Structural basis for isoform-specific inhibition of human CTPS1 von Lynch, Eric M., DiMattia, Michael A., Albanese, Steven, van Zundert, Gydo C. P., Hansen, Jesse M., Quispe, Joel D., Kennedy, Madison A., Verras, Andreas, Borrelli, Kenneth, Toms, Angela V., Kaila, Neelu, Kreutter, Kevin D., McElwee, Joshua J., Kollman, Justin M.

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Discovery of JNJ-64264681: A Potent and Selective Covalent Inhibitor of Bruton’s Tyrosine Kinase von Tichenor, Mark S., Wiener, John J. M., Rao, Navin L., Bacani, Genesis M., Wei, Jianmei, Pooley Deckhut, Charlotte, Barbay, J. Kent, Kreutter, Kevin D., Chang, Leon, Clancy, Kathleen W., Murrey, Heather E., Wang, Weixue, Ahn, Kay, Huber, Michael, Rex, Elizabeth, Coe, Kevin J., Wu, Jiejun, Rui, Haopeng, Sepassi, Kia, Gaudiano, Marcello, Bekkers, Mariette, Cornelissen, Ivo, Packman, Kathryn, Seierstad, Mark, Xiouras, Christos, Bembenek, Scott D., Alexander, Richard, Milligan, Cynthia, Balasubramanian, Sriram, Lebsack, Alec D., Venable, Jennifer D., Philippar, Ulrike, Edwards, James P., Hirst, Gavin

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Discovery of a Gut-Restricted JAK Inhibitor for the Treatment of Inflammatory Bowel Disease von Leonard, Kristi A, Madge, Lisa A, Krawczuk, Paul J, Wang, Aihua, Kreutter, Kevin D, Bacani, Genesis M, Chai, Wenying, Smith, Russell C, Tichenor, Mark S, Harris, Michael C, Malaviya, Ravi, Seierstad, Mark, Johnson, Marguerite E, Venable, Jennifer D, Kim, Suzie, Hirst, Gavin C, Mathur, Ashok S, Rao, Tadimeti S, Edwards, James P, Rizzolio, Michele C, Koudriakova, Tatiana

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Identification and structure activity relationships of quinoline tertiary alcohol modulators of RORγt von Kummer, David A., Cummings, Maxwell D., Abad, Marta, Barbay, Joseph, Castro, Glenda, Wolin, Ronald, Kreutter, Kevin D., Maharoof, Umar, Milligan, Cynthia, Nishimura, Rachel, Pierce, Joan, Schalk-Hihi, Celine, Spurlino, John, Urbanski, Maud, Venkatesan, Hariharan, Wang, Aihua, Woods, Craig, Xue, Xiaohua, Edwards, James P., Fourie, Anne M., Leonard, Kristi

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6-Substituted quinolines as RORγt inverse agonists von Barbay, J. Kent, Cummings, Maxwell D., Abad, Marta, Castro, Glenda, Kreutter, Kevin D., Kummer, David A., Maharoof, Umar, Milligan, Cynthia, Nishimura, Rachel, Pierce, Joan, Schalk-Hihi, Celine, Spurlino, John, Tanis, Virginia M., Urbanski, Maud, Venkatesan, Hariharan, Wang, Aihua, Woods, Craig, Wolin, Ronald, Xue, Xiaohua, Edwards, James P., Fourie, Anne M., Leonard, Kristi

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Discovery of a Potent and Selective Covalent Inhibitor of Bruton’s Tyrosine Kinase with Oral Anti-Inflammatory Activity von Tichenor, Mark S, Wiener, John J. M, Rao, Navin L, Pooley Deckhut, Charlotte, Barbay, J. Kent, Kreutter, Kevin D, Bacani, Genesis M, Wei, Jianmei, Chang, Leon, Murrey, Heather E, Wang, Weixue, Ahn, Kay, Huber, Michael, Rex, Elizabeth, Coe, Kevin J, Wu, JieJun, Seierstad, Mark, Bembenek, Scott D, Leonard, Kristi A, Lebsack, Alec D, Venable, Jennifer D, Edwards, James P

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2-(2-Chloro-6-fluorophenyl)acetamides as potent thrombin inhibitors von Lee, Lily, Kreutter, Kevin D., Pan, Wenxi, Crysler, Carl, Spurlino, John, Player, Mark R., Tomczuk, Bruce, Lu, Tianbao

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Orally efficacious thrombin inhibitors with cyanofluorophenylacetamide as the P2 motif von Kreutter, Kevin D., Lu, Tianbao, Lee, Lily, Giardino, Edward C., Patel, Sharmila, Huang, Hui, Xu, Guozhang, Fitzgerald, Mark, Haertlein, Barbara J., Mohan, Venkatraman, Crysler, Carl, Eisennagel, Stephen, Dasgupta, Malini, McMillan, Martin, Spurlino, John C., Huebert, Norman D., Maryanoff, Bruce E., Tomczuk, Bruce E., Damiano, Bruce P., Player, Mark R.

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A novel reagent combination for the oxidation of highly electron deficient pyridines to N-oxides: trifluoromethanesulfonic anhydride/sodium percarbonate von Zhu, Xizhen, Kreutter, Kevin D., Hu, Huaping, Player, Mark R., Gaul, Micheal D.

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Composés d'imidazo[4,5-d]pyrrolo[2,3-b]pyridine comme inhibiteurs de janus kinases von WANG, Aihua, TICHENOR, Mark S, KOUDRIAKOVA, Tatiana, RIZZOLIO, Michele C, SMITH, Russell C, KREUTTER, Kevin D, LEONARD, Kristi

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Stereochemical Dependence of Base-Catalyzed Cleavage of Cyclic Peroxy Ketals von Snider, Barry B, Shi, Zhongping, O'Neil, Steven V, Kreutter, Kevin D, Arakaki, Tracy L

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Small molecule inhibitors of the jak family of kinases von Koudriakova, Tatiana, Kreutter, Kevin D, Rizzolio, Michele C, Tichenor, Mark S, Smith, Russell C, Wang, Aihua, Leonard, Kristi

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USEFUL COMPOUNDS FOR MODULATING INFLAMMATION von YANG, Sabrina Yusang, KELLEHER, III, PARK, Jason, MAHIEU, Nathaniel G, WEST, Alexander Vincent, KREUTTER, Kevin D, KASPER, Amanda Clare

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CTPS1 INHIBITORS AND USES THEREOF von VERRAS, Andreas, WEST, Angela V, CAMPOS, Sebastien, KAILA, Neelu, ALBANESE, Steven K, WHITEHEAD, Lewis, DEMARCO, Kevin, KREUTTER, Kevin D

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CTPS1 INHIBITORS AND USES THEREOF von VERRAS, Andreas, WEST, Angela V, CAMPOS, Sebastien, WHITEHEAD, Lewis, ALBANESE, Steven K, KAILA, Neelu, KREUTTER, Kevin D, DEMARCO, Kevin, ROBINSON, Shaughnessy

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Small molecule inhibitors of the JAK family of kinases von WANG, Aihua, TICHENOR, Mark S, KOUDRIAKOVA, Tatiana, RIZZOLIO, Michele C, SMITH, Russell C, KREUTTER, Kevin D, LEONARD, Kristi

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INHIBITORS OF ANTIGEN PRESENTATION BY HLA-DR von Kreutter, Kevin D, Becart, Stephane, Hirst, Gavin C, Damm-Ganamet, Kelly L, Lebsack, Alec D, Barbay, Joseph Kent

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SMALL MOLECULE INHIBITORS OF NF-KB INDUCING KINASE von Jones, William M, Krawczuk, Paul J, Kreutter, Kevin D, Eccles, Wendy, Hack, Michael D, Barbay, J. Kent, Chai, Wenying, Herrmann, Aaron T, Lebsack, Alec D, Pippel, Daniel J, Rovira, Alexander R, Wolin, Ronald L

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SMALL MOLECULE INHIBITORS OF NF-KB INDUCING KINASE von HACK, MICHAEL D, ECCLES, WENDY, HERRMANN, AARON T, KRAWCZUK, PAUL J, CHAI, WENYING, ROVIRA, ALEXANDER R, BARBAY, J. KENT, JONES, WILLIAM M, KREUTTER, KEVIN D, WOLIN, RONALD L, LEBSACK, ALEC D, PIPPEL, DANIEL J

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SMALL MOLECULE INHIBITORS OF NF-KB INDUCING KINASE von PIPPEL, DANIEL, J, WOLIN, RONALD, L, LEBSACK, ALEC, D, HACK, MICHAEL, D, ECCLES, WENDY, ROVIRA, ALEXANDER, R, CHAI, WENYING, BARBAY, J. KENT, JONES, WILLIAM, M, KREUTTER, KEVIN, D, HERRMANN, AARON, T, KRAWCZUK, PAUL, J

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