Safety and Efficacy of Durvalumab (MEDI4736), an Anti-Programmed Cell Death Ligand-1 Immune Checkpoint Inhibitor, in Patients With Advanced Urothelial Bladder Cancer von Massard, Christophe, Gordon, Michael S, Sharma, Sunil, Rafii, Saeed, Wainberg, Zev A, Luke, Jason, Curiel, Tyler J, Colon-Otero, Gerardo, Hamid, Omid, Sanborn, Rachel E, O'Donnell, Peter H, Drakaki, Alexandra, Tan, Winston, Kurland, John F, Rebelatto, Marlon C, Jin, Xiaoping, Blake-Haskins, John A, Gupta, Ashok, Segal, Neil H

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Immunomodulatory Activity of Nivolumab in Metastatic Renal Cell Carcinoma von Choueiri, Toni K, Fishman, Mayer N, Escudier, Bernard, McDermott, David F, Drake, Charles G, Kluger, Harriet, Stadler, Walter M, Perez-Gracia, Jose Luis, McNeel, Douglas G, Curti, Brendan, Harrison, Michael R, Plimack, Elizabeth R, Appleman, Leonard, Fong, Lawrence, Albiges, Laurence, Cohen, Lewis, Young, Tina C, Chasalow, Scott D, Ross-Macdonald, Petra, Srivastava, Shivani, Jure-Kunkel, Maria, Kurland, John F, Simon, Jason S, Sznol, Mario

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Exposure-Response Analyses of Tremelimumab Monotherapy or in Combination with Durvalumab in Patients with Unresectable Hepatocellular Carcinoma von Song, Xuyang, Kelley, Robin Kate, Khan, Anis A, Standifer, Nathan, Zhou, Diansong, Lim, KyoungSoo, Krishna, Rajesh, Liu, Lu, Wang, Kun, McCoon, Patricia, Negro, Alejandra, He, Philip, Gibbs, Megan, Kurland, John F, Abou-Alfa, Ghassan K

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Histone Deacetylase Inhibitors Radiosensitize Human Melanoma Cells by Suppressing DNA Repair Activity von MUNSHI, Anupama, KURLAND, John F, NISHIKAWA, Takashi, TANAKA, Toshimitsu, HOBBS, Marvette L, TUCKER, Susan L, ISMAIL, Sheikh, STEVENS, Craig, MEYN, Raymond E

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Modeling of Proliferating CD4 and CD8 T‐Cell Changes to Tremelimumab Exposure in Patients with Unresectable Hepatocellular Carcinoma von Song, Xuyang, Kelley, Robin Kate, Green, Michelle, Standifer, Nathan, Lim, KyoungSoo, Zhou, Diansong, Dunyak, James, Negro, Alejandra, Kurland, John F., Ren, Song, Khan, Anis A., Gibbs, Megan, Abou‐Alfa, Ghassan K.

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Myc-mediated transcriptional repression by recruitment of histone deacetylase von Kurland, John F, Tansey, William P

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Plain language summary of the HIMALAYA study: tremelimumab and durvalumab for unresectable hepatocellular carcinoma (liver cancer) von Abou-Alfa, Ghassan K, Lau, George, Kudo, Masatoshi, Chan, Stephen L, Kelley, Robin Kate, Furuse, Junji, Sukeepaisarnjaroen, Wattana, Kang, Yoon Koo, Dao, Tu Van, De Toni, Enrico N, Rimassa, Lorenza, Breder, Valeriy, Vasilyev, Alexander, Heurgué, Alexandra, Tam, Vincent C, Mody, Kabir, Thungappa, Satheesh Chiradoni, Ostapenko, Yurii, Yau, Thomas, Azevedo, Sergio, Varela, María, Cheng, Ann-Lii, Qin, Shukui, Galle, Peter R, Ali, Sajid, Gupta, Charu, Makowsky, Mallory, Kurland, John F, Negro, Alejandra, Sangro, Bruno

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Plain language summary of the TOPAZ-1 study: durvalumab and chemotherapy for advanced biliary tract cancer von Oh, Do-Youn, He, Aiwu Ruth, Qin, Shukui, Chen, Li-Tzong, Okusaka, Takuji, Vogel, Arndt, Kim, Jin Won, Suksombooncharoen, Thatthan, Lee, Myung Ah, Kitano, Masayuki, Burris, Howard, Bouattour, Mohamed, Tanasanvimon, Suebpong, McNamara, Mairead G, Zaucha, Renata, Avallone, Antonio, Tan, Benjamin, Cundom, Juan, Lee, Choong-Kun, Takahashi, Hidenori, Ikeda, Masafumi, Chen, Jen-Shi, Wang, Julie, Makowsky, Mallory, Rokutanda, Nana, Żotkiewicz, Magdalena, Kurland, John F, Cohen, Gordon, Valle, Juan W

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Phase I–IIa study of BMS-690514, an EGFR, HER-2 and -4 and VEGFR-1 to -3 oral tyrosine kinase inhibitor, in patients with advanced or metastatic solid tumours von Soria, Jean-Charles, Baselga, José, Hanna, Nasser, Laurie, Scott A, Bahleda, Rastislav, Felip, Enriqueta, Calvo, Emiliano, Armand, Jean-Pierre, Shepherd, Frances A, Harbison, Christopher T, Berman, David, Park, Jong-Soon, Zhang, Steven, Vakkalagadda, Blisse, Kurland, John F, Pathak, Ashutosh K, Herbst, Roy S

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The MEK/ERK pathway acts upstream of NF kappa B1 (p50) homodimer activity and Bcl-2 expression in a murine B-cell lymphoma cell line. MEK inhibition restores radiation-induced apop... von Kurland, John F, Voehringer, David W, Meyn, Raymond E

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Inhibitory Effect of Ketoconazole on the Pharmacokinetics of a Multireceptor Tyrosine Kinase Inhibitor BMS-690514 in Healthy Participants: Assessing the Mechanism of the Interactio... von Yang, Zheng, Vakkalagadda, Blisse, Shen, Guoxiang, Ahlers, Christoph M., Has, Teresa, Christopher, Lisa J., Kurland, John F., Roongta, Vikram, Masson, Eric, Zhang, Steven

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Translation Inhibitors Sensitize Prostate Cancer Cells to Apoptosis Induced by Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL) by Activating c-Jun N-terminal Kinase von Sah, Nand K., Munshi, Anupama, Kurland, John F., McDonnell, Timothy J., Su, Bing, Meyn, Raymond E.

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Protease inhibitors restore radiation‐induced apoptosis to Bcl‐2‐expressing lymphoma cells von Kurland, John F., Meyn, Raymond E.

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Crashing waves of destruction: the cell cycle and APC(Cdh1) regulation of SCF(Skp2) von Kurland, John F, Tansey, William P

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Mo1250 PATHOLOGICAL COMPLETE RESPONSE (PCR) TO DURVALUMAB PLUS 5-FLUOROURACIL, LEUCOVORIN, OXALIPLATIN AND DOCETAXEL (FLOT) IN RESECTABLE GASTRIC AND GASTROESOPHAGEAL JUNCTION CANC... von Molena, Daniela, Janjigian, Yelena, Al-Batran, Salah-Eddin, Wainberg, Zev A., Van Cutsem, Eric, Muro, Kei, Hyung, Woo J., Wyrwicz, Lucjan, Oh, Do-Youn, Omori, Takeshi, Moehler, Markus, Garrido, Marcelo, Oliveira, Sulene C., Liberman, Moishe, Oliden, Victor Castro, Bilici, Mehmet, Kurland, John F., Xynos, Ioannis, Mann, Helen, Tabernero, Josep

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Inhibition of constitutively activated nuclear factor-κB radiosensitizes human melanoma cells von Munshi, Anupama, Kurland, John F., Nishikawa, Takashi, Chiao, Paul J., Andreeff, Michael, Meyn, Raymond E.

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T-cell receptor pharmacodynamics associated with survival and response to tremelimumab (T) in combination with durvalumab (D) in patients (pts) with unresectable hepatocellular car... von McCoon, Patricia, Lee, Young S, Kelley, Robin Kate, Guthrie, Violeta Beleva, Wu, Song, Bien, Stephanie A, Negro, Alejandra, He, Philip, Kurland, John, Barrett, J Carl, Pilataxi, Fernanda, Ching, Steven, Abou-Alfa, Ghassan K.

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680. P02.06 MATTERHORN PCR BY REGION von Janjigian, Yelena Y, Al-Batran, Salah-Eddin, Wainberg, Zev A, Van Cutsem, Eric, Molena, Daniela, Muro, Kei, Hyung, Woo Jin, Wyrwicz, Lucjan, Oh, Do-Youn, Omori, Takeshi, Moehler, Markus, Garrido, Marcelo, Oliveira, Sulene CS, Liberman, Moishe, Oliden, Victor Castro, Bilici, Mehmet, Kurland, John F, Xynos, Ioannis, Mann, Helen, Tabernero, Josep

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Safety and efficacy of durvalumab (MEDI4736), a PD-L1 antibody, in urothelial bladder cancer von Massard, Christophe, Gordon, Michael S., Sharma, Sunil, Rafii, Saeed, Wainberg, Zev A., Luke, Jason John, Curiel, Tyler J., Colon-Otero, Gerardo, Hamid, Omid, Sanborn, Rachel E., O'Donnell, Peter H., Drakaki, Alexandra, Kurland, John, Rebelatto, Marlon C., Jin, Xiaoping, Blake-Haskins, John A., Gupta, Ashok Kumar, Segal, Neil Howard

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Safety and clinical activity of durvalumab (MEDI4736), an anti-PD-L1 antibody, in treatment-naïve patients with advanced non‒small-cell lung cancer von Antonia, Scott Joseph, Kim, Sang-We, Spira, Alexander I., Ahn, Myung-Ju, Ou, Sai-Hong Ignatius, Stjepanovic, Neda, Fasolo, Angela, Jäger, Dirk, Ott, Patrick Alexander, Wainberg, Zev A., Wakelee, Heather A., Goldman, Jonathan Wade, Kurland, John, Rebelatto, Marlon C., Yao, Wenliang, Gupta, Ashok Kumar, Blake-Haskins, John A., Segal, Neil Howard

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