Structural Basis for G Protein-Coupled Receptor Activation von Manglik, Aashish, Kruse, Andrew C

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Distinctive Activation Mechanism for Angiotensin Receptor Revealed by a Synthetic Nanobody von Wingler, Laura M., McMahon, Conor, Staus, Dean P., Lefkowitz, Robert J., Kruse, Andrew C.

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Yeast surface display platform for rapid discovery of conformationally selective nanobodies von McMahon, Conor, Baier, Alexander S., Pascolutti, Roberta, Wegrecki, Marcin, Zheng, Sanduo, Ong, Janice X., Erlandson, Sarah C., Hilger, Daniel, Rasmussen, Søren G. F., Ring, Aaron M., Manglik, Aashish, Kruse, Andrew C.

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Autoantibodies as Endogenous Modulators of GPCR Signaling von Skiba, Meredith A., Kruse, Andrew C.

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Molecular mechanism of biased signaling in a prototypical G protein-coupled receptor von Suomivuori, Carl-Mikael, Latorraca, Naomi R., Wingler, Laura M., Eismann, Stephan, King, Matthew C., Kleinhenz, Alissa L. W., Skiba, Meredith A., Staus, Dean P., Kruse, Andrew C., Lefkowitz, Robert J., Dror, Ron O.

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Structure of the human M2 muscarinic acetylcholine receptor bound to an antagonist von Haga, Kazuko, Kruse, Andrew C., Asada, Hidetsugu, Yurugi-Kobayashi, Takami, Shiroishi, Mitsunori, Zhang, Cheng, Weis, William I., Okada, Tetsuji, Kobilka, Brian K., Haga, Tatsuya, Kobayashi, Takuya

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Muscarinic acetylcholine receptors: novel opportunities for drug development von Kruse, Andrew C., Kobilka, Brian K., Gautam, Dinesh, Sexton, Patrick M., Christopoulos, Arthur, Wess, Jürgen

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Angiotensin and biased analogs induce structurally distinct active conformations within a GPCR von Wingler, Laura M., Skiba, Meredith A., McMahon, Conor, Staus, Dean P., Kleinhenz, Alissa L. W., Suomivuori, Carl-Mikael, Latorraca, Naomi R., Dror, Ron O., Lefkowitz, Robert J., Kruse, Andrew C.

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Drug-induced phospholipidosis confounds drug repurposing for SARS-CoV-2 von Tummino, Tia A., Rezelj, Veronica V., Fischer, Benoit, Fischer, Audrey, O'Meara, Matthew J., Monel, Blandine, Vallet, Thomas, White, Kris M., Zhang, Ziyang, Alon, Assaf, Schadt, Heiko, O'Donnell, Henry R., Lyu, Jiankun, Rosales, Romel, McGovern, Briana L., Rathnasinghe, Raveen, Jangra, Sonia, Schotsaert, Michael, Galarneau, Jean-Rene, Krogan, Nevan J., Urban, Laszlo, Shokat, Kevan M., Kruse, Andrew C., Garcia-Sastre, Adolfo, Schwartz, Olivier, Moretti, Francesca, Vignuzzi, Marco, Pognan, Francois, Shoichet, Brian K.

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Structural Basis of Smoothened Activation in Hedgehog Signaling von Huang, Pengxiang, Zheng, Sanduo, Wierbowski, Bradley M., Kim, Youngchang, Nedelcu, Daniel, Aravena, Laura, Liu, Jing, Kruse, Andrew C., Salic, Adrian

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Allosteric nanobodies reveal the dynamic range and diverse mechanisms of G-protein-coupled receptor activation von Staus, Dean P., Strachan, Ryan T., Manglik, Aashish, Pani, Biswaranjan, Kahsai, Alem W., Kim, Tae Hun, Wingler, Laura M., Ahn, Seungkirl, Chatterjee, Arnab, Masoudi, Ali, Kruse, Andrew C., Pardon, Els, Steyaert, Jan, Weis, William I., Prosser, R. Scott, Kobilka, Brian K., Costa, Tommaso, Lefkowitz, Robert J.

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Identification of the gene that codes for the σ₂ receptor von Alon, Assaf, Schmidt, Hayden R., Wood, Michael D., Sahn, James J., Martin, Stephen F., Kruse, Andrew C.

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Engineering high-affinity PD-1 variants for optimized immunotherapy and immuno-PET imaging von Maute, Roy L., Gordon, Sydney R., Mayer, Aaron T., McCracken, Melissa N., Natarajan, Arutselvan, Ring, Nan Guo, Kimura, Richard, Tsai, Jonathan M., Manglik, Aashish, Kruse, Andrew C., Gambhir, Sanjiv S., Weissman, Irving L., Ring, Aaron M.

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Cryo-EM structure of the B cell co-receptor CD19 bound to the tetraspanin CD81 von Susa, Katherine J., Rawson, Shaun, Kruse, Andrew C., Blacklow, Stephen C.

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Tetraspanins: structure, dynamics, and principles of partner-protein recognition von Susa, Katherine J., Kruse, Andrew C., Blacklow, Stephen C.

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Structure and dynamics of the M3 muscarinic acetylcholine receptor von Kruse, Andrew C., Hu, Jianxin, Pan, Albert C., Arlow, Daniel H., Rosenbaum, Daniel M., Rosemond, Erica, Green, Hillary F., Liu, Tong, Chae, Pil Seok, Dror, Ron O., Shaw, David E., Weis, William I., Wess, Jürgen, Kobilka, Brian K.

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SEDS proteins are a widespread family of bacterial cell wall polymerases von Meeske, Alexander J., Riley, Eammon P., Robins, William P., Uehara, Tsuyoshi, Mekalanos, John J., Kahne, Daniel, Walker, Suzanne, Kruse, Andrew C., Bernhardt, Thomas G., Rudner, David Z.

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Crystal structure of the β2 adrenergic receptor–Gs protein complex von Rasmussen, Søren G. F., DeVree, Brian T., Zou, Yaozhong, Kruse, Andrew C., Chung, Ka Young, Kobilka, Tong Sun, Thian, Foon Sun, Chae, Pil Seok, Pardon, Els, Calinski, Diane, Mathiesen, Jesper M., Shah, Syed T. A., Lyons, Joseph A., Caffrey, Martin, Gellman, Samuel H., Steyaert, Jan, Skiniotis, Georgios, Weis, William I., Sunahara, Roger K., Kobilka, Brian K.

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Rapid generation of potent antibodies by autonomous hypermutation in yeast von Wellner, Alon, McMahon, Conor, Gilman, Morgan S. A., Clements, Jonathan R., Clark, Sarah, Nguyen, Kianna M., Ho, Ming H., Hu, Vincent J., Shin, Jung-Eun, Feldman, Jared, Hauser, Blake M., Caradonna, Timothy M., Wingler, Laura M., Schmidt, Aaron G., Marks, Debora S., Abraham, Jonathan, Kruse, Andrew C., Liu, Chang C.

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A two-step transport pathway allows the mother cell to nurture the developing spore in Bacillus subtilis von Ramírez-Guadiana, Fernando H, Meeske, Alexander J, Rodrigues, Christopher D A, Barajas-Ornelas, Rocío Del Carmen, Kruse, Andrew C, Rudner, David Z

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