The essential reading list for AML: the m6A transcripts von Kranc, Kamil R.

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Targeting the RNA m6A Reader YTHDF2 Selectively Compromises Cancer Stem Cells in Acute Myeloid Leukemia von Paris, Jasmin, Morgan, Marcos, Campos, Joana, Spencer, Gary J., Shmakova, Alena, Ivanova, Ivayla, Mapperley, Christopher, Lawson, Hannah, Wotherspoon, David A., Sepulveda, Catarina, Vukovic, Milica, Allen, Lewis, Sarapuu, Annika, Tavosanis, Andrea, Guitart, Amelie V., Villacreces, Arnaud, Much, Christian, Choe, Junho, Azar, Ali, van de Lagemaat, Louie N., Vernimmen, Douglas, Nehme, Ali, Mazurier, Frederic, Somervaille, Tim C.P., Gregory, Richard I., O’Carroll, Dónal, Kranc, Kamil R.

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The mRNA m6A reader YTHDF2 suppresses proinflammatory pathways and sustains hematopoietic stem cell function von Mapperley, Christopher, van de Lagemaat, Louie N, Lawson, Hannah, Tavosanis, Andrea, Paris, Jasmin, Campos, Joana, Wotherspoon, David, Durko, Jozef, Sarapuu, Annika, Choe, Junho, Ivanova, Ivayla, Krause, Daniela S, von Kriegsheim, Alex, Much, Christian, Morgan, Marcos, Gregory, Richard I, Mead, Adam J, O'Carroll, Dónal, Kranc, Kamil R

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The autophagy protein Atg7 is essential for hematopoietic stem cell maintenance von Mortensen, Monika, Soilleux, Elizabeth J, Djordjevic, Gordana, Tripp, Rebecca, Lutteropp, Michael, Sadighi-Akha, Elham, Stranks, Amanda J, Glanville, Julie, Knight, Samantha, Jacobsen, Sten-Eirik W, Kranc, Kamil R, Simon, Anna Katharina

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Haematopoietic stem cell health in sickle cell disease and its implications for stem cell therapies and secondary haematological disorders von Gorur, Vishaka, Kranc, Kamil R, Ganuza, Miguel, Telfer, Paul

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Adult hematopoietic stem cells lacking Hif-1α self-renew normally von Vukovic, Milica, Sepulveda, Catarina, Subramani, Chithra, Guitart, Amélie V., Mohr, Jasmine, Allen, Lewis, Panagopoulou, Theano I., Paris, Jasmin, Lawson, Hannah, Villacreces, Arnaud, Armesilla-Diaz, Alejandro, Gezer, Deniz, Holyoake, Tessa L., Ratcliffe, Peter J., Kranc, Kamil R.

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Divide and Rule: Mitochondrial Fission Regulates Quiescence in Hematopoietic Stem Cells von Luis, Tiago C., Lawson, Hannah, Kranc, Kamil R.

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CXCR2 and CXCL4 regulate survival and self-renewal of hematopoietic stem/progenitor cells von Sinclair, Amy, Park, Laura, Shah, Mansi, Drotar, Mark, Calaminus, Simon, Hopcroft, Lisa E.M., Kinstrie, Ross, Guitart, Amelie V., Dunn, Karen, Abraham, Sheela A., Sansom, Owen, Michie, Alison M., Machesky, Laura, Kranc, Kamil R., Graham, Gerard J., Pellicano, Francesca, Holyoake, Tessa L.

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MYC sensitises cells to apoptosis by driving energetic demand von Edwards-Hicks, Joy, Su, Huizhong, Mangolini, Maurizio, Yoneten, Kubra K., Wills, Jimi, Rodriguez-Blanco, Giovanny, Young, Christine, Cho, Kevin, Barker, Heather, Muir, Morwenna, Guerrieri, Ania Naila, Li, Xue-Feng, White, Rachel, Manasterski, Piotr, Mandrou, Elena, Wills, Karen, Chen, Jingyu, Abraham, Emily, Sateri, Kianoosh, Qian, Bin-Zhi, Bankhead, Peter, Arends, Mark, Gammoh, Noor, von Kriegsheim, Alex, Patti, Gary J., Sims, Andrew H., Acosta, Juan Carlos, Brunton, Valerie, Kranc, Kamil R., Christophorou, Maria, Pearce, Erika L., Ringshausen, Ingo, Finch, Andrew J.

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Hif-2α is not essential for cell-autonomous hematopoietic stem cell maintenance von Guitart, Amelie V., Subramani, Chithra, Armesilla-Diaz, Alejandro, Smith, Gillian, Sepulveda, Catarina, Gezer, Deniz, Vukovic, Milica, Dunn, Karen, Pollard, Patrick, Holyoake, Tessa L., Enver, Tariq, Ratcliffe, Peter J., Kranc, Kamil R.

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Lineage tracing of Pf4-Cre marks hematopoietic stem cells and their progeny von Calaminus, Simon D J, Guitart, Amelie V, Guitart, Amelie, Sinclair, Amy, Schachtner, Hannah, Watson, Steve P, Holyoake, Tessa L, Kranc, Kamil R, Machesky, Laura M

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A time- and single-cell-resolved model of murine bone marrow hematopoiesis von Kucinski, Iwo, Campos, Joana, Barile, Melania, Severi, Francesco, Bohin, Natacha, Moreira, Pedro N, Allen, Lewis, Lawson, Hannah, Haltalli, Myriam L R, Kinston, Sarah J, O'Carroll, Dónal, Kranc, Kamil R, Göttgens, Berthold

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Hif-1α and Hif-2α synergize to suppress AML development but are dispensable for disease maintenance von Vukovic, Milica, Guitart, Amelie V, Sepulveda, Catarina, Villacreces, Arnaud, O'Duibhir, Eoghan, Panagopoulou, Theano I, Ivens, Alasdair, Menendez-Gonzalez, Juan, Iglesias, Juan Manuel, Allen, Lewis, Glykofrydis, Fokion, Subramani, Chithra, Armesilla-Diaz, Alejandro, Post, Annemarie E M, Schaak, Katrin, Gezer, Deniz, So, Chi Wai Eric, Holyoake, Tessa L, Wood, Andrew, O'Carroll, Dónal, Ratcliffe, Peter J, Kranc, Kamil R

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Ca2+tapulting HSCs into action von Guitart, Amelie V., Finch, Andrew J., Kranc, Kamil R.

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Mannose metabolism inhibition sensitizes acute myeloid leukaemia cells to therapy by driving ferroptotic cell death von Woodley, Keith, Dillingh, Laura S., Giotopoulos, George, Madrigal, Pedro, Rattigan, Kevin M., Philippe, Céline, Dembitz, Vilma, Magee, Aoife M. S., Asby, Ryan, van de Lagemaat, Louie N., Mapperley, Christopher, James, Sophie C., Prehn, Jochen H. M., Tzelepis, Konstantinos, Rouault-Pierre, Kevin, Vassiliou, George S., Kranc, Kamil R., Helgason, G. Vignir, Huntly, Brian J. P., Gallipoli, Paolo

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Hypoxia-inducible factor 1 (HIF-1) is a new therapeutic target in JAK2V617F-positive myeloproliferative neoplasms von Baumeister, Julian, Chatain, Nicolas, Hubrich, Annika, Maié, Tiago, Costa, Ivan G., Denecke, Bernd, Han, Lijuan, Küstermann, Caroline, Sontag, Stephanie, Seré, Kristin, Strathmann, Klaus, Zenke, Martin, Schuppert, Andreas, Brümmendorf, Tim H., Kranc, Kamil R., Koschmieder, Steffen, Gezer, Deniz

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hsa-mir183/EGR1–mediated regulation of E2F1 is required for CML stem/progenitor cell survival von Pellicano, Francesca, Park, Laura, Hopcroft, Lisa E.M., Shah, Mansi M., Jackson, Lorna, Scott, Mary T., Clarke, Cassie J., Sinclair, Amy, Abraham, Sheela A., Hair, Alan, Helgason, G. Vignir, Aspinall-O'Dea, Mark, Bhatia, Ravi, Leone, Gustavo, Kranc, Kamil R., Whetton, Anthony D., Holyoake, Tessa L.

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Gata2 as a Crucial Regulator of Stem Cells in Adult Hematopoiesis and Acute Myeloid Leukemia von Menendez-Gonzalez, Juan Bautista, Vukovic, Milica, Abdelfattah, Ali, Saleh, Lubaid, Almotiri, Alhomidi, Thomas, Leigh-anne, Agirre-Lizaso, Aloña, Azevedo, Aleksandra, Menezes, Ana Catarina, Tornillo, Giusy, Edkins, Sarah, Kong, Kay, Giles, Peter, Anjos-Afonso, Fernando, Tonks, Alex, Boyd, Ashleigh S., Kranc, Kamil R., Rodrigues, Neil P.

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A functional screen of RNA binding proteins identifies genes that promote or limit the accumulation of CD138+ plasma cells von Turner, David J, Saveliev, Alexander, Salerno, Fiamma, Matheson, Louise S, Screen, Michael, Lawson, Hannah, Wotherspoon, David, Kranc, Kamil R, Turner, Martin

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m6A RNA modifications: Key regulators of normal and malignant hematopoiesis von Sommerkamp, Pia, Brown, Jessie A., Haltalli, Myriam L.R., Mercier, François E., Vu, Ly P., Kranc, Kamil R.

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