael, Schmucki, Roland, Mason, Clive S., Bradley, Kenneth, Jacob, Asha Ivy, Lerner, Christian, Araujo del Rosario, Andrea, Burcin, Mark, Amrein, Kurt E., Prunotto, Marco

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How do cyclic antibiotics with activity against Gram-negative bacteria permeate membranes? A machine learning informed experimental study von Lee, Michelle W., de Anda, Jaime, Kroll, Carsten, Bieniossek, Christoph, Bradley, Kenneth, Amrein, Kurt E., Wong, Gerard C.L.

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Author Correction: A novel antibiotic class targeting the lipopolysaccharide transporter von Zampaloni, Claudia, Mattei, Patrizio, Bleicher, Konrad, Winther, Lotte, Thäte, Claudia, Bucher, Christian, Adam, Jean-Michel, Alanine, Alexander, Amrein, Kurt E., Baidin, Vadim, Bieniossek, Christoph, Bissantz, Caterina, Boess, Franziska, Cantrill, Carina, Clairfeuille, Thomas, Dey, Fabian, Di Giorgio, Patrick, du Castel, Pauline, Dylus, David, Dzygiel, Pawel, Felici, Antonio, García-Alcalde, Fernando, Haldimann, Andreas, Leipner, Matthew, Leyn, Semen, Louvel, Séverine, Misson, Pauline, Osterman, Andrei, Pahil, Karanbir, Rigo, Sébastien, Schäublin, Adrian, Scharf, Sebastian, Schmitz, Petra, Stoll, Theodor, Trauner, Andrej, Zoffmann, Sannah, Kahne, Daniel, Young, John A. T., Lobritz, Michael A., Bradley, Kenneth A.

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Discovery of 3‑Pyridyl Isoindolin-1-one Derivatives as Potent, Selective, and Orally Active Aldosterone Synthase (CYP11B2) Inhibitors von Liu, Yongfu, Wu, Jun, Zhou, Mingwei, Chen, Wenming, Li, Dongbo, Wang, Zhanguo, Hornsperger, Benoit, Aebi, Johannes D, Märki, Hans-Peter, Kuhn, Bernd, Wang, Lisha, Kuglstatter, Andreas, Benz, Jörg, Müller, Stephan, Hochstrasser, Remo, Ottaviani, Giorgio, Xin, Jian, Kirchner, Stephan, Mohr, Susanne, Verry, Philippe, Riboulet, William, Shen, Hong C, Mayweg, Alexander V, Amrein, Kurt, Tan, Xuefei

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Discovery of 4‑Aryl-5,6,7,8-tetrahydroisoquinolines as Potent, Selective, and Orally Active Aldosterone Synthase (CYP11B2) Inhibitors: In Vivo Evaluation in Rodents and Cynomolgus... von Martin, Rainer E, Aebi, Johannes D, Hornsperger, Benoit, Krebs, Hans-Jakob, Kuhn, Bernd, Kuglstatter, Andreas, Alker, André M, Märki, Hans Peter, Müller, Stephan, Burger, Dominique, Ottaviani, Giorgio, Riboulet, William, Verry, Philippe, Tan, Xuefei, Amrein, Kurt, Mayweg, Alexander V

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Synthesis of annulated pyridines as inhibitors of aldosterone synthase (CYP11B2) von Martin, Rainer E, Lehmann, Johannes, Alzieu, Thibaut, Lenz, Mario, Carnero Corrales, Marjorie A, Aebi, Johannes D, Märki, Hans Peter, Kuhn, Bernd, Amrein, Kurt, Mayweg, Alexander V, Britton, Robert

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11β-Hydroxysteroid dehydrogenase blockade prevents age-induced skin structure and function defects von Tiganescu, Ana, Tahrani, Abd A, Morgan, Stuart A, Otranto, Marcela, Desmouliere, Alexis, Abrahams, Lianne, Hassan-Smith, Zaki, Walker, Elizabeth A, Rabbitt, Elizabeth H, Cooper, Mark S, Kurt, Amrein, Lavery, Gareth G, Stewart, Paul M

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11 beta -Hydroxysteroid dehydrogenase 1 reductase activity is dependent on a high ratio of NADPH/NADP[super]+ and is stimulated by extracellular glucose von Dzyakanchuk, Anna A, Balazs, Zoltan, Nashev, Lyubomir G, Amrein, Kurt E, Odermatt, Alex

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THP-1 Macrophages and SGBS Adipocytes - A New Human in vitro Model System of Inflamed Adipose Tissue von Keuper, Michaela, Dzyakanchuk, Anna, Amrein, Kurt E, Wabitsch, Martin, Fischer-Posovszky, Pamela

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Separation of Fast from Slow Anabolism by Site-specific PEGylation of Insulin-like Growth Factor I (IGF-I) von Metzger, Friedrich, Sajid, Waseem, Saenger, Stefanie, Staudenmaier, Christian, van der Poel, Chris, Sobottka, Bettina, Schuler, Angelika, Sawitzky, Mandy, Poirier, Raphael, Tuerck, Dietrich, Schick, Eginhard, Schaubmar, Andreas, Hesse, Friederike, Amrein, Kurt, Loetscher, Hansruedi, Lynch, Gordon S., Hoeflich, Andreas, De Meyts, Pierre, Schoenfeld, Hans-Joachim

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Domain organization and molecular characterization of 13 two-component systems identified by genome sequencing of Streptococcus pneumoniae von Lange, Roland, Wagner, Christian, de Saizieu, Antoine, Flint, Nicholas, Molnos, Juliette, Stieger, Martin, Caspers, Patrick, Kamber, Markus, Keck, Wolfgang, Amrein, Kurt E

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Challenges and Rewards in Medicinal Chemistry Targeting Cardiovascular and Metabolic Diseases von Neidhart, Werner, Ackermann, Jean, Amrein, Kurt, Conte, Aurelia, Hunziker, Daniel, Kuhn, Bernd, Märki, Hans Peter, Nettekoven, Matthias, Ruf, Armin, Schulz-Gasch, Tanja, Mayweg, Alexander V

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Preclinical and Early Clinical Profile of a Highly Selective and Potent Oral Inhibitor of Aldosterone Synthase (CYP11B2) von Bogman, Katrijn, Schwab, Dietmar, Delporte, Marie-Laure, Palermo, Giuseppe, Amrein, Kurt, Mohr, Susanne, De Vera Mudry, Maria Cristina, Brown, Morris J, Ferber, Philippe

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11 beta -Hydroxysteroid dehydrogenase blockade prevents age-induced skin structure and function defects von Tiganescu, Ana, Tahrani, Abd A, Morgan, Stuart A, Otranto, Marcela, Desmouliere, Alexis, Abrahams, Lianne, Hassan-Smith, Zaki, Walker, Elizabeth A, Rabbitt, Elizabeth H, Cooper, Mark S, Amrein, Kurt, Lavery, Gareth G, Stewart, Paul M

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A novel antibiotic class targeting the lipopolysaccharide transporter von Zampaloni, Claudia, Mattei, Patrizio, Bleicher, Konrad, Winther, Lotte, Thäte, Claudia, Bucher, Christian, Adam, Jean-Michel, Alanine, Alexander, Amrein, Kurt E, Baidin, Vadim, Bieniossek, Christoph, Bissantz, Caterina, Boess, Franziska, Cantrill, Carina, Clairfeuille, Thomas, Dey, Fabian, Di Giorgio, Patrick, du Castel, Pauline, Dylus, David, Dzygiel, Pawel, Felici, Antonio, García-Alcalde, Fernando, Haldimann, Andreas, Leipner, Matthew, Leyn, Semen, Louvel, Séverine, Misson, Pauline, Osterman, Andrei, Pahil, Karanbir, Rigo, Sébastien, Schäublin, Adrian, Scharf, Sebastian, Schmitz, Petra, Stoll, Theodor, Trauner, Andrej, Zoffmann, Sannah, Kahne, Daniel, Young, John A. T, Lobritz, Michael A, Bradley, Kenneth A

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Protein-tyrosine Phosphatases PTP1B and Syp Are Modulators of Insulin-stimulated Translocation of GLUT4 in Transfected Rat Adipose Cells von Chen, Hui, Wertheimer, Stanley J., Lin, Chung H., Katz, Susan L., Amrein, Kurt E., Burn, Paul, Quon, Michael J.

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11β-Hydroxysteroid dehydrogenase 1 reductase activity is dependent on a high ratio of NADPH/NADP + and is stimulated by extracellular glucose von Dzyakanchuk, Anna A., Balázs, Zoltán, Nashev, Lyubomir G., Amrein, Kurt E., Odermatt, Alex

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An inflammatory micro-environment promotes human adipocyte apoptosis von Keuper, Michaela, Blüher, Matthias, Schön, Michael R., Möller, Peter, Dzyakanchuk, Anna, Amrein, Kurt, Debatin, Klaus-Michael, Wabitsch, Martin, Fischer-Posovszky, Pamela

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