Adaptive Reprogramming of De Novo Pyrimidine Synthesis Is a Metabolic Vulnerability in Triple-Negative Breast Cancer von Brown, Kristin K, Spinelli, Jessica B, Asara, John M, Toker, Alex

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The phosphoinositide 3-kinase pathway and therapy resistance in cancer von Brown, Kristin K, Toker, Alex

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Yap reprograms glutamine metabolism to increase nucleotide biosynthesis and enable liver growth von Cox, Andrew G., Hwang, Katie L., Brown, Kristin K., Evason, Kimberley J., Beltz, Sebastian, Tsomides, Allison, O’Connor, Keelin, Galli, Giorgio G., Yimlamai, Dean, Chhangawala, Sagar, Yuan, Min, Lien, Evan C., Wucherpfennig, Julia, Nissim, Sahar, Minami, Akihiro, Cohen, David E., Camargo, Fernando D., Asara, John M., Houvras, Yariv, Stainier, Didier Y. R., Goessling, Wolfram

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Autolytic Proteolysis within the Function to Find Domain (FIIND) Is Required for NLRP1 Inflammasome Activity von Finger, Joshua N., Lich, John D., Dare, Lauren C., Cook, Michael N., Brown, Kristin K., Duraiswami, Chaya, Bertin, John J., Gough, Peter J.

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MERIT40 Is an Akt Substrate that Promotes Resolution of DNA Damage Induced by Chemotherapy von Brown, Kristin K., Montaser-Kouhsari, Laleh, Beck, Andrew H., Toker, Alex

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PKD Controls αvβ3 Integrin Recycling and Tumor Cell Invasive Migration through Its Substrate Rabaptin-5 von Christoforides, Claudine, Rainero, Elena, Brown, Kristin K., Norman, Jim C., Toker, Alex

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Characterization of the Src-regulated kinome identifies SGK1 as a key mediator of Src-induced transformation von Ma, Xiuquan, Zhang, Luxi, Song, Jiangning, Nguyen, Elizabeth, Lee, Rachel S., Rodgers, Samuel J., Li, Fuyi, Huang, Cheng, Schittenhelm, Ralf B., Chan, Howard, Chheang, Chanly, Wu, Jianmin, Brown, Kristin K., Mitchell, Christina A., Simpson, Kaylene J., Daly, Roger J.

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AMPK CA(R)Sts a new light on amino acid sensing von Brown, Kristin K

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S-Nitrosothiol Signaling Regulates Liver Development and Improves Outcome following Toxic Liver Injury von Cox, Andrew G., Saunders, Diane C., Kelsey, Peter B., Conway, Allie A., Tesmenitsky, Yevgenia, Marchini, Julio F., Brown, Kristin K., Stamler, Jonathan S., Colagiovanni, Dorothy B., Rosenthal, Gary J., Croce, Kevin J., North, Trista E., Goessling, Wolfram

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Direct Modification of the Proinflammatory Cytokine Macrophage Migration Inhibitory Factor by Dietary Isothiocyanates von Brown, Kristin K., Blaikie, Frances H., Smith, Robin A.J., Tyndall, Joel D.A., Lue, Hongqi, Bernhagen, Jürgen, Winterbourn, Christine C., Hampton, Mark B.

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YAP regulates an SGK1/mTORC1/SREBP-dependent lipogenic program to support proliferation and tissue growth von Vaidyanathan, Srimayee, Salmi, Talhah M., Sathiqu, Rasan M., McConville, Malcolm J., Cox, Andrew G., Brown, Kristin K.

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Biological targets of isothiocyanates von Brown, Kristin K., Hampton, Mark B.

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Glutamine addiction promotes glucose oxidation in triple-negative breast cancer von Quek, Lake-Ee, van Geldermalsen, Michelle, Guan, Yi Fang, Wahi, Kanu, Mayoh, Chelsea, Balaban, Seher, Pang, Angel, Wang, Qian, Cowley, Mark J., Brown, Kristin K., Turner, Nigel, Hoy, Andrew J., Holst, Jeff

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Yap regulates glucose utilization and sustains nucleotide synthesis to enable organ growth von Cox, Andrew G, Tsomides, Allison, Yimlamai, Dean, Hwang, Katie L, Miesfeld, Joel, Galli, Giorgio G, Fowl, Brendan H, Fort, Michael, Ma, Kimberly Y, Sullivan, Mark R, Hosios, Aaron M, Snay, Erin, Yuan, Min, Brown, Kristin K, Lien, Evan C, Chhangawala, Sagar, Steinhauser, Matthew L, Asara, John M, Houvras, Yariv, Link, Brian, Vander Heiden, Matthew G, Camargo, Fernando D, Goessling, Wolfram

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Serine Biosynthesis Is a Metabolic Vulnerability in FLT3-ITD-Driven Acute Myeloid Leukemia von Bjelosevic, Stefan, Gruber, Emily, Newbold, Andrea, Shembrey, Carolyn, Devlin, Jennifer R, Hogg, Simon J, Kats, Lev, Todorovski, Izabela, Fan, Zheng, Abrehart, Thomas C, Pomilio, Giovanna, Wei, Andrew, Gregory, Gareth P, Vervoort, Stephin J, Brown, Kristin K, Johnstone, Ricky W

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The KEAP1-NRF2 pathway regulates TFEB/TFE3-dependent lysosomal biogenesis von Ong, Athena Jessica S, Bladen, Cerys E, Tigani, Tara A, Karamalakis, Anthony P, Evason, Kimberley J, Brown, Kristin K, Cox, Andrew G

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Efficient Biocatalytic Reductive Aminations by Extending the Imine Reductase Toolbox von Roiban, Gheorghe‐Doru, Kern, Marcelo, Liu, Zhi, Hyslop, Julia, Tey, Pei Lyn, Levine, Matthew S., Jordan, Lydia S., Brown, Kristin K., Hadi, Timin, Ihnken, Leigh Anne F., Brown, Murray J. B.

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SLAM-ITseq identifies that Nrf2 induces liver regeneration through the pentose phosphate pathway von Tan, Vicky W.T., Salmi, Talhah M., Karamalakis, Anthony P., Gillespie, Andrea, Ong, Athena Jessica S., Balic, Jesse J., Chan, Yih-Chih, Bladen, Cerys E., Brown, Kristin K., Dawson, Mark A., Cox, Andrew G.

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Biocatalytic Synthesis of Chiral N‐Functionalized Amino Acids von Hyslop, Julia F., Lovelock, Sarah L., Sutton, Peter W., Brown, Kristin K., Watson, Allan J. B., Roiban, Gheorghe‐Doru

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Approaches to target tractability assessment - a practical perspective von Brown, Kristin K, Hann, Michael M, Lakdawala, Ami S, Santos, Rita, Thomas, Pamela J, Todd, Kieran

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