The role of AKT/mTOR pathway in stress response to UV-irradiation: implication in skin carcinogenesis by regulation of apoptosis, autophagy and senescence von Strozyk, Elwira, Kulms, Dagmar

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Neutrophil-Derived Proteases Escalate Inflammation through Activation of IL-36 Family Cytokines von Henry, Conor M., Sullivan, Graeme P., Clancy, Danielle M., Afonina, Inna S., Kulms, Dagmar, Martin, Seamus J.

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Convergence of pathway analysis and pattern recognition predicts sensitization to latest generation TRAIL therapeutics by IAP antagonism von Vetma, Vesna, Guttà, Cristiano, Peters, Nathalie, Praetorius, Christian, Hutt, Meike, Seifert, Oliver, Meier, Friedegund, Kontermann, Roland, Kulms, Dagmar, Rehm, Markus

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Focal adhesion kinase plays a dual role in TRAIL resistance and metastatic outgrowth of malignant melanoma von Del Mistro, Greta, Riemann, Shamala, Schindler, Sebastian, Beissert, Stefan, Kontermann, Roland E., Ginolhac, Aurelien, Halder, Rashi, Presta, Luana, Sinkkonen, Lasse, Sauter, Thomas, Kulms, Dagmar

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Superior Properties of Fc-comprising scTRAIL Fusion Proteins von Hutt, Meike, Marquardt, Lisa, Seifert, Oliver, Siegemund, Martin, Müller, Ines, Kulms, Dagmar, Pfizenmaier, Klaus, Kontermann, Roland E

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A cytosolic mutp53(E285K) variant confers chemoresistance of malignant melanoma von Dunsche, Luise, Ivanisenko, Nikita, Riemann, Shamala, Schindler, Sebastian, Beissert, Stefan, Angeli, Cristian, Kreis, Stephanie, Tavassoli, Mahvash, Lavrik, Inna, Kulms, Dagmar

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Mechanistically Coupled PK (MCPK) Model to Describe Enzyme Induction and Occupancy Dependent DDI of Dabrafenib Metabolism von Albrecht, Marco, Kogan, Yuri, Kulms, Dagmar, Sauter, Thomas

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BRAF Inhibitors Amplify the Proapoptotic Activity of MEK Inhibitors by Inducing ER Stress in NRAS-Mutant Melanoma von Niessner, Heike, Sinnberg, Tobias, Kosnopfel, Corinna, Smalley, Keiran S M, Beck, Daniela, Praetorius, Christian, Mai, Marion, Beissert, Stefan, Kulms, Dagmar, Schaller, Martin, Garbe, Claus, Flaherty, Keith T, Westphal, Dana, Wanke, Ines, Meier, Friedegund

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DNA damage, death receptor activation and reactive oxygen species contribute to ultraviolet radiation-induced apoptosis in an essential and independent way von KULMS, Dagmar, ZEISE, Elke, PÖPPELMANN, Birgit, SCHWARZ, Thomas

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Kinase inhibitor library screening identifies synergistic drug combinations effective in sensitive and resistant melanoma cells von Margue, Christiane, Philippidou, Demetra, Kozar, Ines, Cesi, Giulia, Felten, Paul, Kulms, Dagmar, Letellier, Elisabeth, Haan, Claude, Kreis, Stephanie

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Metabolic modelling-based in silico drug target prediction identifies six novel repurposable drugs for melanoma von Bintener, Tamara, Pacheco, Maria Pires, Philippidou, Demetra, Margue, Christiane, Kishk, Ali, Del Mistro, Greta, Di Leo, Luca, Moscardó Garcia, Maria, Halder, Rashi, Sinkkonen, Lasse, De Zio, Daniela, Kreis, Stephanie, Kulms, Dagmar, Sauter, Thomas

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Keratinocytes control skin immune homeostasis through de novo-synthesized glucocorticoids von Phan, Truong San, Schink, Leonhard, Mann, Jasmin, Merk, Verena M, Zwicky, Pascale, Mundt, Sarah, Simon, Dagmar, Kulms, Dagmar, Abraham, Susanne, Legler, Daniel F, Noti, Mario, Brunner, Thomas

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Inhibition of PI3K-AKT-mTOR Signaling Sensitizes Melanoma Cells to Cisplatin and Temozolomide von Sinnberg, Tobias, Lasithiotakis, Konstantinos, Niessner, Heike, Schittek, Birgit, Flaherty, Keith T., Kulms, Dagmar, Maczey, Evelyn, Campos, Minia, Gogel, Jeannette, Garbe, Claus, Meier, Friedegund

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Vemurafenib potently induces endoplasmic reticulum stress-mediated apoptosis in BRAFV600E melanoma cells von Beck, Daniela, Niessner, Heike, Smalley, Keiran S M, Flaherty, Keith, Paraiso, Kim H T, Busch, Christian, Sinnberg, Tobias, Vasseur, Sophie, Iovanna, Juan Lucio, Drießen, Stefan, Stork, Björn, Wesselborg, Sebastian, Schaller, Martin, Biedermann, Tilo, Bauer, Jürgen, Lasithiotakis, Konstantinos, Weide, Benjamin, Eberle, Jürgen, Schittek, Birgit, Schadendorf, Dirk, Garbe, Claus, Kulms, Dagmar, Meier, Friedegund

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Pharmacological targeting of caspase-8/c-FLIPL heterodimer enhances complex II assembly and elimination of pancreatic cancer cells von König, Corinna, Ivanisenko, Nikita V., Ivanisenko, Vladimir A., Kulms, Dagmar, Lavrik, Inna N.

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RL2 Enhances the Elimination of Breast Cancer Cells by Doxorubicin von Wohlfromm, Fabian, Seyrek, Kamil, Ivanisenko, Nikita, Troitskaya, Olga, Kulms, Dagmar, Richter, Vladimir, Koval, Olga, Lavrik, Inna N

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Identification of new IκBα complexes by an iterative experimental and mathematical modeling approach von Konrath, Fabian, Witt, Johannes, Sauter, Thomas, Kulms, Dagmar

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Combined Inhibition of MAPK and mTOR Signaling Inhibits Growth, Induces Cell Death, and Abrogates Invasive Growth of Melanoma Cells von Lasithiotakis, Konstantinos G., Sinnberg, Tobias W., Schittek, Birgit, Flaherty, Keith T., Kulms, Dagmar, Maczey, Evelyn, Garbe, Claus, Meier, Friedegund E.

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Independent contribution of three different pathways to ultraviolet-B-induced apoptosis von Kulms, Dagmar, Schwarz, Thomas

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The TAT-RasGAP317-326 anti-cancer peptide can kill in a caspase-, apoptosis-, and necroptosis-independent manner von Heulot, Mathieu, Chevalier, Nadja, Puyal, Julien, Margue, Christiane, Michel, Sébastien, Kreis, Stephanie, Kulms, Dagmar, Barras, David, Nahimana, Aimable, Widmann, Christian

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