Adaptive resistance to therapeutic PD-1 blockade is associated with upregulation of alternative immune checkpoints von Koyama, Shohei, Akbay, Esra A., Li, Yvonne Y., Herter-Sprie, Grit S., Buczkowski, Kevin A., Richards, William G., Gandhi, Leena, Redig, Amanda J., Rodig, Scott J., Asahina, Hajime, Jones, Robert E., Kulkarni, Meghana M., Kuraguchi, Mari, Palakurthi, Sangeetha, Fecci, Peter E., Johnson, Bruce E., Janne, Pasi A., Engelman, Jeffrey A., Gangadharan, Sidharta P., Costa, Daniel B., Freeman, Gordon J., Bueno, Raphael, Hodi, F. Stephen, Dranoff, Glenn, Wong, Kwok-Kin, Hammerman, Peter S.

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EGFR Inhibition Enhances the Cellular Uptake and Antitumor-Activity of the HER3 Antibody-Drug Conjugate HER3-DXd von Haikala, Heidi M, Lopez, Timothy, Köhler, Jens, Eser, Pinar O, Xu, Man, Zeng, Qing, Teceno, Tyler J, Ngo, Kenneth, Zhao, Yutong, Ivanova, Elena V, Bertram, Arrien A, Leeper, Brittaney A, Chambers, Emily S, Adeni, Anika E, Taus, Luke J, Kuraguchi, Mari, Kirschmeier, Paul T, Yu, Channing, Shiose, Yoshinobu, Kamai, Yasuki, Qiu, Yang, Paweletz, Cloud P, Gokhale, Prafulla C, Jänne, Pasi A

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The Combined Effect of FGFR Inhibition and PD-1 Blockade Promotes Tumor-Intrinsic Induction of Antitumor Immunity von Palakurthi, Sangeetha, Kuraguchi, Mari, Zacharek, Sima J, Zudaire, Enrique, Huang, Wei, Bonal, Dennis M, Liu, Jeffrey, Dhaneshwar, Abha, DePeaux, Kristin, Gowaski, Martha R, Bailey, Dyane, Regan, Samuel N, Ivanova, Elena, Ferrante, Catherine, English, Jessie M, Khosla, Aditya, Beck, Andrew H, Rytlewski, Julie A, Sanders, Catherine, Laquerre, Sylvie, Bittinger, Mark A, Kirschmeier, Paul T, Packman, Kathryn, Janne, Pasi A, Moy, Christopher, Wong, Kwok-Kin, Verona, Raluca I, Lorenzi, Matthew V

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Use of Ex Vivo Patient-Derived Tumor Organotypic Spheroids to Identify Combination Therapies for HER2 Mutant Non-Small Cell Lung Cancer von Ivanova, Elena, Kuraguchi, Mari, Xu, Man, Portell, Andrew J, Taus, Luke, Diala, Irmina, Lalani, Alshad S, Choi, Jihyun, Chambers, Emily S, Li, Shuai, Liu, Shengwu, Chen, Ting, Barbie, Thanh U, Oxnard, Geoffrey R, Haworth, Jacob J, Wong, Kwok-Kin, Dahlberg, Suzanne E, Aref, Amir A, Barbie, David A, Bahcall, Magda, Paweletz, Cloud P, Jänne, Pasi A

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Apc inhibition of Wnt signaling regulates supernumerary tooth formation during embryogenesis and throughout adulthood von Wang, Xiu-Ping, O'Connell, Daniel J, Lund, Jennifer J, Saadi, Irfan, Kuraguchi, Mari, Turbe-Doan, Annick, Cavallesco, Resy, Kim, Hyunsoo, Park, Peter J, Harada, Hidemitsu, Kucherlapati, Raju, Maas, Richard L

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Adenomatous polyposis coli (APC) is required for normal development of skin and thymus von Kuraguchi, Mari, Wang, Xiu-Ping, Bronson, Roderick T, Rothenberg, Rebecca, Ohene-Baah, Nana Yaw, Lund, Jennifer J, Kucherlapati, Melanie, Maas, Richard L, Kucherlapati, Raju

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Genetic mechanisms in Apc-mediated mammary tumorigenesis von Kuraguchi, Mari, Ohene-Baah, Nana Yaw, Sonkin, Dmitriy, Bronson, Roderick Terry, Kucherlapati, Raju

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Haploinsufficiency of Flap Endonuclease (Fen1) Leads to Rapid Tumor Progression von Kucherlapati, Melanie, Yang, Kan, Kuraguchi, Mari, Zhao, Jie, Lia, Maria, Heyer, Joerg, Kane, Michael F., Fan, Kunhua, Russell, Robert, Anthony M. C. Brown, Kneitz, Burkhard, Edelmann, Winfried, Kolodner, Richard D., Lipkin, Martin, Kucherlapati, Raju

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Mbd4 Inactivation Increases C→T Transition Mutations and Promotes Gastrointestinal Tumor Formation von Wong, Edmund, Yang, Kan, Kuraguchi, Mari, Werling, Uwe, Avdievich, Elena, Fan, Kunhua, Fazzari, Melissa, Jin, Bo, Anthony M.C. Brown, Lipkin, Martin, Edelmann, Winfried

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Novel roles for MLH3 deficiency and TLE6-like amplification in DNA mismatch repair-deficient gastrointestinal tumorigenesis and progression von Chen, Peng-Chieh, Kuraguchi, Mari, Velasquez, John, Wang, Yuxun, Yang, Kan, Edwards, Robert, Gillen, Dan, Edelmann, Winfried, Kucherlapati, Raju, Lipkin, Steven M

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Abstract 3286: B-hCD94/hNKG2A mice provide a preclinical tool for evaluating therapeutic antibodies targeting human NKG2A von Shang, Chengzhang, He, Fang, Kuraguchi, Mari, Zhang, Jing, Lin, Qingcong

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Abstract 3993: In vivo efficacy of an anti-human IL11RA antibody in B-hIL11RA mice with APAP-induced liver damage von He, Fang, Zhang, Rufeng, Kuraguchi, Mari, Zhao, Lei, Yu, Zhaoxue

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Loss of Rb1 in the gastrointestinal tract of Apc1638N mice promotes tumors of the cecum and proximal colon von Kucherlapati, Melanie H, Yang, Kan, Fan, Kunhua, Kuraguchi, Mari, Sonkin, Dmitriy, Rosulek, Andrew, Lipkin, Martin, Bronson, Roderick T, Aronow, Bruce J, Kucherlapati, Raju

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A High-Throughput Immune-Oncology Screen Identifies EGFR Inhibitors as Potent Enhancers of Antigen-Specific Cytotoxic T-lymphocyte Tumor Cell Killing von Lizotte, Patrick H, Hong, Ruey-Long, Luster, Troy A, Cavanaugh, Megan E, Taus, Luke J, Wang, Stephen, Dhaneshwar, Abha, Mayman, Naomi, Yang, Aaron, Kulkarni, Meghana, Badalucco, Lauren, Fitzpatrick, Erica, Kao, Hsiang-Fong, Kuraguchi, Mari, Bittinger, Mark, Kirschmeier, Paul T, Gray, Nathanael S, Barbie, David A, Jänne, Pasi A

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Abstract 2089: Evaluating in vivo efficacy of anti-TSLP antibodies in humanized B-hTSLP/hTSLPR mice von Zhang, Shujin, Nie, Yanhui, Chang, Jiahui, Chromikova, Veronika, Yu, Luke (Zhaoxue), Kuraguchi, Mari

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Abstract 1643: B-hIL12A/hIL12B/hIL12RB1/hIL12RB2: A novel animal model for generation of IL12 therapies von Wang, Linlin, Liu, Chang, Chromikova, Veronika, Lyu, Ruili, Jin, Tianquan, Kuraguchi, Mari

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Abstract 4806: Exploring optimal targeted combination therapies with neratinib for HER2 mutated NSCLC von Kuraguchi, Mari, Taus, Luke J., Zhou, Shan, Avogadri-Connors, Francesca, Cutler, Richard E., Lalani, Alshad S., Kirschmeier, Paul, Jänne, Pasi A.

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Abstract 4778: Assessing efficacy of neratinib in HER2-driven lung cancer von Li, Shuai, Liu, Shengwu, Chen, Ting, Deng, Jiehui, Wu, Min, Kuraguchi, Mari, Tran, Cam Anh, Kirschmeier, Paul T., Avogadri-Connors, Francesca, Cutler, Richard E., Lalani, Alshad S., Wong, Kwok-Kin

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Down-regulation of β-catenin TCF signaling is linked to colonic epithelial cell differentiation von MARIADASON, John M, BORDONARO, Michael, ASLAM, Fauzia, LI SHI, KURAGUCHI, Mari, VELCICH, Anna, AUGENLICHT, Leonard H

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Tumor-associated Apc mutations in Mlh1-/- Apc1638N mice reveal a mutational signature of Mlh1 deficiency von Kuraguchi, M, Edelmann, W, Yang, K, Lipkin, M, Kucherlapati, R, Brown, A M

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