Increasing the efficiency of homology-directed repair for CRISPR-Cas9-induced precise gene editing in mammalian cells von Chu, Van Trung, Weber, Timm, Wefers, Benedikt, Wurst, Wolfgang, Sander, Sandrine, Rajewsky, Klaus, Kühn, Ralf

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Loss of a mammalian circular RNA locus causes miRNA deregulation and affects brain function von Piwecka, Monika, Glažar, Petar, Hernandez-Miranda, Luis R., Memczak, Sebastian, Wolf, Susanne A., Rybak-Wolf, Agnieszka, Filipchyk, Andrei, Klironomos, Filippos, Jara, Cledi Alicia Cerda, Fenske, Pascal, Trimbuch, Thorsten, Zywitza, Vera, Plass, Mireya, Schreyer, Luisa, Ayoub, Salah, Kocks, Christine, Kühn, Ralf, Rosenmund, Christian, Birchmeier, Carmen, Rajewsky, Nikolaus

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Limbic corticotropin-releasing hormone receptor 1 mediates anxiety-related behavior and hormonal adaptation to stress von Wurst, Wolfgang, Müller, Marianne B, Zimmermann, Stephan, Sillaber, Inge, Hagemeyer, Thomas P, Deussing, Jan M, Timpl, Peter, Kormann, Michael S D, Droste, Susanne K, Kühn, Ralf, Reul, Johannes M H M, Holsboer, Florian

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DNA Hypomethylation Perturbs the Function and Survival of CNS Neurons in Postnatal Animals von Fan, Guoping, Beard, Caroline, Chen, Richard Z, Csankovszki, Gyorgyi, Sun, Yi, Siniaia, Marina, Biniszkiewicz, Detlev, Bates, Brian, Lee, Peggy P, Kuhn, Ralf, Trumpp, Andreas, Poon, Chi-Sang, Wilson, Christopher B, Jaenisch, Rudolf

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Cell-type-specific profiling of brain mitochondria reveals functional and molecular diversity von Fecher, Caroline, Trovò, Laura, Müller, Stephan A., Snaidero, Nicolas, Wettmarshausen, Jennifer, Heink, Sylvia, Ortiz, Oskar, Wagner, Ingrid, Kühn, Ralf, Hartmann, Jana, Karl, Rosa Maria, Konnerth, Arthur, Korn, Thomas, Wurst, Wolfgang, Merkler, Doron, Lichtenthaler, Stefan F., Perocchi, Fabiana, Misgeld, Thomas

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Efficient generation of Rosa26 knock-in mice using CRISPR/Cas9 in C57BL/6 zygotes von Chu, Van Trung, Weber, Timm, Graf, Robin, Sommermann, Thomas, Petsch, Kerstin, Sack, Ulrike, Volchkov, Pavel, Rajewsky, Klaus, Kühn, Ralf

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AMEGIC++ 1.0, A Matrix Element Generator In C++ von Krauss, Frank, Kuhn, Ralf, Soff, Gerhard

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Gene targeting by homologous recombination in mouse zygotes mediated by zinc-finger nucleases von Meyer, Melanie, de Angelis, Martin Hrabé, Wurst, Wolfgang, Kühn, Ralf, Chambon, Pierre

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Efficient CRISPR-mediated mutagenesis in primary immune cells using CrispRGold and a C57BL/6 Cas9 transgenic mouse line von Chu, Van Trung, Graf, Robin, Wirtz, Tristan, Weber, Timm, Favret, Jeremy, Li, Xun, Petsch, Kerstin, Tran, Ngoc Tung, Sieweke, Michael H., Berek, Claudia, Kühn, Ralf, Rajewsky, Klaus

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Mechanical forces couple bone matrix mineralization with inhibition of angiogenesis to limit adolescent bone growth von Dzamukova, Maria, Brunner, Tobias M., Miotla-Zarebska, Jadwiga, Heinrich, Frederik, Brylka, Laura, Mashreghi, Mir-Farzin, Kusumbe, Anjali, Kühn, Ralf, Schinke, Thorsten, Vincent, Tonia L., Löhning, Max

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Mutations in Disordered Regions Can Cause Disease by Creating Dileucine Motifs von Meyer, Katrina, Kirchner, Marieluise, Uyar, Bora, Cheng, Jing-Yuan, Russo, Giulia, Hernandez-Miranda, Luis R., Szymborska, Anna, Zauber, Henrik, Rudolph, Ina-Maria, Willnow, Thomas E., Akalin, Altuna, Haucke, Volker, Gerhardt, Holger, Birchmeier, Carmen, Kühn, Ralf, Krauss, Michael, Diecke, Sebastian, Pascual, Juan M., Selbach, Matthias

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Generation of targeted mouse mutants by embryo microinjection of TALEN mRNA von Wefers, Benedikt, Panda, Sudeepta K, Ortiz, Oskar, Brandl, Christina, Hensler, Svenja, Hansen, Jens, Wurst, Wolfgang, Kühn, Ralf

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A homology independent sequence replacement strategy in human cells using a CRISPR nuclease von Danner, Eric, Lebedin, Mikhail, de la Rosa, Kathrin, Kühn, Ralf

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Prox2 and Runx3 vagal sensory neurons regulate esophageal motility von Lowenstein, Elijah D., Ruffault, Pierre-Louis, Misios, Aristotelis, Osman, Kate L., Li, Huimin, Greenberg, Rachel S., Thompson, Rebecca, Song, Kun, Dietrich, Stephan, Li, Xun, Vladimirov, Nikita, Woehler, Andrew, Brunet, Jean-François, Zampieri, Niccolò, Kühn, Ralf, Liberles, Stephen D., Jia, Shiqi, Lewin, Gary R., Rajewsky, Nikolaus, Lever, Teresa E., Birchmeier, Carmen

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Oscillations of MyoD and Hes1 proteins regulate the maintenance of activated muscle stem cells von Lahmann, Ines, Bröhl, Dominique, Zyrianova, Tatiana, Isomura, Akihiro, Czajkowski, Maciej T, Kapoor, Varun, Griger, Joscha, Ruffault, Pierre-Louis, Mademtzoglou, Despoina, Zammit, Peter S, Wunderlich, Thomas, Spuler, Simone, Kühn, Ralf, Preibisch, Stephan, Wolf, Jana, Kageyama, Ryoichiro, Birchmeier, Carmen

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The Parkinson’s disease-linked Leucine-rich repeat kinase 2 (LRRK2) is required for insulin-stimulated translocation of GLUT4 von Funk, Natalja, Munz, Marita, Ott, Thomas, Brockmann, Kathrin, Wenninger-Weinzierl, Andrea, Kühn, Ralf, Vogt-Weisenhorn, Daniela, Giesert, Florian, Wurst, Wolfgang, Gasser, Thomas, Biskup, Saskia

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CRISPR-Cas9-Mediated ELANE Mutation Correction in Hematopoietic Stem and Progenitor Cells to Treat Severe Congenital Neutropenia von Tran, Ngoc Tung, Graf, Robin, Wulf-Goldenberg, Annika, Stecklum, Maria, Strauß, Gabriele, Kühn, Ralf, Kocks, Christine, Rajewsky, Klaus, Chu, Van Trung

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Defective metabolic programming impairs early neuronal morphogenesis in neural cultures and an organoid model of Leigh syndrome von Inak, Gizem, Rybak-Wolf, Agnieszka, Lisowski, Pawel, Pentimalli, Tancredi M., Jüttner, René, Glažar, Petar, Uppal, Karan, Bottani, Emanuela, Brunetti, Dario, Secker, Christopher, Zink, Annika, Meierhofer, David, Henke, Marie-Thérèse, Dey, Monishita, Ciptasari, Ummi, Mlody, Barbara, Hahn, Tobias, Berruezo-Llacuna, Maria, Karaiskos, Nikos, Di Virgilio, Michela, Mayr, Johannes A., Wortmann, Saskia B., Priller, Josef, Gotthardt, Michael, Jones, Dean P., Mayatepek, Ertan, Stenzel, Werner, Diecke, Sebastian, Kühn, Ralf, Wanker, Erich E., Rajewsky, Nikolaus, Schuelke, Markus, Prigione, Alessandro

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Novel human neurodevelopmental and neurodegenerative disease associated with IRF2BPL gene variants-mechanisms and therapeutic avenues von Bauersachs, Daniel, Bomholtz, Louise, Del Rey Mateos, Sara, Kühn, Ralf, Lisowski, Pawel

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Direct production of mouse disease models by embryo microinjection of TALENs and oligodeoxynucleotides von Wefers, Benedikt, Meyer, Melanie, Ortiz, Oskar, de Angelis, Martin Hrabé, Hansen, Jens, Wurst, Wolfgang, Kühn, Ralf

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