Clinical, Pharmacodynamic, and Pharmacokinetic Evaluation of BNC105P: A Phase I Trial of a Novel Vascular Disrupting Agent and Inhibitor of Cancer Cell Proliferation von RISCHIN, Danny, BIBBY, David C, CHONG, Geoff, KREMMIDIOTIS, Gabriel, LESKE, Annabell F, MATTHEWS, ClaytonA, WONG, ShirleyS, ROSEN, Mark A, DESAI, Jayesh

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Cystin, a novel cilia-associated protein, is disrupted in the cpk mouse model of polycystic kidney disease von Hou, Xiaoying, Mrug, Michal, Yoder, Bradley K, Lefkowitz, Elliot J, Kremmidiotis, Gabriel, D'Eustachio, Peter, Beier, David R, Guay-Woodford, Lisa M

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The de novo chromosome 16 translocations of two patients with abnormal phenotypes (mental retardation and epilepsy) disrupt the A2BP1 gene von Bhalla, Kavita, Phillips, Hilary A., Crawford, Joanna, McKenzie, Olivia L. D., Mulley, John C., Eyre, Helen, Gardner, Alison E., Kremmidiotis, Gabriel, Callen, David F.

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ZNF652, A Novel Zinc Finger Protein, Interacts with the Putative Breast Tumor Suppressor CBFA2T3 to Repress Transcription von Kumar, Raman, Manning, Jantina, Spendlove, Hayley E, Kremmidiotis, Gabriel, McKirdy, Ross, Lee, Jaclyn, Millband, David N, Cheney, Kelly M, Stampfer, Martha R, Dwivedi, Prem P, Morris, Howard A, Callen, David F

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A Vascular Cell-Restricted RhoGAP, p73RhoGAP, Is a Key Regulator of Angiogenesis von Su, Zhi-Jian, Hahn, Christopher N., Goodall, Gregory J., Reck, Niamh M., Leske, Annabell F., Davy, Ann, Kremmidiotis, Gabriel, Vadas, Mathew A., Gamble, Jennifer R., Jacques F. A. P. Miller

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Abstract 1551: Identification of plasma biomarker concentration changes resulting from the administration of the Vascular Disrupting Agent BNC105 across 3 clinical trials in mesoth... von Kremmidiotis, Gabriel, Leske, Annabel, Simpson, Jeremy, Doolin, Elizabeth, Iglesias, Jose

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Discovery of 7-Hydroxy-6-methoxy-2-methyl-3-(3,4,5-trimethoxybenzoyl)benzo[b]furan (BNC105), a Tubulin Polymerization Inhibitor with Potent Antiproliferative and Tumor Vascular Dis... von Flynn, Bernard L, Gill, Gurmit S, Grobelny, Damian W, Chaplin, Jason H, Paul, Dharam, Leske, Annabell F, Lavranos, Tina C, Chalmers, David K, Charman, Susan A, Kostewicz, Edmund, Shackleford, David M, Morizzi, Julia, Hamel, Ernest, Jung, M. Katherine, Kremmidiotis, Gabriel

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Localization of Human Cadherin Genes to Chromosome Regions Exhibiting Cancer-Related Loss of Heterozygosity von Kremmidiotis, Gabriel, Baker, Elizabeth, Crawford, Joanna, Eyre, Helen J., Nahmias, Joseph, Callen, David F.

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A Phase I/II Trial of BNC105P with Everolimus in Metastatic Renal Cell Carcinoma von Pal, Sumanta, Azad, Arun, Bhatia, Shailender, Drabkin, Harry, Costello, Brian, Sarantopoulos, John, Kanesvaran, Ravindran, Lauer, Richard, Starodub, Alexander, Hauke, Ralph, Sweeney, Christopher J, Hahn, Noah M, Sonpavde, Guru, Richey, Stephen, Breen, Timothy, Kremmidiotis, Gabriel, Leske, Annabell, Doolin, Elizabeth, Bibby, David C, Simpson, Jeremy, Iglesias, Jose, Hutson, Thomas

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Abstract B92: The tubulin-targeting agent BNC105 potentiates the efficacy of immune checkpoint inhibitors in preclinical models of colorectal cancer von Lavranos, Tina C., Beaumont, Donna, Inglis, Daniel, Scherer, Michaela, Hawkins, Chloe, Leske, Annabell F., Kremmidiotis, Gabriel

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BNC105: a novel tubulin polymerization inhibitor that selectively disrupts tumor vasculature and displays single-agent antitumor efficacy von Kremmidiotis, Gabriel, Leske, Annabell F, Lavranos, Tina C, Beaumont, Donna, Gasic, Jelena, Hall, Allison, O'Callaghan, Michael, Matthews, Clayton A, Flynn, Bernard

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Abstract 4115: BNC420 is a novel VEGFR3 selective inhibitor, which unlike the pan-VEGFR inhibitor Sunitinib, suppresses lymphatic metastasis in a model of metastatic melanoma von Leske, Annabell, Lavranos, Tina, Beaumont, Donna, Brown, Chloe, Paul, Darham, Inglis, Daniel, Scherer, Michaela, Harvey, Andrew, Kremmidiotis, Gabriel

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A phase II clinical trial of the Vascular Disrupting Agent BNC105P as second line chemotherapy for advanced Malignant Pleural Mesothelioma von Nowak, Anna K, Brown, Chris, Millward, Michael J, Creaney, Jenette, Byrne, Michael J, Hughes, Brett, Kremmidiotis, Gabriel, Bibby, David C, Leske, Annabell F, Mitchell, Paul L.R, Pavlakis, Nick, Boyer, Michael, Stockler, Martin R

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Phase I study of BNC105P, carboplatin and gemcitabine in partially platinum-sensitive ovarian cancer patients in first or second relapse (ANZGOG-1103) von Lindemann, Kristina, Beale, Philip J., Rossi, Emma, Goh, Jeff C., Vaughan, Michelle M., Tenney, Meaghan E., Martyn, Julie K., Sommeijer, Dirkje, Iglesias, Jose L., Kremmidiotis, Gabriel, Simpson, Jeremy, Doolin, Elizabeth, Lavranos, Tina C., Leske, Annabell, Veillard, Anneso S., Espinoza, David, Stockler, Martin R., Rischin, Danny

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Abstract B174: Complementary activity of the vascular disruption agent BNC105 and the hypoxia-activated prodrug evofosfamide (TH-302) in suppressing the growth of preclinical renal... von Lavranos, Tina C., Inglis, Daniel, Beaumont, Donna, Leske, Annabell F., Hawkins, Chloe, Scherer, Michaela, Hart, Charles, Sun, Jessica, Elenbaas, Brian, Kremmidiotis, Gabriel

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The vascular disrupting agent BNC105 potentiates the efficacy of VEGF and mTOR inhibitors in renal and breast cancer von Inglis, Daniel J, Lavranos, Tina C, Beaumont, Donna M, Leske, Annabell F, Brown, Chloe K, Hall, Allison J, Kremmidiotis, Gabriel

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Aberrant CBFA2T3B gene promoter methylation in breast tumors von Bais, Anthony J, Gardner, Alison E, McKenzie, Olivia L D, Callen, David F, Sutherland, Grant R, Kremmidiotis, Gabriel

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Abstract B67: Induction of tumor hypoxia synergises with inhibitors of tumor metabolic and angiogenic adaptive responses to suppress tumor growth and enhance host survival von Inglis, Daniel J., Lavranos, Tina C., Beaumont, Donna M., Leske, Annabell F., Brown, Chloe K., Kremmidiotis, Gabriel

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Abstract 4039: Harnessing the tumor adaptive response to hypoxia to identify novel combinations of the vascular disrupting agent BNC105 with targeted therapeutics von Lavranos, Tina C., Inglis, Daniel J., Beaumont, Donna M., Leske, Annabell F., Brown, Chloe K., Kremmidiotis, Gabriel

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Common chromosomal fragile site FRA16D sequence : identification of the FOR gene spanning FRA16D and homozygous deletions and translocation breakpoints in cancer cells von RIED, K, FINNIS, M, BAKER, E, RICHARDS, R. I, HOBSON, L, MANGELSDORF, M, DAYAN, S, NANCARROW, J. K, WOOLLATT, E, KREMMIDIOTIS, G, GARDNER, A, VENTER, D

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