Tissue inhibitor of metalloproteinases (TIMP)‐1 creates a premetastatic niche in the liver through SDF‐1/CXCR4‐dependent neutrophil recruitment in mice von Seubert, Bastian, Grünwald, Barbara, Kobuch, Julia, Cui, Haissi, Schelter, Florian, Schaten, Susanne, Siveke, Jens T., Lim, Ngee H., Nagase, Hideaki, Simonavicius, Nicole, Heikenwalder, Mathias, Reinheckel, Thomas, Sleeman, Jonathan P., Janssen, Klaus‐Peter, Knolle, Percy A., Krüger, Achim

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Systemic Ablation of MMP-9 Triggers Invasive Growth and Metastasis of Pancreatic Cancer via Deregulation of IL6 Expression in the Bone Marrow von Grünwald, Barbara, Vandooren, Jennifer, Gerg, Michael, Ahomaa, Kaarin, Hunger, Annique, Berchtold, Sonja, Akbareian, Sophia, Schaten, Susanne, Knolle, Percy, Edwards, Dylan R, Opdenakker, Ghislain, Krüger, Achim

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Selective Inhibition of the Immunoproteasome by Ligand-Induced Crosslinking of the Active Site von Dubiella, Christian, Cui, Haissi, Gersch, Malte, Brouwer, Arwin J., Sieber, Stephan A., Krüger, Achim, Liskamp, Rob M. J., Groll, Michael

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Recognizing the Molecular Multifunctionality and Interactome of TIMP-1 von Grünwald, Barbara, Schoeps, Benjamin, Krüger, Achim

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Metalloproteinase‐dependent and ‐independent processes contribute to inhibition of breast cancer cell migration, angiogenesis and liver metastasis by a disintegrin and metalloprote... von Kelwick, Richard, Wagstaff, Laura, Decock, Julie, Roghi, Christian, Cooley, Lindsay S., Robinson, Stephen D., Arnold, Hugh, Gavrilović, Jelena, Jaworski, Diane M., Yamamoto, Kazuhiro, Nagase, Hideaki, Seubert, Bastian, Krüger, Achim, Edwards, Dylan R.

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Human monocyte-derived macrophages shift subcellular metalloprotease activity depending on their activation state von Bernaerts, Eline, Ahmadzadeh, Kourosh, De Visscher, Amber, Malengier-Devlies, Bert, Häuβler, Daniel, Mitera, Tania, Martens, Erik, Krüger, Achim, De Somer, Lien, Matthys, Patrick, Vandooren, Jennifer

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Conformation-Specific Inhibitory Anti-MMP-7 Monoclonal Antibody Sensitizes Pancreatic Ductal Adenocarcinoma Cells to Chemotherapeutic Cell Kill von Mohan, Vishnu, Gaffney, Jean P, Solomonov, Inna, Levin, Maxim, Klepfish, Mordehay, Akbareian, Sophia, Grünwald, Barbara, Dym, Orly, Eisenstein, Miriam, Yu, Kenneth H, Kelsen, David P, Krüger, Achim, Edwards, Dylan R, Sagi, Irit

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Premetastatic niche formation in the liver: emerging mechanisms and mouse models von Krüger, Achim

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Tumor cell-derived and macrophage-derived cathepsin B promotes progression and lung metastasis of mammary cancer von VASILJEVA, Olga, PAPAZOGLOU, Anna, PETERS, Christoph, REINHECKEL, Thomas, KRÜGER, Achim, BRODOEFEL, Harald, KOROVIN, Matvey, DEUSSING, Jan, AUGUSTIN, Nicole, NIELSEN, Boye S, ALMHOLT, Kasper, BOGYO, Matthew

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Targeted Delivery of Proteasome Inhibitors to Somatostatin-Receptor-Expressing Cancer Cells by Octreotide Conjugation von Beck, Philipp, Cui, Haissi, Hegemann, Julian D., Marahiel, Mohammed A., Krüger, Achim, Groll, Michael

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Overexpression of the urokinase receptor splice variant uPAR-del4/5 in breast cancer cells affects cell adhesion and invasion in a dose-dependent manner and modulates transcription... von Grismayer, Bettina, Sato, Sumito, Kopitz, Charlotte, Ries, Christian, Soelch, Susanne, Schmitt, Manfred, Baretton, Gustavo, Krüger, Achim, Luther, Thomas, Kotzsch, Matthias, Magdolen, Viktor

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Systematic Comparison of Peptidic Proteasome Inhibitors Highlights the [alpha]-Ketoamide Electrophile as an Auspicious Reversible Lead Motif von Stein, Martin L, Cui, Haissi, Beck, Philipp, Dubiella, Christian, Voss, Constantin, Kruger, Achim, Schmidt, Boris, Groll, Michael

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Use of Intestinal Ultrasound to Monitor Crohn’s Disease Activity von Kucharzik, Torsten, Wittig, Bianca M, Helwig, Ulf, Börner, Norbert, Rössler, Alexander, Rath, Stefan, Maaser, Christian

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Levels of the Autophagy-Related 5 Protein Affect Progression and Metastasis of Pancreatic Tumors in Mice von Görgülü, Kivanc, Diakopoulos, Kalliope N., Ai, Jiaoyu, Schoeps, Benjamin, Kabacaoglu, Derya, Karpathaki, Angeliki-Faidra, Ciecielski, Katrin J., Kaya-Aksoy, Ezgi, Ruess, Dietrich A., Berninger, Alexandra, Kowalska, Marlena, Stevanovic, Marija, Wörmann, Sonja M., Wartmann, Thomas, Zhao, Yue, Halangk, Walter, Voronina, Svetlana, Tepikin, Alexey, Schlitter, Anna Melissa, Steiger, Katja, Artati, Anna, Adamski, Jerzy, Aichler, Michaela, Walch, Axel, Jastroch, Martin, Hartleben, Götz, Mantzoros, Christos S., Weichert, Wilko, Schmid, Roland M., Herzig, Stephan, Krüger, Achim, Sainz, Bruno, Lesina, Marina, Algül, Hana

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Overexpression of the urokinase receptor mRNA splice variant uPAR-del4/5 affects tumor-associated processes of breast cancer cells in vitro and in vivo von Sato, Sumito, Kopitz, Charlotte, Grismayer, Bettina, Beaufort, Nathalie, Reuning, Ute, Schmitt, Manfred, Luther, Thomas, Kotzsch, Matthias, Krüger, Achim, Magdolen, Viktor

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Enhanced benefit from adjuvant chemotherapy in breast cancer patients classified high-risk according to urokinase-type plasminogen activator (uPA) and plasminogen activator inhibit... von HARBECK, Nadia, KATES, Ronald E, LOOK, Maxime P, MEIJER-VAN GELDER, Marion E, KLIJN, Jan G. M, KRÜGER, Achim, KIECHLE, Marion, JÄNICKE, Fritz, SCHMITT, Manfred, FOEKENS, John A

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Inside Cover: Targeted Delivery of Proteasome Inhibitors to Somatostatin-Receptor-Expressing Cancer Cells by Octreotide Conjugation (ChemMedChem 12/2015) von Beck, Philipp, Cui, Haissi, Hegemann, Julian D., Marahiel, Mohammed A., Krüger, Achim, Groll, Michael

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The influence of the stable expression of BMP2 in fibrin clots on the remodelling and repair of osteochondral defects von Vogt, Stephan, Wexel, Gabriele, Tischer, Thomas, Schillinger, Ulrike, Ueblacker, Peter, Wagner, Bettina, Hensler, Daniel, Wilisch, Jonas, Geis, Christopher, Wübbenhorst, Daniela, Aigner, Joachim, Gerg, Michael, Krüger, Achim, Salzmann, Gian M, Martinek, Vladimir, Anton, Martina, Plank, Christian, Imhoff, Andreas B, Gansbacher, Bernd

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Pancreatic Premalignant Lesions Secrete Tissue Inhibitor of Metalloproteinases-1, Which Activates Hepatic Stellate Cells Via CD63 Signaling to Create a Premetastatic Niche in the L... von Grünwald, Barbara, Harant, Veronika, Schaten, Susanne, Frühschütz, Monika, Spallek, Ria, Höchst, Bastian, Stutzer, Katharina, Berchtold, Sonja, Erkan, Mert, Prokopchuk, Olga, Martignoni, Marc, Esposito, Irene, Heikenwalder, Mathias, Gupta, Aayush, Siveke, Jens, Saftig, Paul, Knolle, Percy, Wohlleber, Dirk, Krüger, Achim

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Tissue inhibitor of metalloproteinases-1 promotes liver metastasis by induction of hepatocyte growth factor signaling von KOPITZ, Charlotte, GERG, Michael, NAGASE, Hideaki, STANGI, Manfred, VON WEYHERN, Claus W. Hann, BRÜCHER, Björn L. D. M, BRAND, Karsten, COUSSENS, Lisa M, EDWARDS, Dylan R, KRÜGER, Achim, BANDAPALLI, Obul Reddy, ISTER, Dilek, PENNINGTON, Caroline J, HAUSER, Stephanie, FLECHSIG, Christin, KRELL, Hans-Willi, ANTOLOVIC, Dalibor, BREW, Keith

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