FXR agonists for NASH: How are they different and what difference do they make? von Kremoser, Claus

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Cold-induced conversion of cholesterol to bile acids in mice shapes the gut microbiome and promotes adaptive thermogenesis von Worthmann, Anna, John, Clara, Rühlemann, Malte C, Baguhl, Miriam, Heinsen, Femke-Anouska, Schaltenberg, Nicola, Heine, Markus, Schlein, Christian, Evangelakos, Ioannis, Mineo, Chieko, Fischer, Markus, Dandri, Maura, Kremoser, Claus, Scheja, Ludger, Franke, Andre, Shaul, Philip W, Heeren, Joerg

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FXR controls the tumor suppressor NDRG2 and FXR agonists reduce liver tumor growth and metastasis in an orthotopic mouse xenograft model von Deuschle, Ulrich, Schüler, Julia, Schulz, Andreas, Schlüter, Thomas, Kinzel, Olaf, Abel, Ulrich, Kremoser, Claus

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Synthetic Farnesoid X Receptor Agonists Induce High-Density Lipoprotein-Mediated Transhepatic Cholesterol Efflux in Mice and Monkeys and Prevent Atherosclerosis in Cholesteryl Este... von Hambruch, Eva, Miyazaki-Anzai, Shinobu, Hahn, Ulrike, Matysik, Silke, Boettcher, Alfred, Perović-Ottstadt, Sanja, Schlüter, Thomas, Kinzel, Olaf, Krol, Helen Desiree, Deuschle, Ulrich, Burnet, Michael, Levi, Moshe, Schmitz, Gerd, Miyazaki, Makoto, Kremoser, Claus

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The Non-Steroidal FXR Agonist Cilofexor Improves Portal Hypertension and Reduces Hepatic Fibrosis in a Rat NASH Model von Schwabl, Philipp, Hambruch, Eva, Budas, Grant R, Supper, Paul, Burnet, Michael, Liles, John T, Birkel, Manfred, Brusilovskaya, Ksenia, Königshofer, Philipp, Peck-Radosavljevic, Markus, Watkins, William J, Trauner, Michael, Breckenridge, David G, Kremoser, Claus, Reiberger, Thomas

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Free Deoxycholic Acid Exacerbates Vascular Calcification in CKD through ER Stress-Mediated ATF4 Activation von Miyazaki-Anzai, Shinobu, Masuda, Masashi, Shiozaki, Yuji, Keenan, Audrey L, Chonchol, Michel, Kremoser, Claus, Miyazaki, Makoto

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The nuclear bile acid receptor FXR controls the liver derived tumor suppressor histidine‐rich glycoprotein von Deuschle, Ulrich, Birkel, Manfred, Hambruch, Eva, Hornberger, Martin, Kinzel, Olaf, Perović‐Ottstadt, Sanja, Schulz, Andreas, Hahn, Ulrike, Burnet, Michael, Kremoser, Claus

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In vitro guidance of retinal ganglion cell axons by RAGS, a 25 kDa tectal protein related to ligands for Eph receptor tyrosine kinases von Drescher, Uwe, Kremoser, Claus, Handwerker, Claudia, Löschinger, Jürgen, Noda, Masaharu, Bonhoeffer, Friedrich

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Identification of Farnesoid X Receptor β as a Novel Mammalian Nuclear Receptor Sensing Lanosterol von Otte, Kerstin, Kranz, Harald, Kober, Ingo, Thompson, Paul, Hoefer, Michael, Haubold, Bernhard, Remmel, Bettina, Voss, Hartmut, Kaiser, Carmen, Albers, Michael, Cheruvallath, Zaccharias, Jackson, David, Casari, Georg, Koegl, Manfred, Pääbo, Svante, Mous, Jan, Kremoser, Claus, Deuschle, Ulrich

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The FXR agonist PX20606 ameliorates portal hypertension by targeting vascular remodelling and sinusoidal dysfunction von Schwabl, Philipp, Hambruch, Eva, Seeland, Berit A, Hayden, Hubert, Wagner, Michael, Garnys, Lukas, Strobel, Bastian, Schubert, Tim-Lukas, Riedl, Florian, Mitteregger, Dieter, Burnet, Michael, Starlinger, Patrick, Oberhuber, Georg, Deuschle, Ulrich, Rohr-Udilova, Nataliya, Podesser, Bruno K, Peck-Radosavljevic, Markus, Reiberger, Thomas, Kremoser, Claus, Trauner, Michael

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Intestinal Farnesoid X Receptor Controls Transintestinal Cholesterol Excretion in Mice von de Boer, Jan Freark, Schonewille, Marleen, Boesjes, Marije, Wolters, Henk, Bloks, Vincent W, Bos, Trijnie, van Dijk, Theo H, Jurdzinski, Angelika, Boverhof, Renze, Wolters, Justina C, Kuivenhoven, Jan A, van Deursen, Jan M, Oude Elferink, Ronald P.J, Moschetta, Antonio, Kremoser, Claus, Verkade, Henkjan J, Kuipers, Folkert, Groen, Albert K

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PS-133-LXR inverse agonists reduce steatosis and fibrosis in the STAM mouse model but also improve insulin sensitivity in a high fat diet mouse clamp study von Hambruch, Eva, Gege, Christian, Kinzel, Olaf, Hauser, Katharina, Birkel, Manfred, Deuschle, Ulrich, Kremoser, Claus

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Dietary α-tocopherol and atorvastatin reduce high-fat-induced lipid accumulation and down-regulate CD36 protein in the liver of guinea pigs von Podszun, Maren C., Grebenstein, Nadine, Spruss, Astrid, Schlueter, Thomas, Kremoser, Claus, Bergheim, Ina, Frank, Jan

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Abstract 1210: Targeting the IDO1-Kynurenine-AhR pathway for cancer immunotherapy von Pinto, Sheena, Steeneck, Christoph, Albers, Michael, Anderhub, Simon, Birkel, Manfred, Buselic-Wölfel, Larisa, Eisenhardt, Gisela, Kremoser, Claus, Hoffmann, Thomas, Deuschle, Ulrich

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FRI-303-How to develop a differentiated FXR agonist: GS-9674 shows a reduced side effect profile in mice, monkeys amd human phase 1 studies compared to its predecessor Px-102 von Hambruch, Eva, Hollenback, David, Liles, John, Kinzel, Olaf, Birkel, Manfred, Fink, Gero, French, Dorothy, Gege, Christian, Hornberger, Martin, Watkins, William, Kremoser, Claus

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Abstract 3588: Identification of a potent, orally bioavailable and selective MCT4 Inhibitor for the treatment of solid Warburg tumors von Hambruch, Nina, Herkert, Barbara, Gege, Christian, Mallinger, Aurelie, Fabian, Johannes, Kinzel, Olaf, Wang, Yansong, Fink, Gero, Albers, Michael, Funk, Anette, Bittman-Waetzig, Annika, Fleckenstein, Tilly, Braun, Floriane, Kremoser, Claus

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Novel substituted isoxazole FXR agonists with cyclopropyl, hydroxycyclobutyl and hydroxyazetidinyl linkers: Understanding and improving key determinants of pharmacological properti... von Kinzel, Olaf, Steeneck, Christoph, Schlüter, Thomas, Schulz, Andreas, Gege, Christian, Hahn, Ulrike, Hambruch, Eva, Hornberger, Martin, Spalwisz, Adriana, Frick, Katharina, Perović-Ottstadt, Sanja, Deuschle, Ulrich, Burnet, Michael, Kremoser, Claus

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A Novel Principle for Partial Agonism of Liver X Receptor Ligands von Albers, Michael, Blume, Beatrix, Schlueter, Thomas, Wright, Matthew B., Kober, Ingo, Kremoser, Claus, Deuschle, Ulrich, Koegl, Manfred

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A novel principle for partial agonism of liver X receptor ligands. Competitive recruitment of activators and repressors von Albers, Michael, Blume, Beatrix, Schlueter, Thomas, Wright, Matthew B, Kober, Ingo, Kremoser, Claus, Deuschle, Ulrich, Koegl, Manfred

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On the Pharmacology of Farnesoid X Receptor Agonists: Give me an “A”, Like in “Acid” von Hambruch, Eva, Kinzel, Olaf, Kremoser, Claus

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